REACTOME_SIGNALING_BY_PTK6			Return to index
Order	Gene	Description	ref_hepatocyte	HepG2	HepG2.C3A	HuH.7	SNU475	THLE	liver
1	UBB	Polyubiquitin-B	[1]	-1.35[2]	-1.27[3]	-1.32[4]	-1.69[5]	-1.36[6]	-0.85[7]
2	RPS27A	Ubiquitin-40S ribosomal protein S27a	[8]	[9]	[10]	[11]	[12]	[13]	[14]
3	UBC	Polyubiquitin-C	[15]	-0.91[16]	-0.52[17]	-0.96[18]	-0.84[19]	-0.98[20]	-0.40[21]
4	RHOA	Transforming protein RhoA	[22]	-0.09[23]	-0.31[24]	-0.29[25]	-0.14[26]	0.19[27]	-0.30[28]
5	SFPQ	Splicing factor, proline- and glutamine-rich	[29]	0.51[30]	0.59[31]	0.72[32]	0.71[33]	0.52[34]	-0.04[35]
6	UBA52	Ubiquitin-60S ribosomal protein L40	[36]	1.52[37]	1.71[38]	2.55[39]	0.56[40]	1.24[41]	0.37[42]
7	RAC1	Ras-related C3 botulinum toxin substrate 1	[43]	0.45[44]	0.40[45]	0.91[46]	1.10[47]	0.96[48]	0.06[49]
8	AKT1	RAC-alpha serine/threonine-protein kinase	[50]	0.93[51]	0.97[52]	-0.31[53]	1.04[54]	0.93[55]	0.78[56]
9	STAT3	Signal transducer and activator of transcription 3	[57]	1.40[58]	0.18[59]	0.71[60]	1.33[61]	0.48[62]	3.43[63]
10	HIF1A	Hypoxia-inducible factor 1-alpha	[64]	0.69[65]	0.64[66]	1.24[67]	3.37[68]	3.63[69]	0.22[70]
11	STAP2	Signal-transducing adaptor protein 2	[71]	-1.59[72]	0.59[73]	-1.53[74]	-4.09[75]	-2.12[76]	-1.04[77]
12	CCND1	G1/S-specific cyclin-D1	[78]	3.90[79]	1.67[80]	2.30[81]	2.97[82]	1.36[83]	2.08[84]
13	CDK4	Cyclin-dependent kinase 4	[85]	2.18[86]	3.04[87]	2.47[88]	1.27[89]	1.79[90]	0.19[91]
14	CRK	Adapter molecule crk	[92]	0.64[93]	0.86[94]	0.72[95]	0.85[96]	1.12[97]	1.87[98]
15	PELP1	Proline-, glutamic acid- and leucine-rich protein 1	[99]	1.16[100]	0.65[101]	1.42[102]	0.94[103]	0.45[104]	-1.20[105]
16	KHDRBS1	KH domain-containing, RNA-binding, signal transduction-associated protein 1		1.92[106]	1.90[107]	2.87[108]	2.30[109]	1.98[110]	0.31[111]
17	NRAS	GTPase NRas	[112]	1.47[113]	2.19[114]	2.40[115]	2.08[116]	1.53[117]	0.78[118]
18	CDKN1B	Cyclin-dependent kinase inhibitor 1B	[119]	0.76[120]	1.48[121]	1.48[122]	-0.02[123]	0.32[124]	0.12[125]
19	EPAS1	Endothelial PAS domain-containing protein 1	[126]	3.55[127]	3.04[128]	2.50[129]	0.52[130]	3.41[131]	2.95[132]
20	CDK2	Cyclin-dependent kinase 2	[133]	0.43[134]	0.88[135]	1.05[136]	1.07[137]	1.53[138]	-1.16[139]
21	HRAS	GTPase HRas	[140]	-0.16[141]	-0.59[142]	-1.58[143]	0.14[144]	-0.20[145]	-1.63[146]
22	SOCS3	Suppressor of cytokine signaling 3	[147]	-3.29[148]	-3.43[149]	-1.91[150]	0.29[151]	-0.91[152]	1.16[153]
23	KHDRBS3	KH domain-containing, RNA-binding, signal transduction-associated protein 3		-1.26[154]	-0.71[155]	-4.64[156]	-5.91[157]	-2.51[158]	-1.54[159]
24	BCAR1	Breast cancer anti-estrogen resistance protein 1	[160]	1.98[161]	2.13[162]	0.81[163]	2.46[164]	2.06[165]	1.09[166]
25	PXN	Paxillin	[167]	1.85[168]	1.84[169]	1.68[170]	3.20[171]	3.04[172]	0.67[173]
26	KRAS	GTPase KRas	[174]	0.33[175]	0.59[176]	1.99[177]	1.89[178]	1.42[179]	1.70[180]
27	PTPN1	Tyrosine-protein phosphatase non-receptor type 1	[181]	1.96[182]	1.90[183]	1.23[184]	2.91[185]	2.08[186]	0.72[187]
28	ERBB3	Receptor tyrosine-protein kinase erbB-3	[188]	2.85[189]	4.51[190]	3.35[191]	-4.78[192]	-4.66[193]	3.33[194]
29	NR3C1	Glucocorticoid receptor	[195]	0.88[196]	0.74[197]	0.84[198]	2.56[199]	2.55[200]	2.80[201]
30	ARAP1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1		2.99[202]	2.40[203]	1.72[204]	2.48[205]	1.87[206]	2.47[207]
31	ERBB2	Receptor tyrosine-protein kinase erbB-2	[208]	3.22[209]	2.32[210]	3.29[211]	2.34[212]	1.82[213]	1.18[214]
32	ELMO2	Engulfment and cell motility protein 2	[215]	1.81[216]	2.26[217]	0.45[218]	2.53[219]	1.41[220]	1.19[221]
33	EGFR	Epidermal growth factor receptor	[222]	0.15[223]	0.05[224]	2.73[225]	1.52[226]	2.01[227]	3.68[228]
34	ARHGAP35	Rho GTPase-activating protein 35	[229]	3.19[230]	3.60[231]	3.94[232]	3.82[233]	3.27[234]	4.29[235]
35	CCNE1	G1/S-specific cyclin-E1	[236]	2.08[237]	2.47[238]	0.46[239]	0.68[240]	1.15[241]	-3.60[242]
36	RASA1	Ras GTPase-activating protein 1	[243]	1.22[244]	2.42[245]	2.32[246]	3.00[247]	1.93[248]	2.24[249]
37	DOCK1	Dedicator of cytokinesis protein 1	[250]	2.83[251]	3.64[252]	3.43[253]	-1.56[254]	3.12[255]	3.54[256]
38	HBEGF	Proheparin-binding EGF-like growth factor	[257]	-0.14[258]	-0.67[259]	-1.94[260]	1.39[261]	0.95[262]	-1.40[263]
39	GPNMB	Transmembrane glycoprotein NMB	[264]	-0.03[265]	1.26[266]	1.44[267]	3.50[268]	4.26[269]	1.15[270]
40	ELMO1	Engulfment and cell motility protein 1	[271]	-4.96[272]	-3.00[273]	1.00[274]	-2.47[275]	-5.41[276]	3.88[277]
41	NRG1	Pro-neuregulin-1, membrane-bound isoform	[278]	1.18[279]	-4.68[280]	-1.99[281]	3.14[282]	-4.46[283]	1.80[284]
42	DOK1	Docking protein 1	[285]	-0.45[286]	-0.58[287]	2.43[288]	1.34[289]	2.62[290]	0.75[291]
43	BTC	Probetacellulin	[292]	-7.30[293]	-7.41[294]	-3.39[295]	-1.79[296]	-1.94[297]	-1.89[298]
44	NRG4	Pro-neuregulin-4, membrane-bound isoform	[299]	-3.25[300]	-0.09[301]	-0.34[302]	1.37[303]	-0.95[304]	0.09[305]
45	PTK6	Protein-tyrosine kinase 6	[306]	-0.28[307]	2.21[308]	0.25[309]	-0.57[310]	-1.12[311]	0.45[312]
46	CBL	E3 ubiquitin-protein ligase CBL	[313]	5.29[314]	4.52[315]	4.54[316]	6.22[317]	5.58[318]	4.78[319]
47	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2	[320]	[321]	-3.72[322]	[323]	0.51[324]	4.50[325]	5.66[326]
48	EREG	Proepiregulin	[327]	2.60[328]	2.80[329]	-1.81[330]	-0.48[331]	4.64[332]	-0.45[333]
49	EGF	Pro-epidermal growth factor	[334]	2.81[335]	4.88[336]	8.29[337]	10.11[338]	7.40[339]	2.60[340]
50	NRG2	Pro-neuregulin-2, membrane-bound isoform	[341]	[342]	[343]	[344]	[345]	[346]	[347]
51	NRG3	Pro-neuregulin-3, membrane-bound isoform	[348]	[349]	[350]	[351]	[352]	[353]	[354]
52	SRMS	Tyrosine-protein kinase Srms	[355]	[356]	[357]	[358]	[359]	[360]	[361]
53	KHDRBS2	KH domain-containing, RNA-binding, signal transduction-associated protein 2		[362]	[363]	[364]	[365]	[366]	[367]
54	ERBB4	Receptor tyrosine-protein kinase erbB-4	[368]	[369]	[370]	[371]	[372]	[373]	[374]