REACTOME_SIGNALING_BY_PDGFR_IN_DISEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.02[2] -1.65[3] -1.24[4] -0.78[5] -1.02[6] 0.75[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.67[9] 0.33[10] 0.12[11] -0.47[12] -0.06[13] -1.36[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -0.60[16] -1.70[17] -0.91[18] 1.50[19] -0.27[20] -0.71[21]
4 NRAS GTPase NRas [22] 0.10[23] 0.36[24] 0.44[25] -0.03[26] 0.04[27] -1.91[28]
5 GOLGA4 Golgin subfamily A member 4 [29] -1.52[30] 0.92[31] 1.06[32] -1.05[33] -0.29[34] 0.73[35]
6 HRAS GTPase HRas [36] -1.54[37] -2.42[38] -3.54[39] -1.97[40] -1.70[41] -4.32[42]
7 FIP1L1 Pre-mRNA 3'-end-processing factor FIP1 [43] -1.26[44] -1.14[45] -1.33[46] -0.96[47] -0.69[48] -2.52[49]
8 KRAS GTPase KRas [50] -1.04[51] -1.24[52] 0.03[53] -0.22[54] -0.07[55] -0.98[56]
9 KANK1 KN motif and ankyrin repeat domain-containing protein 1 [57] 1.48[58] 1.45[59] 0.57[60] -1.87[61] -1.64[62] 0.96[63]
10 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [64] -1.00[65] -1.06[66] -0.29[67] 1.04[68] 1.04[69] 1.34[70]
11 SOS1 Son of sevenless homolog 1 [71] -0.63[72] 0.72[73] -0.09[74] -0.18[75] -0.45[76] -1.12[77]
12 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [78] 1.35[79] 1.39[80] 1.68[81] -0.32[82] 0.73[83] -1.95[84]
13 WDR48 WD repeat-containing protein 48 [85] 0.52[86] 1.20[87] 1.07[88] -0.53[89] 0.55[90] -0.44[91]
14 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.68[92] 1.01[93] 0.85[94] 0.03[95] 0.68[96] -0.50[97]
15 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.91[98] 0.55[99] 0.42[100] 0.10[101] 0.80[102] 0.26[103]
16 ETV6 Transcription factor ETV6 [104] -0.20[105] -0.32[106] -0.51[107] 0.64[108] 0.72[109] -0.07[110]
17 STRN Striatin [111] 1.44[112] 2.22[113] 1.52[114] 2.30[115] 2.69[116] 1.24[117]
18 BIN2 Bridging integrator 2 [118] -6.72[119] -6.67[120] -10.11[121] -7.30[122] -8.27[123] -0.23[124]
19 PDGFRA Platelet-derived growth factor receptor alpha [125] -4.15[126] -5.30[127] 2.01[128] -0.50[129] 4.67[130] 3.66[131]
20 KDR Vascular endothelial growth factor receptor 2 [132] -6.15[133] -7.99[134] -7.60[135] -2.76[136] 4.19[137] 4.64[138]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte GOLGA4
Mean 12.5
Standard deviation 8
Values 22 20 7.9 7.2 5
[30]
HepG2 GOLGA4
Mean 13.8
Standard deviation 4
Values 11 17
[31]
HepG2.C3A GOLGA4
Mean 75.7
Standard deviation 2.1
Values 74 77
[32]
HuH.7 GOLGA4
Mean 100
Standard deviation 33
Values 91 1.4e+02 73
[33]
SNU475 GOLGA4
Mean 22.5
Standard deviation 6
Values 18 27
[34]
THLE GOLGA4
Mean 30.4
Standard deviation 15
Values 41 20
[35]
liver GOLGA4
Mean 93
Standard deviation 19
Values 98 1.1e+02 65 98
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte FIP1L1
Mean 10.9
Standard deviation 7.6
Values 11 11 23 6.3 2.8
[44]
HepG2 FIP1L1
Mean 14.4
Standard deviation 1.5
Values 13 15
[45]
HepG2.C3A FIP1L1
Mean 15.9
Standard deviation 1.3
Values 15 17
[46]
HuH.7 FIP1L1
Mean 16.7
Standard deviation 1.9
Values 18 15 18
[47]
SNU475 FIP1L1
Mean 20.9
Standard deviation 2
Values 20 22
[48]
THLE FIP1L1
Mean 20.1
Standard deviation 2
Values 19 22
[49]
liver FIP1L1
Mean 8.49
Standard deviation 1.1
Values 8.8 9.6 8.6 6.9
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte KANK1
Mean 8.36
Standard deviation 2.5
Values 12 7.4 5.5 8.5 8.2
[58]
HepG2 KANK1
Mean 74.3
Standard deviation 3.3
Values 72 77
[59]
HepG2.C3A KANK1
Mean 73.1
Standard deviation 12
Values 81 65
[60]
HuH.7 KANK1
Mean 47.9
Standard deviation 12
Values 45 61 37
[61]
SNU475 KANK1
Mean 8.52
Standard deviation 2.1
Values 10 7
[62]
THLE KANK1
Mean 7.96
Standard deviation 0.9
Values 7.3 8.6
[63]
liver KANK1
Mean 73.1
Standard deviation 24
Values 47 95 59 91
[64]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[65]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[66]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[67]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[68]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[69]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[70]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[71]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[72]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[73]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[74]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[75]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[76]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[77]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[78]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[79]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[80]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[81]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[82]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[83]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[84]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[85]
ref_hepatocyte WDR48
Mean 3.72
Standard deviation 0.86
Values 4.8 3.8 4.3 2.9 2.9
[86]
HepG2 WDR48
Mean 17
Standard deviation 4.7
Values 14 20
[87]
HepG2.C3A WDR48
Mean 27.4
Standard deviation 4.4
Values 31 24
[88]
HuH.7 WDR48
Mean 30.1
Standard deviation 1.1
Values 31 30 29
[89]
SNU475 WDR48
Mean 9.62
Standard deviation 1.2
Values 10 8.8
[90]
THLE WDR48
Mean 16.2
Standard deviation 0.42
Values 16 17
[91]
liver WDR48
Mean 12.3
Standard deviation 2.1
Values 11 15 12 11
[92]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[93]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[94]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[95]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[96]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[97]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[98]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[99]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[100]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[101]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[102]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[103]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[104]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[105]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[106]
ref_hepatocyte ETV6
Mean 1.23
Standard deviation 0.82
Values 0.7 0.22 1.6 2.4 1.3
[107]
HepG2 ETV6
Mean 3.42
Standard deviation 0.44
Values 3.7 3.1
[108]
HepG2.C3A ETV6
Mean 3.16
Standard deviation 0.23
Values 3.3 3
[109]
HuH.7 ETV6
Mean 3.34
Standard deviation 0.2
Values 3.2 3.6 3.3
[110]
SNU475 ETV6
Mean 7.17
Standard deviation 0.95
Values 6.5 7.8
[111]
THLE ETV6
Mean 6.06
Standard deviation 0.68
Values 6.5 5.6
[112]
liver ETV6
Mean 5.28
Standard deviation 1.4
Values 5.8 5.3 3.4 6.6
[113]
ref_hepatocyte STRN
Mean 1.09
Standard deviation 0.66
Values 1 1.8 1.7 0.36 0.54
[114]
HepG2 STRN
Mean 9.37
Standard deviation 2.4
Values 7.7 11
[115]
HepG2.C3A STRN
Mean 16.3
Standard deviation 1.3
Values 15 17
[116]
HuH.7 STRN
Mean 12
Standard deviation 3.1
Values 14 14 8.4
[117]
SNU475 STRN
Mean 20
Standard deviation 0.35
Values 20 20
[118]
THLE STRN
Mean 20.8
Standard deviation 0.87
Values 20 21
[119]
liver STRN
Mean 11.5
Standard deviation 5
Values 9.4 16 5.4 15
[120]
ref_hepatocyte BIN2
Mean 0.615
Standard deviation 0.91
Values 0 0 0.16 0.77 2.1
[121]
HepG2 BIN2
Mean 0.0186
Standard deviation 0.01
Values 0.011 0.026
[122]
HepG2.C3A BIN2
Mean 0.0194
Standard deviation 0.027
Values 0.039 0
[123]
HuH.7 BIN2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[124]
SNU475 BIN2
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[125]
THLE BIN2
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[126]
liver BIN2
Mean 2.35
Standard deviation 0.59
Values 1.9 1.9 3.1 2.5
[127]
ref_hepatocyte PDGFRA
Mean 0.51
Standard deviation 0.67
Values 0 0.018 1.5 0.93 0.11
[128]
HepG2 PDGFRA
Mean 0.0916
Standard deviation 0.016
Values 0.08 0.1
[129]
HepG2.C3A PDGFRA
Mean 0.0414
Standard deviation 0.017
Values 0.029 0.054
[130]
HuH.7 PDGFRA
Mean 7.89
Standard deviation 0.88
Values 8.3 8.5 6.9
[131]
SNU475 PDGFRA
Mean 1.35
Standard deviation 1.4
Values 0.38 2.3
[132]
THLE PDGFRA
Mean 38.6
Standard deviation 7.6
Values 33 44
[133]
liver PDGFRA
Mean 28.9
Standard deviation 13
Values 23 35 15 43
[134]
ref_hepatocyte KDR
Mean 0.384
Standard deviation 0.38
Values 0.021 0.075 0.38 0.47 0.98
[135]
HepG2 KDR
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[136]
HepG2.C3A KDR
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[137]
HuH.7 KDR
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[138]
SNU475 KDR
Mean 0.211
Standard deviation 0.25
Values 0.037 0.39
[139]
THLE KDR
Mean 20.9
Standard deviation 3.6
Values 18 23
[140]
liver KDR
Mean 42.9
Standard deviation 25
Values 17 76 45 33