REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.06[2] -1.32[3] -1.05[4] -0.94[5] -0.99[6] 0.95[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.70[9] 0.66[10] 0.31[11] -0.63[12] -0.04[13] -1.16[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -0.57[16] -1.36[17] -0.73[18] 1.35[19] -0.24[20] -0.51[21]
4 NRAS GTPase NRas [22] 0.13[23] 0.69[24] 0.63[25] -0.18[26] 0.06[27] -1.71[28]
5 HRAS GTPase HRas [29] -1.50[30] -2.08[31] -3.35[32] -2.13[33] -1.67[34] -4.12[35]
6 KRAS GTPase KRas [36] -1.01[37] -0.91[38] 0.22[39] -0.38[40] -0.05[41] -0.79[42]
7 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [43] -0.97[44] -0.72[45] -0.11[46] 0.89[47] 1.06[48] 1.54[49]
8 SOS1 Son of sevenless homolog 1 [50] -0.60[51] 1.06[52] 0.09[53] -0.34[54] -0.43[55] -0.92[56]
9 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [57] 1.38[58] 1.73[59] 1.86[60] -0.47[61] 0.76[62] -1.75[63]
10 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.72[64] 1.35[65] 1.03[66] -0.13[67] 0.70[68] -0.30[69]
11 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.88[70] 0.89[71] 0.60[72] -0.05[73] 0.83[74] 0.45[75]
12 PDGFRA Platelet-derived growth factor receptor alpha [76] -4.12[77] -4.97[78] 2.19[79] -0.65[80] 4.70[81] 3.86[82]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[37]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[38]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[39]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[40]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[41]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[42]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[43]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[44]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[45]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[46]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[47]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[48]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[49]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[58]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[59]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[60]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[61]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[62]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[63]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[64]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[65]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[66]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[67]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[68]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[69]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[70]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[71]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[72]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[73]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[74]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[75]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[76]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[77]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[78]
ref_hepatocyte PDGFRA
Mean 0.51
Standard deviation 0.67
Values 0 0.018 1.5 0.93 0.11
[79]
HepG2 PDGFRA
Mean 0.0916
Standard deviation 0.016
Values 0.08 0.1
[80]
HepG2.C3A PDGFRA
Mean 0.0414
Standard deviation 0.017
Values 0.029 0.054
[81]
HuH.7 PDGFRA
Mean 7.89
Standard deviation 0.88
Values 8.3 8.5 6.9
[82]
SNU475 PDGFRA
Mean 1.35
Standard deviation 1.4
Values 0.38 2.3
[83]
THLE PDGFRA
Mean 38.6
Standard deviation 7.6
Values 33 44
[84]
liver PDGFRA
Mean 28.9
Standard deviation 13
Values 23 35 15 43