REACTOME_SIGNALING_BY_PDGF | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PLG | Plasminogen | [1] | -12.10[2] | -9.32[3] | -2.13[4] | -13.29[5] | -10.97[6] | -0.37[7] |
2 | FURIN | Furin | [8] | 1.29[9] | -1.80[10] | 0.03[11] | -2.38[12] | -1.27[13] | 0.58[14] |
3 | STAT3 | Signal transducer and activator of transcription 3 | [15] | 0.21[16] | -0.62[17] | -0.22[18] | -0.87[19] | -0.95[20] | 1.34[21] |
4 | SPP1 | Osteopontin | [22] | 2.83[23] | 2.27[24] | -6.57[25] | 0.79[26] | -6.63[27] | -2.15[28] |
5 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [29] | 0.10[30] | 1.20[31] | 0.82[32] | -0.22[33] | 1.06[34] | 0.19[35] |
6 | GRB2 | Growth factor receptor-bound protein 2 | [36] | 0.85[37] | 1.36[38] | 1.14[39] | -0.56[40] | 0.00[41] | -0.77[42] |
7 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [43] | -0.42[44] | -0.67[45] | 0.10[46] | 1.42[47] | -0.20[48] | -0.12[49] |
8 | CRK | Adapter molecule crk | [50] | -0.55[51] | 0.06[52] | -0.22[53] | -1.35[54] | -0.31[55] | -0.23[56] |
9 | STAT6 | Signal transducer and activator of transcription 6 | [57] | 0.01[58] | 0.92[59] | -0.51[60] | -0.26[61] | 0.28[62] | -0.37[63] |
10 | NRAS | GTPase NRas | [64] | 0.29[65] | 1.39[66] | 1.46[67] | -0.11[68] | 0.10[69] | -1.32[70] |
11 | HRAS | GTPase HRas | [71] | -1.35[72] | -1.39[73] | -2.52[74] | -2.06[75] | -1.63[76] | -3.73[77] |
12 | NCK1 | Cytoplasmic protein NCK1 | [78] | -1.94[79] | -1.17[80] | -1.40[81] | -1.67[82] | -0.92[83] | -1.54[84] |
13 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | [85] | 0.79[86] | 1.33[87] | -0.13[88] | 0.26[89] | 0.63[90] | -1.00[91] |
14 | THBS1 | Thrombospondin-1 | [92] | 2.16[93] | -2.00[94] | -2.34[95] | 1.73[96] | 2.07[97] | 0.05[98] |
15 | PTPN12 | Tyrosine-protein phosphatase non-receptor type 12 | [99] | 0.44[100] | 1.49[101] | 0.11[102] | 0.64[103] | 0.37[104] | -1.52[105] |
16 | KRAS | GTPase KRas | [106] | -0.86[107] | -0.21[108] | 1.05[109] | -0.31[110] | 0.00[111] | -0.39[112] |
17 | CRKL | Crk-like protein | [113] | 1.36[114] | 2.12[115] | 2.39[116] | 0.01[117] | 0.86[118] | 0.38[119] |
18 | COL9A3 | Collagen alpha-3(IX) chain | [120] | 2.47[121] | 2.13[122] | -2.29[123] | -4.86[124] | -6.12[125] | -6.22[126] |
19 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [127] | -0.81[128] | -0.03[129] | 0.72[130] | 0.96[131] | 1.10[132] | 1.93[133] |
20 | SOS1 | Son of sevenless homolog 1 | [134] | -0.44[135] | 1.75[136] | 0.92[137] | -0.27[138] | -0.39[139] | -0.53[140] |
21 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [141] | 1.53[142] | 2.42[143] | 2.69[144] | -0.40[145] | 0.80[146] | -1.36[147] |
22 | PDGFC | Platelet-derived growth factor C | [148] | -1.62[149] | -0.01[150] | -0.41[151] | -0.21[152] | 0.67[153] | -0.87[154] |
23 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [155] | 1.74[156] | 2.24[157] | 1.62[158] | 0.15[159] | 0.46[160] | 0.10[161] |
24 | NCK2 | Cytoplasmic protein NCK2 | [162] | 0.45[163] | 0.71[164] | -1.22[165] | -1.44[166] | -0.05[167] | -1.89[168] |
25 | STAT5B | Signal transducer and activator of transcription 5B | [169] | 1.02[170] | 1.31[171] | 1.67[172] | 0.44[173] | 0.23[174] | 0.55[175] |
26 | SRC | Proto-oncogene tyrosine-protein kinase Src | [176] | 2.68[177] | 3.33[178] | 1.99[179] | 1.29[180] | 1.11[181] | -1.92[182] |
27 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.15[183] | 3.43[184] | 2.43[185] | 1.71[186] | 1.85[187] | -0.73[188] | |
28 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.87[189] | 2.04[190] | 1.87[191] | -0.06[192] | 0.74[193] | 0.09[194] | |
29 | RASA1 | Ras GTPase-activating protein 1 | [195] | 0.03[196] | 1.62[197] | 1.38[198] | 0.81[199] | 0.51[200] | 0.14[201] |
30 | COL6A1 | Collagen alpha-1(VI) chain | [202] | -0.09[203] | -1.33[204] | 1.79[205] | 2.36[206] | 3.48[207] | 1.80[208] |
31 | STAT5A | Signal transducer and activator of transcription 5A | [209] | -2.29[210] | -0.45[211] | -1.72[212] | -1.96[213] | -0.55[214] | -0.83[215] |
32 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.72[216] | 1.58[217] | 1.43[218] | 0.02[219] | 0.87[220] | 0.84[221] | |
33 | GRB7 | Growth factor receptor-bound protein 7 | [222] | 2.06[223] | 3.05[224] | -0.12[225] | -3.76[226] | -2.39[227] | -1.39[228] |
34 | PDGFA | Platelet-derived growth factor subunit A | [229] | -1.35[230] | -0.47[231] | 1.28[232] | -1.45[233] | -1.72[234] | -1.82[235] |
35 | COL4A5 | Collagen alpha-5(IV) chain | [236] | 2.92[237] | -5.71[238] | -0.25[239] | 1.60[240] | 3.53[241] | -1.73[242] |
36 | COL5A2 | Collagen alpha-2(V) chain | [243] | -1.56[244] | -0.85[245] | 6.76[246] | 5.69[247] | 5.62[248] | 1.86[249] |
37 | COL9A2 | Collagen alpha-2(IX) chain | [250] | 3.44[251] | 3.54[252] | 2.36[253] | -0.24[254] | -2.92[255] | -4.46[256] |
38 | COL5A3 | Collagen alpha-3(V) chain | [257] | -4.37[258] | -3.99[259] | 0.14[260] | -2.82[261] | -4.28[262] | -0.03[263] |
39 | COL6A2 | Collagen alpha-2(VI) chain | [264] | -0.88[265] | -3.20[266] | 1.69[267] | 3.93[268] | 4.71[269] | 3.02[270] |
40 | PDGFB | Platelet-derived growth factor subunit B | [271] | 2.71[272] | 3.24[273] | 0.09[274] | -1.05[275] | -0.83[276] | -0.70[277] |
41 | THBS3 | Thrombospondin-3 | [278] | 0.35[279] | -0.04[280] | 2.04[281] | 0.31[282] | 1.90[283] | 0.55[284] |
42 | COL4A2 | Collagen alpha-2(IV) chain | [285] | -0.41[286] | 0.57[287] | -2.46[288] | 6.08[289] | 6.63[290] | 4.09[291] |
43 | PDGFRA | Platelet-derived growth factor receptor alpha | [292] | -3.96[293] | -4.28[294] | 3.02[295] | -0.58[296] | 4.74[297] | 4.25[298] |
44 | PDGFRB | Platelet-derived growth factor receptor beta | [299] | 0.96[300] | 2.02[301] | -0.77[302] | 0.74[303] | 1.95[304] | 2.34[305] |
45 | COL3A1 | Collagen alpha-1(III) chain | [306] | -1.34[307] | -2.27[308] | -0.22[309] | 8.84[310] | 7.71[311] | 6.54[312] |
46 | COL4A1 | Collagen alpha-1(IV) chain | [313] | -3.07[314] | -3.40[315] | -2.38[316] | 6.28[317] | 6.70[318] | 5.00[319] |
47 | PLAT | Tissue-type plasminogen activator | [320] | 1.36[321] | 2.64[322] | -0.57[323] | 3.70[324] | 4.58[325] | 2.49[326] |
48 | COL2A1 | Collagen alpha-1(II) chain | [327] | 0.24[328] | 3.68[329] | 5.82[330] | -3.46[331] | -3.09[332] | [333] |
49 | COL6A3 | Collagen alpha-3(VI) chain | [334] | -0.21[335] | -2.10[336] | -2.86[337] | 6.30[338] | 7.61[339] | 6.74[340] |
50 | COL4A3 | Collagen alpha-3(IV) chain | [341] | -3.64[342] | -2.73[343] | -1.65[344] | 5.03[345] | -1.54[346] | 2.45[347] |
51 | THBS2 | Thrombospondin-2 | [348] | 3.63[349] | 0.04[350] | -2.48[351] | 2.87[352] | 8.88[353] | 6.19[354] |
52 | THBS4 | Thrombospondin-4 | [355] | 0.98[356] | 2.10[357] | 8.65[358] | 0.71[359] | 1.28[360] | 0.49[361] |
53 | COL4A4 | Collagen alpha-4(IV) chain | [362] | -1.73[363] | -3.90[364] | 0.00[365] | 7.23[366] | 3.48[367] | 4.94[368] |
54 | COL5A1 | Collagen alpha-1(V) chain | [369] | 3.09[370] | 0.14[371] | 1.09[372] | 9.99[373] | 9.68[374] | 6.04[375] |
55 | PDGFD | Platelet-derived growth factor D | [376] | 2.03[377] | -2.11[378] | -4.65[379] | 1.72[380] | 3.92[381] | 5.00[382] |
56 | COL9A1 | Collagen alpha-1(IX) chain | [383] | -2.89[384] | [385] | [386] | -4.70[387] | [388] | -2.15[389] |
57 | COL6A5 | Collagen alpha-5(VI) chain | [390] | [391] | [392] | [393] | [394] | [395] | [396] |
58 | COL6A6 | Collagen alpha-6(VI) chain | [397] | [398] | [399] | [400] | [401] | [402] | [403] |