REACTOME_SIGNALING_BY_NTRK3_TRKC Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 BAX Apoptosis regulator BAX [1] -0.88[2] -1.57[3] -2.05[4] -2.94[5] -2.20[6] -4.60[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] -0.01[9] -0.07[10] 0.03[11] -0.78[12] -0.52[13] -0.35[14]
3 SHC1 SHC-transforming protein 1 [15] -0.04[16] 0.28[17] 0.34[18] 1.32[19] 1.15[20] 0.13[21]
4 NRAS GTPase NRas [22] -0.58[23] -0.04[24] 0.35[25] -0.34[26] -0.42[27] -0.90[28]
5 HRAS GTPase HRas [29] -2.22[30] -2.81[31] -3.62[32] -2.28[33] -2.15[34] -3.31[35]
6 KRAS GTPase KRas [36] -1.72[37] -1.64[38] -0.06[39] -0.53[40] -0.53[41] 0.03[42]
7 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [43] -1.68[44] -1.45[45] -0.38[46] 0.73[47] 0.58[48] 2.35[49]
8 SOS1 Son of sevenless homolog 1 [50] -1.31[51] 0.33[52] -0.18[53] -0.49[54] -0.91[55] -0.11[56]
9 SRC Proto-oncogene tyrosine-protein kinase Src [57] 1.82[58] 1.91[59] 0.89[60] 1.06[61] 0.59[62] -1.50[63]
10 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.28[64] 2.01[65] 1.32[66] 1.49[67] 1.33[68] -0.31[69]
11 IRS1 Insulin receptor substrate 1 [70] 0.88[71] 0.44[72] 1.84[73] 0.37[74] 0.30[75] 1.47[76]
12 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.59[77] 0.16[78] 0.33[79] -0.21[80] 0.35[81] 1.27[82]
13 PTPRS Receptor-type tyrosine-protein phosphatase S [83] 2.88[84] 1.94[85] -6.19[86] 1.32[87] 2.39[88] 2.33[89]
14 NTF3 Neurotrophin-3 [90] -7.08[91] -9.75[92] -1.11[93] -7.67[94] [95] -1.61[96]
15 PTPRO Receptor-type tyrosine-protein phosphatase O [97] -2.99[98] -3.82[99] -1.96[100] -0.09[101] 1.48[102] 2.90[103]
16 NTRK3 NT-3 growth factor receptor [104] [105] [106] [107] 2.43[108] -1.77[109] 3.20[110]
17 NELFB Negative elongation factor B [111] [112] [113] [114] [115] [116] [117]
[1]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 30 21 34 27 11
[2]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 80 58
[3]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 38 33
[4]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 26 14 34
[5]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 14 16
[6]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[7]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 2.3 2.5 2.9 1.4
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[16]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[17]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[18]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[19]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[20]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[21]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[37]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[38]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[39]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[40]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[41]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[42]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[43]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[44]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[45]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[46]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[47]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[48]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[49]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[58]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[59]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[60]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[61]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[62]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[63]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[64]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[65]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[66]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[67]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[68]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[69]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[70]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[71]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[72]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[73]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[74]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[75]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[76]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[77]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[78]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[79]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[80]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[81]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[82]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[83]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[84]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[85]
ref_hepatocyte PTPRS
Mean 1.45
Standard deviation 1.4
Values 3.3 0.25 0.31 0.75 2.6
[86]
HepG2 PTPRS
Mean 54.5
Standard deviation 14
Values 65 44
[87]
HepG2.C3A PTPRS
Mean 23.5
Standard deviation 6.3
Values 28 19
[88]
HuH.7 PTPRS
Mean 0.0815
Standard deviation 0.063
Values 0.11 0.13 0.0094
[89]
SNU475 PTPRS
Mean 16.7
Standard deviation 0.21
Values 17 17
[90]
THLE PTPRS
Mean 30.8
Standard deviation 2.8
Values 33 29
[91]
liver PTPRS
Mean 16.2
Standard deviation 9.9
Values 10 17 8 30
[92]
ref_hepatocyte NTF3
Mean 0.991
Standard deviation 1
Values 0 0 2.4 1.1 1.5
[93]
HepG2 NTF3
Mean 0.0372
Standard deviation 0.053
Values 0.074 0
[94]
HepG2.C3A NTF3
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 NTF3
Mean 1.88
Standard deviation 0.92
Values 2.1 0.89 2.7
[96]
SNU475 NTF3
Mean 0.0226
Standard deviation 0.025
Values 0.0046 0.041
[97]
THLE NTF3
Mean 0
Standard deviation 0
Values 0 0
[98]
liver NTF3
Mean 0.724
Standard deviation 0.63
Values 0.78 0.34 1.6 0.19
[99]
ref_hepatocyte PTPRO
Mean 0.0523
Standard deviation 0.055
Values 0.031 0.12 0 0.1 0.0081
[100]
HepG2 PTPRO
Mean 0.0336
Standard deviation 0.007
Values 0.029 0.039
[101]
HepG2.C3A PTPRO
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[102]
HuH.7 PTPRO
Mean 0.055
Standard deviation 0.0032
Values 0.057 0.051 0.056
[103]
SNU475 PTPRO
Mean 0.228
Standard deviation 0.17
Values 0.11 0.34
[104]
THLE PTPRO
Mean 0.594
Standard deviation 0.15
Values 0.49 0.7
[105]
liver PTPRO
Mean 0.868
Standard deviation 0.56
Values 0.47 1.7 0.67 0.64
[106]
ref_hepatocyte NTRK3
Mean 0.0299
Standard deviation 0.054
Values 0 0 0.12 0 0.024
[107]
HepG2 NTRK3
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A NTRK3
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 NTRK3
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 NTRK3
Mean 0.747
Standard deviation 1
Values 1.5 0.015
[111]
THLE NTRK3
Mean 0.0358
Standard deviation 0.017
Values 0.024 0.048
[112]
liver NTRK3
Mean 0.61
Standard deviation 0.92
Values 0.19 0.21 0.051 2
[113]
ref_hepatocyte NELFB
Missing
[114]
HepG2 NELFB
Mean 45.4
Standard deviation 0.54
Values 46 45
[115]
HepG2.C3A NELFB
Mean 34
Standard deviation 1.1
Values 35 33
[116]
HuH.7 NELFB
Mean 35.6
Standard deviation 11
Values 39 23 44
[117]
SNU475 NELFB
Mean 24.7
Standard deviation 0.29
Values 25 24
[118]
THLE NELFB
Mean 26.9
Standard deviation 6.7
Values 22 32
[119]
liver NELFB
Mean 6
Standard deviation 2.1
Values 5.8 7.6 3.1 7.5