REACTOME_SIGNALING_BY_NTRK2_TRKB Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAC1 Ras-related C3 botulinum toxin substrate 1 [1] -1.06[2] -1.46[3] -0.88[4] -1.14[5] -0.96[6] -1.58[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] -0.23[9] 0.14[10] -0.04[11] -0.27[12] 0.56[13] 0.64[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 0.53[16] 0.29[17] 0.28[18] -0.60[19] -0.49[20] -0.32[21]
4 SHC1 SHC-transforming protein 1 [22] 0.49[23] 0.64[24] 0.59[25] 1.49[26] 1.18[27] 0.16[28]
5 NRAS GTPase NRas [29] -0.04[30] 0.32[31] 0.60[32] -0.16[33] -0.39[34] -0.87[35]
6 HRAS GTPase HRas [36] -1.68[37] -2.45[38] -3.38[39] -2.11[40] -2.13[41] -3.28[42]
7 KRAS GTPase KRas [43] -1.19[44] -1.27[45] 0.19[46] -0.36[47] -0.50[48] 0.06[49]
8 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [50] -1.14[51] -1.09[52] -0.13[53] 0.91[54] 0.61[55] 2.38[56]
9 SOS1 Son of sevenless homolog 1 [57] -0.77[58] 0.69[59] 0.07[60] -0.31[61] -0.88[62] -0.08[63]
10 CDK5 Cyclin-dependent-like kinase 5 [64] -0.43[65] -1.19[66] -1.28[67] -0.53[68] -1.54[69] -1.50[70]
11 SRC Proto-oncogene tyrosine-protein kinase Src [71] 2.35[72] 2.27[73] 1.14[74] 1.24[75] 0.61[76] -1.47[77]
12 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.82[78] 2.37[79] 1.57[80] 1.66[81] 1.35[82] -0.28[83]
13 FYN Tyrosine-protein kinase Fyn [84] 0.27[85] -8.40[86] 0.04[87] 0.31[88] 2.04[89] 0.35[90]
14 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.05[91] 0.52[92] 0.58[93] -0.03[94] 0.37[95] 1.30[96]
15 FRS2 Fibroblast growth factor receptor substrate 2 [97] 0.62[98] 1.64[99] 2.01[100] 1.75[101] 1.57[102] 2.72[103]
16 NTF3 Neurotrophin-3 [104] -6.55[105] -9.39[106] -0.86[107] -7.49[108] [109] -1.58[110]
17 FRS3 Fibroblast growth factor receptor substrate 3 [111] -0.04[112] -0.28[113] -1.43[114] -0.87[115] -1.01[116] -1.53[117]
18 GAB1 GRB2-associated-binding protein 1 [118] 0.63[119] 1.65[120] 1.64[121] 0.78[122] 0.83[123] 2.26[124]
19 TIAM1 T-lymphoma invasion and metastasis-inducing protein 1 [125] -5.37[126] -2.76[127] -8.09[128] -2.52[129] -0.27[130] 2.73[131]
20 CDK5R1 Cyclin-dependent kinase 5 activator 1 [132] 1.41[133] 1.12[134] 1.15[135] 0.82[136] 0.37[137] -0.99[138]
21 BDNF Brain-derived neurotrophic factor [139] -2.33[140] -5.17[141] -3.37[142] 5.59[143] 4.54[144] 1.48[145]
22 DOCK3 Dedicator of cytokinesis protein 3 [146] 0.05[147] -0.11[148] 0.66[149] 3.87[150] 0.51[151] 2.40[152]
23 GRIN2B Glutamate receptor ionotropic, NMDA 2B [153] -3.13[154] [155] [156] -0.07[157] -2.68[158] 1.25[159]
24 NTF4 Neurotrophin-4 [160] [161] [162] [163] [164] [165] [166]
25 NTRK2 BDNF/NT-3 growth factors receptor [167] [168] [169] [170] [171] [172] [173]
[1]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[2]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[3]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[4]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[5]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[6]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[7]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[23]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[24]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[25]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[26]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[27]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[28]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[51]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[52]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[53]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[54]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[55]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[56]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[64]
ref_hepatocyte CDK5
Mean 4.43
Standard deviation 2.1
Values 4.3 1.4 4.6 7.2 4.7
[65]
HepG2 CDK5
Mean 11.6
Standard deviation 2.3
Values 9.9 13
[66]
HepG2.C3A CDK5
Mean 6.36
Standard deviation 1.4
Values 5.3 7.4
[67]
HuH.7 CDK5
Mean 6.32
Standard deviation 1.5
Values 6.1 4.9 8
[68]
SNU475 CDK5
Mean 12.6
Standard deviation 1.1
Values 13 12
[69]
THLE CDK5
Mean 6.09
Standard deviation 0.67
Values 5.6 6.6
[70]
liver CDK5
Mean 3.42
Standard deviation 1.7
Values 5.5 1.8 4.1 2.3
[71]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[72]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[73]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[74]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[75]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[76]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[77]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[78]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[79]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[80]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[81]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[82]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[83]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[84]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[85]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[86]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[87]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[88]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[89]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[90]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[91]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[92]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[93]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[94]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[95]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[96]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[97]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[98]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[99]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[100]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[101]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[102]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[103]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[104]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[105]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[106]
ref_hepatocyte NTF3
Mean 0.991
Standard deviation 1
Values 0 0 2.4 1.1 1.5
[107]
HepG2 NTF3
Mean 0.0372
Standard deviation 0.053
Values 0.074 0
[108]
HepG2.C3A NTF3
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[109]
HuH.7 NTF3
Mean 1.88
Standard deviation 0.92
Values 2.1 0.89 2.7
[110]
SNU475 NTF3
Mean 0.0226
Standard deviation 0.025
Values 0.0046 0.041
[111]
THLE NTF3
Mean 0
Standard deviation 0
Values 0 0
[112]
liver NTF3
Mean 0.724
Standard deviation 0.63
Values 0.78 0.34 1.6 0.19
[113]
ref_hepatocyte FRS3
Mean 0.88
Standard deviation 0.75
Values 2 0.11 0.65 0.39 1.3
[114]
HepG2 FRS3
Mean 3
Standard deviation 0.84
Values 3.6 2.4
[115]
HepG2.C3A FRS3
Mean 2.38
Standard deviation 0.57
Values 2.8 2
[116]
HuH.7 FRS3
Mean 1.13
Standard deviation 0.22
Values 1.1 0.94 1.4
[117]
SNU475 FRS3
Mean 1.98
Standard deviation 0.18
Values 2.1 1.9
[118]
THLE FRS3
Mean 1.75
Standard deviation 0.21
Values 1.9 1.6
[119]
liver FRS3
Mean 0.666
Standard deviation 0.45
Values 1.1 0.26 0.98 0.3
[120]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[121]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[122]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[123]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[124]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[125]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[126]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[127]
ref_hepatocyte TIAM1
Mean 0.599
Standard deviation 0.46
Values 0.15 0.77 1.3 0.33 0.43
[128]
HepG2 TIAM1
Mean 0.0508
Standard deviation 0.042
Values 0.08 0.021
[129]
HepG2.C3A TIAM1
Mean 0.289
Standard deviation 0.18
Values 0.42 0.16
[130]
HuH.7 TIAM1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[131]
SNU475 TIAM1
Mean 0.429
Standard deviation 0.48
Values 0.093 0.77
[132]
THLE TIAM1
Mean 1.99
Standard deviation 0.037
Values 2 2
[133]
liver TIAM1
Mean 8.65
Standard deviation 3.9
Values 6.4 14 7.4 6.3
[134]
ref_hepatocyte CDK5R1
Mean 0.325
Standard deviation 0.3
Values 0.85 0.33 0.17 0.15 0.12
[135]
HepG2 CDK5R1
Mean 3.05
Standard deviation 0.82
Values 3.6 2.5
[136]
HepG2.C3A CDK5R1
Mean 2.32
Standard deviation 0.57
Values 1.9 2.7
[137]
HuH.7 CDK5R1
Mean 2.5
Standard deviation 0.94
Values 3 1.4 3.1
[138]
SNU475 CDK5R1
Mean 2.35
Standard deviation 0.21
Values 2.2 2.5
[139]
THLE CDK5R1
Mean 1.69
Standard deviation 0.024
Values 1.7 1.7
[140]
liver CDK5R1
Mean 0.358
Standard deviation 0.31
Values 0.19 0.39 0.077 0.78
[141]
ref_hepatocyte BDNF
Mean 0.0532
Standard deviation 0.065
Values 0 0 0.095 0.15 0.024
[142]
HepG2 BDNF
Mean 0.0372
Standard deviation 0.0041
Values 0.04 0.034
[143]
HepG2.C3A BDNF
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 BDNF
Mean 0.0177
Standard deviation 0.024
Values 0.0082 0.045 0
[145]
SNU475 BDNF
Mean 10.5
Standard deviation 1.7
Values 9.3 12
[146]
THLE BDNF
Mean 4.97
Standard deviation 1.1
Values 5.7 4.2
[147]
liver BDNF
Mean 0.324
Standard deviation 0.17
Values 0.19 0.57 0.23 0.3
[148]
ref_hepatocyte DOCK3
Mean 0.0348
Standard deviation 0.037
Values 0.012 0.039 0.098 0.017 0.0081
[149]
HepG2 DOCK3
Mean 0.127
Standard deviation 0.015
Values 0.14 0.12
[150]
HepG2.C3A DOCK3
Mean 0.106
Standard deviation 0.043
Values 0.14 0.075
[151]
HuH.7 DOCK3
Mean 0.189
Standard deviation 0.1
Values 0.074 0.23 0.26
[152]
SNU475 DOCK3
Mean 2.08
Standard deviation 0.79
Values 2.6 1.5
[153]
THLE DOCK3
Mean 0.199
Standard deviation 0.16
Values 0.089 0.31
[154]
liver DOCK3
Mean 0.401
Standard deviation 0.26
Values 0.26 0.24 0.31 0.79
[155]
ref_hepatocyte GRIN2B
Mean 0.0213
Standard deviation 0.039
Values 0 0 0 0.017 0.089
[156]
HepG2 GRIN2B
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[157]
HepG2.C3A GRIN2B
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GRIN2B
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 GRIN2B
Mean 0.0833
Standard deviation 0.046
Values 0.12 0.051
[160]
THLE GRIN2B
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[161]
liver GRIN2B
Mean 0.11
Standard deviation 0.05
Values 0.12 0.1 0.051 0.17
[162]
ref_hepatocyte NTF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 NTF4
Mean 0.0243
Standard deviation 0.022
Values 0.04 0.0086
[164]
HepG2.C3A NTF4
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 NTF4
Mean 0.0204
Standard deviation 0.023
Values 0.016 0.045 0
[166]
SNU475 NTF4
Mean 0.0814
Standard deviation 0.029
Values 0.1 0.061
[167]
THLE NTF4
Mean 0.0683
Standard deviation 0.029
Values 0.089 0.048
[168]
liver NTF4
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[169]
ref_hepatocyte NTRK2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 NTRK2
Mean 0.0201
Standard deviation 0.028
Values 0.04 0
[171]
HepG2.C3A NTRK2
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 NTRK2
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 NTRK2
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[174]
THLE NTRK2
Mean 0
Standard deviation 0
Values 0 0
[175]
liver NTRK2
Mean 1.46
Standard deviation 0.52
Values 0.89 1.2 1.8 2