REACTOME_SIGNALING_BY_NOTCH4 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.24[2] | -1.25[3] | -1.13[4] | -1.77[5] | -1.20[6] | -0.59[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.80[16] | -0.50[17] | -0.77[18] | -0.91[19] | -0.82[20] | -0.14[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.57[23] | -2.09[24] | -1.74[25] | -1.63[26] | -2.05[27] | -1.09[28] |
5 | YWHAZ | 14-3-3 protein zeta/delta | [29] | 0.39[30] | 0.42[31] | 0.71[32] | 1.92[33] | 0.61[34] | -0.35[35] |
6 | PSME2 | Proteasome activator complex subunit 2 | [36] | -0.38[37] | -1.71[38] | -1.83[39] | -1.42[40] | -1.58[41] | -0.71[42] |
7 | PSMA7 | Proteasome subunit alpha type-7 | [43] | 0.57[44] | 0.76[45] | -0.58[46] | 0.21[47] | -0.11[48] | 0.31[49] |
8 | PSMB1 | Proteasome subunit beta type-1 | [50] | 0.12[51] | 0.31[52] | -0.78[53] | -1.03[54] | -0.15[55] | 0.15[56] |
9 | PSMB3 | Proteasome subunit beta type-3 | [57] | -0.37[58] | -1.07[59] | -0.05[60] | -1.05[61] | -1.05[62] | -0.15[63] |
10 | PSMB4 | Proteasome subunit beta type-4 | [64] | -0.12[65] | 0.13[66] | 0.24[67] | 0.37[68] | 0.49[69] | -0.47[70] |
11 | PSMB7 | Proteasome subunit beta type-7 | [71] | -1.06[72] | -0.97[73] | -0.85[74] | -1.40[75] | -0.84[76] | -0.91[77] |
12 | PSMB5 | Proteasome subunit beta type-5 | [78] | 1.34[79] | -0.01[80] | -0.10[81] | -0.68[82] | -0.27[83] | -0.44[84] |
13 | PSMA6 | Proteasome subunit alpha type-6 | [85] | 1.46[86] | 0.27[87] | 0.19[88] | -0.15[89] | -0.01[90] | -0.36[91] |
14 | PSMA4 | Proteasome subunit alpha type-4 | [92] | -0.47[93] | 0.28[94] | 0.06[95] | 0.15[96] | 0.10[97] | -0.44[98] |
15 | SKP1 | S-phase kinase-associated protein 1 | [99] | -0.02[100] | 0.56[101] | -0.34[102] | 0.51[103] | 0.84[104] | 0.60[105] |
16 | PSMC3 | 26S proteasome regulatory subunit 6A | [106] | -0.50[107] | -0.48[108] | 0.13[109] | -1.05[110] | -0.72[111] | 0.03[112] |
17 | PSMA3 | Proteasome subunit alpha type-3 | [113] | -1.09[114] | 0.00[115] | -0.69[116] | -0.30[117] | -0.62[118] | -0.19[119] |
18 | PSMB6 | Proteasome subunit beta type-6 | [120] | -0.54[121] | -0.30[122] | -0.17[123] | -0.85[124] | -0.99[125] | -0.03[126] |
19 | PSMA2 | Proteasome subunit alpha type-2 | [127] | -0.62[128] | 0.42[129] | 0.74[130] | -0.35[131] | 0.15[132] | 0.19[133] |
20 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [134] | -0.11[135] | 0.00[136] | 0.18[137] | 0.35[138] | -0.05[139] | -0.13[140] |
21 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [141] | -0.19[142] | 0.27[143] | 0.12[144] | -0.73[145] | -0.13[146] | -0.31[147] |
22 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [148] | -0.02[149] | 0.31[150] | 0.43[151] | -0.46[152] | 0.43[153] | -0.28[154] |
23 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [155] | 1.51[156] | 0.78[157] | 0.84[158] | 0.65[159] | 2.07[160] | 0.75[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.17[163] | -0.01[164] | -0.68[165] | 0.84[166] | 0.49[167] | -0.09[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | 0.02[170] | 0.50[171] | 0.54[172] | 0.41[173] | 0.04[174] | 0.40[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.64[177] | 1.74[178] | 2.74[179] | 0.48[180] | 1.40[181] | 0.63[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.34[184] | 0.32[185] | 0.38[186] | -0.18[187] | 0.36[188] | 0.17[189] |
28 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [190] | -1.10[191] | -0.48[192] | -0.63[193] | -1.69[194] | -1.16[195] | -0.81[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.73[198] | 0.31[199] | 0.89[200] | 0.35[201] | 0.70[202] | -0.12[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.66[205] | -2.17[206] | -9.40[207] | 0.32[208] | -0.85[209] | -0.80[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.09[212] | 0.61[213] | 0.85[214] | 0.21[215] | 0.38[216] | -0.26[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.34[219] | 0.45[220] | 0.38[221] | -0.16[222] | 0.09[223] | 0.22[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.82[226] | -0.25[227] | -1.35[228] | -0.78[229] | 0.16[230] | -0.37[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.38[233] | 0.58[234] | 1.07[235] | 0.28[236] | -0.08[237] | -0.18[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.44[240] | -0.27[241] | -0.59[242] | -0.10[243] | 0.09[244] | -0.26[245] |
36 | AKT1 | RAC-alpha serine/threonine-protein kinase | [246] | 1.04[247] | 1.00[248] | -0.12[249] | 0.96[250] | 1.09[251] | 1.05[252] |
37 | PSMC6 | 26S proteasome regulatory subunit 10B | [253] | -0.14[254] | 1.52[255] | 0.33[256] | 0.25[257] | 0.32[258] | 0.39[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 0.74[261] | 0.44[262] | 1.02[263] | 0.66[264] | 0.95[265] | 1.22[266] |
39 | APH1A | Gamma-secretase subunit APH-1A | [267] | 0.89[268] | 1.36[269] | 1.54[270] | 0.75[271] | 0.75[272] | 0.28[273] |
40 | PSMC2 | 26S proteasome regulatory subunit 7 | [274] | 0.49[275] | 0.98[276] | 0.75[277] | 1.06[278] | 1.01[279] | 1.27[280] |
41 | PSME3 | Proteasome activator complex subunit 3 | [281] | 1.72[282] | 1.53[283] | 1.20[284] | 1.08[285] | 1.48[286] | 0.84[287] |
42 | PSENEN | Gamma-secretase subunit PEN-2 | [288] | -1.11[289] | -0.90[290] | -0.47[291] | -0.87[292] | -1.19[293] | -0.78[294] |
43 | SNW1 | SNW domain-containing protein 1 | [295] | -0.04[296] | 0.32[297] | 0.30[298] | 0.88[299] | 0.74[300] | -0.34[301] |
44 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [302] | 1.48[303] | 1.89[304] | 1.75[305] | 1.89[306] | 2.02[307] | 2.02[308] |
45 | PSMB10 | Proteasome subunit beta type-10 | [309] | -1.24[310] | -0.56[311] | -2.46[312] | -0.32[313] | -1.36[314] | -0.13[315] |
46 | PSMA5 | Proteasome subunit alpha type-5 | [316] | 1.81[317] | 2.32[318] | 1.87[319] | 1.94[320] | 1.63[321] | 1.86[322] |
47 | PSMF1 | Proteasome inhibitor PI31 subunit | [323] | 2.19[324] | 2.32[325] | 1.11[326] | 0.95[327] | 0.84[328] | 1.80[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 1.97[331] | 1.79[332] | 2.16[333] | 2.24[334] | 2.36[335] | 2.35[336] |
49 | NCSTN | Nicastrin | [337] | 2.31[338] | 1.65[339] | 1.77[340] | 2.10[341] | 2.09[342] | 1.68[343] |
50 | PSMB9 | Proteasome subunit beta type-9 | [344] | -2.04[345] | -4.57[346] | -6.89[347] | 1.50[348] | -0.64[349] | -0.54[350] |
51 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [351] | 0.34[352] | 0.92[353] | -0.07[354] | 0.12[355] | 0.69[356] | 0.68[357] |
52 | CUL1 | Cullin-1 | [358] | 0.58[359] | 1.44[360] | 0.96[361] | 1.60[362] | 1.35[363] | 2.04[364] |
53 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [365] | 0.90[366] | 1.31[367] | 1.32[368] | 1.79[369] | 1.24[370] | 0.66[371] |
54 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [372] | 1.94[373] | 2.61[374] | 2.61[375] | 2.29[376] | 2.81[377] | 2.09[378] |
55 | HES1 | Transcription factor HES-1 | [379] | 0.53[380] | -1.78[381] | 0.43[382] | -0.26[383] | -0.99[384] | -0.11[385] |
56 | PSEN1 | Presenilin-1 | [386] | 2.02[387] | 2.43[388] | 1.96[389] | 2.27[390] | 2.25[391] | 2.29[392] |
57 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [393] | 1.32[394] | 0.96[395] | 2.51[396] | 2.18[397] | 2.39[398] | 2.11[399] |
58 | SMAD3 | Mothers against decapentaplegic homolog 3 | [400] | 2.89[401] | 2.48[402] | 2.67[403] | 2.81[404] | 3.80[405] | 1.50[406] |
59 | NOTCH2 | Neurogenic locus notch homolog protein 2 | [407] | 1.09[408] | -4.45[409] | 2.99[410] | 4.05[411] | 4.95[412] | 4.62[413] |
60 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | [414] | 2.53[415] | 2.64[416] | 3.76[417] | 3.43[418] | 3.45[419] | -0.46[420] |
61 | KAT2A | Histone acetyltransferase KAT2A | [421] | 2.99[422] | 3.04[423] | 2.11[424] | 2.14[425] | 2.10[426] | 1.57[427] |
62 | PSEN2 | Presenilin-2 | [428] | 0.27[429] | -0.40[430] | -4.25[431] | 1.10[432] | -0.17[433] | 1.19[434] |
63 | ACTA2 | Actin, aortic smooth muscle | [435] | 3.08[436] | 2.80[437] | -3.51[438] | 6.07[439] | 2.01[440] | 4.29[441] |
64 | RBPJ | Recombining binding protein suppressor of hairless | [442] | 2.30[443] | 3.06[444] | 4.03[445] | 3.03[446] | 3.07[447] | 3.14[448] |
65 | FBXW7 | F-box/WD repeat-containing protein 7 | [449] | 0.22[450] | 1.09[451] | 1.03[452] | 0.12[453] | 1.23[454] | 2.44[455] |
66 | KAT2B | Histone acetyltransferase KAT2B | [456] | -1.09[457] | -2.02[458] | 0.31[459] | 0.95[460] | 1.48[461] | 3.08[462] |
67 | JAG1 | Protein jagged-1 | [463] | 5.73[464] | 4.51[465] | 3.95[466] | 2.53[467] | 1.28[468] | 2.34[469] |
68 | EP300 | Histone acetyltransferase p300 | [470] | 3.68[471] | 3.46[472] | 4.32[473] | 3.59[474] | 3.74[475] | 4.04[476] |
69 | MAML1 | Mastermind-like protein 1 | [477] | 3.07[478] | 3.23[479] | 3.73[480] | 3.26[481] | 3.50[482] | 2.37[483] |
70 | CREBBP | CREB-binding protein | [484] | 3.86[485] | 3.27[486] | 3.84[487] | 3.77[488] | 3.88[489] | 4.53[490] |
71 | MAMLD1 | Mastermind-like domain-containing protein 1 | [491] | -0.94[492] | -7.25[493] | -1.03[494] | 2.07[495] | 1.99[496] | 0.96[497] |
72 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [498] | 2.60[499] | 1.24[500] | 1.28[501] | 0.52[502] | -0.57[503] | 1.34[504] |
73 | APH1B | Gamma-secretase subunit APH-1B | [505] | 0.72[506] | 1.72[507] | 4.81[508] | 4.11[509] | 3.25[510] | 2.51[511] |
74 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [512] | 2.86[513] | 1.89[514] | 3.19[515] | 3.60[516] | 4.06[517] | 5.93[518] |
75 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [519] | -2.76[520] | -4.37[521] | -4.50[522] | -2.85[523] | -5.57[524] | 2.04[525] |
76 | MAML3 | Mastermind-like protein 3 | [526] | 0.58[527] | 1.51[528] | 4.50[529] | 2.42[530] | 1.14[531] | 4.79[532] |
77 | FLT4 | Vascular endothelial growth factor receptor 3 | [533] | -0.41[534] | 1.02[535] | -0.22[536] | -0.22[537] | -0.21[538] | 5.81[539] |
78 | MAML2 | Mastermind-like protein 2 | [540] | 4.45[541] | 5.26[542] | -1.34[543] | 5.79[544] | 4.76[545] | 3.65[546] |
79 | DLL4 | Delta-like protein 4 | [547] | 1.70[548] | 2.61[549] | 1.34[550] | -2.11[551] | -0.72[552] | 4.49[553] |
80 | NOTCH4 | Neurogenic locus notch homolog protein 4 | [554] | 1.53[555] | 2.28[556] | -0.39[557] | -0.99[558] | 1.72[559] | 7.50[560] |
81 | HES5 | Transcription factor HES-5 | [561] | 4.19[562] | 0.16[563] | [564] | [565] | -1.24[566] | 1.67[567] |
82 | SEM1 | Putative protein SEM1, isoform 2 | [568] | [569] | [570] | [571] | [572] | [573] | [574] |