REACTOME_SIGNALING_BY_NOTCH3 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.94[2] | -0.96[3] | -1.14[4] | -1.48[5] | -0.89[6] | -0.35[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.50[16] | -0.21[17] | -0.78[18] | -0.63[19] | -0.51[20] | 0.11[21] |
4 | YBX1 | Nuclease-sensitive element-binding protein 1 | [22] | 0.27[23] | 0.30[24] | 0.41[25] | -0.03[26] | 0.47[27] | -1.26[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 1.94[30] | 2.03[31] | 2.73[32] | 0.77[33] | 1.72[34] | 0.88[35] |
6 | APH1A | Gamma-secretase subunit APH-1A | [36] | 1.19[37] | 1.65[38] | 1.54[39] | 1.03[40] | 1.06[41] | 0.52[42] |
7 | PSENEN | Gamma-secretase subunit PEN-2 | [43] | -0.81[44] | -0.62[45] | -0.48[46] | -0.59[47] | -0.88[48] | -0.53[49] |
8 | SNW1 | SNW domain-containing protein 1 | [50] | 0.26[51] | 0.61[52] | 0.30[53] | 1.16[54] | 1.05[55] | -0.10[56] |
9 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [57] | 1.19[58] | 0.45[59] | 1.22[60] | 3.83[61] | 1.70[62] | 2.48[63] |
10 | NCSTN | Nicastrin | [64] | 2.61[65] | 1.94[66] | 1.77[67] | 2.39[68] | 2.40[69] | 1.92[70] |
11 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [71] | 2.24[72] | 2.90[73] | 2.60[74] | 2.58[75] | 3.12[76] | 2.33[77] |
12 | HES1 | Transcription factor HES-1 | [78] | 0.83[79] | -1.49[80] | 0.43[81] | 0.02[82] | -0.67[83] | 0.13[84] |
13 | WWC1 | Protein KIBRA | [85] | 2.11[86] | 1.54[87] | 1.65[88] | -0.45[89] | 1.63[90] | 1.99[91] |
14 | PSEN1 | Presenilin-1 | [92] | 2.32[93] | 2.71[94] | 1.95[95] | 2.55[96] | 2.56[97] | 2.53[98] |
15 | EGFR | Epidermal growth factor receptor | [99] | 0.56[100] | 0.37[101] | 2.92[102] | 1.73[103] | 2.48[104] | 4.18[105] |
16 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | [106] | 2.84[107] | 2.93[108] | 3.76[109] | 3.71[110] | 3.76[111] | -0.21[112] |
17 | KAT2A | Histone acetyltransferase KAT2A | [113] | 3.29[114] | 3.33[115] | 2.11[116] | 2.42[117] | 2.41[118] | 1.81[119] |
18 | WWP2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | [120] | 3.01[121] | 3.19[122] | 2.61[123] | 2.04[124] | 2.19[125] | 2.61[126] |
19 | DLGAP5 | Disks large-associated protein 5 | [127] | 0.78[128] | 2.74[129] | 2.59[130] | 2.80[131] | 3.42[132] | -1.61[133] |
20 | PSEN2 | Presenilin-2 | [134] | 0.57[135] | -0.11[136] | -4.25[137] | 1.38[138] | 0.14[139] | 1.43[140] |
21 | MIB2 | E3 ubiquitin-protein ligase MIB2 | [141] | 2.37[142] | 3.00[143] | 2.04[144] | 1.66[145] | 2.10[146] | 1.65[147] |
22 | RBPJ | Recombining binding protein suppressor of hairless | [148] | 2.60[149] | 3.35[150] | 4.03[151] | 3.31[152] | 3.38[153] | 3.39[154] |
23 | MIB1 | E3 ubiquitin-protein ligase MIB1 | [155] | 2.76[156] | 4.15[157] | 4.04[158] | 4.22[159] | 3.40[160] | 4.22[161] |
24 | KAT2B | Histone acetyltransferase KAT2B | [162] | -0.79[163] | -1.73[164] | 0.31[165] | 1.23[166] | 1.79[167] | 3.32[168] |
25 | JAG1 | Protein jagged-1 | [169] | 6.04[170] | 4.80[171] | 3.94[172] | 2.81[173] | 1.59[174] | 2.58[175] |
26 | EP300 | Histone acetyltransferase p300 | [176] | 3.98[177] | 3.75[178] | 4.32[179] | 3.87[180] | 4.05[181] | 4.29[182] |
27 | MAML1 | Mastermind-like protein 1 | [183] | 3.38[184] | 3.52[185] | 3.73[186] | 3.54[187] | 3.81[188] | 2.61[189] |
28 | CREBBP | CREB-binding protein | [190] | 4.16[191] | 3.55[192] | 3.83[193] | 4.05[194] | 4.19[195] | 4.77[196] |
29 | PLXND1 | Plexin-D1 | [197] | 6.88[198] | 5.86[199] | 3.36[200] | 7.42[201] | 3.86[202] | 5.31[203] |
30 | MAMLD1 | Mastermind-like domain-containing protein 1 | [204] | -0.64[205] | -6.96[206] | -1.04[207] | 2.35[208] | 2.31[209] | 1.20[210] |
31 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [211] | 2.90[212] | 1.53[213] | 1.27[214] | 0.80[215] | -0.26[216] | 1.58[217] |
32 | APH1B | Gamma-secretase subunit APH-1B | [218] | 1.02[219] | 2.01[220] | 4.81[221] | 4.39[222] | 3.57[223] | 2.76[224] |
33 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [225] | 3.16[226] | 2.18[227] | 3.19[228] | 3.88[229] | 4.37[230] | 6.17[231] |
34 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [232] | -2.46[233] | -4.08[234] | -4.51[235] | -2.57[236] | -5.26[237] | 2.28[238] |
35 | PBX1 | Pre-B-cell leukemia transcription factor 1 | [239] | -1.64[240] | -3.35[241] | 4.76[242] | 7.08[243] | 6.45[244] | 3.70[245] |
36 | MAML3 | Mastermind-like protein 3 | [246] | 0.88[247] | 1.80[248] | 4.50[249] | 2.70[250] | 1.45[251] | 5.03[252] |
37 | MAML2 | Mastermind-like protein 2 | [253] | 4.75[254] | 5.55[255] | -1.35[256] | 6.07[257] | 5.07[258] | 3.89[259] |
38 | DLL4 | Delta-like protein 4 | [260] | 2.00[261] | 2.90[262] | 1.33[263] | -1.83[264] | -0.41[265] | 4.73[266] |
39 | IKZF1 | DNA-binding protein Ikaros | [267] | -4.66[268] | [269] | [270] | [271] | -4.51[272] | 5.02[273] |
40 | DLL1 | Delta-like protein 1 | [274] | -3.10[275] | -1.72[276] | -1.99[277] | -5.49[278] | 1.74[279] | 4.04[280] |
41 | NOTCH3 | Neurogenic locus notch homolog protein 3 | [281] | 5.33[282] | 1.15[283] | 6.78[284] | 7.55[285] | 5.52[286] | 5.61[287] |
42 | JAG2 | Protein jagged-2 | [288] | 4.71[289] | 0.94[290] | 4.65[291] | 7.15[292] | 4.45[293] | 3.43[294] |
43 | PTCRA | Pre T-cell antigen receptor alpha | [295] | [296] | -2.88[297] | [298] | -3.28[299] | [300] | 0.36[301] |
44 | NEURL1B | E3 ubiquitin-protein ligase NEURL1B | [302] | 4.36[303] | 0.65[304] | 2.40[305] | 6.18[306] | 7.17[307] | 8.05[308] |
45 | HES5 | Transcription factor HES-5 | [309] | 4.49[310] | 0.45[311] | [312] | [313] | -0.93[314] | 1.91[315] |
46 | HEYL | Hairy/enhancer-of-split related with YRPW motif-like protein | [316] | 3.50[317] | 2.51[318] | 4.12[319] | 7.05[320] | 4.29[321] | 7.66[322] |
47 | EGF | Pro-epidermal growth factor | [323] | 3.23[324] | 5.19[325] | 8.48[326] | 10.32[327] | 7.88[328] | 3.11[329] |
48 | NEURL1 | E3 ubiquitin-protein ligase NEURL1 | [330] | [331] | [332] | [333] | [334] | [335] | [336] |
49 | FABP7 | Fatty acid-binding protein, brain | [337] | [338] | [339] | [340] | [341] | [342] | [343] |