REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.04[2] | -1.29[3] | -1.25[4] | -1.42[5] | -1.03[6] | -0.65[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.60[16] | -0.54[17] | -0.89[18] | -0.57[19] | -0.65[20] | -0.20[21] |
4 | SKP1 | S-phase kinase-associated protein 1 | [22] | 0.17[23] | 0.52[24] | -0.46[25] | 0.85[26] | 1.01[27] | 0.53[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 1.83[30] | 1.70[31] | 2.62[32] | 0.83[33] | 1.58[34] | 0.57[35] |
6 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [36] | -0.90[37] | -0.52[38] | -0.75[39] | -1.35[40] | -0.99[41] | -0.88[42] |
7 | APH1A | Gamma-secretase subunit APH-1A | [43] | 1.09[44] | 1.32[45] | 1.43[46] | 1.09[47] | 0.92[48] | 0.21[49] |
8 | MYC | Myc proto-oncogene protein | [50] | 1.58[51] | 1.20[52] | -0.94[53] | -1.43[54] | 0.87[55] | -0.78[56] |
9 | CCNC | Cyclin-C | [57] | 0.23[58] | 1.57[59] | 0.97[60] | 0.27[61] | 0.44[62] | 1.12[63] |
10 | PSENEN | Gamma-secretase subunit PEN-2 | [64] | -0.91[65] | -0.94[66] | -0.59[67] | -0.53[68] | -1.02[69] | -0.84[70] |
11 | SNW1 | SNW domain-containing protein 1 | [71] | 0.16[72] | 0.28[73] | 0.19[74] | 1.22[75] | 0.91[76] | -0.41[77] |
12 | HDAC1 | Histone deacetylase 1 | [78] | 1.66[79] | 1.63[80] | 2.20[81] | 2.00[82] | 1.72[83] | 0.76[84] |
13 | NCSTN | Nicastrin | [85] | 2.50[86] | 1.62[87] | 1.66[88] | 2.45[89] | 2.26[90] | 1.61[91] |
14 | CUL1 | Cullin-1 | [92] | 0.77[93] | 1.41[94] | 0.84[95] | 1.94[96] | 1.53[97] | 1.97[98] |
15 | HDAC3 | Histone deacetylase 3 | [99] | 1.64[100] | 1.65[101] | 1.34[102] | 1.31[103] | 1.40[104] | 0.82[105] |
16 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [106] | 2.14[107] | 2.58[108] | 2.49[109] | 2.64[110] | 2.98[111] | 2.02[112] |
17 | HES1 | Transcription factor HES-1 | [113] | 0.72[114] | -1.82[115] | 0.31[116] | 0.08[117] | -0.81[118] | -0.18[119] |
18 | NCOR1 | Nuclear receptor corepressor 1 | [120] | 2.24[121] | 2.69[122] | 3.23[123] | 2.92[124] | 2.90[125] | 4.02[126] |
19 | HDAC2 | Histone deacetylase 2 | [127] | 2.88[128] | 4.16[129] | 3.42[130] | 3.52[131] | 3.59[132] | 1.42[133] |
20 | PSEN1 | Presenilin-1 | [134] | 2.21[135] | 2.39[136] | 1.84[137] | 2.61[138] | 2.42[139] | 2.22[140] |
21 | HDAC6 | Histone deacetylase 6 | [141] | 1.81[142] | 2.71[143] | 2.69[144] | 1.64[145] | 1.05[146] | 3.38[147] |
22 | HDAC8 | Histone deacetylase 8 | [148] | 0.18[149] | -0.06[150] | 0.09[151] | 0.58[152] | 0.75[153] | 0.86[154] |
23 | CDK8 | Cyclin-dependent kinase 8 | [155] | 0.31[156] | 0.81[157] | -0.23[158] | 0.86[159] | 0.40[160] | -0.53[161] |
24 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [162] | 1.83[163] | 1.67[164] | 1.29[165] | 3.10[166] | 2.16[167] | 1.30[168] |
25 | KAT2A | Histone acetyltransferase KAT2A | [169] | 3.18[170] | 3.00[171] | 2.00[172] | 2.49[173] | 2.27[174] | 1.51[175] |
26 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [176] | 2.24[177] | 2.73[178] | 3.26[179] | 3.77[180] | 3.26[181] | 4.09[182] |
27 | PSEN2 | Presenilin-2 | [183] | 0.47[184] | -0.43[185] | -4.36[186] | 1.44[187] | 0.00[188] | 1.13[189] |
28 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [190] | 2.49[191] | 2.85[192] | 4.30[193] | -3.05[194] | 2.38[195] | 2.97[196] |
29 | MIB2 | E3 ubiquitin-protein ligase MIB2 | [197] | 2.27[198] | 2.67[199] | 1.93[200] | 1.73[201] | 1.96[202] | 1.34[203] |
30 | RBPJ | Recombining binding protein suppressor of hairless | [204] | 2.49[205] | 3.03[206] | 3.92[207] | 3.37[208] | 3.24[209] | 3.08[210] |
31 | FBXW7 | F-box/WD repeat-containing protein 7 | [211] | 0.42[212] | 1.05[213] | 0.91[214] | 0.46[215] | 1.41[216] | 2.37[217] |
32 | HDAC10 | Histone deacetylase 10 | [218] | 1.26[219] | 1.79[220] | 2.47[221] | 1.07[222] | 0.65[223] | 1.40[224] |
33 | MIB1 | E3 ubiquitin-protein ligase MIB1 | [225] | 2.65[226] | 3.83[227] | 3.93[228] | 4.28[229] | 3.26[230] | 3.91[231] |
34 | KAT2B | Histone acetyltransferase KAT2B | [232] | -0.89[233] | -2.06[234] | 0.20[235] | 1.29[236] | 1.65[237] | 3.01[238] |
35 | JAG1 | Protein jagged-1 | [239] | 5.93[240] | 4.47[241] | 3.83[242] | 2.87[243] | 1.45[244] | 2.27[245] |
36 | NCOR2 | Nuclear receptor corepressor 2 | [246] | 4.50[247] | 2.85[248] | 2.84[249] | 5.51[250] | 4.94[251] | 3.11[252] |
37 | EP300 | Histone acetyltransferase p300 | [253] | 3.88[254] | 3.43[255] | 4.21[256] | 3.93[257] | 3.91[258] | 3.98[259] |
38 | HDAC5 | Histone deacetylase 5 | [260] | 3.84[261] | 4.63[262] | 3.86[263] | 3.01[264] | 2.34[265] | 2.42[266] |
39 | MAML1 | Mastermind-like protein 1 | [267] | 3.27[268] | 3.19[269] | 3.61[270] | 3.60[271] | 3.67[272] | 2.30[273] |
40 | CREBBP | CREB-binding protein | [274] | 4.05[275] | 3.23[276] | 3.72[277] | 4.11[278] | 4.05[279] | 4.46[280] |
41 | HDAC7 | Histone deacetylase 7 | [281] | 3.54[282] | 2.85[283] | 2.43[284] | 4.46[285] | 4.71[286] | 2.20[287] |
42 | HDAC11 | Histone deacetylase 11 | [288] | 3.72[289] | 4.33[290] | 3.05[291] | 2.74[292] | 2.07[293] | 1.00[294] |
43 | MAMLD1 | Mastermind-like domain-containing protein 1 | [295] | -0.75[296] | -7.29[297] | -1.15[298] | 2.41[299] | 2.16[300] | 0.89[301] |
44 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [302] | 2.79[303] | 1.21[304] | 1.16[305] | 0.86[306] | -0.40[307] | 1.27[308] |
45 | APH1B | Gamma-secretase subunit APH-1B | [309] | 0.92[310] | 1.68[311] | 4.69[312] | 4.45[313] | 3.43[314] | 2.45[315] |
46 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [316] | 3.06[317] | 1.86[318] | 3.08[319] | 3.94[320] | 4.23[321] | 5.86[322] |
47 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [323] | -2.57[324] | -4.41[325] | -4.62[326] | -2.51[327] | -5.40[328] | 1.98[329] |
48 | HDAC4 | Histone deacetylase 4 | [330] | 4.62[331] | 4.41[332] | 4.07[333] | 4.06[334] | 4.31[335] | 4.61[336] |
49 | MAML3 | Mastermind-like protein 3 | [337] | 0.78[338] | 1.47[339] | 4.39[340] | 2.76[341] | 1.31[342] | 4.72[343] |
50 | MAML2 | Mastermind-like protein 2 | [344] | 4.64[345] | 5.22[346] | -1.46[347] | 6.13[348] | 4.93[349] | 3.59[350] |
51 | DLL4 | Delta-like protein 4 | [351] | 1.90[352] | 2.57[353] | 1.22[354] | -1.77[355] | -0.55[356] | 4.42[357] |
52 | HDAC9 | Histone deacetylase 9 | [358] | 1.47[359] | -1.47[360] | 3.02[361] | 6.95[362] | 4.99[363] | 4.08[364] |
53 | DLL1 | Delta-like protein 1 | [365] | -3.20[366] | -2.05[367] | -2.10[368] | -5.43[369] | 1.60[370] | 3.73[371] |
54 | JAG2 | Protein jagged-2 | [372] | 4.60[373] | 0.61[374] | 4.54[375] | 7.21[376] | 4.31[377] | 3.13[378] |
55 | NEURL1B | E3 ubiquitin-protein ligase NEURL1B | [379] | 4.26[380] | 0.32[381] | 2.29[382] | 6.24[383] | 7.03[384] | 7.74[385] |
56 | HES5 | Transcription factor HES-5 | [386] | 4.39[387] | 0.12[388] | [389] | [390] | -1.07[391] | 1.60[392] |
57 | HEYL | Hairy/enhancer-of-split related with YRPW motif-like protein | [393] | 3.39[394] | 2.18[395] | 4.01[396] | 7.11[397] | 4.15[398] | 7.35[399] |
58 | NEURL1 | E3 ubiquitin-protein ligase NEURL1 | [400] | [401] | [402] | [403] | [404] | [405] | [406] |