REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.38[2] -0.46[3] -0.52[4] -0.45[5] -0.19[6] 0.00[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.06[16] 0.29[17] -0.16[18] 0.40[19] 0.19[20] 0.45[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.50[23] 2.53[24] 3.35[25] 1.80[26] 2.42[27] 1.22[28]
5 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 [29] 2.80[30] 3.41[31] 3.22[32] 3.61[33] 3.82[34] 2.67[35]
6 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 [36] 2.49[37] 2.50[38] 2.02[39] 4.07[40] 3.01[41] 1.95[42]
7 MIB2 E3 ubiquitin-protein ligase MIB2 [43] 2.93[44] 3.50[45] 2.66[46] 2.70[47] 2.81[48] 1.99[49]
8 MIB1 E3 ubiquitin-protein ligase MIB1 [50] 3.31[51] 4.66[52] 4.65[53] 5.25[54] 4.11[55] 4.57[56]
9 JAG1 Protein jagged-1 [57] 6.59[58] 5.30[59] 4.56[60] 3.85[61] 2.29[62] 2.92[63]
10 NOTCH1 Neurogenic locus notch homolog protein 1 [64] 3.72[65] 2.69[66] 3.80[67] 4.91[68] 5.07[69] 6.51[70]
11 DLL4 Delta-like protein 4 [71] 2.56[72] 3.40[73] 1.95[74] -0.80[75] 0.30[76] 5.07[77]
12 DLL1 Delta-like protein 1 [78] -2.54[79] -1.22[80] -1.37[81] -4.46[82] 2.45[83] 4.38[84]
13 JAG2 Protein jagged-2 [85] 5.26[86] 1.44[87] 5.27[88] 8.18[89] 5.16[90] 3.78[91]
14 NEURL1B E3 ubiquitin-protein ligase NEURL1B [92] 4.92[93] 1.15[94] 3.02[95] 7.22[96] 7.87[97] 8.40[98]
15 NEURL1 E3 ubiquitin-protein ligase NEURL1 [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte ADAM10
Mean 8.78
Standard deviation 8.3
Values 21 13 2.8 3.4 3.4
[30]
HepG2 ADAM10
Mean 38.3
Standard deviation 10
Values 31 46
[31]
HepG2.C3A ADAM10
Mean 47.7
Standard deviation 4.9
Values 44 51
[32]
HuH.7 ADAM10
Mean 46.6
Standard deviation 9
Values 51 53 36
[33]
SNU475 ADAM10
Mean 39.1
Standard deviation 5.2
Values 43 35
[34]
THLE ADAM10
Mean 58.2
Standard deviation 3.8
Values 56 61
[35]
liver ADAM10
Mean 21.7
Standard deviation 10
Values 13 34 14 26
[36]
ref_hepatocyte ADAM17
Mean 5.04
Standard deviation 4.3
Values 10 8.5 4.3 1 1.1
[37]
HepG2 ADAM17
Mean 17.8
Standard deviation 0.96
Values 18 17
[38]
HepG2.C3A ADAM17
Mean 14.6
Standard deviation 0.94
Values 14 15
[39]
HuH.7 ADAM17
Mean 11.7
Standard deviation 1.5
Values 13 12 10
[40]
SNU475 ADAM17
Mean 31
Standard deviation 2.8
Values 33 29
[41]
THLE ADAM17
Mean 19
Standard deviation 2.3
Values 17 21
[42]
liver ADAM17
Mean 7.57
Standard deviation 0.72
Values 7.2 8.6 7 7.4
[43]
ref_hepatocyte MIB2
Mean 3.64
Standard deviation 1.3
Values 4.4 2.1 2.4 4.9 4.4
[44]
HepG2 MIB2
Mean 17.4
Standard deviation 8.3
Values 23 11
[45]
HepG2.C3A MIB2
Mean 21.1
Standard deviation 11
Values 29 13
[46]
HuH.7 MIB2
Mean 13.1
Standard deviation 1.5
Values 11 14 14
[47]
SNU475 MIB2
Mean 8.62
Standard deviation 0.85
Values 9.2 8
[48]
THLE MIB2
Mean 11.9
Standard deviation 2.4
Values 14 10
[49]
liver MIB2
Mean 5.6
Standard deviation 2.5
Values 4.6 6.1 2.9 8.8
[50]
ref_hepatocyte MIB1
Mean 3.05
Standard deviation 2
Values 4.6 5.4 2.9 0.66 1.7
[51]
HepG2 MIB1
Mean 19
Standard deviation 5.8
Values 15 23
[52]
HepG2.C3A MIB1
Mean 39.4
Standard deviation 4.4
Values 36 42
[53]
HuH.7 MIB1
Mean 43.8
Standard deviation 11
Values 46 54 31
[54]
SNU475 MIB1
Mean 42.3
Standard deviation 11
Values 50 35
[55]
THLE MIB1
Mean 24.6
Standard deviation 1.6
Values 26 23
[56]
liver MIB1
Mean 28
Standard deviation 19
Values 13 49 11 39
[57]
ref_hepatocyte JAG1
Mean 2.61
Standard deviation 3.4
Values 8.4 2.4 1.7 0.3 0.21
[58]
HepG2 JAG1
Mean 158
Standard deviation 86
Values 2.2e+02 97
[59]
HepG2.C3A JAG1
Mean 52.9
Standard deviation 7.2
Values 58 48
[60]
HuH.7 JAG1
Mean 35.1
Standard deviation 12
Values 45 21 39
[61]
SNU475 JAG1
Mean 13.7
Standard deviation 0.39
Values 13 14
[62]
THLE JAG1
Mean 6
Standard deviation 0.4
Values 5.7 6.3
[63]
liver JAG1
Mean 7.68
Standard deviation 5.1
Values 4.1 8.6 3.5 15
[64]
ref_hepatocyte NOTCH1
Mean 0.644
Standard deviation 0.25
Values 0.33 0.55 0.55 0.91 0.89
[65]
HepG2 NOTCH1
Mean 5.33
Standard deviation 3.7
Values 8 2.7
[66]
HepG2.C3A NOTCH1
Mean 2.12
Standard deviation 0.1
Values 2.1 2.2
[67]
HuH.7 NOTCH1
Mean 5.14
Standard deviation 1.4
Values 5.4 6.4 3.6
[68]
SNU475 NOTCH1
Mean 7.09
Standard deviation 0.64
Values 6.6 7.5
[69]
THLE NOTCH1
Mean 10.2
Standard deviation 2.2
Values 8.6 12
[70]
liver NOTCH1
Mean 22.8
Standard deviation 16
Values 10 31 8.8 41
[71]
ref_hepatocyte DLL4
Mean 0.192
Standard deviation 0.12
Values 0.27 0 0.32 0.21 0.16
[72]
HepG2 DLL4
Mean 0.711
Standard deviation 0.21
Values 0.86 0.56
[73]
HepG2.C3A DLL4
Mean 1.04
Standard deviation 0.087
Values 1.1 0.98
[74]
HuH.7 DLL4
Mean 0.424
Standard deviation 0.13
Values 0.45 0.54 0.28
[75]
SNU475 DLL4
Mean 0.0403
Standard deviation 0.05
Values 0.0046 0.076
[76]
THLE DLL4
Mean 0.111
Standard deviation 0.039
Values 0.083 0.14
[77]
liver DLL4
Mean 2.51
Standard deviation 0.68
Values 3.4 2 2 2.7
[78]
ref_hepatocyte DLL1
Mean 0.139
Standard deviation 0.16
Values 0 0 0.22 0.38 0.098
[79]
HepG2 DLL1
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[80]
HepG2.C3A DLL1
Mean 0.0307
Standard deviation 0.0021
Values 0.029 0.032
[81]
HuH.7 DLL1
Mean 0.0308
Standard deviation 0.012
Values 0.016 0.039 0.037
[82]
SNU475 DLL1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[83]
THLE DLL1
Mean 0.356
Standard deviation 0.16
Values 0.47 0.24
[84]
liver DLL1
Mean 1.13
Standard deviation 0.35
Values 1.6 1.2 0.72 1.1
[85]
ref_hepatocyte JAG2
Mean 0.109
Standard deviation 0.15
Values 0 0.38 0.043 0.086 0.041
[86]
HepG2 JAG2
Mean 2.63
Standard deviation 2.9
Values 4.7 0.56
[87]
HepG2.C3A JAG2
Mean 0.152
Standard deviation 0.18
Values 0.28 0.021
[88]
HuH.7 JAG2
Mean 2.4
Standard deviation 0.54
Values 3 1.9 2.3
[89]
SNU475 JAG2
Mean 11.6
Standard deviation 2.5
Values 13 9.8
[90]
THLE JAG2
Mean 1.82
Standard deviation 0.62
Values 2.3 1.4
[91]
liver JAG2
Mean 0.58
Standard deviation 0.49
Values 0.38 0.59 0.1 1.3
[92]
ref_hepatocyte NEURL1B
Mean 0.0666
Standard deviation 0.09
Values 0 0.036 0 0.22 0.081
[93]
HepG2 NEURL1B
Mean 1.26
Standard deviation 0.81
Values 1.8 0.69
[94]
HepG2.C3A NEURL1B
Mean 0.0759
Standard deviation 0.016
Values 0.087 0.064
[95]
HuH.7 NEURL1B
Mean 0.307
Standard deviation 0.12
Values 0.24 0.24 0.44
[96]
SNU475 NEURL1B
Mean 3.62
Standard deviation 0.98
Values 4.3 2.9
[97]
THLE NEURL1B
Mean 7.33
Standard deviation 1.7
Values 6.1 8.5
[98]
liver NEURL1B
Mean 8.7
Standard deviation 5.1
Values 5.1 13 3.5 13
[99]
ref_hepatocyte NEURL1
Missing
[100]
HepG2 NEURL1
Missing
[101]
HepG2.C3A NEURL1
Missing
[102]
HuH.7 NEURL1
Missing
[103]
SNU475 NEURL1
Missing
[104]
THLE NEURL1
Missing
[105]
liver NEURL1
Missing