REACTOME_SIGNALING_BY_NOTCH1 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.16[2] | -1.52[3] | -1.36[4] | -1.68[5] | -1.33[6] | -0.77[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.71[16] | -0.76[17] | -0.99[18] | -0.83[19] | -0.95[20] | -0.32[21] |
4 | SKP1 | S-phase kinase-associated protein 1 | [22] | 0.06[23] | 0.30[24] | -0.57[25] | 0.60[26] | 0.71[27] | 0.41[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 1.72[30] | 1.47[31] | 2.52[32] | 0.57[33] | 1.27[34] | 0.45[35] |
6 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [36] | -1.02[37] | -0.74[38] | -0.85[39] | -1.60[40] | -1.29[41] | -0.99[42] |
7 | APH1A | Gamma-secretase subunit APH-1A | [43] | 0.97[44] | 1.09[45] | 1.32[46] | 0.83[47] | 0.62[48] | 0.09[49] |
8 | MYC | Myc proto-oncogene protein | [50] | 1.47[51] | 0.97[52] | -1.05[53] | -1.69[54] | 0.57[55] | -0.89[56] |
9 | CCNC | Cyclin-C | [57] | 0.12[58] | 1.34[59] | 0.86[60] | 0.01[61] | 0.14[62] | 1.00[63] |
10 | PSENEN | Gamma-secretase subunit PEN-2 | [64] | -1.02[65] | -1.17[66] | -0.69[67] | -0.79[68] | -1.32[69] | -0.96[70] |
11 | HIF1A | Hypoxia-inducible factor 1-alpha | [71] | 0.89[72] | 0.40[73] | 1.20[74] | 3.39[75] | 3.66[76] | 0.30[77] |
12 | SNW1 | SNW domain-containing protein 1 | [78] | 0.04[79] | 0.05[80] | 0.08[81] | 0.96[82] | 0.61[83] | -0.53[84] |
13 | HDAC1 | Histone deacetylase 1 | [85] | 1.55[86] | 1.40[87] | 2.10[88] | 1.75[89] | 1.42[90] | 0.64[91] |
14 | NCSTN | Nicastrin | [92] | 2.39[93] | 1.39[94] | 1.55[95] | 2.19[96] | 1.96[97] | 1.50[98] |
15 | CUL1 | Cullin-1 | [99] | 0.66[100] | 1.18[101] | 0.73[102] | 1.68[103] | 1.22[104] | 1.85[105] |
16 | NUMB | Protein numb homolog | [106] | 0.60[107] | 1.51[108] | 0.64[109] | 1.37[110] | 1.43[111] | 1.32[112] |
17 | HDAC3 | Histone deacetylase 3 | [113] | 1.52[114] | 1.42[115] | 1.23[116] | 1.05[117] | 1.10[118] | 0.70[119] |
18 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [120] | 2.39[121] | 2.76[122] | 2.03[123] | 2.63[124] | 1.85[125] | 3.27[126] |
19 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [127] | 2.02[128] | 2.35[129] | 2.38[130] | 2.38[131] | 2.68[132] | 1.90[133] |
20 | ARRB2 | Beta-arrestin-2 | [134] | 1.21[135] | 1.44[136] | 1.40[137] | -0.21[138] | 0.48[139] | 0.23[140] |
21 | TLE1 | Transducin-like enhancer protein 1 | [141] | 2.61[142] | 1.83[143] | 1.12[144] | 1.20[145] | 0.90[146] | 1.45[147] |
22 | HES1 | Transcription factor HES-1 | [148] | 0.61[149] | -2.05[150] | 0.21[151] | -0.18[152] | -1.12[153] | -0.29[154] |
23 | NCOR1 | Nuclear receptor corepressor 1 | [155] | 2.12[156] | 2.46[157] | 3.12[158] | 2.67[159] | 2.60[160] | 3.90[161] |
24 | HDAC2 | Histone deacetylase 2 | [162] | 2.77[163] | 3.93[164] | 3.31[165] | 3.26[166] | 3.29[167] | 1.30[168] |
25 | PSEN1 | Presenilin-1 | [169] | 2.10[170] | 2.16[171] | 1.73[172] | 2.35[173] | 2.12[174] | 2.10[175] |
26 | HDAC6 | Histone deacetylase 6 | [176] | 1.70[177] | 2.49[178] | 2.58[179] | 1.38[180] | 0.75[181] | 3.26[182] |
27 | HDAC8 | Histone deacetylase 8 | [183] | 0.07[184] | -0.29[185] | -0.01[186] | 0.33[187] | 0.45[188] | 0.75[189] |
28 | DLK1 | Protein delta homolog 1 | [190] | 2.49[191] | 5.17[192] | -6.12[193] | -7.17[194] | -7.75[195] | -3.66[196] |
29 | CDK8 | Cyclin-dependent kinase 8 | [197] | 0.19[198] | 0.59[199] | -0.34[200] | 0.60[201] | 0.10[202] | -0.65[203] |
30 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [204] | 1.72[205] | 1.44[206] | 1.19[207] | 2.84[208] | 1.86[209] | 1.18[210] |
31 | KAT2A | Histone acetyltransferase KAT2A | [211] | 3.07[212] | 2.77[213] | 1.89[214] | 2.23[215] | 1.97[216] | 1.39[217] |
32 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [218] | 2.12[219] | 2.50[220] | 3.15[221] | 3.51[222] | 2.96[223] | 3.98[224] |
33 | PSEN2 | Presenilin-2 | [225] | 0.35[226] | -0.66[227] | -4.47[228] | 1.18[229] | -0.30[230] | 1.01[231] |
34 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [232] | 2.38[233] | 2.63[234] | 4.19[235] | -3.30[236] | 2.08[237] | 2.85[238] |
35 | DTX2 | Probable E3 ubiquitin-protein ligase DTX2 | [239] | 0.73[240] | -0.20[241] | -0.40[242] | 0.85[243] | -0.06[244] | 0.36[245] |
36 | MIB2 | E3 ubiquitin-protein ligase MIB2 | [246] | 2.16[247] | 2.45[248] | 1.82[249] | 1.47[250] | 1.66[251] | 1.22[252] |
37 | RBPJ | Recombining binding protein suppressor of hairless | [253] | 2.38[254] | 2.80[255] | 3.81[256] | 3.12[257] | 2.94[258] | 2.96[259] |
38 | FBXW7 | F-box/WD repeat-containing protein 7 | [260] | 0.31[261] | 0.82[262] | 0.81[263] | 0.20[264] | 1.11[265] | 2.25[266] |
39 | HDAC10 | Histone deacetylase 10 | [267] | 1.14[268] | 1.56[269] | 2.37[270] | 0.81[271] | 0.35[272] | 1.28[273] |
40 | MIB1 | E3 ubiquitin-protein ligase MIB1 | [274] | 2.54[275] | 3.60[276] | 3.82[277] | 4.02[278] | 2.96[279] | 3.80[280] |
41 | KAT2B | Histone acetyltransferase KAT2B | [281] | -1.01[282] | -2.28[283] | 0.09[284] | 1.04[285] | 1.35[286] | 2.89[287] |
42 | JAG1 | Protein jagged-1 | [288] | 5.82[289] | 4.25[290] | 3.72[291] | 2.62[292] | 1.15[293] | 2.15[294] |
43 | NCOR2 | Nuclear receptor corepressor 2 | [295] | 4.39[296] | 2.62[297] | 2.73[298] | 5.25[299] | 4.64[300] | 2.99[301] |
44 | DTX4 | E3 ubiquitin-protein ligase DTX4 | [302] | 1.93[303] | 1.79[304] | 3.01[305] | 1.88[306] | -1.70[307] | 3.49[308] |
45 | DTX1 | E3 ubiquitin-protein ligase DTX1 | [309] | -5.90[310] | -7.00[311] | [312] | -4.71[313] | -6.68[314] | 1.72[315] |
46 | EP300 | Histone acetyltransferase p300 | [316] | 3.76[317] | 3.20[318] | 4.10[319] | 3.67[320] | 3.61[321] | 3.86[322] |
47 | TLE3 | Transducin-like enhancer protein 3 | [323] | 1.41[324] | 1.00[325] | 3.72[326] | 3.45[327] | 2.91[328] | 1.39[329] |
48 | HDAC5 | Histone deacetylase 5 | [330] | 3.72[331] | 4.40[332] | 3.76[333] | 2.75[334] | 2.04[335] | 2.30[336] |
49 | MAML1 | Mastermind-like protein 1 | [337] | 3.16[338] | 2.96[339] | 3.51[340] | 3.34[341] | 3.37[342] | 2.19[343] |
50 | CREBBP | CREB-binding protein | [344] | 3.94[345] | 3.00[346] | 3.61[347] | 3.86[348] | 3.75[349] | 4.34[350] |
51 | HDAC7 | Histone deacetylase 7 | [351] | 3.43[352] | 2.62[353] | 2.32[354] | 4.20[355] | 4.41[356] | 2.08[357] |
52 | HDAC11 | Histone deacetylase 11 | [358] | 3.61[359] | 4.11[360] | 2.95[361] | 2.48[362] | 1.76[363] | 0.88[364] |
53 | TLE2 | Transducin-like enhancer protein 2 | [365] | -1.57[366] | -1.18[367] | 4.36[368] | -0.81[369] | 1.84[370] | 1.78[371] |
54 | MAMLD1 | Mastermind-like domain-containing protein 1 | [372] | -0.86[373] | -7.51[374] | -1.25[375] | 2.15[376] | 1.86[377] | 0.77[378] |
55 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [379] | 2.68[380] | 0.98[381] | 1.06[382] | 0.60[383] | -0.70[384] | 1.16[385] |
56 | APH1B | Gamma-secretase subunit APH-1B | [386] | 0.81[387] | 1.45[388] | 4.59[389] | 4.20[390] | 3.12[391] | 2.33[392] |
57 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [393] | 2.95[394] | 1.63[395] | 2.97[396] | 3.68[397] | 3.93[398] | 5.74[399] |
58 | ARRB1 | Beta-arrestin-1 | [400] | 4.63[401] | 4.27[402] | 3.57[403] | 3.25[404] | 2.95[405] | 4.38[406] |
59 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [407] | -2.68[408] | -4.63[409] | -4.73[410] | -2.76[411] | -5.70[412] | 1.86[413] |
60 | HDAC4 | Histone deacetylase 4 | [414] | 4.51[415] | 4.18[416] | 3.96[417] | 3.80[418] | 4.01[419] | 4.49[420] |
61 | MAML3 | Mastermind-like protein 3 | [421] | 0.67[422] | 1.24[423] | 4.28[424] | 2.50[425] | 1.01[426] | 4.60[427] |
62 | TLE4 | Transducin-like enhancer protein 4 | [428] | 2.44[429] | 4.41[430] | 3.24[431] | 1.21[432] | 4.05[433] | 3.38[434] |
63 | MAML2 | Mastermind-like protein 2 | [435] | 4.53[436] | 4.99[437] | -1.57[438] | 5.88[439] | 4.63[440] | 3.47[441] |
64 | DLL4 | Delta-like protein 4 | [442] | 1.79[443] | 2.34[444] | 1.11[445] | -2.03[446] | -0.85[447] | 4.31[448] |
65 | HDAC9 | Histone deacetylase 9 | [449] | 1.36[450] | -1.70[451] | 2.91[452] | 6.70[453] | 4.69[454] | 3.96[455] |
66 | DLL1 | Delta-like protein 1 | [456] | -3.32[457] | -2.28[458] | -2.21[459] | -5.69[460] | 1.30[461] | 3.61[462] |
67 | JAG2 | Protein jagged-2 | [463] | 4.49[464] | 0.38[465] | 4.43[466] | 6.95[467] | 4.01[468] | 3.01[469] |
68 | NBEA | Neurobeachin | [470] | 5.03[471] | 4.56[472] | 2.36[473] | 3.04[474] | 5.28[475] | 5.93[476] |
69 | NEURL1B | E3 ubiquitin-protein ligase NEURL1B | [477] | 4.14[478] | 0.10[479] | 2.18[480] | 5.99[481] | 6.73[482] | 7.63[483] |
70 | HES5 | Transcription factor HES-5 | [484] | 4.28[485] | -0.11[486] | [487] | [488] | -1.37[489] | 1.48[490] |
71 | HEYL | Hairy/enhancer-of-split related with YRPW motif-like protein | [491] | 3.28[492] | 1.95[493] | 3.90[494] | 6.85[495] | 3.85[496] | 7.23[497] |
72 | CNTN1 | Contactin-1 | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | NEURL1 | E3 ubiquitin-protein ligase NEURL1 | [505] | [506] | [507] | [508] | [509] | [510] | [511] |
74 | DNER | Delta and Notch-like epidermal growth factor-related receptor | [512] | [513] | [514] | [515] | [516] | [517] | [518] |