REACTOME_SIGNALING_BY_NODAL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DRAP1 Dr1-associated corepressor [1] -2.45[2] -2.15[3] -2.74[4] -1.21[5] -1.28[6] -3.74[7]
2 FURIN Furin [8] 0.69[9] -2.37[10] -0.53[11] -1.27[12] -1.10[13] 0.20[14]
3 PCSK6 Proprotein convertase subtilisin/kexin type 6 [15] -0.65[16] -0.13[17] -1.16[18] -6.79[19] -7.41[20] 1.00[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 0.77[23] 1.60[24] 1.10[25] 1.85[26] 1.21[27] 0.32[28]
5 SMAD3 Mothers against decapentaplegic homolog 3 [29] 1.00[30] 1.08[31] 0.98[32] 1.79[33] 2.39[34] -1.24[35]
6 ACVR1B Activin receptor type-1B [36] -0.24[37] 0.41[38] 2.00[39] 1.08[40] 1.11[41] -0.44[42]
7 MAPK3 Mitogen-activated protein kinase 3 [43] 0.92[44] 1.65[45] 1.36[46] 0.42[47] 0.16[48] -2.49[49]
8 SMAD4 Mothers against decapentaplegic homolog 4 [50] 0.46[51] 1.78[52] 1.42[53] 1.91[54] 1.99[55] 1.34[56]
9 FOXO3 Forkhead box protein O3 [57] -0.48[58] 0.30[59] 0.61[60] 0.40[61] 1.35[62] 0.88[63]
10 SMAD2 Mothers against decapentaplegic homolog 2 [64] 1.08[65] 2.04[66] 1.20[67] 2.38[68] 2.29[69] 1.12[70]
11 TDGF1 Teratocarcinoma-derived growth factor 1 [71] -1.70[72] -6.77[73] -5.45[74] -8.94[75] -8.50[76] -2.60[77]
12 ACVR2A Activin receptor type-2A [78] -0.08[79] 1.62[80] 1.13[81] 0.82[82] 1.04[83] 1.23[84]
13 ACVR2B Activin receptor type-2B [85] 1.34[86] 3.43[87] 3.92[88] 1.09[89] 0.61[90] 1.72[91]
14 DAND5 DAN domain family member 5 [92] -2.99[93] -1.48[94] -2.13[95] -0.56[96] -2.19[97] -3.88[98]
15 LEFTY1 Left-right determination factor 1 [99] -1.48[100] -2.26[101] -1.36[102] -4.57[103] -4.80[104] -2.38[105]
16 ACVR1C Activin receptor type-1C [106] -2.21[107] -0.53[108] 4.36[109] -1.04[110] -2.24[111] 2.33[112]
17 FOXH1 Forkhead box protein H1 [113] -3.87[114] 2.59[115] -4.53[116] -3.05[117] -3.40[118] -4.68[119]
18 LEFTY2 Left-right determination factor 2 [120] -0.67[121] -0.18[122] 2.49[123] 0.19[124] -4.67[125] -3.47[126]
19 NODAL Nodal homolog [127] 2.96[128] -0.06[129] 4.42[130] 3.56[131] 1.99[132] 3.22[133]
20 CFC1 Cryptic protein [134] [135] [136] [137] [138] [139] [140]
21 CER1 Cerberus [141] [142] [143] [144] [145] [146] [147]
22 GDF1 Embryonic growth/differentiation factor 1 [148] [149] [150] [151] [152] [153] [154]
23 TDGF1P3 Putative teratocarcinoma-derived growth factor 3 [155] [156] [157] [158] [159] [160] [161]
[1]
ref_hepatocyte DRAP1
Mean 39.9
Standard deviation 23
Values 11 75 47 38 29
[2]
HepG2 DRAP1
Mean 30.9
Standard deviation 7.3
Values 36 26
[3]
HepG2.C3A DRAP1
Mean 20.9
Standard deviation 2
Values 22 20
[4]
HuH.7 DRAP1
Mean 16.8
Standard deviation 3
Values 15 15 20
[5]
SNU475 DRAP1
Mean 31.8
Standard deviation 1.1
Values 31 33
[6]
THLE DRAP1
Mean 41.2
Standard deviation 4.7
Values 38 45
[7]
liver DRAP1
Mean 11.7
Standard deviation 10
Values 22 3.9 19 2.3
[8]
ref_hepatocyte FURIN
Mean 36.4
Standard deviation 35
Values 1.6 11 25 83 62
[9]
HepG2 FURIN
Mean 249
Standard deviation 93
Values 3.1e+02 1.8e+02
[10]
HepG2.C3A FURIN
Mean 16.4
Standard deviation 4.8
Values 13 20
[11]
HuH.7 FURIN
Mean 70.6
Standard deviation 9.9
Values 82 63 67
[12]
SNU475 FURIN
Mean 27.8
Standard deviation 0.065
Values 28 28
[13]
THLE FURIN
Mean 42.8
Standard deviation 10
Values 35 50
[14]
liver FURIN
Mean 163
Standard deviation 30
Values 2e+02 1.5e+02 1.3e+02 1.7e+02
[15]
ref_hepatocyte PCSK6
Mean 25.1
Standard deviation 28
Values 6.6 3.8 3.7 55 57
[16]
HepG2 PCSK6
Mean 67.5
Standard deviation 1.1
Values 67 68
[17]
HepG2.C3A PCSK6
Mean 53.6
Standard deviation 1.4
Values 55 53
[18]
HuH.7 PCSK6
Mean 31.5
Standard deviation 2.8
Values 33 34 28
[19]
SNU475 PCSK6
Mean 0.419
Standard deviation 0.0045
Values 0.42 0.42
[20]
THLE PCSK6
Mean 0.372
Standard deviation 0.22
Values 0.53 0.22
[21]
liver PCSK6
Mean 196
Standard deviation 58
Values 1.8e+02 2.4e+02 1.2e+02 2.4e+02
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[29]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[30]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[31]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[32]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[33]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[34]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[35]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[36]
ref_hepatocyte ACVR1B
Mean 4.32
Standard deviation 1.8
Values 1.8 3.4 5.3 6.3 4.8
[37]
HepG2 ACVR1B
Mean 15.4
Standard deviation 2.5
Values 17 14
[38]
HepG2.C3A ACVR1B
Mean 13.3
Standard deviation 0.78
Values 14 13
[39]
HuH.7 ACVR1B
Mean 48.4
Standard deviation 11
Values 59 37 49
[40]
SNU475 ACVR1B
Mean 16.8
Standard deviation 1.8
Values 18 16
[41]
THLE ACVR1B
Mean 23.4
Standard deviation 6.1
Values 19 28
[42]
liver ACVR1B
Mean 12.4
Standard deviation 7.1
Values 7.6 19 5.1 18
[43]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[44]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[45]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[46]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[47]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[48]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[49]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[50]
ref_hepatocyte SMAD4
Mean 3.16
Standard deviation 0.71
Values 2.9 2.8 4.2 2.4 3.4
[51]
HepG2 SMAD4
Mean 18.3
Standard deviation 3.2
Values 16 21
[52]
HepG2.C3A SMAD4
Mean 25.2
Standard deviation 3
Values 27 23
[53]
HuH.7 SMAD4
Mean 23.6
Standard deviation 3.4
Values 24 27 20
[54]
SNU475 SMAD4
Mean 21.8
Standard deviation 2.7
Values 24 20
[55]
THLE SMAD4
Mean 31.4
Standard deviation 1.4
Values 30 32
[56]
liver SMAD4
Mean 31
Standard deviation 13
Values 23 40 16 44
[57]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[58]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[59]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[60]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[61]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[62]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[63]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[64]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 4.5 2.8 1.9 1.9 1.6
[65]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 21 24
[66]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 25 23
[67]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 17 18 15
[68]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 27 22
[69]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[70]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 17 29 15 25
[71]
ref_hepatocyte TDGF1
Mean 1.24
Standard deviation 1.2
Values 0.8 0.067 3.3 0.78 1.3
[72]
HepG2 TDGF1
Mean 1.6
Standard deviation 0.22
Values 1.4 1.8
[73]
HepG2.C3A TDGF1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[74]
HuH.7 TDGF1
Mean 0.0792
Standard deviation 0.049
Values 0.09 0.026 0.12
[75]
SNU475 TDGF1
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[76]
THLE TDGF1
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[77]
liver TDGF1
Mean 0.794
Standard deviation 0.53
Values 1.5 0.37 0.98 0.37
[78]
ref_hepatocyte ACVR2A
Mean 0.936
Standard deviation 0.37
Values 1.1 0.98 0.3 1.1 1.2
[79]
HepG2 ACVR2A
Mean 3.74
Standard deviation 1
Values 3 4.5
[80]
HepG2.C3A ACVR2A
Mean 6.72
Standard deviation 1.6
Values 7.9 5.6
[81]
HuH.7 ACVR2A
Mean 5.74
Standard deviation 0.84
Values 5.9 6.5 4.8
[82]
SNU475 ACVR2A
Mean 3.04
Standard deviation 0.25
Values 2.9 3.2
[83]
THLE ACVR2A
Mean 4.84
Standard deviation 0.58
Values 5.2 4.4
[84]
liver ACVR2A
Mean 8.52
Standard deviation 0.53
Values 7.8 8.6 9.1 8.6
[85]
ref_hepatocyte ACVR2B
Mean 0.673
Standard deviation 0.59
Values 1.7 0.32 0.36 0.37 0.62
[86]
HepG2 ACVR2B
Mean 7.22
Standard deviation 2
Values 8.6 5.8
[87]
HepG2.C3A ACVR2B
Mean 16.9
Standard deviation 7.7
Values 22 12
[88]
HuH.7 ACVR2B
Mean 28.7
Standard deviation 6.3
Values 32 33 21
[89]
SNU475 ACVR2B
Mean 2.64
Standard deviation 0.036
Values 2.6 2.7
[90]
THLE ACVR2B
Mean 2.58
Standard deviation 0.1
Values 2.5 2.6
[91]
liver ACVR2B
Mean 8.61
Standard deviation 5.5
Values 4.7 11 3.4 15
[92]
ref_hepatocyte DAND5
Mean 0.398
Standard deviation 0.19
Values 0.56 0.63 0.29 0.3 0.2
[93]
HepG2 DAND5
Mean 0.211
Standard deviation 0.026
Values 0.23 0.19
[94]
HepG2.C3A DAND5
Mean 0.332
Standard deviation 0.14
Values 0.43 0.24
[95]
HuH.7 DAND5
Mean 0.255
Standard deviation 0.095
Values 0.15 0.29 0.33
[96]
SNU475 DAND5
Mean 0.497
Standard deviation 0.12
Values 0.58 0.41
[97]
THLE DAND5
Mean 0.218
Standard deviation 0.14
Values 0.32 0.12
[98]
liver DAND5
Mean 0.105
Standard deviation 0.084
Values 0 0.19 0.077 0.16
[99]
ref_hepatocyte LEFTY1
Mean 0.255
Standard deviation 0.27
Values 0.36 0 0.68 0.086 0.15
[100]
HepG2 LEFTY1
Mean 0.387
Standard deviation 0.31
Values 0.61 0.17
[101]
HepG2.C3A LEFTY1
Mean 0.124
Standard deviation 0.052
Values 0.087 0.16
[102]
HuH.7 LEFTY1
Mean 0.28
Standard deviation 0.12
Values 0.35 0.14 0.35
[103]
SNU475 LEFTY1
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[104]
THLE LEFTY1
Mean 0.0231
Standard deviation 0.018
Values 0.035 0.011
[105]
liver LEFTY1
Mean 0.19
Standard deviation 0.11
Values 0.26 0.057 0.15 0.29
[106]
ref_hepatocyte ACVR1C
Mean 0.114
Standard deviation 0.13
Values 0 0.17 0 0.086 0.31
[107]
HepG2 ACVR1C
Mean 0.104
Standard deviation 0.11
Values 0.023 0.18
[108]
HepG2.C3A ACVR1C
Mean 0.183
Standard deviation 0.14
Values 0.087 0.28
[109]
HuH.7 ACVR1C
Mean 6.57
Standard deviation 0.82
Values 7 7.1 5.6
[110]
SNU475 ACVR1C
Mean 0.101
Standard deviation 0.0073
Values 0.11 0.096
[111]
THLE ACVR1C
Mean 0.0606
Standard deviation 0.048
Values 0.095 0.027
[112]
liver ACVR1C
Mean 2.23
Standard deviation 0.55
Values 2.9 2.3 1.6 2.1
[113]
ref_hepatocyte FOXH1
Mean 0.109
Standard deviation 0.064
Values 0.11 0 0.14 0.16 0.13
[114]
HepG2 FOXH1
Mean 0.0315
Standard deviation 0.004
Values 0.029 0.034
[115]
HepG2.C3A FOXH1
Mean 1.53
Standard deviation 0.21
Values 1.4 1.7
[116]
HuH.7 FOXH1
Mean 0.0133
Standard deviation 0.0053
Values 0.0082 0.013 0.019
[117]
SNU475 FOXH1
Mean 0.0243
Standard deviation 0.0015
Values 0.023 0.025
[118]
THLE FOXH1
Mean 0.026
Standard deviation 0.022
Values 0.041 0.011
[119]
liver FOXH1
Mean 0.0166
Standard deviation 0.021
Values 0.024 0.043 0 0
[120]
ref_hepatocyte LEFTY2
Mean 0.0598
Standard deviation 0.13
Values 0 0 0.3 0 0
[121]
HepG2 LEFTY2
Mean 0.158
Standard deviation 0.18
Values 0.29 0.03
[122]
HepG2.C3A LEFTY2
Mean 0.123
Standard deviation 0.023
Values 0.11 0.14
[123]
HuH.7 LEFTY2
Mean 0.94
Standard deviation 0.51
Values 0.76 0.54 1.5
[124]
SNU475 LEFTY2
Mean 0.125
Standard deviation 0.17
Values 0.25 0.0051
[125]
THLE LEFTY2
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[126]
liver LEFTY2
Mean 0.0209
Standard deviation 0.034
Values 0.071 0 0 0.013
[127]
ref_hepatocyte NODAL
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[128]
HepG2 NODAL
Mean 0.214
Standard deviation 0.03
Values 0.23 0.19
[129]
HepG2.C3A NODAL
Mean 0.0146
Standard deviation 0.021
Values 0.029 0
[130]
HuH.7 NODAL
Mean 0.391
Standard deviation 0.15
Values 0.43 0.51 0.22
[131]
SNU475 NODAL
Mean 0.141
Standard deviation 0.029
Values 0.12 0.16
[132]
THLE NODAL
Mean 0.0648
Standard deviation 0.0088
Values 0.071 0.059
[133]
liver NODAL
Mean 0.236
Standard deviation 0.26
Values 0.024 0.29 0.051 0.58
[134]
ref_hepatocyte CFC1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 CFC1
Missing
[136]
HepG2.C3A CFC1
Missing
[137]
HuH.7 CFC1
Missing
[138]
SNU475 CFC1
Missing
[139]
THLE CFC1
Missing
[140]
liver CFC1
Missing
[141]
ref_hepatocyte CER1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 CER1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[143]
HepG2.C3A CER1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 CER1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 CER1
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[146]
THLE CER1
Mean 0
Standard deviation 0
Values 0 0
[147]
liver CER1
Mean 0.00999
Standard deviation 0.012
Values 0 0.014 0.026 0
[148]
ref_hepatocyte GDF1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GDF1
Missing
[150]
HepG2.C3A GDF1
Missing
[151]
HuH.7 GDF1
Missing
[152]
SNU475 GDF1
Missing
[153]
THLE GDF1
Missing
[154]
liver GDF1
Missing
[155]
ref_hepatocyte TDGF1P3
Missing
[156]
HepG2 TDGF1P3
Mean 0.0479
Standard deviation 0.011
Values 0.04 0.056
[157]
HepG2.C3A TDGF1P3
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[158]
HuH.7 TDGF1P3
Mean 0.0248
Standard deviation 0.02
Values 0.0082 0.019 0.047
[159]
SNU475 TDGF1P3
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[160]
THLE TDGF1P3
Mean 0.0281
Standard deviation 0.0021
Values 0.03 0.027
[161]
liver TDGF1P3
Mean 0.054
Standard deviation 0.052
Values 0 0.071 0.026 0.12