REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAB 14-3-3 protein beta/alpha [1] 0.55[2] 0.07[3] -0.75[4] 0.59[5] 0.19[6] -0.37[7]
2 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit [8] -0.73[9] -0.35[10] -0.36[11] 0.05[12] 0.03[13] 0.23[14]
3 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 0.19[15] 0.79[16] 0.90[17] -0.47[18] -0.21[19] -1.35[20]
4 RAF1 RAF proto-oncogene serine/threonine-protein kinase [21] -0.55[22] -0.33[23] 0.83[24] -0.89[25] 0.13[26] 0.83[27]
5 ARAF Serine/threonine-protein kinase A-Raf [28] -0.95[29] -1.44[30] -1.27[31] -0.80[32] -0.61[33] 0.61[34]
6 SHOC2 Leucine-rich repeat protein SHOC-2 [35] -1.25[36] -0.07[37] -0.57[38] -0.58[39] -0.14[40] 0.42[41]
7 MRAS Ras-related protein M-Ras [42] 1.26[43] -4.59[44] -3.52[45] -0.25[46] 0.22[47] -1.93[48]
8 BRAF Serine/threonine-protein kinase B-raf [49] -0.24[50] -0.70[51] 1.23[52] 0.03[53] -0.11[54] 1.58[55]
[1]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[2]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[3]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[4]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[5]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[6]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[7]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[8]
ref_hepatocyte PPP1CB
Mean 31.9
Standard deviation 30
Values 65 64 8.8 6.2 16
[9]
HepG2 PPP1CB
Mean 59.8
Standard deviation 14
Values 50 70
[10]
HepG2.C3A PPP1CB
Mean 78.8
Standard deviation 12
Values 71 87
[11]
HuH.7 PPP1CB
Mean 80.4
Standard deviation 9.9
Values 92 76 74
[12]
SNU475 PPP1CB
Mean 99.4
Standard deviation 25
Values 1.2e+02 82
[13]
THLE PPP1CB
Mean 98.3
Standard deviation 1.6
Values 99 97
[14]
liver PPP1CB
Mean 64.1
Standard deviation 7.2
Values 67 68 67 53
[15]
ref_hepatocyte PPP1CC
Mean 27
Standard deviation 18
Values 56 31 20 14 14
[16]
HepG2 PPP1CC
Mean 95.3
Standard deviation 20
Values 81 1.1e+02
[17]
HepG2.C3A PPP1CC
Mean 146
Standard deviation 2.8
Values 1.5e+02 1.4e+02
[18]
HuH.7 PPP1CC
Mean 164
Standard deviation 10
Values 1.8e+02 1.6e+02 1.6e+02
[19]
SNU475 PPP1CC
Mean 58.5
Standard deviation 7.8
Values 53 64
[20]
THLE PPP1CC
Mean 70.4
Standard deviation 7.7
Values 65 76
[21]
liver PPP1CC
Mean 18.1
Standard deviation 3.3
Values 23 17 15 18
[22]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 6 14 20 20 17
[23]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 29 36
[24]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 41 37
[25]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 85 93 89
[26]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 22 28
[27]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[28]
liver RAF1
Mean 47
Standard deviation 3.6
Values 51 42 49 46
[29]
ref_hepatocyte ARAF
Mean 12.3
Standard deviation 8
Values 4.1 4 13 21 19
[30]
HepG2 ARAF
Mean 19.8
Standard deviation 1.6
Values 21 19
[31]
HepG2.C3A ARAF
Mean 14.3
Standard deviation 2.2
Values 16 13
[32]
HuH.7 ARAF
Mean 16.5
Standard deviation 1.9
Values 18 14 17
[33]
SNU475 ARAF
Mean 21.1
Standard deviation 1.4
Values 22 20
[34]
THLE ARAF
Mean 24.2
Standard deviation 1.6
Values 23 25
[35]
liver ARAF
Mean 32.1
Standard deviation 23
Values 50 11 54 13
[36]
ref_hepatocyte SHOC2
Mean 7.37
Standard deviation 5.7
Values 12 15 2.7 3.2 3.8
[37]
HepG2 SHOC2
Mean 9.65
Standard deviation 4.5
Values 6.5 13
[38]
HepG2.C3A SHOC2
Mean 22.1
Standard deviation 2.6
Values 20 24
[39]
HuH.7 SHOC2
Mean 16.1
Standard deviation 3.7
Values 15 20 13
[40]
SNU475 SHOC2
Mean 14.8
Standard deviation 0.43
Values 15 14
[41]
THLE SHOC2
Mean 20.2
Standard deviation 1.2
Values 21 19
[42]
liver SHOC2
Mean 16.9
Standard deviation 2.1
Values 15 20 16 17
[43]
ref_hepatocyte MRAS
Mean 3.26
Standard deviation 5.7
Values 13 2.1 0.42 0.41 0.15
[44]
HepG2 MRAS
Mean 24.2
Standard deviation 5.3
Values 21 28
[45]
HepG2.C3A MRAS
Mean 0.426
Standard deviation 0.066
Values 0.38 0.47
[46]
HuH.7 MRAS
Mean 0.918
Standard deviation 0.11
Values 0.94 1 0.8
[47]
SNU475 MRAS
Mean 8.2
Standard deviation 1.9
Values 9.5 6.9
[48]
THLE MRAS
Mean 11.4
Standard deviation 0.24
Values 11 12
[49]
liver MRAS
Mean 1.46
Standard deviation 0.22
Values 1.2 1.6 1.7 1.4
[50]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 0.56 1.2 2.3 0.67 0.67
[51]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 2.4 3.2
[52]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 1.6 2.5
[53]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 6.4 15 3.4
[54]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.2 3.4
[55]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[56]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 3.1 8 2.9 7.9