REACTOME_SIGNALING_BY_MET | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -2.42[2] | -2.34[3] | -2.26[4] | -3.24[5] | -2.65[6] | -1.76[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.98[16] | -1.59[17] | -1.90[18] | -2.39[19] | -2.28[20] | -1.31[21] |
4 | FN1 | Fibronectin | [22] | 3.27[23] | 3.02[24] | 2.84[25] | 2.46[26] | 2.79[27] | 2.41[28] |
5 | ITGB1 | Integrin beta-1 | [29] | 0.01[30] | 0.31[31] | 0.37[32] | 1.00[33] | 1.21[34] | 0.28[35] |
6 | HPN | Serine protease hepsin | [36] | -2.73[37] | -0.49[38] | -3.62[39] | -12.05[40] | -10.91[41] | 0.43[42] |
7 | RAP1B | Ras-related protein Rap-1b | [43] | -2.52[44] | -1.63[45] | -1.93[46] | -0.99[47] | -1.10[48] | -1.77[49] |
8 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [50] | 0.46[51] | 0.64[52] | 1.61[53] | -0.99[54] | -0.05[55] | -0.54[56] |
9 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [57] | -0.61[58] | -0.67[59] | -0.03[60] | -0.45[61] | -0.34[62] | -0.85[63] |
10 | RAB4A | Ras-related protein Rab-4A | [64] | -1.51[65] | -0.02[66] | -0.17[67] | -2.38[68] | -3.21[69] | -0.96[70] |
11 | STAT3 | Signal transducer and activator of transcription 3 | [71] | 0.33[72] | -0.89[73] | -0.23[74] | -0.22[75] | -0.82[76] | 2.52[77] |
12 | LAMC2 | Laminin subunit gamma-2 | [78] | -8.55[79] | -9.50[80] | -8.30[81] | -5.43[82] | -4.15[83] | -6.21[84] |
13 | LAMB3 | Laminin subunit beta-3 | [85] | -3.03[86] | -5.61[87] | -4.23[88] | -1.12[89] | -1.96[90] | -2.26[91] |
14 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [92] | 0.23[93] | 0.93[94] | 0.82[95] | 0.43[96] | 1.19[97] | 1.38[98] |
15 | GRB2 | Growth factor receptor-bound protein 2 | [99] | 0.98[100] | 1.09[101] | 1.14[102] | 0.09[103] | 0.13[104] | 0.42[105] |
16 | ARF6 | ADP-ribosylation factor 6 | [106] | -0.65[107] | -0.30[108] | 0.74[109] | -0.75[110] | -0.07[111] | 0.17[112] |
17 | HGFAC | Hepatocyte growth factor activator | [113] | -2.92[114] | 0.21[115] | -7.99[116] | -9.56[117] | -11.00[118] | 0.93[119] |
18 | CRK | Adapter molecule crk | [120] | -0.42[121] | -0.21[122] | -0.22[123] | -0.70[124] | -0.18[125] | 0.96[126] |
19 | RAP1A | Ras-related protein Rap-1A | [127] | -1.27[128] | -1.05[129] | -0.29[130] | -0.68[131] | -0.79[132] | -1.17[133] |
20 | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate | [134] | 0.68[135] | 0.46[136] | -0.14[137] | 0.03[138] | 0.08[139] | -0.66[140] |
21 | SHC1 | SHC-transforming protein 1 | [141] | 0.94[142] | 1.44[143] | 1.44[144] | 2.19[145] | 1.80[146] | 0.90[147] |
22 | NRAS | GTPase NRas | [148] | 0.41[149] | 1.12[150] | 1.46[151] | 0.54[152] | 0.23[153] | -0.13[154] |
23 | MET | Hepatocyte growth factor receptor | [155] | -0.14[156] | 0.17[157] | 0.73[158] | 1.07[159] | -0.08[160] | 1.09[161] |
24 | LAMB2 | Laminin subunit beta-2 | [162] | 1.92[163] | 1.87[164] | 0.75[165] | 0.44[166] | 1.46[167] | 2.21[168] |
25 | SH3GL1 | Endophilin-A2 | [169] | 0.85[170] | 1.52[171] | 0.61[172] | 0.07[173] | 0.54[174] | -0.32[175] |
26 | HRAS | GTPase HRas | [176] | -1.23[177] | -1.66[178] | -2.52[179] | -1.41[180] | -1.50[181] | -2.54[182] |
27 | KRAS | GTPase KRas | [183] | -0.73[184] | -0.48[185] | 1.05[186] | 0.34[187] | 0.13[188] | 0.79[189] |
28 | PTK2 | Focal adhesion kinase 1 | [190] | 0.52[191] | 1.28[192] | 1.59[193] | 1.49[194] | 0.81[195] | 0.88[196] |
29 | LAMC1 | Laminin subunit gamma-1 | [197] | 3.13[198] | 1.67[199] | 2.33[200] | 3.31[201] | 3.07[202] | 1.35[203] |
30 | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | [204] | 0.90[205] | 0.84[206] | 0.29[207] | 1.36[208] | 0.79[209] | -0.19[210] |
31 | PTPN2 | Tyrosine-protein phosphatase non-receptor type 2 | [211] | -1.07[212] | 0.51[213] | 0.83[214] | -1.02[215] | -0.75[216] | -0.14[217] |
32 | CRKL | Crk-like protein | [218] | 1.48[219] | 1.86[220] | 2.39[221] | 0.66[222] | 0.99[223] | 1.57[224] |
33 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [225] | -0.69[226] | -0.30[227] | 0.72[228] | 1.61[229] | 1.23[230] | 3.12[231] |
34 | SOS1 | Son of sevenless homolog 1 | [232] | -0.32[233] | 1.49[234] | 0.92[235] | 0.38[236] | -0.26[237] | 0.66[238] |
35 | USP8 | Ubiquitin carboxyl-terminal hydrolase 8 | [239] | -0.39[240] | 1.00[241] | 0.92[242] | 0.67[243] | 0.54[244] | 1.55[245] |
36 | RANBP9 | Ran-binding protein 9 | [246] | 0.68[247] | 1.12[248] | 0.42[249] | 1.22[250] | 0.68[251] | 0.27[252] |
37 | TNS3 | Tensin-3 | [253] | 2.53[254] | 1.82[255] | 2.50[256] | 2.17[257] | 1.28[258] | 3.45[259] |
38 | SPINT2 | Kunitz-type protease inhibitor 2 | [260] | -3.94[261] | -4.01[262] | -4.52[263] | -6.24[264] | -5.10[265] | -0.97[266] |
39 | RAB4B | Ras-related protein Rab-4B | [267] | [268] | [269] | [270] | [271] | [272] | [273] |
40 | LRIG1 | Leucine-rich repeats and immunoglobulin-like domains protein 1 | [274] | -1.44[275] | 0.20[276] | 0.96[277] | -3.37[278] | -1.35[279] | 1.61[280] |
41 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [281] | 1.87[282] | 1.98[283] | 1.62[284] | 0.80[285] | 0.59[286] | 1.29[287] |
42 | EPS15 | Epidermal growth factor receptor substrate 15 | [288] | -0.07[289] | 1.07[290] | 1.29[291] | 1.13[292] | 0.78[293] | 2.36[294] |
43 | STAM | Signal transducing adapter molecule 1 | [295] | 0.84[296] | 1.55[297] | 0.53[298] | 1.23[299] | 0.66[300] | -0.13[301] |
44 | COL27A1 | Collagen alpha-1(XXVII) chain | [302] | 1.61[303] | 2.70[304] | 1.56[305] | -1.11[306] | -1.15[307] | 0.53[308] |
45 | DOCK7 | Dedicator of cytokinesis protein 7 | [309] | 1.31[310] | 2.20[311] | 1.63[312] | 0.92[313] | 0.67[314] | 1.60[315] |
46 | STAM2 | Signal transducing adapter molecule 2 | [316] | 0.04[317] | 1.10[318] | 0.15[319] | 1.10[320] | 0.51[321] | 1.32[322] |
47 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | [323] | 1.37[324] | 1.52[325] | 2.18[326] | 1.33[327] | 1.94[328] | 0.60[329] |
48 | PTPRJ | Receptor-type tyrosine-protein phosphatase eta | [330] | -1.29[331] | 0.61[332] | 1.86[333] | 1.00[334] | 1.16[335] | 2.08[336] |
49 | SRC | Proto-oncogene tyrosine-protein kinase Src | [337] | 2.80[338] | 3.06[339] | 1.99[340] | 1.94[341] | 1.24[342] | -0.73[343] |
50 | LAMB1 | Laminin subunit beta-1 | [344] | 3.70[345] | 3.53[346] | 4.81[347] | 4.93[348] | 4.24[349] | 2.45[350] |
51 | GGA3 | ADP-ribosylation factor-binding protein GGA3 | [351] | 1.27[352] | 1.70[353] | 1.57[354] | 0.30[355] | 0.70[356] | 0.42[357] |
52 | ITGA3 | Integrin alpha-3 | [358] | 1.74[359] | -2.70[360] | -3.75[361] | 3.92[362] | 3.74[363] | -1.37[364] |
53 | RANBP10 | Ran-binding protein 10 | [365] | 1.24[366] | 2.10[367] | 1.50[368] | 0.74[369] | 1.10[370] | 2.34[371] |
54 | LAMA5 | Laminin subunit alpha-5 | [372] | 4.71[373] | 4.18[374] | 3.73[375] | 5.54[376] | 3.21[377] | 2.88[378] |
55 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.60[379] | 1.31[380] | 1.43[381] | 0.67[382] | 1.00[383] | 2.03[384] | |
56 | ITGA2 | Integrin alpha-2 | [385] | 3.88[386] | 4.11[387] | 1.07[388] | 0.92[389] | 4.03[390] | -0.86[391] |
57 | SPINT1 | Kunitz-type protease inhibitor 1 | [392] | 2.98[393] | 3.03[394] | 0.97[395] | -0.39[396] | 0.04[397] | -0.48[398] |
58 | COL5A2 | Collagen alpha-2(V) chain | [399] | -1.43[400] | -1.12[401] | 6.76[402] | 6.34[403] | 5.76[404] | 3.05[405] |
59 | MUC20 | Mucin-20 | [406] | -2.42[407] | 0.31[408] | -1.79[409] | -3.88[410] | -4.04[411] | 2.16[412] |
60 | LAMA4 | Laminin subunit alpha-4 | [413] | -5.83[414] | -8.48[415] | -0.59[416] | 1.22[417] | 5.01[418] | 1.54[419] |
61 | COL5A3 | Collagen alpha-3(V) chain | [420] | -4.24[421] | -4.26[422] | 0.14[423] | -2.17[424] | -4.14[425] | 1.16[426] |
62 | GAB1 | GRB2-associated-binding protein 1 | [427] | 1.08[428] | 2.45[429] | 2.50[430] | 1.47[431] | 1.46[432] | 2.99[433] |
63 | CBL | E3 ubiquitin-protein ligase CBL | [434] | 4.23[435] | 3.45[436] | 3.60[437] | 4.67[438] | 4.28[439] | 3.88[440] |
64 | COL3A1 | Collagen alpha-1(III) chain | [441] | -1.22[442] | -2.54[443] | -0.22[444] | 9.49[445] | 7.84[446] | 7.72[447] |
65 | COL1A1 | Collagen alpha-1(I) chain | [448] | 4.52[449] | -2.72[450] | -0.97[451] | 6.55[452] | 8.21[453] | 6.47[454] |
66 | LAMA3 | Laminin subunit alpha-3 | [455] | 3.31[456] | 3.42[457] | -0.69[458] | 4.02[459] | 1.45[460] | 1.65[461] |
67 | COL1A2 | Collagen alpha-2(I) chain | [462] | -6.37[463] | -6.02[464] | -3.60[465] | 4.52[466] | 4.68[467] | 6.54[468] |
68 | COL2A1 | Collagen alpha-1(II) chain | [469] | 0.36[470] | 3.42[471] | 5.82[472] | -2.81[473] | -2.96[474] | [475] |
69 | LAMA1 | Laminin subunit alpha-1 | [476] | 0.50[477] | -1.69[478] | -2.40[479] | 6.20[480] | 6.97[481] | 2.37[482] |
70 | SH3GL2 | Endophilin-A1 | [483] | -2.47[484] | [485] | -5.06[486] | 0.55[487] | -0.55[488] | 0.30[489] |
71 | COL5A1 | Collagen alpha-1(V) chain | [490] | 3.21[491] | -0.13[492] | 1.08[493] | 10.64[494] | 9.81[495] | 7.23[496] |
72 | COL11A2 | Collagen alpha-2(XI) chain | [497] | 1.23[498] | 3.07[499] | 2.44[500] | 4.42[501] | 2.25[502] | 2.97[503] |
73 | LAMC3 | Laminin subunit gamma-3 | [504] | 4.72[505] | -1.79[506] | -4.12[507] | 2.66[508] | 0.39[509] | 6.91[510] |
74 | HGF | Hepatocyte growth factor | [511] | [512] | [513] | -1.66[514] | 4.13[515] | 1.29[516] | 9.01[517] |
75 | TNS4 | Tensin-4 | [518] | 10.34[519] | 2.46[520] | 1.08[521] | 2.28[522] | 4.88[523] | 1.67[524] |
76 | COL11A1 | Collagen alpha-1(XI) chain | [525] | 0.18[526] | [527] | -0.87[528] | 5.76[529] | 3.20[530] | 0.39[531] |
77 | LAMA2 | Laminin subunit alpha-2 | [532] | 5.32[533] | 5.49[534] | 3.15[535] | 9.97[536] | 9.86[537] | 13.20[538] |
78 | COL24A1 | Collagen alpha-1(XXIV) chain | [539] | [540] | [541] | [542] | [543] | [544] | [545] |
79 | SH3GL3 | Endophilin-A3 | [546] | [547] | [548] | [549] | [550] | [551] | [552] |