REACTOME_SIGNALING_BY_LEPTIN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.22[2] -1.02[3] -0.77[4] -0.19[5] -1.14[6] 0.22[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 0.11[9] 0.80[10] 0.27[11] 0.45[12] 0.86[13] -0.93[14]
3 SOCS3 Suppressor of cytokine signaling 3 [15] -4.47[16] -4.63[17] -3.39[18] -1.24[19] -2.53[20] -2.05[21]
4 LEPR Leptin receptor [22] -4.92[23] -2.00[24] 0.19[25] -1.74[26] -1.90[27] 2.04[28]
5 STAT5B Signal transducer and activator of transcription 5B [29] 1.02[30] 0.91[31] 1.13[32] 1.12[33] 0.03[34] -0.56[35]
6 SH2B1 SH2B adapter protein 1 [36] 0.81[37] 1.78[38] 0.97[39] -0.11[40] 0.35[41] -2.10[42]
7 IRS1 Insulin receptor substrate 1 [43] 1.76[44] 1.46[45] 2.40[46] 1.27[47] 0.63[48] -0.07[49]
8 STAT5A Signal transducer and activator of transcription 5A [50] -2.28[51] -0.85[52] -2.26[53] -1.28[54] -0.75[55] -1.95[56]
9 IRS2 Insulin receptor substrate 2 [57] -5.99[58] [59] -3.35[60] -1.10[61] 2.50[62] 0.20[63]
10 JAK2 Tyrosine-protein kinase JAK2 [64] -0.11[65] 0.15[66] -0.78[67] 0.33[68] 0.70[69] 0.52[70]
11 LEP Leptin [71] -1.66[72] -0.42[73] -1.45[74] -1.29[75] -2.84[76] 0.12[77]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[16]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[17]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[18]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[19]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[20]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[21]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[22]
ref_hepatocyte LEPR
Mean 6.17
Standard deviation 5.3
Values 0.18 5.1 2.2 12 11
[23]
HepG2 LEPR
Mean 0.566
Standard deviation 0.13
Values 0.48 0.66
[24]
HepG2.C3A LEPR
Mean 3.19
Standard deviation 0.049
Values 3.2 3.2
[25]
HuH.7 LEPR
Mean 19.5
Standard deviation 12
Values 14 33 11
[26]
SNU475 LEPR
Mean 4.59
Standard deviation 0.66
Values 5.1 4.1
[27]
THLE LEPR
Mean 5.37
Standard deviation 0.72
Values 4.9 5.9
[28]
liver LEPR
Mean 165
Standard deviation 89
Values 86 2.7e+02 2.1e+02 96
[29]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[30]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[31]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[32]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[33]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[34]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[35]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[36]
ref_hepatocyte SH2B1
Mean 3.45
Standard deviation 1.7
Values 2.4 1.2 5.6 4.8 3.2
[37]
HepG2 SH2B1
Mean 16.9
Standard deviation 1.7
Values 16 18
[38]
HepG2.C3A SH2B1
Mean 24.6
Standard deviation 4.7
Values 28 21
[39]
HuH.7 SH2B1
Mean 18.8
Standard deviation 3
Values 18 16 22
[40]
SNU475 SH2B1
Mean 7.91
Standard deviation 1.9
Values 9.2 6.6
[41]
THLE SH2B1
Mean 14.3
Standard deviation 0.094
Values 14 14
[42]
liver SH2B1
Mean 5.21
Standard deviation 0.68
Values 5.5 5.1 4.3 5.9
[43]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[44]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[45]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[46]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[47]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[48]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[49]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[50]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[51]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[52]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[53]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[54]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[55]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[56]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[57]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[58]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[59]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[61]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[62]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[63]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[64]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[65]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[66]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[67]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[68]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[69]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[70]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[71]
ref_hepatocyte LEP
Mean 0.0195
Standard deviation 0.035
Values 0 0 0.016 0 0.081
[72]
HepG2 LEP
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[73]
HepG2.C3A LEP
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[74]
HuH.7 LEP
Mean 0.0199
Standard deviation 0.0091
Values 0.025 0.026 0.0094
[75]
SNU475 LEP
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[76]
THLE LEP
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[77]
liver LEP
Mean 0.137
Standard deviation 0.14
Values 0 0.27 0.026 0.25