REACTOME_SIGNALING_BY_KIT_IN_DISEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] 0.02[2] -1.45[3] -1.03[4] -0.92[5] -0.91[6] 1.18[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.67[9] 0.53[10] 0.33[11] -0.60[12] 0.04[13] -0.93[14]
3 YES1 Tyrosine-protein kinase Yes [15] -1.39[16] 0.12[17] 0.03[18] -0.71[19] -0.51[20] -1.11[21]
4 STAT1 Signal transducer and activator of transcription 1-alpha/beta [22] -0.60[23] -1.49[24] -0.71[25] 1.37[26] -0.16[27] -0.28[28]
5 NRAS GTPase NRas [29] 0.10[30] 0.56[31] 0.65[32] -0.16[33] 0.14[34] -1.48[35]
6 HRAS GTPase HRas [36] -1.54[37] -2.22[38] -3.33[39] -2.11[40] -1.59[41] -3.89[42]
7 KRAS GTPase KRas [43] -1.04[44] -1.04[45] 0.24[46] -0.36[47] 0.03[48] -0.55[49]
8 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [50] -1.00[51] -0.86[52] -0.09[53] 0.91[54] 1.14[55] 1.77[56]
9 SOS1 Son of sevenless homolog 1 [57] -0.63[58] 0.93[59] 0.11[60] -0.31[61] -0.35[62] -0.69[63]
10 LYN Tyrosine-protein kinase Lyn [64] -1.39[65] -1.54[66] -1.33[67] -0.10[68] -0.61[69] -1.21[70]
11 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [71] 1.35[72] 1.59[73] 1.88[74] -0.45[75] 0.84[76] -1.52[77]
12 STAT5B Signal transducer and activator of transcription 5B [78] 0.83[79] 0.48[80] 0.86[81] 0.39[82] 0.27[83] 0.39[84]
13 SRC Proto-oncogene tyrosine-protein kinase Src [85] 2.50[86] 2.51[87] 1.18[88] 1.24[89] 1.15[90] -2.08[91]
14 STAT5A Signal transducer and activator of transcription 5A [92] -2.48[93] -1.28[94] -2.53[95] -2.00[96] -0.51[97] -0.99[98]
15 FYN Tyrosine-protein kinase Fyn [99] 0.41[100] -8.16[101] 0.08[102] 0.31[103] 2.57[104] -0.26[105]
16 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.91[106] 0.75[107] 0.62[108] -0.03[109] 0.91[110] 0.68[111]
17 JAK2 Tyrosine-protein kinase JAK2 [112] -0.30[113] -0.28[114] -1.05[115] -0.39[116] 0.93[117] 1.48[118]
18 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma [119] 1.19[120] 1.23[121] 1.75[122] 2.01[123] 1.76[124] 1.45[125]
19 LCK Tyrosine-protein kinase Lck [126] 2.25[127] 2.35[128] -7.96[129] -6.24[130] -5.71[131] 0.00[132]
20 KIT Mast/stem cell growth factor receptor Kit [133] -3.52[134] -5.38[135] [136] 1.34[137] -3.46[138] 2.41[139]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[16]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[17]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[18]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[19]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[20]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[21]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[22]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[23]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[24]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[25]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[26]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[27]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[28]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[51]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[52]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[53]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[54]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[55]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[56]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[64]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[65]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[66]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[67]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[68]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[69]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[70]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[71]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[72]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[73]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[74]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[75]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[76]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[77]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[78]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[79]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[80]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[81]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[82]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[83]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[84]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[85]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[86]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[87]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[88]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[89]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[90]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[91]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[92]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[93]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[94]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[95]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[96]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[97]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[98]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[99]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[100]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[101]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[102]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[103]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[104]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[105]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[106]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[107]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[108]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[109]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[110]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[111]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[112]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[113]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[114]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[115]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[116]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[117]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[118]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[119]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[120]
ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.52 0.81 0.47 0.078 0.15
[121]
HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 1.2 4.7
[122]
HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 1.5 3.8
[123]
HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5.7 3.1 5
[124]
SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.5 6.8
[125]
THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4
[126]
liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 3.7 3.8 3.3 4
[127]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[128]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[129]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[130]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[131]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[132]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[133]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[134]
ref_hepatocyte KIT
Mean 0.0798
Standard deviation 0.075
Values 0 0 0.15 0.1 0.15
[135]
HepG2 KIT
Mean 0.0222
Standard deviation 0.025
Values 0.04 0.0043
[136]
HepG2.C3A KIT
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[137]
HuH.7 KIT
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 KIT
Mean 0.83
Standard deviation 0.64
Values 1.3 0.38
[139]
THLE KIT
Mean 0.0201
Standard deviation 0.013
Values 0.03 0.011
[140]
liver KIT
Mean 1.41
Standard deviation 1.3
Values 0.21 3 1.9 0.54