REACTOME_SIGNALING_BY_HIPPO Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAE 14-3-3 protein epsilon [1] -1.44[2] -1.23[3] -0.82[4] -1.29[5] -1.12[6] -1.30[7]
2 YWHAB 14-3-3 protein beta/alpha [8] 0.83[9] 0.65[10] -0.01[11] 0.88[12] 0.44[13] 0.16[14]
3 TJP2 Tight junction protein ZO-2 [15] 1.21[16] 1.10[17] 1.33[18] -1.93[19] 0.75[20] 0.74[21]
4 MOB1A MOB kinase activator 1A [22] -0.69[23] -0.29[24] -1.07[25] -0.28[26] -0.91[27] -0.49[28]
5 CASP3 Caspase-3 [29] -0.07[30] 0.71[31] -1.78[32] -1.32[33] -0.20[34] -0.55[35]
6 YAP1 Transcriptional coactivator YAP1 [36] 1.76[37] 1.32[38] 1.01[39] 1.86[40] 1.40[41] 0.61[42]
7 WWC1 Protein KIBRA [43] 0.64[44] 0.01[45] 0.50[46] -2.17[47] -0.10[48] 0.72[49]
8 TJP1 Tight junction protein ZO-1 [50] 0.25[51] 0.58[52] 0.41[53] 1.28[54] 0.86[55] 2.09[56]
9 AMOTL2 Angiomotin-like protein 2 [57] 0.53[58] -0.37[59] 1.14[60] 1.84[61] 1.47[62] 1.05[63]
10 WWTR1 WW domain-containing transcription regulator protein 1 [64] 1.69[65] 1.38[66] 0.45[67] 1.89[68] 1.33[69] 1.00[70]
11 STK3 Serine/threonine-protein kinase 3 [71] -1.29[72] -0.32[73] -0.05[74] 0.90[75] -0.31[76] 1.44[77]
12 SAV1 Protein salvador homolog 1 [78] -0.03[79] 0.32[80] -0.67[81] 0.23[82] 0.57[83] 0.60[84]
13 STK4 Serine/threonine-protein kinase 4 [85] 2.79[86] 2.78[87] 2.78[88] 2.10[89] 2.28[90] 2.18[91]
14 MOB1B MOB kinase activator 1B [92] -0.12[93] 0.71[94] 0.47[95] 0.61[96] 1.06[97] 1.34[98]
15 DVL2 Segment polarity protein dishevelled homolog DVL-2 [99] 1.91[100] 1.77[101] 2.81[102] 1.80[103] 1.57[104] 0.27[105]
16 LATS2 Serine/threonine-protein kinase LATS2 [106] 0.76[107] 1.07[108] 1.77[109] 1.77[110] 1.44[111] 1.23[112]
17 LATS1 Serine/threonine-protein kinase LATS1 [113] 1.17[114] 1.83[115] 2.58[116] 2.26[117] 1.97[118] 2.52[119]
18 AMOTL1 Angiomotin-like protein 1 [120] -0.81[121] -4.66[122] 1.41[123] 3.06[124] 3.94[125] 4.75[126]
19 NPHP4 Nephrocystin-4 [127] 2.91[128] 3.82[129] 3.13[130] 1.26[131] 2.29[132] 2.54[133]
20 AMOT Angiomotin [134] 1.20[135] -6.17[136] -0.07[137] 3.54[138] 1.76[139] 2.52[140]
[1]
ref_hepatocyte YWHAE
Mean 195
Standard deviation 97
Values 2.2e+02 3.6e+02 1.6e+02 1.3e+02 1.2e+02
[2]
HepG2 YWHAE
Mean 183
Standard deviation 1.8
Values 1.8e+02 1.8e+02
[3]
HepG2.C3A YWHAE
Mean 175
Standard deviation 29
Values 1.5e+02 2e+02
[4]
HuH.7 YWHAE
Mean 215
Standard deviation 62
Values 2.1e+02 1.5e+02 2.8e+02
[5]
SNU475 YWHAE
Mean 197
Standard deviation 19
Values 2.1e+02 1.8e+02
[6]
THLE YWHAE
Mean 227
Standard deviation 21
Values 2.1e+02 2.4e+02
[7]
liver YWHAE
Mean 94.2
Standard deviation 60
Values 1.3e+02 52 1.6e+02 36
[8]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[9]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[10]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[11]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[12]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[13]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[14]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[15]
ref_hepatocyte TJP2
Mean 19
Standard deviation 9.8
Values 9.3 24 33 13 15
[16]
HepG2 TJP2
Mean 112
Standard deviation 32
Values 89 1.3e+02
[17]
HepG2.C3A TJP2
Mean 85.5
Standard deviation 5.7
Values 90 81
[18]
HuH.7 TJP2
Mean 92.6
Standard deviation 6.9
Values 1e+02 90 88
[19]
SNU475 TJP2
Mean 12.2
Standard deviation 0.49
Values 12 13
[20]
THLE TJP2
Mean 81
Standard deviation 22
Values 65 96
[21]
liver TJP2
Mean 37.6
Standard deviation 13
Values 35 44 21 51
[22]
ref_hepatocyte MOB1A
Mean 14.3
Standard deviation 9.4
Values 29 16 15 5.9 6.2
[23]
HepG2 MOB1A
Mean 22.6
Standard deviation 8
Values 17 28
[24]
HepG2.C3A MOB1A
Mean 24.7
Standard deviation 13
Values 15 34
[25]
HuH.7 MOB1A
Mean 13.2
Standard deviation 3.6
Values 17 12 11
[26]
SNU475 MOB1A
Mean 29.1
Standard deviation 8.2
Values 35 23
[27]
THLE MOB1A
Mean 19.2
Standard deviation 3.9
Values 16 22
[28]
liver MOB1A
Mean 12.2
Standard deviation 1.7
Values 11 14 14 11
[29]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 33 13 6.8 4.9 5.1
[30]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 25 36
[31]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 27 59
[32]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 5.9 7.5 7.8
[33]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 13 12
[34]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[35]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 9.5 9 16 6.1
[36]
ref_hepatocyte YAP1
Mean 11.1
Standard deviation 8.2
Values 25 11 7.6 4.3 7.3
[37]
HepG2 YAP1
Mean 95.6
Standard deviation 11
Values 88 1e+02
[38]
HepG2.C3A YAP1
Mean 58.4
Standard deviation 12
Values 50 67
[39]
HuH.7 YAP1
Mean 43.3
Standard deviation 5.4
Values 49 44 38
[40]
SNU475 YAP1
Mean 99
Standard deviation 6.2
Values 1e+02 95
[41]
THLE YAP1
Mean 73.9
Standard deviation 11
Values 66 81
[42]
liver YAP1
Mean 20.1
Standard deviation 14
Values 9.5 26 7.2 38
[43]
ref_hepatocyte WWC1
Mean 6.99
Standard deviation 6.4
Values 2 16 11 3.1 2.8
[44]
HepG2 WWC1
Mean 27.7
Standard deviation 0.17
Values 28 28
[45]
HepG2.C3A WWC1
Mean 14.8
Standard deviation 2.6
Values 17 13
[46]
HuH.7 WWC1
Mean 19.2
Standard deviation 5.7
Values 25 13 19
[47]
SNU475 WWC1
Mean 3.83
Standard deviation 1.1
Values 3 4.6
[48]
THLE WWC1
Mean 16.5
Standard deviation 2.2
Values 15 18
[49]
liver WWC1
Mean 13.7
Standard deviation 8.6
Values 5.4 22 7.2 20
[50]
ref_hepatocyte TJP1
Mean 6.57
Standard deviation 4.1
Values 5.2 11 11 2.4 3.3
[51]
HepG2 TJP1
Mean 19.9
Standard deviation 4
Values 17 23
[52]
HepG2.C3A TJP1
Mean 20.6
Standard deviation 0.78
Values 21 20
[53]
HuH.7 TJP1
Mean 16.9
Standard deviation 3.9
Values 20 19 12
[54]
SNU475 TJP1
Mean 39.2
Standard deviation 8.2
Values 45 33
[55]
THLE TJP1
Mean 30.2
Standard deviation 3.4
Values 28 33
[56]
liver TJP1
Mean 33.2
Standard deviation 3.8
Values 32 37 36 28
[57]
ref_hepatocyte AMOTL2
Mean 5.58
Standard deviation 4.3
Values 2.3 9.9 11 2.7 2.4
[58]
HepG2 AMOTL2
Mean 20.6
Standard deviation 2.7
Values 23 19
[59]
HepG2.C3A AMOTL2
Mean 9.06
Standard deviation 1.8
Values 10 7.8
[60]
HuH.7 AMOTL2
Mean 23.9
Standard deviation 4.8
Values 23 29 20
[61]
SNU475 AMOTL2
Mean 49.3
Standard deviation 24
Values 66 33
[62]
THLE AMOTL2
Mean 39.1
Standard deviation 5.2
Values 35 43
[63]
liver AMOTL2
Mean 13.7
Standard deviation 3.7
Values 8.4 17 15 14
[64]
ref_hepatocyte WWTR1
Mean 5.02
Standard deviation 4.3
Values 12 3.8 5.4 1.2 2.6
[65]
HepG2 WWTR1
Mean 41.2
Standard deviation 0.072
Values 41 41
[66]
HepG2.C3A WWTR1
Mean 27.5
Standard deviation 7.8
Values 33 22
[67]
HuH.7 WWTR1
Mean 13.3
Standard deviation 1.5
Values 13 15 12
[68]
SNU475 WWTR1
Mean 45.7
Standard deviation 8.3
Values 52 40
[69]
THLE WWTR1
Mean 31.8
Standard deviation 6
Values 28 36
[70]
liver WWTR1
Mean 11.9
Standard deviation 2.9
Values 14 11 15 8.4
[71]
ref_hepatocyte STK3
Mean 3.12
Standard deviation 0.74
Values 3.2 3.6 1.8 3.5 3.6
[72]
HepG2 STK3
Mean 3.25
Standard deviation 0.55
Values 2.9 3.6
[73]
HepG2.C3A STK3
Mean 5.26
Standard deviation 0.47
Values 4.9 5.6
[74]
HuH.7 STK3
Mean 5.85
Standard deviation 1.4
Values 5.4 7.4 4.7
[75]
SNU475 STK3
Mean 14.3
Standard deviation 2.8
Values 16 12
[76]
THLE STK3
Mean 6.38
Standard deviation 0.48
Values 6 6.7
[77]
liver STK3
Mean 10.1
Standard deviation 1.5
Values 12 8.9 9.9 9.3
[78]
ref_hepatocyte SAV1
Mean 3.06
Standard deviation 0.53
Values 4 3 2.8 2.9 2.6
[79]
HepG2 SAV1
Mean 7.65
Standard deviation 0.26
Values 7.8 7.5
[80]
HepG2.C3A SAV1
Mean 8.06
Standard deviation 0.55
Values 7.7 8.4
[81]
HuH.7 SAV1
Mean 3.72
Standard deviation 0.29
Values 4.1 3.6 3.5
[82]
SNU475 SAV1
Mean 8.86
Standard deviation 0.95
Values 9.5 8.2
[83]
THLE SAV1
Mean 11.5
Standard deviation 0.89
Values 11 12
[84]
liver SAV1
Mean 5.51
Standard deviation 2.1
Values 8 4.4 6.3 3.3
[85]
ref_hepatocyte STK4
Mean 2.58
Standard deviation 1.5
Values 4.9 2.5 3 1 1.5
[86]
HepG2 STK4
Mean 45.4
Standard deviation 3.6
Values 43 48
[87]
HepG2.C3A STK4
Mean 37.3
Standard deviation 11
Values 29 45
[88]
HuH.7 STK4
Mean 34.3
Standard deviation 7.9
Values 43 27 33
[89]
SNU475 STK4
Mean 27.3
Standard deviation 0.17
Values 27 27
[90]
THLE STK4
Mean 31.8
Standard deviation 6.9
Values 27 37
[91]
liver STK4
Mean 13.9
Standard deviation 2.5
Values 11 16 12 16
[92]
ref_hepatocyte MOB1B
Mean 2.57
Standard deviation 2.3
Values 5.8 4.2 1.3 0.68 0.91
[93]
HepG2 MOB1B
Mean 6.03
Standard deviation 1.8
Values 4.8 7.3
[94]
HepG2.C3A MOB1B
Mean 8.86
Standard deviation 0.15
Values 8.8 9
[95]
HuH.7 MOB1B
Mean 6.89
Standard deviation 0.38
Values 7.1 7.1 6.4
[96]
SNU475 MOB1B
Mean 9.7
Standard deviation 0.24
Values 9.9 9.5
[97]
THLE MOB1B
Mean 13.6
Standard deviation 2
Values 15 12
[98]
liver MOB1B
Mean 7.75
Standard deviation 2
Values 6.8 11 6.8 6.6
[99]
ref_hepatocyte DVL2
Mean 2.34
Standard deviation 0.94
Values 3.3 0.77 2.7 2.5 2.4
[100]
HepG2 DVL2
Mean 22.4
Standard deviation 2.6
Values 24 21
[101]
HepG2.C3A DVL2
Mean 16.8
Standard deviation 0.55
Values 17 16
[102]
HuH.7 DVL2
Mean 31.8
Standard deviation 1.9
Values 30 34 32
[103]
SNU475 DVL2
Mean 20
Standard deviation 2.6
Values 22 18
[104]
THLE DVL2
Mean 17.6
Standard deviation 1.2
Values 17 18
[105]
liver DVL2
Mean 3.34
Standard deviation 0.75
Values 3.5 3.2 2.5 4.3
[106]
ref_hepatocyte LATS2
Mean 2.17
Standard deviation 1.5
Values 4.5 2.7 1.8 1.3 0.58
[107]
HepG2 LATS2
Mean 9.38
Standard deviation 0.94
Values 8.7 10
[108]
HepG2.C3A LATS2
Mean 9.62
Standard deviation 1
Values 10 8.9
[109]
HuH.7 LATS2
Mean 14.4
Standard deviation 4.6
Values 14 19 9.8
[110]
SNU475 LATS2
Mean 18.3
Standard deviation 4.9
Values 22 15
[111]
THLE LATS2
Mean 14.9
Standard deviation 1.6
Values 14 16
[112]
liver LATS2
Mean 6.04
Standard deviation 2.2
Values 4.3 8 4.1 7.8
[113]
ref_hepatocyte LATS1
Mean 1.57
Standard deviation 1.1
Values 2.3 1.9 2.8 0.51 0.4
[114]
HepG2 LATS1
Mean 9.04
Standard deviation 1.9
Values 7.7 10
[115]
HepG2.C3A LATS1
Mean 11.8
Standard deviation 0.35
Values 12 12
[116]
HuH.7 LATS1
Mean 18.2
Standard deviation 3.9
Values 20 21 14
[117]
SNU475 LATS1
Mean 18.6
Standard deviation 0.19
Values 18 19
[118]
THLE LATS1
Mean 15.6
Standard deviation 0.41
Values 16 15
[119]
liver LATS1
Mean 10.7
Standard deviation 1.5
Values 9.1 13 10 11
[120]
ref_hepatocyte AMOTL1
Mean 1.1
Standard deviation 0.73
Values 0.012 0.8 1.9 1.3 1.5
[121]
HepG2 AMOTL1
Mean 1.61
Standard deviation 0.97
Values 2.3 0.92
[122]
HepG2.C3A AMOTL1
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[123]
HuH.7 AMOTL1
Mean 5.69
Standard deviation 1.4
Values 6.8 6.1 4.1
[124]
SNU475 AMOTL1
Mean 22.7
Standard deviation 5.8
Values 27 19
[125]
THLE AMOTL1
Mean 42.8
Standard deviation 7.4
Values 38 48
[126]
liver AMOTL1
Mean 35.3
Standard deviation 24
Values 9.1 57 21 54
[127]
ref_hepatocyte NPHP4
Mean 0.465
Standard deviation 0.38
Values 1.1 0.16 0.11 0.51 0.46
[128]
HepG2 NPHP4
Mean 8.88
Standard deviation 0.93
Values 8.2 9.5
[129]
HepG2.C3A NPHP4
Mean 13.8
Standard deviation 1.3
Values 15 13
[130]
HuH.7 NPHP4
Mean 7.87
Standard deviation 0.44
Values 8.3 7.5 7.8
[131]
SNU475 NPHP4
Mean 2.75
Standard deviation 0.73
Values 3.3 2.2
[132]
THLE NPHP4
Mean 5.76
Standard deviation 0.17
Values 5.6 5.9
[133]
liver NPHP4
Mean 3.2
Standard deviation 0.71
Values 3.5 4 2.3 3.1
[134]
ref_hepatocyte AMOT
Mean 0.35
Standard deviation 0.22
Values 0.13 0.7 0.2 0.32 0.4
[135]
HepG2 AMOT
Mean 2.05
Standard deviation 1
Values 1.3 2.8
[136]
HepG2.C3A AMOT
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[137]
HuH.7 AMOT
Mean 0.646
Standard deviation 0.33
Values 0.69 0.95 0.3
[138]
SNU475 AMOT
Mean 10
Standard deviation 5.3
Values 14 6.3
[139]
THLE AMOT
Mean 3.01
Standard deviation 0.059
Values 3 3
[140]
liver AMOT
Mean 2.38
Standard deviation 1.3
Values 4.3 2 1.2 2.1