REACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -0.09[2] -1.19[3] -4.23[4] -2.32[5] 0.00[6] -2.21[7]
2 BCL2L1 Bcl-2-like protein 1 [8] 1.21[9] 0.88[10] 1.49[11] -0.95[12] -0.80[13] -1.20[14]
3 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [15] -0.49[16] 0.23[17] -0.16[18] 0.55[19] 0.95[20] 0.88[21]
4 GRB2 Growth factor receptor-bound protein 2 [22] 0.26[23] 0.39[24] 0.16[25] 0.22[26] -0.10[27] -0.08[28]
5 NRAS GTPase NRas [29] -0.30[30] 0.42[31] 0.48[32] 0.66[33] 0.00[34] -0.63[35]
6 HRAS GTPase HRas [36] -1.94[37] -2.36[38] -3.50[39] -1.29[40] -1.74[41] -3.04[42]
7 PIM1 Serine/threonine-protein kinase pim-1 [43] -0.74[44] -0.68[45] -1.66[46] 0.05[47] -1.20[48] -1.50[49]
8 KRAS GTPase KRas [50] -1.45[51] -1.18[52] 0.07[53] 0.46[54] -0.11[55] 0.30[56]
9 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [57] -1.41[58] -1.00[59] -0.25[60] 1.73[61] 1.00[62] 2.62[63]
10 SOS1 Son of sevenless homolog 1 [64] -1.03[65] 0.79[66] -0.05[67] 0.51[68] -0.49[69] 0.16[70]
11 STAT5B Signal transducer and activator of transcription 5B [71] 0.42[72] 0.34[73] 0.69[74] 1.21[75] 0.12[76] 1.24[77]
12 STAT5A Signal transducer and activator of transcription 5A [78] -2.88[79] -1.42[80] -2.70[81] -1.18[82] -0.66[83] -0.14[84]
13 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.31[85] 0.62[86] 0.45[87] 0.79[88] 0.76[89] 1.54[90]
14 GAB2 GRB2-associated-binding protein 2 [91] 0.63[92] 0.71[93] 0.61[94] 0.59[95] 0.44[96] 0.17[97]
15 NOX4 NADPH oxidase 4 [98] -4.17[99] -1.10[100] -1.26[101] -2.93[102] -1.93[103] 1.72[104]
16 FLT3 Receptor-type tyrosine-protein kinase FLT3 [105] [106] [107] -4.49[108] -3.13[109] [110] 2.54[111]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte BCL2L1
Mean 26.8
Standard deviation 12
Values 16 44 34 23 16
[9]
HepG2 BCL2L1
Mean 260
Standard deviation 56
Values 3e+02 2.2e+02
[10]
HepG2.C3A BCL2L1
Mean 152
Standard deviation 4.3
Values 1.5e+02 1.5e+02
[11]
HuH.7 BCL2L1
Mean 283
Standard deviation 60
Values 3.1e+02 2.1e+02 3.2e+02
[12]
SNU475 BCL2L1
Mean 32.1
Standard deviation 4.1
Values 29 35
[13]
THLE BCL2L1
Mean 47
Standard deviation 4.7
Values 44 50
[14]
liver BCL2L1
Mean 21.6
Standard deviation 11
Values 31 9.8 31 14
[15]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[16]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[17]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[18]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[19]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[20]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[21]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[22]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[23]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[24]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[25]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[26]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[27]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[28]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte PIM1
Mean 9.92
Standard deviation 7.8
Values 6.1 2 13 22 6.7
[44]
HepG2 PIM1
Mean 25
Standard deviation 18
Values 38 12
[45]
HepG2.C3A PIM1
Mean 19
Standard deviation 15
Values 29 8.7
[46]
HuH.7 PIM1
Mean 11.7
Standard deviation 6.4
Values 8.2 19 7.9
[47]
SNU475 PIM1
Mean 23.8
Standard deviation 9.3
Values 30 17
[48]
THLE PIM1
Mean 13.2
Standard deviation 2.3
Values 12 15
[49]
liver PIM1
Mean 6.47
Standard deviation 0.83
Values 6.6 5.4 6.4 7.5
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[58]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[59]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[60]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[61]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[62]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[63]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[64]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[65]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[66]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[67]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[68]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[69]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[70]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[71]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[72]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[73]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[74]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[75]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[76]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[77]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[78]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[79]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[80]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[81]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[82]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[83]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[84]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[85]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[86]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[87]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[88]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[89]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[90]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[91]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[92]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[93]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[94]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[95]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[96]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[97]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[98]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[99]
ref_hepatocyte NOX4
Mean 0.125
Standard deviation 0.15
Values 0.38 0.091 0.079 0.043 0.033
[100]
HepG2 NOX4
Mean 0.0293
Standard deviation 0.025
Values 0.011 0.047
[101]
HepG2.C3A NOX4
Mean 0.179
Standard deviation 0.02
Values 0.17 0.19
[102]
HuH.7 NOX4
Mean 0.197
Standard deviation 0.076
Values 0.14 0.28 0.17
[103]
SNU475 NOX4
Mean 0.0382
Standard deviation 0.018
Values 0.051 0.025
[104]
THLE NOX4
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[105]
liver NOX4
Mean 0.762
Standard deviation 0.18
Values 0.52 0.76 0.85 0.93
[106]
ref_hepatocyte FLT3
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[107]
HepG2 FLT3
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A FLT3
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FLT3
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[110]
SNU475 FLT3
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[111]
THLE FLT3
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FLT3
Mean 0.402
Standard deviation 0.15
Values 0.21 0.44 0.39 0.57