REACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -0.37[2] -1.60[3] -4.52[4] -2.77[5] -0.29[6] -3.42[7]
2 SPTBN1 Spectrin beta chain, non-erythrocytic 1 [8] 1.55[9] 1.24[10] 1.41[11] 0.63[12] 0.89[13] 1.37[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] -0.01[16] -0.02[17] -0.12[18] -0.23[19] -0.39[20] -1.29[21]
4 NRAS GTPase NRas [22] -0.58[23] 0.01[24] 0.20[25] 0.22[26] -0.29[27] -1.84[28]
5 HRAS GTPase HRas [29] -2.21[30] -2.76[31] -3.78[32] -1.73[33] -2.02[34] -4.25[35]
6 PIM1 Serine/threonine-protein kinase pim-1 [36] -1.02[37] -1.09[38] -1.95[39] -0.40[40] -1.49[41] -2.71[42]
7 KRAS GTPase KRas [43] -1.72[44] -1.59[45] -0.21[46] 0.02[47] -0.40[48] -0.91[49]
8 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [50] -1.68[51] -1.40[52] -0.54[53] 1.29[54] 0.71[55] 1.42[56]
9 MYO18A Unconventional myosin-XVIIIa [57] -0.13[58] 0.31[59] 0.99[60] 0.25[61] -0.81[62] 1.03[63]
10 SOS1 Son of sevenless homolog 1 [64] -1.31[65] 0.38[66] -0.34[67] 0.06[68] -0.78[69] -1.05[70]
11 STAT5B Signal transducer and activator of transcription 5B [71] 0.15[72] -0.07[73] 0.41[74] 0.77[75] -0.17[76] 0.04[77]
12 GOLGB1 Golgin subfamily B member 1 [78] -0.62[79] 1.73[80] 1.76[81] 1.20[82] 1.26[83] 2.42[84]
13 TRIP11 Thyroid receptor-interacting protein 11 [85] -1.74[86] 0.73[87] 0.28[88] 1.12[89] 0.57[90] 1.51[91]
14 STAT5A Signal transducer and activator of transcription 5A [92] -3.16[93] -1.82[94] -2.98[95] -1.63[96] -0.95[97] -1.35[98]
15 ZMYM2 Zinc finger MYM-type protein 2 [99] 0.42[100] 1.71[101] 1.00[102] 2.19[103] 1.64[104] 1.70[105]
16 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.59[106] 0.21[107] 0.17[108] 0.35[109] 0.47[110] 0.33[111]
17 GAB2 GRB2-associated-binding protein 2 [112] 0.36[113] 0.30[114] 0.32[115] 0.14[116] 0.15[117] -1.04[118]
18 ETV6 Transcription factor ETV6 [119] -0.88[120] -0.67[121] -0.76[122] 0.88[123] 0.40[124] 0.01[125]
19 NOX4 NADPH oxidase 4 [126] -4.44[127] -1.51[128] -1.54[129] -3.37[130] -2.22[131] 0.51[132]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte SPTBN1
Mean 25.8
Standard deviation 13
Values 32 44 25 14 14
[9]
HepG2 SPTBN1
Mean 385
Standard deviation 14
Values 3.9e+02 3.7e+02
[10]
HepG2.C3A SPTBN1
Mean 248
Standard deviation 46
Values 2.8e+02 2.1e+02
[11]
HuH.7 SPTBN1
Mean 314
Standard deviation 86
Values 3.6e+02 3.7e+02 2.1e+02
[12]
SNU475 SPTBN1
Mean 126
Standard deviation 3.7
Values 1.2e+02 1.3e+02
[13]
THLE SPTBN1
Mean 179
Standard deviation 44
Values 1.5e+02 2.1e+02
[14]
liver SPTBN1
Mean 285
Standard deviation 1.2e+02
Values 2.1e+02 4.4e+02 1.7e+02 3.2e+02
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte PIM1
Mean 9.92
Standard deviation 7.8
Values 6.1 2 13 22 6.7
[37]
HepG2 PIM1
Mean 25
Standard deviation 18
Values 38 12
[38]
HepG2.C3A PIM1
Mean 19
Standard deviation 15
Values 29 8.7
[39]
HuH.7 PIM1
Mean 11.7
Standard deviation 6.4
Values 8.2 19 7.9
[40]
SNU475 PIM1
Mean 23.8
Standard deviation 9.3
Values 30 17
[41]
THLE PIM1
Mean 13.2
Standard deviation 2.3
Values 12 15
[42]
liver PIM1
Mean 6.47
Standard deviation 0.83
Values 6.6 5.4 6.4 7.5
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[51]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[52]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[53]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[54]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[55]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[56]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[57]
ref_hepatocyte MYO18A
Mean 6.89
Standard deviation 1.7
Values 7.7 9.1 4.7 7.3 5.7
[58]
HepG2 MYO18A
Mean 32.1
Standard deviation 3
Values 34 30
[59]
HepG2.C3A MYO18A
Mean 34.8
Standard deviation 8.4
Values 41 29
[60]
HuH.7 MYO18A
Mean 62.4
Standard deviation 15
Values 79 58 50
[61]
SNU475 MYO18A
Mean 25.8
Standard deviation 7
Values 31 21
[62]
THLE MYO18A
Mean 14.7
Standard deviation 2.4
Values 13 16
[63]
liver MYO18A
Mean 59.9
Standard deviation 36
Values 26 91 31 91
[64]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[65]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[66]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[67]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[68]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[69]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[70]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[71]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[72]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[73]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[74]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[75]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[76]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[77]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[78]
ref_hepatocyte GOLGB1
Mean 3.92
Standard deviation 2
Values 7.4 3.5 2.1 3.7 3
[79]
HepG2 GOLGB1
Mean 13
Standard deviation 4.7
Values 9.7 16
[80]
HepG2.C3A GOLGB1
Mean 53.1
Standard deviation 5.1
Values 57 49
[81]
HuH.7 GOLGB1
Mean 60.7
Standard deviation 21
Values 60 82 40
[82]
SNU475 GOLGB1
Mean 28.5
Standard deviation 3.5
Values 26 31
[83]
THLE GOLGB1
Mean 35.1
Standard deviation 17
Values 47 23
[84]
liver GOLGB1
Mean 89.7
Standard deviation 25
Values 84 1.2e+02 59 97
[85]
ref_hepatocyte TRIP11
Mean 2.74
Standard deviation 0.83
Values 3.5 3.4 3 2.3 1.5
[86]
HepG2 TRIP11
Mean 4.2
Standard deviation 1.4
Values 3.2 5.2
[87]
HepG2.C3A TRIP11
Mean 18.5
Standard deviation 4.8
Values 15 22
[88]
HuH.7 TRIP11
Mean 15.2
Standard deviation 5.1
Values 16 20 10
[89]
SNU475 TRIP11
Mean 18.8
Standard deviation 2.3
Values 17 20
[90]
THLE TRIP11
Mean 15.2
Standard deviation 6.1
Values 20 11
[91]
liver TRIP11
Mean 33.3
Standard deviation 10
Values 24 46 25 38
[92]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[93]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[94]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[95]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[96]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[97]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[98]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[99]
ref_hepatocyte ZMYM2
Mean 2.15
Standard deviation 0.87
Values 2.9 3.1 1.8 0.99 1.9
[100]
HepG2 ZMYM2
Mean 14.6
Standard deviation 3.9
Values 12 17
[101]
HepG2.C3A ZMYM2
Mean 28.6
Standard deviation 1
Values 28 29
[102]
HuH.7 ZMYM2
Mean 19.6
Standard deviation 0.11
Values 20 20 19
[103]
SNU475 ZMYM2
Mean 30.9
Standard deviation 0.036
Values 31 31
[104]
THLE ZMYM2
Mean 24.9
Standard deviation 7.3
Values 30 20
[105]
liver ZMYM2
Mean 29.6
Standard deviation 12
Values 21 45 18 34
[106]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[107]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[108]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[109]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[110]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[111]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[112]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[113]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[114]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[115]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[116]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[117]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[118]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[119]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[120]
ref_hepatocyte ETV6
Mean 1.23
Standard deviation 0.82
Values 0.7 0.22 1.6 2.4 1.3
[121]
HepG2 ETV6
Mean 3.42
Standard deviation 0.44
Values 3.7 3.1
[122]
HepG2.C3A ETV6
Mean 3.16
Standard deviation 0.23
Values 3.3 3
[123]
HuH.7 ETV6
Mean 3.34
Standard deviation 0.2
Values 3.2 3.6 3.3
[124]
SNU475 ETV6
Mean 7.17
Standard deviation 0.95
Values 6.5 7.8
[125]
THLE ETV6
Mean 6.06
Standard deviation 0.68
Values 6.5 5.6
[126]
liver ETV6
Mean 5.28
Standard deviation 1.4
Values 5.8 5.3 3.4 6.6
[127]
ref_hepatocyte NOX4
Mean 0.125
Standard deviation 0.15
Values 0.38 0.091 0.079 0.043 0.033
[128]
HepG2 NOX4
Mean 0.0293
Standard deviation 0.025
Values 0.011 0.047
[129]
HepG2.C3A NOX4
Mean 0.179
Standard deviation 0.02
Values 0.17 0.19
[130]
HuH.7 NOX4
Mean 0.197
Standard deviation 0.076
Values 0.14 0.28 0.17
[131]
SNU475 NOX4
Mean 0.0382
Standard deviation 0.018
Values 0.051 0.025
[132]
THLE NOX4
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[133]
liver NOX4
Mean 0.762
Standard deviation 0.18
Values 0.52 0.76 0.85 0.93