REACTOME_SIGNALING_BY_FGFR_IN_DISEASE |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
POLR2L |
DNA-directed RNA polymerases I, II, and III subunit RPABC5 |
[1] |
-2.82[2] |
-2.80[3] |
-3.35[4] |
-2.40[5] |
-2.29[6] |
-1.79[7] |
2 |
POLR2J |
DNA-directed RNA polymerase II subunit RPB11-a |
[8] |
-3.52[9] |
-3.20[10] |
-3.23[11] |
-3.62[12] |
-3.13[13] |
-3.54[14] |
3 |
STAT3 |
Signal transducer and activator of transcription 3 |
[15] |
0.20[16] |
-1.26[17] |
-0.84[18] |
0.04[19] |
-0.52[20] |
1.95[21] |
4 |
POLR2E |
DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
[22] |
0.26[23] |
0.25[24] |
0.02[25] |
-0.76[26] |
0.27[27] |
0.03[28] |
5 |
POLR2H |
DNA-directed RNA polymerases I, II, and III subunit RPABC3 |
[29] |
-1.92[30] |
-1.26[31] |
-1.60[32] |
-2.87[33] |
-2.01[34] |
-2.41[35] |
6 |
POLR2F |
DNA-directed RNA polymerases I, II, and III subunit RPABC2 |
[36] |
-1.62[37] |
-1.34[38] |
-2.47[39] |
-2.80[40] |
-1.89[41] |
-1.52[42] |
7 |
POLR2K |
DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
[43] |
-1.94[44] |
-1.05[45] |
-1.47[46] |
-1.15[47] |
-1.08[48] |
-1.73[49] |
8 |
POLR2G |
DNA-directed RNA polymerase II subunit RPB7 |
[50] |
-1.51[51] |
-1.19[52] |
-2.02[53] |
-1.36[54] |
-1.31[55] |
-2.28[56] |
9 |
GTF2F2 |
General transcription factor IIF subunit 2 |
[57] |
-2.30[58] |
-1.62[59] |
-1.62[60] |
-2.32[61] |
-1.92[62] |
-3.03[63] |
10 |
NCBP2 |
Nuclear cap-binding protein subunit 2 |
[64] |
-0.82[65] |
-0.31[66] |
-0.55[67] |
-1.07[68] |
-0.64[69] |
-1.79[70] |
11 |
GRB2 |
Growth factor receptor-bound protein 2 |
[71] |
0.85[72] |
0.72[73] |
0.52[74] |
0.35[75] |
0.44[76] |
-0.15[77] |
12 |
STAT1 |
Signal transducer and activator of transcription 1-alpha/beta |
[78] |
-0.42[79] |
-1.30[80] |
-0.51[81] |
2.33[82] |
0.23[83] |
0.50[84] |
13 |
LRRFIP1 |
Leucine-rich repeat flightless-interacting protein 1 |
[85] |
-1.00[86] |
-0.47[87] |
-1.48[88] |
-0.55[89] |
0.22[90] |
0.23[91] |
14 |
POLR2C |
DNA-directed RNA polymerase II subunit RPB3 |
[92] |
0.47[93] |
0.62[94] |
-0.21[95] |
-0.44[96] |
-0.04[97] |
-0.91[98] |
15 |
FGFR4 |
Fibroblast growth factor receptor 4 |
[99] |
1.61[100] |
1.98[101] |
2.25[102] |
-4.43[103] |
-4.39[104] |
0.05[105] |
16 |
POLR2I |
DNA-directed RNA polymerase II subunit RPB9 |
[106] |
-1.94[107] |
-1.77[108] |
-2.17[109] |
-2.47[110] |
-2.22[111] |
-1.48[112] |
17 |
NRAS |
GTPase NRas |
[113] |
0.28[114] |
0.75[115] |
0.84[116] |
0.80[117] |
0.54[118] |
-0.70[119] |
18 |
GTF2F1 |
General transcription factor IIF subunit 1 |
[120] |
0.04[121] |
-0.33[122] |
0.82[123] |
-0.59[124] |
0.09[125] |
-1.72[126] |
19 |
HRAS |
GTPase HRas |
[127] |
-1.36[128] |
-2.03[129] |
-3.13[130] |
-1.15[131] |
-1.19[132] |
-3.11[133] |
20 |
POLR2B |
DNA-directed RNA polymerase II subunit RPB2 |
[134] |
0.87[135] |
1.29[136] |
0.91[137] |
0.91[138] |
1.78[139] |
0.50[140] |
21 |
POLR2D |
DNA-directed RNA polymerase II subunit RPB4 |
[141] |
-0.10[142] |
0.07[143] |
-0.95[144] |
-0.61[145] |
-0.21[146] |
-0.89[147] |
22 |
TRIM24 |
Transcription intermediary factor 1-alpha |
[148] |
1.48[149] |
0.64[150] |
0.43[151] |
-1.90[152] |
-1.46[153] |
-0.57[154] |
23 |
FGFR1OP2 |
FGFR1 oncogene partner 2 |
[155] |
-1.68[156] |
-0.53[157] |
-0.79[158] |
-1.55[159] |
-0.63[160] |
-0.77[161] |
24 |
KRAS |
GTPase KRas |
[162] |
-0.86[163] |
-0.85[164] |
0.43[165] |
0.60[166] |
0.43[167] |
0.22[168] |
25 |
ERLIN2 |
Erlin-2 |
[169] |
0.44[170] |
0.62[171] |
1.27[172] |
0.05[173] |
0.14[174] |
0.26[175] |
26 |
POLR2A |
DNA-directed RNA polymerase II subunit RPB1 |
[176] |
2.38[177] |
0.96[178] |
1.64[179] |
1.96[180] |
2.52[181] |
1.34[182] |
27 |
FGFR3 |
Fibroblast growth factor receptor 3 |
[183] |
2.38[184] |
2.33[185] |
2.34[186] |
-3.49[187] |
-1.98[188] |
0.00[189] |
28 |
PIK3R1 |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
[190] |
-0.82[191] |
-0.67[192] |
0.11[193] |
1.87[194] |
1.54[195] |
2.55[196] |
29 |
MYO18A |
Unconventional myosin-XVIIIa |
[197] |
0.73[198] |
1.05[199] |
1.63[200] |
0.83[201] |
0.02[202] |
2.16[203] |
30 |
SOS1 |
Son of sevenless homolog 1 |
[204] |
-0.45[205] |
1.12[206] |
0.31[207] |
0.65[208] |
0.05[209] |
0.09[210] |
31 |
CUX1 |
Homeobox protein cut-like 1 |
[211] |
1.18[212] |
0.36[213] |
0.67[214] |
1.43[215] |
2.01[216] |
1.03[217] |
32 |
NCBP1 |
Nuclear cap-binding protein subunit 1 |
[218] |
0.90[219] |
1.16[220] |
0.66[221] |
1.56[222] |
2.27[223] |
0.79[224] |
33 |
CPSF6 |
Cleavage and polyadenylation specificity factor subunit 6 |
[225] |
1.11[226] |
1.78[227] |
1.66[228] |
1.70[229] |
1.68[230] |
1.33[231] |
34 |
FGF2 |
Fibroblast growth factor 2 |
[232] |
-7.04[233] |
-6.75[234] |
-2.91[235] |
0.73[236] |
2.48[237] |
-2.12[238] |
35 |
STAT5B |
Signal transducer and activator of transcription 5B |
[239] |
1.01[240] |
0.67[241] |
1.06[242] |
1.35[243] |
0.66[244] |
1.17[245] |
36 |
BCR |
Breakpoint cluster region protein |
[246] |
1.88[247] |
1.16[248] |
1.10[249] |
0.82[250] |
1.36[251] |
1.25[252] |
37 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
3.14[253] |
2.80[254] |
1.81[255] |
2.62[256] |
2.28[257] |
-0.11[258] |
38 |
BAG4 |
BAG family molecular chaperone regulator 4 |
[259] |
0.01[260] |
0.99[261] |
1.98[262] |
-0.26[263] |
0.13[264] |
1.37[265] |
39 |
STAT5A |
Signal transducer and activator of transcription 5A |
[266] |
-2.30[267] |
-1.09[268] |
-2.33[269] |
-1.05[270] |
-0.12[271] |
-0.22[272] |
40 |
ZMYM2 |
Zinc finger MYM-type protein 2 |
[273] |
1.28[274] |
2.45[275] |
1.65[276] |
2.77[277] |
2.47[278] |
2.83[279] |
41 |
PIK3CA |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
-0.73[280] |
0.95[281] |
0.82[282] |
0.93[283] |
1.30[284] |
1.46[285] |
42 |
GAB2 |
GRB2-associated-binding protein 2 |
[286] |
1.21[287] |
1.04[288] |
0.97[289] |
0.72[290] |
0.98[291] |
0.09[292] |
43 |
FGFR2 |
Fibroblast growth factor receptor 2 |
[293] |
-2.86[294] |
-1.62[295] |
2.01[296] |
1.26[297] |
-3.42[298] |
2.97[299] |
44 |
FRS2 |
Fibroblast growth factor receptor substrate 2 |
[300] |
0.94[301] |
2.07[302] |
2.25[303] |
2.70[304] |
2.50[305] |
2.89[306] |
45 |
FGFR1 |
Fibroblast growth factor receptor 1 |
[307] |
4.23[308] |
2.58[309] |
3.91[310] |
4.86[311] |
4.29[312] |
1.21[313] |
46 |
GAB1 |
GRB2-associated-binding protein 1 |
[314] |
0.95[315] |
2.08[316] |
1.88[317] |
1.73[318] |
1.76[319] |
2.42[320] |
47 |
CNTRL |
Centriolin |
[321] |
0.66[322] |
2.94[323] |
3.46[324] |
2.56[325] |
2.43[326] |
2.13[327] |
48 |
FGF7 |
Fibroblast growth factor 7 |
[328] |
-9.64[329] |
-5.91[330] |
[331] |
-5.57[332] |
-1.14[333] |
-1.90[334] |
49 |
FGF5 |
Fibroblast growth factor 5 |
[335] |
-1.34[336] |
0.02[337] |
-0.37[338] |
1.28[339] |
1.14[340] |
2.68[341] |
50 |
FGF1 |
Fibroblast growth factor 1 |
[342] |
-3.11[343] |
-2.29[344] |
-7.07[345] |
0.39[346] |
2.13[347] |
-0.41[348] |
51 |
FGF8 |
Fibroblast growth factor 8 |
[349] |
-3.68[350] |
-3.29[351] |
0.88[352] |
-2.12[353] |
[354] |
2.24[355] |
52 |
FGF18 |
Fibroblast growth factor 18 |
[356] |
1.43[357] |
-2.65[358] |
-0.80[359] |
0.42[360] |
1.18[361] |
0.13[362] |
53 |
FGF9 |
Fibroblast growth factor 9 |
[363] |
1.91[364] |
-1.71[365] |
[366] |
2.58[367] |
-2.36[368] |
-0.35[369] |
54 |
FGF4 |
Fibroblast growth factor 4 |
[370] |
[371] |
[372] |
[373] |
[374] |
[375] |
[376] |
55 |
FGF20 |
Fibroblast growth factor 20 |
[377] |
[378] |
[379] |
[380] |
[381] |
[382] |
[383] |
56 |
FGF3 |
Fibroblast growth factor 3 |
[384] |
[385] |
[386] |
[387] |
[388] |
[389] |
[390] |
57 |
FGF16 |
Fibroblast growth factor 16 |
[391] |
[392] |
[393] |
[394] |
[395] |
[396] |
[397] |
58 |
FGF23 |
Fibroblast growth factor 23 |
[398] |
[399] |
[400] |
[401] |
[402] |
[403] |
[404] |
59 |
FGF17 |
Fibroblast growth factor 17 |
[405] |
[406] |
[407] |
[408] |
[409] |
[410] |
[411] |
60 |
FGF22 |
Fibroblast growth factor 22 |
[412] |
[413] |
[414] |
[415] |
[416] |
[417] |
[418] |
61 |
FGF10 |
Fibroblast growth factor 10 |
[419] |
[420] |
[421] |
[422] |
[423] |
[424] |
[425] |
62 |
CEP43 |
|
[426] |
[427] |
[428] |
[429] |
[430] |
[431] |
[432] |
63 |
FGF6 |
Fibroblast growth factor 6 |
[433] |
[434] |
[435] |
[436] |
[437] |
[438] |
[439] |
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