REACTOME_SIGNALING_BY_FGFR4_IN_DISEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.10[2] -0.26[3] -0.45[4] -0.29[5] -0.02[6] -0.61[7]
2 FGFR4 Fibroblast growth factor receptor 4 [8] 0.86[9] 1.01[10] 1.28[11] -5.08[12] -4.85[13] -0.41[14]
3 NRAS GTPase NRas [15] -0.47[16] -0.23[17] -0.13[18] 0.15[19] 0.08[20] -1.16[21]
4 HRAS GTPase HRas [22] -2.11[23] -3.00[24] -4.11[25] -1.79[26] -1.65[27] -3.57[28]
5 KRAS GTPase KRas [29] -1.61[30] -1.82[31] -0.54[32] -0.04[33] -0.02[34] -0.23[35]
6 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [36] -1.57[37] -1.64[38] -0.87[39] 1.22[40] 1.08[41] 2.09[42]
7 SOS1 Son of sevenless homolog 1 [43] -1.20[44] 0.14[45] -0.67[46] 0.00[47] -0.41[48] -0.37[49]
8 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.39[50] 1.82[51] 0.84[52] 1.98[53] 1.83[54] -0.57[55]
9 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.48[56] -0.03[57] -0.16[58] 0.29[59] 0.85[60] 1.00[61]
10 FRS2 Fibroblast growth factor receptor substrate 2 [62] 0.19[63] 1.09[64] 1.28[65] 2.06[66] 2.05[67] 2.43[68]
11 GAB1 GRB2-associated-binding protein 1 [69] 0.20[70] 1.10[71] 0.91[72] 1.09[73] 1.31[74] 1.96[75]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[9]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[10]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[11]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[12]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[13]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[14]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[37]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[38]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[39]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[40]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[41]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[42]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[43]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[44]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[45]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[46]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[47]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[48]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[49]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[50]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[51]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[52]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[53]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[54]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[55]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[56]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[57]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[58]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[59]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[60]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[61]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[62]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[63]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[64]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[65]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[66]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[67]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[68]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[69]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[70]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[71]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[72]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[73]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[74]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[75]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[76]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[77]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10