REACTOME_SIGNALING_BY_FGFR4 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.98[2] | -1.21[3] | -1.28[4] | -1.45[5] | -0.98[6] | -0.59[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.54[16] | -0.45[17] | -0.92[18] | -0.59[19] | -0.60[20] | -0.13[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 1.90[23] | 1.78[24] | 2.59[25] | 0.80[26] | 1.62[27] | 0.63[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.02[29] | 1.82[30] | 1.52[31] | 2.54[32] | 1.87[33] | 1.44[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.49[35] | 1.56[36] | 0.70[37] | 2.08[38] | 2.19[39] | 1.19[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.83[41] | 0.46[42] | 0.31[43] | 0.88[44] | 0.78[45] | 0.30[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.66[48] | 2.07[49] | 1.80[50] | 2.22[51] | 2.86[52] | 2.55[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.41[55] | 2.23[56] | 2.12[57] | 1.89[58] | 1.81[59] | 1.59[60] |
10 | SHC1 | SHC-transforming protein 1 | [61] | 2.38[62] | 2.58[63] | 2.42[64] | 3.98[65] | 3.48[66] | 2.07[67] |
11 | FGFR4 | Fibroblast growth factor receptor 4 | [68] | 3.17[69] | 3.49[70] | 3.84[71] | -2.90[72] | -3.02[73] | 1.79[74] |
12 | NRAS | GTPase NRas | [75] | 1.85[76] | 2.25[77] | 2.44[78] | 2.33[79] | 1.91[80] | 1.04[81] |
13 | HRAS | GTPase HRas | [82] | 0.21[83] | -0.52[84] | -1.54[85] | 0.39[86] | 0.17[87] | -1.37[88] |
14 | MAPK1 | Mitogen-activated protein kinase 1 | [89] | 2.93[90] | 3.04[91] | 2.64[92] | 3.18[93] | 2.84[94] | 3.07[95] |
15 | KLB | Beta-klotho | [96] | 1.81[97] | 1.62[98] | 2.85[99] | -4.63[100] | -5.27[101] | 2.84[102] |
16 | KRAS | GTPase KRas | [103] | 0.70[104] | 0.66[105] | 2.03[106] | 2.14[107] | 1.80[108] | 1.97[109] |
17 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [110] | 0.75[111] | 0.84[112] | 1.70[113] | 3.40[114] | 2.91[115] | 4.29[116] |
18 | SOS1 | Son of sevenless homolog 1 | [117] | 1.12[118] | 2.62[119] | 1.90[120] | 2.18[121] | 1.42[122] | 1.83[123] |
19 | MAPK3 | Mitogen-activated protein kinase 3 | [124] | 3.07[125] | 3.09[126] | 2.90[127] | 1.76[128] | 1.78[129] | 0.25[130] |
20 | FGF2 | Fibroblast growth factor 2 | [131] | -5.47[132] | -5.24[133] | -1.32[134] | 2.27[135] | 3.85[136] | -0.37[137] |
21 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [138] | 1.58[139] | 1.19[140] | 1.48[141] | 1.68[142] | 1.28[143] | 1.99[144] |
22 | SRC | Proto-oncogene tyrosine-protein kinase Src | [145] | 4.24[146] | 4.20[147] | 2.97[148] | 3.73[149] | 2.91[150] | 0.44[151] |
23 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.71[152] | 4.30[153] | 3.41[154] | 4.16[155] | 3.65[156] | 1.63[157] | |
24 | SPRY2 | Protein sprouty homolog 2 | [158] | 0.62[159] | 0.75[160] | 2.94[161] | -0.94[162] | 1.09[163] | 1.46[164] |
25 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.84[165] | 2.45[166] | 2.41[167] | 2.46[168] | 2.67[169] | 3.20[170] | |
26 | FRS2 | Fibroblast growth factor receptor substrate 2 | [171] | 2.51[172] | 3.57[173] | 3.85[174] | 4.24[175] | 3.87[176] | 4.63[177] |
27 | BRAF | Serine/threonine-protein kinase B-raf | [178] | 1.47[179] | 1.17[180] | 2.98[181] | 2.07[182] | 1.77[183] | 3.14[184] |
28 | FRS3 | Fibroblast growth factor receptor substrate 3 | [185] | 1.85[186] | 1.65[187] | 0.41[188] | 1.63[189] | 1.29[190] | 0.38[191] |
29 | GAB1 | GRB2-associated-binding protein 1 | [192] | 2.52[193] | 3.58[194] | 3.48[195] | 3.27[196] | 3.13[197] | 4.16[198] |
30 | CBL | E3 ubiquitin-protein ligase CBL | [199] | 5.67[200] | 4.59[201] | 4.58[202] | 6.47[203] | 5.96[204] | 5.05[205] |
31 | FGF1 | Fibroblast growth factor 1 | [206] | -1.55[207] | -0.78[208] | -5.47[209] | 1.92[210] | 3.50[211] | 1.33[212] |
32 | FGF19 | Fibroblast growth factor 19 | [213] | -0.84[214] | 0.28[215] | 6.80[216] | 2.16[217] | -1.30[218] | [219] |
33 | FGF8 | Fibroblast growth factor 8 | [220] | -2.11[221] | -1.79[222] | 2.48[223] | -0.58[224] | [225] | 3.99[226] |
34 | FGF18 | Fibroblast growth factor 18 | [227] | 3.00[228] | -1.15[229] | 0.80[230] | 1.95[231] | 2.55[232] | 1.87[233] |
35 | FGF9 | Fibroblast growth factor 9 | [234] | 3.48[235] | -0.20[236] | [237] | 4.12[238] | -0.99[239] | 1.39[240] |
36 | FGF4 | Fibroblast growth factor 4 | [241] | [242] | [243] | [244] | [245] | [246] | [247] |
37 | FGF20 | Fibroblast growth factor 20 | [248] | [249] | [250] | [251] | [252] | [253] | [254] |
38 | FGF16 | Fibroblast growth factor 16 | [255] | [256] | [257] | [258] | [259] | [260] | [261] |
39 | FGF17 | Fibroblast growth factor 17 | [262] | [263] | [264] | [265] | [266] | [267] | [268] |
40 | FGF23 | Fibroblast growth factor 23 | [269] | [270] | [271] | [272] | [273] | [274] | [275] |
41 | FGF6 | Fibroblast growth factor 6 | [276] | [277] | [278] | [279] | [280] | [281] | [282] |