REACTOME_SIGNALING_BY_FGFR3_FUSIONS_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.32[2] -0.01[3] -0.21[4] -0.24[5] -0.01[6] -0.66[7]
2 NRAS GTPase NRas [8] -0.25[9] 0.02[10] 0.11[11] 0.20[12] 0.09[13] -1.21[14]
3 HRAS GTPase HRas [15] -1.88[16] -2.76[17] -3.87[18] -1.74[19] -1.64[20] -3.62[21]
4 KRAS GTPase KRas [22] -1.39[23] -1.58[24] -0.30[25] 0.01[26] -0.01[27] -0.28[28]
5 FGFR3 Fibroblast growth factor receptor 3 [29] 1.85[30] 1.60[31] 1.61[32] -4.09[33] -2.42[34] -0.51[35]
6 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [36] -1.35[37] -1.40[38] -0.63[39] 1.27[40] 1.09[41] 2.04[42]
7 SOS1 Son of sevenless homolog 1 [43] -0.98[44] 0.39[45] -0.43[46] 0.05[47] -0.40[48] -0.42[49]
8 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.26[50] 0.21[51] 0.08[52] 0.34[53] 0.86[54] 0.95[55]
9 FRS2 Fibroblast growth factor receptor substrate 2 [56] 0.41[57] 1.34[58] 1.52[59] 2.11[60] 2.06[61] 2.38[62]
10 GAB1 GRB2-associated-binding protein 1 [63] 0.43[64] 1.35[65] 1.15[66] 1.14[67] 1.32[68] 1.91[69]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[22]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[23]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[24]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[25]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[26]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[27]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[28]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[29]
ref_hepatocyte FGFR3
Mean 7.46
Standard deviation 9.2
Values 23 2.7 0.18 4.6 6.4
[30]
HepG2 FGFR3
Mean 109
Standard deviation 1.1
Values 1.1e+02 1.1e+02
[31]
HepG2.C3A FGFR3
Mean 91.5
Standard deviation 12
Values 1e+02 83
[32]
HuH.7 FGFR3
Mean 110
Standard deviation 12
Values 1.2e+02 97 1.2e+02
[33]
SNU475 FGFR3
Mean 1.4
Standard deviation 0.25
Values 1.6 1.2
[34]
THLE FGFR3
Mean 3.99
Standard deviation 0.31
Values 3.8 4.2
[35]
liver FGFR3
Mean 14.5
Standard deviation 8.7
Values 9.3 18 5.8 25
[36]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[37]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[38]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[39]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[40]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[41]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[42]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[43]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[44]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[45]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[46]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[47]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[48]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[49]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[50]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[51]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[52]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[53]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[54]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[55]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[56]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[57]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[58]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[59]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[60]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[61]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[62]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[63]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[64]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[65]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[66]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[67]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[68]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[69]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[70]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10