REACTOME_SIGNALING_BY_FGFR3 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.95[2] | -1.15[3] | -1.16[4] | -1.46[5] | -1.00[6] | -0.53[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.51[16] | -0.40[17] | -0.79[18] | -0.61[19] | -0.62[20] | -0.08[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 1.93[23] | 1.83[24] | 2.72[25] | 0.79[26] | 1.61[27] | 0.69[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 2.05[29] | 1.87[30] | 1.64[31] | 2.53[32] | 1.86[33] | 1.49[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.52[35] | 1.61[36] | 0.82[37] | 2.06[38] | 2.18[39] | 1.24[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.85[41] | 0.51[42] | 0.44[43] | 0.86[44] | 0.76[45] | 0.36[46] | |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [47] | 1.69[48] | 2.12[49] | 1.92[50] | 2.21[51] | 2.84[52] | 2.60[53] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [54] | 2.44[55] | 2.28[56] | 2.24[57] | 1.87[58] | 1.79[59] | 1.64[60] |
10 | SHC1 | SHC-transforming protein 1 | [61] | 2.41[62] | 2.63[63] | 2.55[64] | 3.97[65] | 3.46[66] | 2.12[67] |
11 | NRAS | GTPase NRas | [68] | 1.88[69] | 2.31[70] | 2.56[71] | 2.32[72] | 1.89[73] | 1.09[74] |
12 | HRAS | GTPase HRas | [75] | 0.24[76] | -0.47[77] | -1.41[78] | 0.37[79] | 0.16[80] | -1.32[81] |
13 | MAPK1 | Mitogen-activated protein kinase 1 | [82] | 2.96[83] | 3.09[84] | 2.77[85] | 3.17[86] | 2.82[87] | 3.12[88] |
14 | KRAS | GTPase KRas | [89] | 0.73[90] | 0.71[91] | 2.15[92] | 2.12[93] | 1.78[94] | 2.02[95] |
15 | FGFR3 | Fibroblast growth factor receptor 3 | [96] | 3.97[97] | 3.89[98] | 4.06[99] | -1.97[100] | -0.62[101] | 1.79[102] |
16 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [103] | 0.77[104] | 0.89[105] | 1.83[106] | 3.39[107] | 2.89[108] | 4.34[109] |
17 | SOS1 | Son of sevenless homolog 1 | [110] | 1.15[111] | 2.68[112] | 2.03[113] | 2.17[114] | 1.40[115] | 1.88[116] |
18 | MAPK3 | Mitogen-activated protein kinase 3 | [117] | 3.10[118] | 3.14[119] | 3.03[120] | 1.74[121] | 1.77[122] | 0.30[123] |
19 | FGF2 | Fibroblast growth factor 2 | [124] | -5.44[125] | -5.19[126] | -1.19[127] | 2.26[128] | 3.84[129] | -0.32[130] |
20 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [131] | 1.61[132] | 1.24[133] | 1.60[134] | 1.66[135] | 1.27[136] | 2.04[137] |
21 | SRC | Proto-oncogene tyrosine-protein kinase Src | [138] | 4.27[139] | 4.26[140] | 3.10[141] | 3.72[142] | 2.90[143] | 0.49[144] |
22 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.74[145] | 4.36[146] | 3.53[147] | 4.14[148] | 3.64[149] | 1.68[150] | |
23 | SPRY2 | Protein sprouty homolog 2 | [151] | 0.65[152] | 0.80[153] | 3.07[154] | -0.95[155] | 1.08[156] | 1.52[157] |
24 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.87[158] | 2.51[159] | 2.54[160] | 2.45[161] | 2.65[162] | 3.26[163] | |
25 | FRS2 | Fibroblast growth factor receptor substrate 2 | [164] | 2.53[165] | 3.63[166] | 3.97[167] | 4.22[168] | 3.85[169] | 4.68[170] |
26 | BRAF | Serine/threonine-protein kinase B-raf | [171] | 1.49[172] | 1.22[173] | 3.10[174] | 2.06[175] | 1.76[176] | 3.20[177] |
27 | FRS3 | Fibroblast growth factor receptor substrate 3 | [178] | 1.87[179] | 1.70[180] | 0.53[181] | 1.61[182] | 1.27[183] | 0.43[184] |
28 | GAB1 | GRB2-associated-binding protein 1 | [185] | 2.55[186] | 3.64[187] | 3.60[188] | 3.25[189] | 3.12[190] | 4.22[191] |
29 | CBL | E3 ubiquitin-protein ligase CBL | [192] | 5.69[193] | 4.64[194] | 4.70[195] | 6.46[196] | 5.94[197] | 5.10[198] |
30 | FGF5 | Fibroblast growth factor 5 | [199] | 0.26[200] | 1.58[201] | 1.35[202] | 2.80[203] | 2.49[204] | 4.48[205] |
31 | FGF1 | Fibroblast growth factor 1 | [206] | -1.52[207] | -0.73[208] | -5.35[209] | 1.91[210] | 3.49[211] | 1.38[212] |
32 | GALNT3 | Polypeptide N-acetylgalactosaminyltransferase 3 | [213] | 0.19[214] | 0.11[215] | 3.31[216] | -0.19[217] | 3.97[218] | 4.48[219] |
33 | FGF8 | Fibroblast growth factor 8 | [220] | -2.08[221] | -1.73[222] | 2.60[223] | -0.60[224] | [225] | 4.04[226] |
34 | FGF18 | Fibroblast growth factor 18 | [227] | 3.03[228] | -1.09[229] | 0.92[230] | 1.94[231] | 2.53[232] | 1.93[233] |
35 | FGF9 | Fibroblast growth factor 9 | [234] | 3.50[235] | -0.15[236] | [237] | 4.10[238] | -1.01[239] | 1.45[240] |
36 | FGF17 | Fibroblast growth factor 17 | [241] | [242] | [243] | [244] | [245] | [246] | [247] |
37 | FGF23 | Fibroblast growth factor 23 | [248] | [249] | [250] | [251] | [252] | [253] | [254] |
38 | FGF16 | Fibroblast growth factor 16 | [255] | [256] | [257] | [258] | [259] | [260] | [261] |
39 | FGF20 | Fibroblast growth factor 20 | [262] | [263] | [264] | [265] | [266] | [267] | [268] |
40 | FGF4 | Fibroblast growth factor 4 | [269] | [270] | [271] | [272] | [273] | [274] | [275] |