REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | STAT3 | Signal transducer and activator of transcription 3 | [1] | -0.26[2] | -1.63[3] | -1.28[4] | -0.92[5] | -1.16[6] | 1.03[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | 0.38[9] | 0.35[10] | 0.08[11] | -0.61[12] | -0.21[13] | -1.08[14] |
3 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [15] | -0.89[16] | -1.67[17] | -0.95[18] | 1.36[19] | -0.41[20] | -0.43[21] |
4 | LRRFIP1 | Leucine-rich repeat flightless-interacting protein 1 | [22] | -1.47[23] | -0.84[24] | -1.93[25] | -1.52[26] | -0.43[27] | -0.69[28] |
5 | NRAS | GTPase NRas | [29] | -0.19[30] | 0.38[31] | 0.40[32] | -0.17[33] | -0.11[34] | -1.63[35] |
6 | HRAS | GTPase HRas | [36] | -1.82[37] | -2.40[38] | -3.58[39] | -2.11[40] | -1.84[41] | -4.04[42] |
7 | TRIM24 | Transcription intermediary factor 1-alpha | [43] | 1.02[44] | 0.27[45] | -0.01[46] | -2.86[47] | -2.11[48] | -1.50[49] |
8 | FGFR1OP2 | FGFR1 oncogene partner 2 | [50] | -2.15[51] | -0.90[52] | -1.23[53] | -2.52[54] | -1.28[55] | -1.69[56] |
9 | KRAS | GTPase KRas | [57] | -1.33[58] | -1.22[59] | -0.01[60] | -0.36[61] | -0.22[62] | -0.70[63] |
10 | ERLIN2 | Erlin-2 | [64] | -0.03[65] | 0.25[66] | 0.83[67] | -0.92[68] | -0.51[69] | -0.67[70] |
11 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [71] | -1.29[72] | -1.04[73] | -0.33[74] | 0.90[75] | 0.89[76] | 1.62[77] |
12 | MYO18A | Unconventional myosin-XVIIIa | [78] | 0.26[79] | 0.68[80] | 1.19[81] | -0.14[82] | -0.63[83] | 1.23[84] |
13 | SOS1 | Son of sevenless homolog 1 | [85] | -0.92[86] | 0.75[87] | -0.13[88] | -0.32[89] | -0.60[90] | -0.84[91] |
14 | CUX1 | Homeobox protein cut-like 1 | [92] | 0.72[93] | -0.01[94] | 0.23[95] | 0.46[96] | 1.36[97] | 0.11[98] |
15 | CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 | [99] | 0.64[100] | 1.41[101] | 1.22[102] | 0.73[103] | 1.03[104] | 0.41[105] |
16 | FGF2 | Fibroblast growth factor 2 | [106] | -7.50[107] | -7.12[108] | -3.35[109] | -0.23[110] | 1.84[111] | -3.04[112] |
17 | STAT5B | Signal transducer and activator of transcription 5B | [113] | 0.54[114] | 0.30[115] | 0.61[116] | 0.38[117] | 0.01[118] | 0.24[119] |
18 | BCR | Breakpoint cluster region protein | [120] | 1.41[121] | 0.79[122] | 0.66[123] | -0.15[124] | 0.71[125] | 0.32[126] |
19 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.67[127] | 2.43[128] | 1.37[129] | 1.66[130] | 1.64[131] | -1.04[132] | |
20 | BAG4 | BAG family molecular chaperone regulator 4 | [133] | -0.46[134] | 0.62[135] | 1.53[136] | -1.23[137] | -0.52[138] | 0.44[139] |
21 | STAT5A | Signal transducer and activator of transcription 5A | [140] | -2.77[141] | -1.46[142] | -2.78[143] | -2.01[144] | -0.77[145] | -1.14[146] |
22 | ZMYM2 | Zinc finger MYM-type protein 2 | [147] | 0.81[148] | 2.08[149] | 1.21[150] | 1.81[151] | 1.82[152] | 1.90[153] |
23 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.20[154] | 0.57[155] | 0.38[156] | -0.04[157] | 0.65[158] | 0.54[159] | |
24 | GAB2 | GRB2-associated-binding protein 2 | [160] | 0.75[161] | 0.67[162] | 0.53[163] | -0.24[164] | 0.33[165] | -0.84[166] |
25 | FRS2 | Fibroblast growth factor receptor substrate 2 | [167] | 0.47[168] | 1.70[169] | 1.81[170] | 1.74[171] | 1.85[172] | 1.96[173] |
26 | FGFR1 | Fibroblast growth factor receptor 1 | [174] | 3.76[175] | 2.21[176] | 3.47[177] | 3.89[178] | 3.65[179] | 0.28[180] |
27 | GAB1 | GRB2-associated-binding protein 1 | [181] | 0.49[182] | 1.71[183] | 1.44[184] | 0.77[185] | 1.12[186] | 1.50[187] |
28 | CNTRL | Centriolin | [188] | 0.19[189] | 2.57[190] | 3.02[191] | 1.59[192] | 1.78[193] | 1.20[194] |
29 | FGF5 | Fibroblast growth factor 5 | [195] | -1.81[196] | -0.35[197] | -0.81[198] | 0.32[199] | 0.49[200] | 1.76[201] |
30 | FGF1 | Fibroblast growth factor 1 | [202] | -3.58[203] | -2.66[204] | -7.51[205] | -0.58[206] | 1.49[207] | -1.34[208] |
31 | FGF8 | Fibroblast growth factor 8 | [209] | -4.14[210] | -3.66[211] | 0.44[212] | -3.08[213] | [214] | 1.32[215] |
32 | FGF9 | Fibroblast growth factor 9 | [216] | 1.44[217] | -2.08[218] | [219] | 1.62[220] | -3.01[221] | -1.28[222] |
33 | FGF23 | Fibroblast growth factor 23 | [223] | [224] | [225] | [226] | [227] | [228] | [229] |
34 | FGF17 | Fibroblast growth factor 17 | [230] | [231] | [232] | [233] | [234] | [235] | [236] |
35 | CEP43 | [237] | [238] | [239] | [240] | [241] | [242] | [243] | |
36 | FGF6 | Fibroblast growth factor 6 | [244] | [245] | [246] | [247] | [248] | [249] | [250] |
37 | FGF4 | Fibroblast growth factor 4 | [251] | [252] | [253] | [254] | [255] | [256] | [257] |
38 | FGF20 | Fibroblast growth factor 20 | [258] | [259] | [260] | [261] | [262] | [263] | [264] |