REACTOME_SIGNALING_BY_ERYTHROPOIETIN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.26[2] -0.08[3] -0.04[4] -0.75[5] -0.58[6] -0.71[7]
2 SHC1 SHC-transforming protein 1 [8] 0.22[9] 0.27[10] 0.26[11] 1.34[12] 1.09[13] -0.23[14]
3 NRAS GTPase NRas [15] -0.31[16] -0.05[17] 0.28[18] -0.31[19] -0.48[20] -1.26[21]
4 HRAS GTPase HRas [22] -1.95[23] -2.82[24] -3.70[25] -2.26[26] -2.21[27] -3.67[28]
5 KRAS GTPase KRas [29] -1.45[30] -1.64[31] -0.13[32] -0.51[33] -0.58[34] -0.33[35]
6 CRKL Crk-like protein [36] 0.76[37] 0.69[38] 1.21[39] -0.18[40] 0.28[41] 0.44[42]
7 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [43] -1.41[44] -1.46[45] -0.46[46] 0.76[47] 0.52[48] 1.99[49]
8 SOS1 Son of sevenless homolog 1 [50] -1.04[51] 0.32[52] -0.26[53] -0.46[54] -0.97[55] -0.47[56]
9 LYN Tyrosine-protein kinase Lyn [57] -1.80[58] -2.15[59] -1.71[60] -0.25[61] -1.23[62] -0.99[63]
10 RAPGEF1 Rap guanine nucleotide exchange factor 1 [64] 1.15[65] 0.81[66] 0.44[67] -0.05[68] -0.12[69] 0.16[70]
11 EPO Erythropoietin [71] -2.07[72] -0.08[73] -4.02[74] -10.98[75] -12.59[76] -1.02[77]
12 STAT5B Signal transducer and activator of transcription 5B [78] 0.42[79] -0.12[80] 0.49[81] 0.24[82] -0.35[83] 0.61[84]
13 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.55[85] 2.00[86] 1.24[87] 1.51[88] 1.27[89] -0.67[90]
14 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.27[91] 0.61[92] 0.68[93] -0.26[94] 0.16[95] 0.15[96]
15 STAT5A Signal transducer and activator of transcription 5A [97] -2.89[98] -1.88[99] -2.90[100] -2.15[101] -1.13[102] -0.77[103]
16 IRS2 Insulin receptor substrate 2 [104] -6.59[105] [106] -3.99[107] -1.97[108] 2.12[109] 1.37[110]
17 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.32[111] 0.15[112] 0.25[113] -0.18[114] 0.29[115] 0.90[116]
18 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 0.95[117] 1.87[118] -2.04[119] -1.03[120] 0.00[121] -0.71[122]
19 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 -2.22[123] -8.14[124] -0.78[125] -4.04[126] -2.63[127] 1.71[128]
20 GAB1 GRB2-associated-binding protein 1 [129] 0.36[130] 1.28[131] 1.32[132] 0.62[133] 0.75[134] 1.86[135]
21 JAK2 Tyrosine-protein kinase JAK2 [136] -0.71[137] -0.89[138] -1.42[139] -0.55[140] 0.31[141] 1.70[142]
22 EPOR Erythropoietin receptor [143] 0.33[144] 1.28[145] 2.21[146] -0.14[147] 0.96[148] 1.57[149]
23 VAV1 Proto-oncogene vav [150] -9.44[151] -4.78[152] -6.58[153] -7.40[154] -8.39[155] 0.17[156]
24 PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 [157] -8.11[158] [159] -3.73[160] -5.23[161] -4.62[162] 1.33[163]
25 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [164] [165] [166] 0.03[167] -4.59[168] 3.09[169]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte CRKL
Mean 7.86
Standard deviation 3.2
Values 13 7.5 7.1 6.1 5.2
[37]
HepG2 CRKL
Mean 56.6
Standard deviation 7.1
Values 52 62
[38]
HepG2.C3A CRKL
Mean 53.9
Standard deviation 8
Values 60 48
[39]
HuH.7 CRKL
Mean 78.7
Standard deviation 6.8
Values 86 76 74
[40]
SNU475 CRKL
Mean 31.5
Standard deviation 0.52
Values 32 31
[41]
THLE CRKL
Mean 40.6
Standard deviation 0.46
Values 41 40
[42]
liver CRKL
Mean 30.6
Standard deviation 3.9
Values 25 32 32 33
[43]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[44]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[45]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[46]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[47]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[48]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[49]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[58]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[59]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[60]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[61]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[62]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[63]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[64]
ref_hepatocyte RAPGEF1
Mean 4.9
Standard deviation 2.3
Values 6.6 5.4 7.5 2.5 2.6
[65]
HepG2 RAPGEF1
Mean 46
Standard deviation 2.9
Values 48 44
[66]
HepG2.C3A RAPGEF1
Mean 36.5
Standard deviation 6.8
Values 41 32
[67]
HuH.7 RAPGEF1
Mean 28.7
Standard deviation 4.9
Values 30 33 23
[68]
SNU475 RAPGEF1
Mean 21.5
Standard deviation 2.8
Values 23 20
[69]
THLE RAPGEF1
Mean 19.2
Standard deviation 5.1
Values 16 23
[70]
liver RAPGEF1
Mean 15.7
Standard deviation 4.8
Values 16 19 8.9 19
[71]
ref_hepatocyte EPO
Mean 4.3
Standard deviation 5.9
Values 1.1 0 0.32 14 6.2
[72]
HepG2 EPO
Mean 4.34
Standard deviation 2.9
Values 2.3 6.4
[73]
HepG2.C3A EPO
Mean 17.3
Standard deviation 2.6
Values 15 19
[74]
HuH.7 EPO
Mean 1.15
Standard deviation 0.76
Values 0.71 2 0.72
[75]
SNU475 EPO
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[76]
THLE EPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[77]
liver EPO
Mean 6.05
Standard deviation 8
Values 3.1 2.9 18 0.3
[78]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[79]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[80]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[81]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[82]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[83]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[84]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[85]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[86]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[87]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[88]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[89]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[90]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[91]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[92]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[93]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[94]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[95]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[96]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[97]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[98]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[99]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[100]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[101]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[102]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[103]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[104]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[105]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[106]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[107]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[108]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[110]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[111]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[112]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[113]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[114]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[115]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[116]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[117]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[118]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[119]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[120]
ref_hepatocyte PIK3CD
Mean 1.86
Standard deviation 1.7
Values 4.1 0.94 3.3 0.38 0.66
[121]
HepG2 PIK3CD
Mean 15.2
Standard deviation 3.8
Values 18 13
[122]
HepG2.C3A PIK3CD
Mean 28.8
Standard deviation 2.6
Values 31 27
[123]
HuH.7 PIK3CD
Mean 1.97
Standard deviation 0.32
Values 2 2.3 1.6
[124]
SNU475 PIK3CD
Mean 4.15
Standard deviation 0.57
Values 4.6 3.7
[125]
THLE PIK3CD
Mean 7.91
Standard deviation 1.1
Values 7.1 8.7
[126]
liver PIK3CD
Mean 3.25
Standard deviation 1.3
Values 2.4 3 2.6 5.1
[127]
ref_hepatocyte PLCG2
Mean 0.967
Standard deviation 0.77
Values 0 0.93 0.46 1.9 1.6
[128]
HepG2 PLCG2
Mean 0.879
Standard deviation 0.82
Values 1.5 0.3
[129]
HepG2.C3A PLCG2
Mean 0.0146
Standard deviation 0.021
Values 0.029 0
[130]
HuH.7 PLCG2
Mean 2.44
Standard deviation 1.1
Values 1.9 3.7 1.8
[131]
SNU475 PLCG2
Mean 0.267
Standard deviation 0.089
Values 0.2 0.33
[132]
THLE PLCG2
Mean 0.664
Standard deviation 0.061
Values 0.62 0.71
[133]
liver PLCG2
Mean 9.03
Standard deviation 2.5
Values 12 10 5.7 8.7
[134]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[135]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[136]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[137]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[138]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[139]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[140]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[141]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[142]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[143]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[144]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[145]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[146]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[147]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[148]
ref_hepatocyte EPOR
Mean 0.552
Standard deviation 0.22
Values 0.24 0.48 0.53 0.69 0.82
[149]
HepG2 EPOR
Mean 2.93
Standard deviation 0.93
Values 3.6 2.3
[150]
HepG2.C3A EPOR
Mean 5.68
Standard deviation 2.7
Values 7.6 3.8
[151]
HuH.7 EPOR
Mean 11.1
Standard deviation 0.46
Values 11 11 11
[152]
SNU475 EPOR
Mean 2.28
Standard deviation 0.26
Values 2.1 2.5
[153]
THLE EPOR
Mean 4.55
Standard deviation 0.058
Values 4.5 4.6
[154]
liver EPOR
Mean 4.7
Standard deviation 1.7
Values 6.5 3.4 5.7 3.1
[155]
ref_hepatocyte VAV1
Mean 0.469
Standard deviation 0.4
Values 0 0.2 0.63 0.48 1
[156]
HepG2 VAV1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[157]
HepG2.C3A VAV1
Mean 0.0726
Standard deviation 0.034
Values 0.049 0.097
[158]
HuH.7 VAV1
Mean 0.0213
Standard deviation 0.0061
Values 0.016 0.019 0.028
[159]
SNU475 VAV1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[160]
THLE VAV1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[161]
liver VAV1
Mean 1.51
Standard deviation 0.9
Values 0.75 1.8 0.82 2.6
[162]
ref_hepatocyte PIK3R5
Mean 0.373
Standard deviation 0.52
Values 0 0 1.3 0.29 0.3
[163]
HepG2 PIK3R5
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[164]
HepG2.C3A PIK3R5
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 PIK3R5
Mean 0.122
Standard deviation 0.035
Values 0.09 0.12 0.16
[166]
SNU475 PIK3R5
Mean 0.0452
Standard deviation 0.051
Values 0.0093 0.081
[167]
THLE PIK3R5
Mean 0.0642
Standard deviation 0.068
Values 0.11 0.016
[168]
liver PIK3R5
Mean 2.68
Standard deviation 0.95
Values 1.9 2.9 2 3.9
[169]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0 0 0.026 0.29
[170]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.22 0.37
[174]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[175]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 0.94 1.9 1.7 1.6