REACTOME_SIGNALING_BY_ERBB4 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | APOE | Apolipoprotein E | [1] | -1.51[2] | -1.34[3] | -1.47[4] | -8.55[5] | -7.80[6] | -0.39[7] |
2 | UBB | Polyubiquitin-B | [8] | -0.06[9] | -0.46[10] | -0.41[11] | -0.56[12] | -0.10[13] | -0.43[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | 0.38[23] | 0.29[24] | -0.05[25] | 0.30[26] | 0.28[27] | 0.02[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 2.82[30] | 2.53[31] | 3.46[32] | 1.69[33] | 2.50[34] | 0.79[35] |
6 | APH1A | Gamma-secretase subunit APH-1A | [36] | 2.07[37] | 2.15[38] | 2.26[39] | 1.96[40] | 1.85[41] | 0.43[42] |
7 | PSENEN | Gamma-secretase subunit PEN-2 | [43] | 0.07[44] | -0.11[45] | 0.25[46] | 0.34[47] | -0.09[48] | -0.62[49] |
8 | STMN1 | Stathmin | [50] | 3.13[51] | 3.74[52] | 3.85[53] | 3.11[54] | 3.66[55] | -1.10[56] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [57] | 3.34[58] | 2.97[59] | 2.99[60] | 2.78[61] | 2.69[62] | 1.74[63] |
10 | SHC1 | SHC-transforming protein 1 | [64] | 3.30[65] | 3.32[66] | 3.29[67] | 4.87[68] | 4.36[69] | 2.22[70] |
11 | NCSTN | Nicastrin | [71] | 3.49[72] | 2.44[73] | 2.49[74] | 3.31[75] | 3.19[76] | 1.83[77] |
12 | NRAS | GTPase NRas | [78] | 2.77[79] | 3.00[80] | 3.31[81] | 3.22[82] | 2.79[83] | 1.19[84] |
13 | HRAS | GTPase HRas | [85] | 1.13[86] | 0.23[87] | -0.67[88] | 1.27[89] | 1.05[90] | -1.22[91] |
14 | YAP1 | Transcriptional coactivator YAP1 | [92] | 4.11[93] | 3.36[94] | 2.89[95] | 4.51[96] | 3.91[97] | 1.80[98] |
15 | WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | [99] | 2.15[100] | 2.98[101] | 3.25[102] | 2.00[103] | 1.59[104] | 3.61[105] |
16 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [106] | 2.51[107] | 2.47[108] | 2.63[109] | 3.92[110] | 3.38[111] | 1.69[112] |
17 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [113] | 3.49[114] | 3.82[115] | 2.97[116] | 3.75[117] | 3.08[118] | 3.61[119] |
18 | KRAS | GTPase KRas | [120] | 1.63[121] | 1.40[122] | 2.90[123] | 3.02[124] | 2.68[125] | 2.12[126] |
19 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [127] | 4.15[128] | 5.32[129] | 4.26[130] | -3.65[131] | -3.40[132] | 3.75[133] |
20 | SPARC | SPARC | [134] | 3.18[135] | 0.81[136] | -2.92[137] | 6.81[138] | 6.83[139] | 4.47[140] |
21 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [141] | 1.67[142] | 1.59[143] | 2.57[144] | 4.29[145] | 3.79[146] | 4.44[147] |
22 | NCOR1 | Nuclear receptor corepressor 1 | [148] | 3.22[149] | 3.52[150] | 4.07[151] | 3.79[152] | 3.83[153] | 4.24[154] |
23 | SOS1 | Son of sevenless homolog 1 | [155] | 2.04[156] | 3.37[157] | 2.77[158] | 3.07[159] | 2.30[160] | 1.98[161] |
24 | PSEN1 | Presenilin-1 | [162] | 3.20[163] | 3.22[164] | 2.68[165] | 3.48[166] | 3.35[167] | 2.44[168] |
25 | EGFR | Epidermal growth factor receptor | [169] | 1.44[170] | 0.87[171] | 3.64[172] | 2.66[173] | 3.27[174] | 4.10[175] |
26 | MXD4 | Max dimerization protein 4 | [176] | 3.73[177] | 3.96[178] | 4.64[179] | 3.13[180] | 4.21[181] | 1.99[182] |
27 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [183] | 2.82[184] | 2.50[185] | 2.13[186] | 3.96[187] | 3.09[188] | 1.52[189] |
28 | PSEN2 | Presenilin-2 | [190] | 1.45[191] | 0.39[192] | -3.53[193] | 2.30[194] | 0.93[195] | 1.35[196] |
29 | SRC | Proto-oncogene tyrosine-protein kinase Src | [197] | 5.16[198] | 4.95[199] | 3.84[200] | 4.62[201] | 3.79[202] | 0.59[203] |
30 | NEDD4 | E3 ubiquitin-protein ligase NEDD4 | [204] | 1.68[205] | 3.55[206] | 3.59[207] | 3.23[208] | 3.48[209] | 3.64[210] |
31 | WWOX | WW domain-containing oxidoreductase | [211] | 1.46[212] | 1.66[213] | 1.30[214] | -0.46[215] | 0.91[216] | 2.15[217] |
32 | ADAP1 | Arf-GAP with dual PH domain-containing protein 1 | [218] | 3.69[219] | 3.88[220] | 0.73[221] | 2.14[222] | 0.15[223] | -0.56[224] |
33 | STAT5A | Signal transducer and activator of transcription 5A | [225] | 0.19[226] | 1.17[227] | 0.13[228] | 1.38[229] | 2.13[230] | 1.68[231] |
34 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1.76[232] | 3.20[233] | 3.28[234] | 3.35[235] | 3.55[236] | 3.36[237] | |
35 | HBEGF | Proheparin-binding EGF-like growth factor | [238] | 1.15[239] | 0.14[240] | -1.03[241] | 2.53[242] | 2.21[243] | -0.99[244] |
36 | ESR1 | Estrogen receptor | [245] | -5.16[246] | [247] | -3.95[248] | -1.95[249] | -4.21[250] | 3.84[251] |
37 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [252] | 2.48[253] | -3.86[254] | -1.08[255] | 4.27[256] | -3.21[257] | 2.21[258] |
38 | BTC | Probetacellulin | [259] | -6.00[260] | -6.59[261] | -2.48[262] | -0.65[263] | -0.69[264] | -1.47[265] |
39 | CXCL12 | Stromal cell-derived factor 1 | [266] | -4.44[267] | -4.09[268] | -3.65[269] | 5.71[270] | 7.39[271] | 5.97[272] |
40 | APH1B | Gamma-secretase subunit APH-1B | [273] | 1.90[274] | 2.51[275] | 5.53[276] | 5.32[277] | 4.35[278] | 2.67[279] |
41 | NRG4 | Pro-neuregulin-4, membrane-bound isoform | [280] | -1.95[281] | 0.72[282] | 0.57[283] | 2.51[284] | 0.31[285] | 0.51[286] |
42 | DLG4 | Disks large homolog 4 | [287] | 4.92[288] | 5.01[289] | 3.66[290] | 4.18[291] | 6.39[292] | 3.14[293] |
43 | EREG | Proepiregulin | [294] | 3.89[295] | 3.62[296] | -0.90[297] | 0.66[298] | 5.90[299] | -0.03[300] |
44 | GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 | [301] | -4.12[302] | [303] | [304] | 1.50[305] | -4.05[306] | 3.31[307] |
45 | S100B | Protein S100-B | [308] | -1.72[309] | -2.90[310] | [311] | 0.47[312] | -3.55[313] | 2.59[314] |
46 | GABRB1 | Gamma-aminobutyric acid receptor subunit beta-1 | [315] | -3.57[316] | [317] | 4.95[318] | -1.46[319] | -3.50[320] | -0.59[321] |
47 | GFAP | Glial fibrillary acidic protein | [322] | 4.53[323] | 3.01[324] | 2.26[325] | 4.05[326] | 5.10[327] | 2.75[328] |
48 | EGF | Pro-epidermal growth factor | [329] | 4.11[330] | 5.70[331] | 9.20[332] | 11.25[333] | 8.66[334] | 3.02[335] |
49 | NRG2 | Pro-neuregulin-2, membrane-bound isoform | [336] | [337] | [338] | [339] | [340] | [341] | [342] |
50 | CSN2 | Beta-casein | [343] | [344] | [345] | [346] | [347] | [348] | [349] |
51 | GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 | [350] | [351] | [352] | [353] | [354] | [355] | [356] |
52 | GABRQ | Gamma-aminobutyric acid receptor subunit theta | [357] | [358] | [359] | [360] | [361] | [362] | [363] |
53 | GABRG3 | Gamma-aminobutyric acid receptor subunit gamma-3 | [364] | [365] | [366] | [367] | [368] | [369] | [370] |
54 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | [371] | [372] | [373] | [374] | [375] | [376] | [377] |
55 | PGR | Progesterone receptor | [378] | [379] | [380] | [381] | [382] | [383] | [384] |
56 | NRG3 | Pro-neuregulin-3, membrane-bound isoform | [385] | [386] | [387] | [388] | [389] | [390] | [391] |
57 | GABRG2 | Gamma-aminobutyric acid receptor subunit gamma-2 | [392] | [393] | [394] | [395] | [396] | [397] | [398] |
58 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [399] | [400] | [401] | [402] | [403] | [404] | [405] |