REACTOME_SIGNALING_BY_ERBB2_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSP90AA1 Heat shock protein HSP 90-alpha [1] -0.58[2] -0.17[3] -0.58[4] -0.28[5] -0.27[6] -0.87[7]
2 CDC37 Hsp90 co-chaperone Cdc37 [8] -0.69[9] -1.90[10] -1.17[11] -2.18[12] -1.27[13] -1.60[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 1.26[16] 0.54[17] 1.02[18] 0.18[19] 0.42[20] 0.68[21]
4 SHC1 SHC-transforming protein 1 [22] 1.23[23] 0.89[24] 1.33[25] 2.28[26] 2.09[27] 1.16[28]
5 NRAS GTPase NRas [29] 0.69[30] 0.57[31] 1.34[32] 0.62[33] 0.52[34] 0.13[35]
6 HRAS GTPase HRas [36] -0.94[37] -2.21[38] -2.64[39] -1.32[40] -1.21[41] -2.28[42]
7 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 [43] 0.85[44] 0.67[45] -0.01[46] 1.38[47] 0.79[48] -0.07[49]
8 KRAS GTPase KRas [50] -0.45[51] -1.03[52] 0.93[53] 0.43[54] 0.42[55] 1.06[56]
9 ERBB3 Receptor tyrosine-protein kinase erbB-3 [57] 2.07[58] 2.89[59] 2.29[60] -6.24[61] -5.67[62] 2.69[63]
10 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [64] -0.41[65] -0.85[66] 0.60[67] 1.69[68] 1.52[69] 3.38[70]
11 SOS1 Son of sevenless homolog 1 [71] -0.04[72] 0.94[73] 0.80[74] 0.47[75] 0.03[76] 0.92[77]
12 ERBB2 Receptor tyrosine-protein kinase erbB-2 [78] 2.44[79] 0.70[80] 2.23[81] 0.88[82] 0.82[83] 0.54[84]
13 EGFR Epidermal growth factor receptor [85] -0.63[86] -1.56[87] 1.68[88] 0.06[89] 1.01[90] 3.03[91]
14 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 3.55[92] 2.62[93] 2.31[94] 2.45[95] 2.27[96] 0.72[97]
15 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.32[98] 0.76[99] 1.31[100] 0.76[101] 1.29[102] 2.30[103]
16 HBEGF Proheparin-binding EGF-like growth factor [104] -0.92[105] -2.29[106] -3.00[107] -0.07[108] -0.05[109] -2.05[110]
17 NRG1 Pro-neuregulin-1, membrane-bound isoform [111] 0.40[112] -6.30[113] -3.04[114] 1.68[115] -5.47[116] 1.15[117]
18 BTC Probetacellulin [118] -8.08[119] -9.03[120] -4.44[121] -3.25[122] -2.95[123] -2.54[124]
19 GAB1 GRB2-associated-binding protein 1 [125] 1.37[126] 1.90[127] 2.38[128] 1.56[129] 1.75[130] 3.26[131]
20 NRG4 Pro-neuregulin-4, membrane-bound isoform [132] -4.03[133] -1.71[134] -1.40[135] -0.09[136] -1.96[137] -0.55[138]
21 EREG Proepiregulin [139] 1.82[140] 1.19[141] -2.87[142] -1.94[143] 3.64[144] -1.09[145]
22 EGF Pro-epidermal growth factor [146] 2.03[147] 3.26[148] 7.24[149] 8.65[150] 6.40[151] 1.96[152]
23 ERBB4 Receptor tyrosine-protein kinase erbB-4 [153] [154] [155] [156] [157] [158] [159]
24 NRG3 Pro-neuregulin-3, membrane-bound isoform [160] [161] [162] [163] [164] [165] [166]
25 ERBIN Erbin [167] [168] [169] [170] [171] [172] [173]
26 NRG2 Pro-neuregulin-2, membrane-bound isoform [174] [175] [176] [177] [178] [179] [180]
[1]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[2]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[3]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[4]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[5]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[6]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[7]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[8]
ref_hepatocyte CDC37
Mean 77.7
Standard deviation 56
Values 42 1.3e+02 1.5e+02 40 29
[9]
HepG2 CDC37
Mean 102
Standard deviation 8.8
Values 1.1e+02 95
[10]
HepG2.C3A CDC37
Mean 57.6
Standard deviation 0.71
Values 57 58
[11]
HuH.7 CDC37
Mean 71.5
Standard deviation 19
Values 75 51 88
[12]
SNU475 CDC37
Mean 40.8
Standard deviation 3.1
Values 39 43
[13]
THLE CDC37
Mean 68.3
Standard deviation 6.1
Values 64 73
[14]
liver CDC37
Mean 28
Standard deviation 16
Values 40 14 45 13
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[23]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[24]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[25]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[26]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[27]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[28]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte PTPN12
Mean 9.2
Standard deviation 4.5
Values 11 14 12 5.3 3.4
[44]
HepG2 PTPN12
Mean 35
Standard deviation 1.2
Values 34 36
[45]
HepG2.C3A PTPN12
Mean 40.5
Standard deviation 2.5
Values 42 39
[46]
HuH.7 PTPN12
Mean 18.9
Standard deviation 1.1
Values 19 18 20
[47]
SNU475 PTPN12
Mean 57
Standard deviation 14
Values 47 67
[48]
THLE PTPN12
Mean 33.7
Standard deviation 3.5
Values 36 31
[49]
liver PTPN12
Mean 9.55
Standard deviation 3.7
Values 15 9.1 6.7 7.5
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[58]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[59]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[60]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[61]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[62]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[63]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[64]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[65]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[66]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[67]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[68]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[69]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[70]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[71]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[72]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[73]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[74]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[75]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[76]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[77]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[78]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[79]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[80]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[81]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[82]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[83]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[84]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[85]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[86]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[87]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[88]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[89]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[90]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[91]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[92]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[93]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[94]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[95]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[96]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[97]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[98]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[99]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[100]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[101]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[102]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[103]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[104]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[105]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[106]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[107]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[108]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[109]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[110]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[111]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[112]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[113]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[114]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[115]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[116]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[117]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[118]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[119]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[120]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[121]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[122]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[123]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[124]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[125]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[126]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[127]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[128]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[129]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[130]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[131]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[132]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[133]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[134]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[135]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[136]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[137]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[138]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[139]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[140]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[141]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[142]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[143]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[144]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[145]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[146]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[147]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[148]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[149]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[150]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[151]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[152]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[153]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[154]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[155]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[157]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[158]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[159]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[160]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[161]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[162]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[166]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[168]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[169]
ref_hepatocyte ERBIN
Missing
[170]
HepG2 ERBIN
Missing
[171]
HepG2.C3A ERBIN
Missing
[172]
HuH.7 ERBIN
Missing
[173]
SNU475 ERBIN
Missing
[174]
THLE ERBIN
Missing
[175]
liver ERBIN
Missing
[176]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[178]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[181]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[182]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053