REACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSP90AA1 Heat shock protein HSP 90-alpha [1] -0.49[2] -0.01[3] -0.50[4] -0.26[5] -0.27[6] -0.75[7]
2 CDC37 Hsp90 co-chaperone Cdc37 [8] -0.60[9] -1.75[10] -1.09[11] -2.16[12] -1.27[13] -1.48[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 1.35[16] 0.69[17] 1.10[18] 0.20[19] 0.42[20] 0.80[21]
4 SHC1 SHC-transforming protein 1 [22] 1.32[23] 1.04[24] 1.40[25] 2.30[26] 2.09[27] 1.28[28]
5 NRAS GTPase NRas [29] 0.78[30] 0.72[31] 1.42[32] 0.65[33] 0.52[34] 0.25[35]
6 HRAS GTPase HRas [36] -0.85[37] -2.05[38] -2.56[39] -1.30[40] -1.21[41] -2.16[42]
7 KRAS GTPase KRas [43] -0.36[44] -0.88[45] 1.01[46] 0.45[47] 0.41[48] 1.18[49]
8 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [50] -0.32[51] -0.69[52] 0.68[53] 1.72[54] 1.52[55] 3.51[56]
9 SOS1 Son of sevenless homolog 1 [57] 0.05[58] 1.09[59] 0.88[60] 0.49[61] 0.03[62] 1.04[63]
10 ERBB2 Receptor tyrosine-protein kinase erbB-2 [64] 2.52[65] 0.85[66] 2.31[67] 0.90[68] 0.81[69] 0.66[70]
11 EGFR Epidermal growth factor receptor [71] -0.54[72] -1.41[73] 1.76[74] 0.08[75] 1.01[76] 3.16[77]
12 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 3.64[78] 2.77[79] 2.39[80] 2.47[81] 2.27[82] 0.84[83]
13 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.23[84] 0.92[85] 1.39[86] 0.78[87] 1.29[88] 2.42[89]
14 GAB1 GRB2-associated-binding protein 1 [90] 1.45[91] 2.05[92] 2.46[93] 1.58[94] 1.75[95] 3.38[96]
15 EGF Pro-epidermal growth factor [97] 2.12[98] 3.42[99] 7.31[100] 8.67[101] 6.40[102] 2.08[103]
16 ERBIN Erbin [104] [105] [106] [107] [108] [109] [110]
[1]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[2]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[3]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[4]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[5]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[6]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[7]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[8]
ref_hepatocyte CDC37
Mean 77.7
Standard deviation 56
Values 42 1.3e+02 1.5e+02 40 29
[9]
HepG2 CDC37
Mean 102
Standard deviation 8.8
Values 1.1e+02 95
[10]
HepG2.C3A CDC37
Mean 57.6
Standard deviation 0.71
Values 57 58
[11]
HuH.7 CDC37
Mean 71.5
Standard deviation 19
Values 75 51 88
[12]
SNU475 CDC37
Mean 40.8
Standard deviation 3.1
Values 39 43
[13]
THLE CDC37
Mean 68.3
Standard deviation 6.1
Values 64 73
[14]
liver CDC37
Mean 28
Standard deviation 16
Values 40 14 45 13
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[23]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[24]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[25]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[26]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[27]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[28]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[51]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[52]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[53]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[54]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[55]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[56]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[64]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[65]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[66]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[67]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[68]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[69]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[70]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[71]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[72]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[73]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[74]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[75]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[76]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[77]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[78]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[79]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[80]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[81]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[82]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[83]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[84]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[85]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[86]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[87]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[88]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[89]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[90]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[91]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[92]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[93]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[94]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[95]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[96]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[97]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[98]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[99]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[100]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[101]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[102]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[103]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[104]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[105]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[106]
ref_hepatocyte ERBIN
Missing
[107]
HepG2 ERBIN
Missing
[108]
HepG2.C3A ERBIN
Missing
[109]
HuH.7 ERBIN
Missing
[110]
SNU475 ERBIN
Missing
[111]
THLE ERBIN
Missing
[112]
liver ERBIN
Missing