REACTOME_SIGNALING_BY_ERBB2 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -1.09[2] -1.54[3] -1.28[4] -1.73[5] -1.20[6] -0.64[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.64[16] -0.79[17] -0.92[18] -0.88[19] -0.82[20] -0.19[21]
4 HSP90AA1 Heat shock protein HSP 90-alpha [22] 0.47[23] 1.18[24] 0.52[25] 1.14[26] 0.89[27] -0.02[28]
5 RHOA Transforming protein RhoA [29] 0.17[30] -0.58[31] -0.25[32] -0.17[33] 0.35[34] -0.08[35]
6 CDC37 Hsp90 co-chaperone Cdc37 [36] 0.36[37] -0.55[38] -0.07[39] -0.76[40] -0.11[41] -0.74[42]
7 UBA52 Ubiquitin-60S ribosomal protein L40 [43] 1.79[44] 1.44[45] 2.60[46] 0.52[47] 1.40[48] 0.58[49]
8 AKT1 RAC-alpha serine/threonine-protein kinase [50] 1.19[51] 0.70[52] -0.26[53] 1.00[54] 1.09[55] 1.00[56]
9 STUB1 E3 ubiquitin-protein ligase CHIP [57] -0.87[58] -1.10[59] -1.65[60] -1.61[61] -1.22[62] -1.01[63]
10 DIAPH1 Protein diaphanous homolog 1 [64] 1.72[65] 1.12[66] 1.67[67] 0.97[68] 1.46[69] 2.17[70]
11 GRB2 Growth factor receptor-bound protein 2 [71] 2.31[72] 1.89[73] 2.12[74] 1.61[75] 1.59[76] 1.54[77]
12 YES1 Tyrosine-protein kinase Yes [78] 0.25[79] 1.48[80] 1.82[81] 1.50[82] 1.03[83] 1.36[84]
13 MEMO1 Protein MEMO1 [85] 0.38[86] 0.59[87] 0.01[88] 0.43[89] -0.40[90] 0.13[91]
14 SHC1 SHC-transforming protein 1 [92] 2.28[93] 2.24[94] 2.43[95] 3.70[96] 3.26[97] 2.02[98]
15 NRAS GTPase NRas [99] 1.74[100] 1.92[101] 2.44[102] 2.05[103] 1.69[104] 0.99[105]
16 HRAS GTPase HRas [106] 0.11[107] -0.86[108] -1.54[109] 0.10[110] -0.04[111] -1.42[112]
17 AKT2 RAC-beta serine/threonine-protein kinase [113] 2.07[114] 2.09[115] 2.33[116] 1.91[117] 1.77[118] 2.37[119]
18 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 [120] 1.90[121] 2.02[122] 1.09[123] 2.81[124] 1.95[125] 0.79[126]
19 KRAS GTPase KRas [127] 0.60[128] 0.32[129] 2.03[130] 1.85[131] 1.58[132] 1.91[133]
20 ERBB3 Receptor tyrosine-protein kinase erbB-3 [134] 3.12[135] 4.24[136] 3.39[137] -4.82[138] -4.50[139] 3.55[140]
21 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [141] 0.64[142] 0.50[143] 1.70[144] 3.12[145] 2.69[146] 4.24[147]
22 SOS1 Son of sevenless homolog 1 [148] 1.01[149] 2.29[150] 1.90[151] 1.90[152] 1.20[153] 1.78[154]
23 USP8 Ubiquitin carboxyl-terminal hydrolase 8 [155] 0.94[156] 1.80[157] 1.91[158] 2.18[159] 2.00[160] 2.67[161]
24 ERBB2 Receptor tyrosine-protein kinase erbB-2 [162] 3.48[163] 2.05[164] 3.33[165] 2.31[166] 1.98[167] 1.39[168]
25 EGFR Epidermal growth factor receptor [169] 0.42[170] -0.21[171] 2.78[172] 1.49[173] 2.17[174] 3.89[175]
26 PTPN18 Tyrosine-protein phosphatase non-receptor type 18 [176] 1.09[177] 1.35[178] 0.08[179] -1.03[180] 1.33[181] 1.72[182]
27 SRC Proto-oncogene tyrosine-protein kinase Src [183] 4.14[184] 3.87[185] 2.98[186] 3.45[187] 2.70[188] 0.39[189]
28 PRKCD Protein kinase C delta type [190] 2.21[191] 2.20[192] 1.79[193] 0.55[194] 1.77[195] 0.17[196]
29 CUL5 Cullin-5 [197] 1.69[198] 2.92[199] 2.52[200] 3.57[201] 2.79[202] 3.57[203]
30 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 4.60[204] 3.97[205] 3.41[206] 3.87[207] 3.43[208] 1.58[209]
31 RNF41 E3 ubiquitin-protein ligase NRDP1 [210] 2.77[211] 2.80[212] 3.28[213] 2.62[214] 3.10[215] 2.61[216]
32 PRKCA Protein kinase C alpha type [217] 3.95[218] 3.73[219] 4.20[220] 3.20[221] 3.63[222] 3.16[223]
33 FYN Tyrosine-protein kinase Fyn [224] 2.06[225] -6.80[226] 1.88[227] 2.52[228] 4.12[229] 2.21[230]
34 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0.73[231] 2.11[232] 2.41[233] 2.18[234] 2.45[235] 3.15[236]
35 HBEGF Proheparin-binding EGF-like growth factor [237] 0.13[238] -0.94[239] -1.90[240] 1.36[241] 1.11[242] -1.19[243]
36 GRB7 Growth factor receptor-bound protein 7 [244] 3.52[245] 3.58[246] 0.86[247] -1.60[248] -0.80[249] 0.92[250]
37 NRG1 Pro-neuregulin-1, membrane-bound isoform [251] 1.45[252] -4.95[253] -1.94[254] 3.10[255] -4.31[256] 2.01[257]
38 BTC Probetacellulin [258] -7.03[259] -7.68[260] -3.34[261] -1.82[262] -1.79[263] -1.68[264]
39 GAB1 GRB2-associated-binding protein 1 [265] 2.41[266] 3.25[267] 3.48[268] 2.98[269] 2.91[270] 4.11[271]
40 PRKCE Protein kinase C epsilon type [272] 1.76[273] -0.01[274] 2.59[275] 2.03[276] 2.46[277] 4.80[278]
41 NRG4 Pro-neuregulin-4, membrane-bound isoform [279] -2.98[280] -0.36[281] -0.30[282] 1.34[283] -0.79[284] 0.30[285]
42 PTK6 Protein-tyrosine kinase 6 [286] -0.01[287] 1.95[288] 0.30[289] -0.60[290] -0.96[291] 0.66[292]
43 AKT3 RAC-gamma serine/threonine-protein kinase [293] -0.73[294] -3.54[295] -2.75[296] 6.89[297] 5.92[298] 4.85[299]
44 EREG Proepiregulin [300] 2.87[301] 2.54[302] -1.77[303] -0.51[304] 4.80[305] -0.23[306]
45 MATK Megakaryocyte-associated tyrosine-protein kinase [307] 1.34[308] [309] [310] -3.16[311] -0.57[312] 2.53[313]
46 EGF Pro-epidermal growth factor [314] 3.08[315] 4.61[316] 8.34[317] 10.08[318] 7.56[319] 2.82[320]
47 ERBIN Erbin [321] [322] [323] [324] [325] [326] [327]
48 NRG3 Pro-neuregulin-3, membrane-bound isoform [328] [329] [330] [331] [332] [333] [334]
49 NRG2 Pro-neuregulin-2, membrane-bound isoform [335] [336] [337] [338] [339] [340] [341]
50 ERBB4 Receptor tyrosine-protein kinase erbB-4 [342] [343] [344] [345] [346] [347] [348]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[23]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[24]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[25]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[26]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[27]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[28]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[29]
ref_hepatocyte RHOA
Mean 177
Standard deviation 1.2e+02
Values 2.2e+02 3.8e+02 1.4e+02 75 79
[30]
HepG2 RHOA
Mean 204
Standard deviation 38
Values 2.3e+02 1.8e+02
[31]
HepG2.C3A RHOA
Mean 129
Standard deviation 1.6
Values 1.3e+02 1.3e+02
[32]
HuH.7 RHOA
Mean 144
Standard deviation 23
Values 1.6e+02 1.2e+02 1.6e+02
[33]
SNU475 RHOA
Mean 139
Standard deviation 21
Values 1.5e+02 1.2e+02
[34]
THLE RHOA
Mean 214
Standard deviation 38
Values 1.9e+02 2.4e+02
[35]
liver RHOA
Mean 101
Standard deviation 59
Values 1.6e+02 54 1.4e+02 46
[36]
ref_hepatocyte CDC37
Mean 77.7
Standard deviation 56
Values 42 1.3e+02 1.5e+02 40 29
[37]
HepG2 CDC37
Mean 102
Standard deviation 8.8
Values 1.1e+02 95
[38]
HepG2.C3A CDC37
Mean 57.6
Standard deviation 0.71
Values 57 58
[39]
HuH.7 CDC37
Mean 71.5
Standard deviation 19
Values 75 51 88
[40]
SNU475 CDC37
Mean 40.8
Standard deviation 3.1
Values 39 43
[41]
THLE CDC37
Mean 68.3
Standard deviation 6.1
Values 64 73
[42]
liver CDC37
Mean 28
Standard deviation 16
Values 40 14 45 13
[43]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[44]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[45]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[46]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[47]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[48]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[49]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[50]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[51]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[52]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[53]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[54]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[55]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[56]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[57]
ref_hepatocyte STUB1
Mean 35.4
Standard deviation 14
Values 24 59 27 30 37
[58]
HepG2 STUB1
Mean 19.8
Standard deviation 3.3
Values 22 17
[59]
HepG2.C3A STUB1
Mean 17.9
Standard deviation 1.3
Values 19 17
[60]
HuH.7 STUB1
Mean 10.9
Standard deviation 1.8
Values 11 9 13
[61]
SNU475 STUB1
Mean 10.3
Standard deviation 1.7
Values 12 9
[62]
THLE STUB1
Mean 14.4
Standard deviation 1.6
Values 13 16
[63]
liver STUB1
Mean 10.6
Standard deviation 7.6
Values 18 4.2 16 3.9
[64]
ref_hepatocyte DIAPH1
Mean 27.3
Standard deviation 11
Values 30 44 27 20 17
[65]
HepG2 DIAPH1
Mean 92.2
Standard deviation 5.3
Values 88 96
[66]
HepG2.C3A DIAPH1
Mean 64.8
Standard deviation 5.9
Values 61 69
[67]
HuH.7 DIAPH1
Mean 83.7
Standard deviation 19
Values 1.1e+02 70 75
[68]
SNU475 DIAPH1
Mean 47.5
Standard deviation 4.1
Values 45 50
[69]
THLE DIAPH1
Mean 71.3
Standard deviation 15
Values 61 82
[70]
liver DIAPH1
Mean 73.8
Standard deviation 23
Values 1e+02 56 79 56
[71]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[72]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[73]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[74]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[75]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[76]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[77]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[78]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[79]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[80]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[81]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[82]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[83]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[84]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[85]
ref_hepatocyte MEMO1
Mean 16.8
Standard deviation 8.7
Values 16 31 8.2 14 14
[86]
HepG2 MEMO1
Mean 22.3
Standard deviation 0.51
Values 22 23
[87]
HepG2.C3A MEMO1
Mean 27.4
Standard deviation 0.43
Values 27 28
[88]
HuH.7 MEMO1
Mean 16.3
Standard deviation 2.7
Values 14 19 16
[89]
SNU475 MEMO1
Mean 20.1
Standard deviation 2.9
Values 22 18
[90]
THLE MEMO1
Mean 12
Standard deviation 2
Values 11 13
[91]
liver MEMO1
Mean 11.1
Standard deviation 5.2
Values 19 7.4 11 7.7
[92]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[93]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[94]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[95]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[96]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[97]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[98]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[99]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[100]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[101]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[102]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[103]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[104]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[105]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[106]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[107]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[108]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[109]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[110]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[111]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[112]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[113]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[114]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[115]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[116]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[117]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[118]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[119]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[120]
ref_hepatocyte PTPN12
Mean 9.2
Standard deviation 4.5
Values 11 14 12 5.3 3.4
[121]
HepG2 PTPN12
Mean 35
Standard deviation 1.2
Values 34 36
[122]
HepG2.C3A PTPN12
Mean 40.5
Standard deviation 2.5
Values 42 39
[123]
HuH.7 PTPN12
Mean 18.9
Standard deviation 1.1
Values 19 18 20
[124]
SNU475 PTPN12
Mean 57
Standard deviation 14
Values 47 67
[125]
THLE PTPN12
Mean 33.7
Standard deviation 3.5
Values 36 31
[126]
liver PTPN12
Mean 9.55
Standard deviation 3.7
Values 15 9.1 6.7 7.5
[127]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[128]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[129]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[130]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[131]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[132]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[133]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[134]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[135]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[136]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[137]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[138]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[139]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[140]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[141]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[142]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[143]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[144]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[145]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[146]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[147]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[148]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[149]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[150]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[151]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[152]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[153]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[154]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[155]
ref_hepatocyte USP8
Mean 6.73
Standard deviation 4.3
Values 12 10 3.2 3.5 4.3
[156]
HepG2 USP8
Mean 13.2
Standard deviation 5.6
Values 9.2 17
[157]
HepG2.C3A USP8
Mean 25.5
Standard deviation 2.2
Values 24 27
[158]
HuH.7 USP8
Mean 24.3
Standard deviation 2.7
Values 26 26 21
[159]
SNU475 USP8
Mean 27.1
Standard deviation 1.4
Values 26 28
[160]
THLE USP8
Mean 25.4
Standard deviation 6.5
Values 30 21
[161]
liver USP8
Mean 25.8
Standard deviation 2.7
Values 29 26 25 23
[162]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[163]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[164]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[165]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[166]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[167]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[168]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[169]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[170]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[171]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[172]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[173]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[174]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[175]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[176]
ref_hepatocyte PTPN18
Mean 5.24
Standard deviation 1.6
Values 5.5 3 7.6 5.3 4.8
[177]
HepG2 PTPN18
Mean 11.4
Standard deviation 0.65
Values 11 12
[178]
HepG2.C3A PTPN18
Mean 14.5
Standard deviation 3.1
Values 17 12
[179]
HuH.7 PTPN18
Mean 5.35
Standard deviation 1.2
Values 6.5 4 5.5
[180]
SNU475 PTPN18
Mean 2.27
Standard deviation 0.32
Values 2.5 2
[181]
THLE PTPN18
Mean 12.4
Standard deviation 2.2
Values 11 14
[182]
liver PTPN18
Mean 10.4
Standard deviation 2.7
Values 13 7.9 13 8.1
[183]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[184]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[185]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[186]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[187]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[188]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[189]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[190]
ref_hepatocyte PRKCD
Mean 3.58
Standard deviation 2
Values 5.9 2.9 5.5 2.1 1.5
[191]
HepG2 PRKCD
Mean 16.9
Standard deviation 3.4
Values 19 15
[192]
HepG2.C3A PRKCD
Mean 17.9
Standard deviation 3.3
Values 20 16
[193]
HuH.7 PRKCD
Mean 12
Standard deviation 0.2
Values 12 12 12
[194]
SNU475 PRKCD
Mean 4.64
Standard deviation 0.32
Values 4.4 4.9
[195]
THLE PRKCD
Mean 11.6
Standard deviation 1.2
Values 11 12
[196]
liver PRKCD
Mean 2.43
Standard deviation 1
Values 3.9 1.4 2.2 2.3
[197]
ref_hepatocyte CUL5
Mean 3.55
Standard deviation 1.9
Values 6 4.8 1.6 1.6 3.8
[198]
HepG2 CUL5
Mean 11.7
Standard deviation 4.4
Values 8.6 15
[199]
HepG2.C3A CUL5
Mean 29.2
Standard deviation 7.1
Values 24 34
[200]
HuH.7 CUL5
Mean 19.6
Standard deviation 1.5
Values 20 21 18
[201]
SNU475 CUL5
Mean 37.4
Standard deviation 5
Values 41 34
[202]
THLE CUL5
Mean 23.2
Standard deviation 2.7
Values 25 21
[203]
liver CUL5
Mean 25.3
Standard deviation 3.6
Values 26 30 22 24
[204]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[205]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[206]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[207]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[208]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[209]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[210]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[211]
ref_hepatocyte RNF41
Mean 3.02
Standard deviation 0.95
Values 2.6 3.1 4.3 3.4 1.7
[212]
HepG2 RNF41
Mean 20.9
Standard deviation 2.4
Values 23 19
[213]
HepG2.C3A RNF41
Mean 22.9
Standard deviation 1.4
Values 24 22
[214]
HuH.7 RNF41
Mean 28.2
Standard deviation 1.9
Values 30 26 28
[215]
SNU475 RNF41
Mean 16.5
Standard deviation 2.7
Values 18 15
[216]
THLE RNF41
Mean 24.5
Standard deviation 1
Values 25 24
[217]
liver RNF41
Mean 11.1
Standard deviation 1.6
Values 11 13 9.1 12
[218]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[219]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[220]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[221]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[222]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[223]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[224]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[225]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[226]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[227]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[228]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[229]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[230]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[231]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[232]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[233]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[234]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[235]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[236]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[237]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[238]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[239]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[240]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[241]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[242]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[243]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[244]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[245]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[246]
ref_hepatocyte GRB7
Mean 1.79
Standard deviation 1
Values 1.9 0.17 2.4 1.8 2.8
[247]
HepG2 GRB7
Mean 21
Standard deviation 1.2
Values 20 22
[248]
HepG2.C3A GRB7
Mean 23.3
Standard deviation 14
Values 34 13
[249]
HuH.7 GRB7
Mean 3.15
Standard deviation 1.7
Values 3.5 1.4 4.6
[250]
SNU475 GRB7
Mean 0.525
Standard deviation 0.097
Values 0.59 0.46
[251]
THLE GRB7
Mean 0.975
Standard deviation 0.065
Values 0.93 1
[252]
liver GRB7
Mean 2.04
Standard deviation 1.6
Values 4 0.68 2.5 0.89
[253]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[254]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[255]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[256]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[257]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[258]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[259]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[260]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[261]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[262]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[263]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[264]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[265]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[266]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[267]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[268]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[269]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[270]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[271]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[272]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[273]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[274]
ref_hepatocyte PRKCE
Mean 0.713
Standard deviation 0.29
Values 0.58 0.57 0.38 0.94 1.1
[275]
HepG2 PRKCE
Mean 2.46
Standard deviation 0.34
Values 2.7 2.2
[276]
HepG2.C3A PRKCE
Mean 0.767
Standard deviation 0.098
Values 0.84 0.7
[277]
HuH.7 PRKCE
Mean 4.14
Standard deviation 0.97
Values 4.1 5.1 3.2
[278]
SNU475 PRKCE
Mean 2.58
Standard deviation 0.11
Values 2.5 2.7
[279]
THLE PRKCE
Mean 3.72
Standard deviation 0.4
Values 3.4 4
[280]
liver PRKCE
Mean 12
Standard deviation 13
Values 5.6 7.3 3.9 31
[281]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[282]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[283]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[284]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[285]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[286]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[287]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[288]
ref_hepatocyte PTK6
Mean 0.543
Standard deviation 0.59
Values 0 0.55 1.5 0.39 0.24
[289]
HepG2 PTK6
Mean 0.551
Standard deviation 0.28
Values 0.75 0.35
[290]
HepG2.C3A PTK6
Mean 2.27
Standard deviation 0.8
Values 2.8 1.7
[291]
HuH.7 PTK6
Mean 0.643
Standard deviation 0.082
Values 0.66 0.55 0.71
[292]
SNU475 PTK6
Mean 0.316
Standard deviation 0.047
Values 0.28 0.35
[293]
THLE PTK6
Mean 0.264
Standard deviation 0.02
Values 0.28 0.25
[294]
liver PTK6
Mean 0.517
Standard deviation 0.32
Values 0.12 0.64 0.44 0.87
[295]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[296]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[297]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[298]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[299]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[300]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[301]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[302]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[303]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[304]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[305]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[306]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[307]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[308]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[309]
ref_hepatocyte MATK
Mean 0.175
Standard deviation 0.28
Values 0 0.12 0 0.078 0.67
[310]
HepG2 MATK
Mean 0.451
Standard deviation 0.52
Values 0.82 0.082
[311]
HepG2.C3A MATK
Mean 0
Standard deviation 0
Values 0 0
[312]
HuH.7 MATK
Mean 0
Standard deviation 0
Values 0 0 0
[313]
SNU475 MATK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[314]
THLE MATK
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[315]
liver MATK
Mean 0.607
Standard deviation 0.23
Values 0.35 0.49 0.74 0.85
[316]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[317]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[318]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[319]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[320]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[321]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[322]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[323]
ref_hepatocyte ERBIN
Missing
[324]
HepG2 ERBIN
Missing
[325]
HepG2.C3A ERBIN
Missing
[326]
HuH.7 ERBIN
Missing
[327]
SNU475 ERBIN
Missing
[328]
THLE ERBIN
Missing
[329]
liver ERBIN
Missing
[330]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[331]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[332]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[333]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[334]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[335]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[336]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[337]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[338]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[339]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[340]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[341]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[342]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[343]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053
[344]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[345]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[346]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[347]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[348]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[349]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[350]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78