REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.77[2] | -1.27[3] | -1.02[4] | -1.51[5] | -0.97[6] | -0.34[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.33[16] | -0.52[17] | -0.66[18] | -0.65[19] | -0.59[20] | 0.12[21] |
4 | HSP90AA1 | Heat shock protein HSP 90-alpha | [22] | 0.78[23] | 1.45[24] | 0.78[25] | 1.36[26] | 1.12[27] | 0.29[28] |
5 | CDC37 | Hsp90 co-chaperone Cdc37 | [29] | 0.67[30] | -0.28[31] | 0.19[32] | -0.53[33] | 0.12[34] | -0.44[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 2.11[37] | 1.72[38] | 2.85[39] | 0.74[40] | 1.63[41] | 0.89[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.62[44] | 2.16[45] | 2.38[46] | 1.83[47] | 1.82[48] | 1.84[49] |
8 | SHC1 | SHC-transforming protein 1 | [50] | 2.59[51] | 2.51[52] | 2.69[53] | 3.92[54] | 3.49[55] | 2.32[56] |
9 | NRAS | GTPase NRas | [57] | 2.06[58] | 2.19[59] | 2.70[60] | 2.27[61] | 1.92[62] | 1.29[63] |
10 | HRAS | GTPase HRas | [64] | 0.42[65] | -0.59[66] | -1.28[67] | 0.32[68] | 0.18[69] | -1.12[70] |
11 | KRAS | GTPase KRas | [71] | 0.91[72] | 0.59[73] | 2.29[74] | 2.07[75] | 1.81[76] | 2.22[77] |
12 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [78] | 0.95[79] | 0.77[80] | 1.96[81] | 3.34[82] | 2.92[83] | 4.54[84] |
13 | SOS1 | Son of sevenless homolog 1 | [85] | 1.33[86] | 2.56[87] | 2.16[88] | 2.12[89] | 1.43[90] | 2.08[91] |
14 | EGFR | Epidermal growth factor receptor | [92] | 0.73[93] | 0.06[94] | 3.04[95] | 1.71[96] | 2.40[97] | 4.19[98] |
15 | AREG | Amphiregulin | [99] | -1.44[100] | -4.97[101] | -6.64[102] | -8.42[103] | 1.95[104] | -8.77[105] |
16 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.92[106] | 4.24[107] | 3.67[108] | 4.09[109] | 3.66[110] | 1.88[111] | |
17 | TGFA | Protransforming growth factor alpha | [112] | 3.22[113] | 3.98[114] | -6.97[115] | 0.31[116] | -0.84[117] | 1.15[118] |
18 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1.05[119] | 2.39[120] | 2.67[121] | 2.40[122] | 2.68[123] | 3.46[124] | |
19 | HBEGF | Proheparin-binding EGF-like growth factor | [125] | 0.44[126] | -0.67[127] | -1.64[128] | 1.58[129] | 1.34[130] | -0.89[131] |
20 | BTC | Probetacellulin | [132] | -6.71[133] | -7.40[134] | -3.08[135] | -1.60[136] | -1.56[137] | -1.38[138] |
21 | GAB1 | GRB2-associated-binding protein 1 | [139] | 2.73[140] | 3.52[141] | 3.74[142] | 3.20[143] | 3.14[144] | 4.42[145] |
22 | CBL | E3 ubiquitin-protein ligase CBL | [146] | 5.87[147] | 4.52[148] | 4.84[149] | 6.41[150] | 5.97[151] | 5.30[152] |
23 | EREG | Proepiregulin | [153] | 3.18[154] | 2.81[155] | -1.51[156] | -0.29[157] | 5.03[158] | 0.07[159] |
24 | EGF | Pro-epidermal growth factor | [160] | 3.39[161] | 4.88[162] | 8.60[163] | 10.30[164] | 7.79[165] | 3.12[166] |
25 | EPGN | Epigen | [167] | [168] | [169] | [170] | [171] | [172] | [173] |