REACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 STAT3 Signal transducer and activator of transcription 3 [1] -0.21[2] -1.46[3] -1.07[4] -0.91[5] -1.01[6] 0.78[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.44[9] 0.52[10] 0.29[11] -0.60[12] -0.06[13] -1.33[14]
3 STAT1 Signal transducer and activator of transcription 1-alpha/beta [15] -0.83[16] -1.51[17] -0.75[18] 1.38[19] -0.27[20] -0.68[21]
4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 [22] -1.41[23] -0.67[24] -1.72[25] -1.50[26] -0.28[27] -0.94[28]
5 TRIM24 Transcription intermediary factor 1-alpha [29] 1.07[30] 0.44[31] 0.20[32] -2.85[33] -1.96[34] -1.75[35]
6 FGFR1OP2 FGFR1 oncogene partner 2 [36] -2.09[37] -0.73[38] -1.03[39] -2.50[40] -1.13[41] -1.94[42]
7 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [43] -1.23[44] -0.87[45] -0.13[46] 0.92[47] 1.04[48] 1.37[49]
8 MYO18A Unconventional myosin-XVIIIa [50] 0.32[51] 0.85[52] 1.40[53] -0.12[54] -0.48[55] 0.98[56]
9 CUX1 Homeobox protein cut-like 1 [57] 0.77[58] 0.16[59] 0.44[60] 0.48[61] 1.51[62] -0.14[63]
10 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 [64] 0.70[65] 1.58[66] 1.42[67] 0.75[68] 1.18[69] 0.16[70]
11 STAT5B Signal transducer and activator of transcription 5B [71] 0.60[72] 0.47[73] 0.82[74] 0.40[75] 0.16[76] -0.01[77]
12 BCR Breakpoint cluster region protein [78] 1.47[79] 0.96[80] 0.86[81] -0.13[82] 0.86[83] 0.07[84]
13 STAT5A Signal transducer and activator of transcription 5A [85] -2.71[86] -1.29[87] -2.57[88] -1.99[89] -0.62[90] -1.39[91]
14 ZMYM2 Zinc finger MYM-type protein 2 [92] 0.87[93] 2.25[94] 1.41[95] 1.82[96] 1.97[97] 1.65[98]
15 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.14[99] 0.74[100] 0.58[101] -0.02[102] 0.80[103] 0.28[104]
16 GAB2 GRB2-associated-binding protein 2 [105] 0.81[106] 0.84[107] 0.73[108] -0.23[109] 0.48[110] -1.09[111]
17 CNTRL Centriolin [112] 0.25[113] 2.73[114] 3.23[115] 1.61[116] 1.93[117] 0.95[118]
18 CEP43 [119] [120] [121] [122] [123] [124] [125]
[1]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[2]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[3]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[4]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[5]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[6]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[7]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[16]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[17]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[18]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[19]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[20]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[21]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[22]
ref_hepatocyte LRRFIP1
Mean 19
Standard deviation 15
Values 11 29 40 9 5.7
[23]
HepG2 LRRFIP1
Mean 26.7
Standard deviation 1.8
Values 25 28
[24]
HepG2.C3A LRRFIP1
Mean 33.6
Standard deviation 0.18
Values 34 33
[25]
HuH.7 LRRFIP1
Mean 19.8
Standard deviation 0.86
Values 21 19 19
[26]
SNU475 LRRFIP1
Mean 27.4
Standard deviation 1.1
Values 28 27
[27]
THLE LRRFIP1
Mean 46.4
Standard deviation 1.6
Values 45 48
[28]
liver LRRFIP1
Mean 43.4
Standard deviation 14
Values 51 38 58 26
[29]
ref_hepatocyte TRIM24
Mean 10.3
Standard deviation 8.8
Values 26 7.8 5.5 4.8 7.4
[30]
HepG2 TRIM24
Mean 80.9
Standard deviation 15
Values 70 92
[31]
HepG2.C3A TRIM24
Mean 39.3
Standard deviation 0.7
Values 40 39
[32]
HuH.7 TRIM24
Mean 40.5
Standard deviation 10
Values 38 52 32
[33]
SNU475 TRIM24
Mean 5.83
Standard deviation 0.3
Values 5.6 6
[34]
THLE TRIM24
Mean 7.85
Standard deviation 0.1
Values 7.8 7.9
[35]
liver TRIM24
Mean 13.5
Standard deviation 2
Values 15 15 11 13
[36]
ref_hepatocyte FGFR1OP2
Mean 9.61
Standard deviation 2.7
Values 8.9 14 9.5 9.2 6.5
[37]
HepG2 FGFR1OP2
Mean 8.42
Standard deviation 2.8
Values 6.4 10
[38]
HepG2.C3A FGFR1OP2
Mean 16.2
Standard deviation 2.9
Values 14 18
[39]
HuH.7 FGFR1OP2
Mean 16.2
Standard deviation 0.93
Values 15 17 16
[40]
SNU475 FGFR1OP2
Mean 6.91
Standard deviation 0.093
Values 7 6.8
[41]
THLE FGFR1OP2
Mean 13
Standard deviation 1.8
Values 14 12
[42]
liver FGFR1OP2
Mean 11
Standard deviation 4
Values 16 8.7 13 6.8
[43]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[44]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[45]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[46]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[47]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[48]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[49]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[50]
ref_hepatocyte MYO18A
Mean 6.89
Standard deviation 1.7
Values 7.7 9.1 4.7 7.3 5.7
[51]
HepG2 MYO18A
Mean 32.1
Standard deviation 3
Values 34 30
[52]
HepG2.C3A MYO18A
Mean 34.8
Standard deviation 8.4
Values 41 29
[53]
HuH.7 MYO18A
Mean 62.4
Standard deviation 15
Values 79 58 50
[54]
SNU475 MYO18A
Mean 25.8
Standard deviation 7
Values 31 21
[55]
THLE MYO18A
Mean 14.7
Standard deviation 2.4
Values 13 16
[56]
liver MYO18A
Mean 59.9
Standard deviation 36
Values 26 91 31 91
[57]
ref_hepatocyte CUX1
Mean 5.75
Standard deviation 3.4
Values 3.1 2.8 4 8.9 9.9
[58]
HepG2 CUX1
Mean 36.7
Standard deviation 7.4
Values 42 31
[59]
HepG2.C3A CUX1
Mean 18.1
Standard deviation 3.9
Values 21 15
[60]
HuH.7 CUX1
Mean 26.8
Standard deviation 4.4
Values 30 28 22
[61]
SNU475 CUX1
Mean 32.7
Standard deviation 6.7
Values 37 28
[62]
THLE CUX1
Mean 48.7
Standard deviation 4.1
Values 46 52
[63]
liver CUX1
Mean 22.9
Standard deviation 1.4
Values 22 24 22 25
[64]
ref_hepatocyte CPSF6
Mean 5.06
Standard deviation 2.4
Values 6.1 5.3 8.4 2.9 2.6
[65]
HepG2 CPSF6
Mean 30.7
Standard deviation 9.9
Values 24 38
[66]
HepG2.C3A CPSF6
Mean 42.5
Standard deviation 4.1
Values 40 45
[67]
HuH.7 CPSF6
Mean 46.5
Standard deviation 10
Values 52 35 53
[68]
SNU475 CPSF6
Mean 34.6
Standard deviation 2.4
Values 36 33
[69]
THLE CPSF6
Mean 34.1
Standard deviation 1.9
Values 33 35
[70]
liver CPSF6
Mean 24.8
Standard deviation 0.69
Values 24 25 25 25
[71]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[72]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[73]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[74]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[75]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[76]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[77]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[78]
ref_hepatocyte BCR
Mean 3.7
Standard deviation 0.66
Values 3.5 4.7 3.6 3.9 2.9
[79]
HepG2 BCR
Mean 38.2
Standard deviation 4.3
Values 41 35
[80]
HepG2.C3A BCR
Mean 20.2
Standard deviation 1.8
Values 22 19
[81]
HuH.7 BCR
Mean 23.1
Standard deviation 5.7
Values 29 18 22
[82]
SNU475 BCR
Mean 13.8
Standard deviation 3.1
Values 16 12
[83]
THLE BCR
Mean 20
Standard deviation 5.2
Values 16 24
[84]
liver BCR
Mean 17.1
Standard deviation 6.7
Values 12 22 11 23
[85]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[86]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[87]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[88]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[89]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[90]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[91]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[92]
ref_hepatocyte ZMYM2
Mean 2.15
Standard deviation 0.87
Values 2.9 3.1 1.8 0.99 1.9
[93]
HepG2 ZMYM2
Mean 14.6
Standard deviation 3.9
Values 12 17
[94]
HepG2.C3A ZMYM2
Mean 28.6
Standard deviation 1
Values 28 29
[95]
HuH.7 ZMYM2
Mean 19.6
Standard deviation 0.11
Values 20 20 19
[96]
SNU475 ZMYM2
Mean 30.9
Standard deviation 0.036
Values 31 31
[97]
THLE ZMYM2
Mean 24.9
Standard deviation 7.3
Values 30 20
[98]
liver ZMYM2
Mean 29.6
Standard deviation 12
Values 21 45 18 34
[99]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[100]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[101]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[102]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[103]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[104]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[105]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[106]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[107]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[108]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[109]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[110]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[111]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[112]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[113]
ref_hepatocyte CNTRL
Mean 0.619
Standard deviation 0.26
Values 0.82 0.64 0.44 0.28 0.91
[114]
HepG2 CNTRL
Mean 2.75
Standard deviation 0.57
Values 2.3 3.2
[115]
HepG2.C3A CNTRL
Mean 11.6
Standard deviation 0.96
Values 11 12
[116]
HuH.7 CNTRL
Mean 19.9
Standard deviation 5.9
Values 25 13 22
[117]
SNU475 CNTRL
Mean 7.69
Standard deviation 0.12
Values 7.8 7.6
[118]
THLE CNTRL
Mean 7.01
Standard deviation 1.5
Values 8.1 6
[119]
liver CNTRL
Mean 5.26
Standard deviation 2.5
Values 3.4 7.7 2.9 7
[120]
ref_hepatocyte CEP43
Missing
[121]
HepG2 CEP43
Missing
[122]
HepG2.C3A CEP43
Missing
[123]
HuH.7 CEP43
Missing
[124]
SNU475 CEP43
Missing
[125]
THLE CEP43
Missing
[126]
liver CEP43
Missing