REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CTNNB1 Catenin beta-1 [1] 0.92[2] 0.55[3] 1.26[4] 0.04[5] 0.33[6] 0.32[7]
2 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.10[8] 0.07[9] -0.20[10] 0.50[11] -0.12[12] -0.65[13]
3 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.43[14] -0.19[15] -1.01[16] 0.03[17] 0.20[18] -0.89[19]
4 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -1.09[20] -1.29[21] -1.40[22] -1.17[23] -1.21[24] -1.78[25]
5 CSNK1A1 Casein kinase I isoform alpha [26] -0.36[27] -0.23[28] -0.65[29] 0.12[30] 0.28[31] -0.10[32]
6 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform -1.82[33] -0.79[34] -0.26[35] -0.96[36] -2.03[37] -0.15[38]
7 PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform -1.01[39] 0.01[40] -0.48[41] 0.23[42] 0.10[43] -0.99[44]
8 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.25[45] -0.63[46] -0.40[47] -0.44[48] -0.60[49] 2.14[50]
9 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 0.55[51] 0.45[52] -0.18[53] 0.58[54] 0.52[55] -1.06[56]
10 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform -0.59[57] -0.27[58] -0.92[59] 0.15[60] -0.01[61] -0.60[62]
11 AXIN1 Axin-1 [63] 0.65[64] 1.11[65] -0.64[66] -9.41[67] -0.50[68] -1.44[69]
12 GSK3B Glycogen synthase kinase-3 beta [70] 0.57[71] 0.34[72] 0.73[73] 1.10[74] 0.99[75] 0.37[76]
13 PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform 0.08[77] -0.02[78] -0.85[79] -0.42[80] 0.80[81] -0.70[82]
14 APC Adenomatous polyposis coli protein [83] -0.13[84] 1.68[85] 1.33[86] 1.51[87] 2.21[88] 2.94[89]
15 AMER1 APC membrane recruitment protein 1 [90] [91] [92] [93] [94] [95] [96]
[1]
ref_hepatocyte CTNNB1
Mean 37.2
Standard deviation 16
Values 57 53 22 23 31
[2]
HepG2 CTNNB1
Mean 252
Standard deviation 27
Values 2.3e+02 2.7e+02
[3]
HepG2.C3A CTNNB1
Mean 158
Standard deviation 34
Values 1.3e+02 1.8e+02
[4]
HuH.7 CTNNB1
Mean 282
Standard deviation 64
Values 3.3e+02 2.1e+02 3.1e+02
[5]
SNU475 CTNNB1
Mean 115
Standard deviation 10
Values 1.2e+02 1.1e+02
[6]
THLE CTNNB1
Mean 151
Standard deviation 19
Values 1.4e+02 1.6e+02
[7]
liver CTNNB1
Mean 114
Standard deviation 15
Values 98 1.3e+02 1.2e+02 1.1e+02
[8]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[9]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[10]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[11]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[12]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[13]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[14]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[15]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[16]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[17]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[18]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[19]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[20]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[21]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[22]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[23]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[24]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[25]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[26]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[27]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[28]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[29]
ref_hepatocyte CSNK1A1
Mean 20.7
Standard deviation 9.8
Values 20 24 35 10 14
[30]
HepG2 CSNK1A1
Mean 57.9
Standard deviation 0.1
Values 58 58
[31]
HepG2.C3A CSNK1A1
Mean 51.1
Standard deviation 2
Values 50 53
[32]
HuH.7 CSNK1A1
Mean 41.8
Standard deviation 2.9
Values 45 39 41
[33]
SNU475 CSNK1A1
Mean 67.7
Standard deviation 7.6
Values 73 62
[34]
THLE CSNK1A1
Mean 81.2
Standard deviation 5.1
Values 78 85
[35]
liver CSNK1A1
Mean 47.5
Standard deviation 6.3
Values 41 56 47 47
[36]
ref_hepatocyte PPP2R5A
Mean 14.2
Standard deviation 11
Values 8.7 5.8 6.2 21 30
[37]
HepG2 PPP2R5A
Mean 14.4
Standard deviation 0.58
Values 14 15
[38]
HepG2.C3A PPP2R5A
Mean 23.8
Standard deviation 5
Values 27 20
[39]
HuH.7 PPP2R5A
Mean 37.7
Standard deviation 14
Values 28 54 31
[40]
SNU475 PPP2R5A
Mean 21.9
Standard deviation 3
Values 24 20
[41]
THLE PPP2R5A
Mean 11.3
Standard deviation 0.33
Values 12 11
[42]
liver PPP2R5A
Mean 31.4
Standard deviation 5.3
Values 33 37 24 32
[43]
ref_hepatocyte PPP2R5C
Mean 14.1
Standard deviation 2.7
Values 15 17 10 13 15
[44]
HepG2 PPP2R5C
Mean 25.2
Standard deviation 5.7
Values 21 29
[45]
HepG2.C3A PPP2R5C
Mean 41.3
Standard deviation 0.87
Values 41 42
[46]
HuH.7 PPP2R5C
Mean 32.2
Standard deviation 4.1
Values 31 37 29
[47]
SNU475 PPP2R5C
Mean 49.7
Standard deviation 5.7
Values 54 46
[48]
THLE PPP2R5C
Mean 48.8
Standard deviation 6.3
Values 44 53
[49]
liver PPP2R5C
Mean 17.5
Standard deviation 1.8
Values 18 20 16 16
[50]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[51]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[52]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[53]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[54]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[55]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[56]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[57]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[58]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[59]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[60]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[61]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[62]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[63]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[64]
ref_hepatocyte PPP2R5E
Mean 5.64
Standard deviation 2
Values 6.5 7.7 6.9 3.9 3.2
[65]
HepG2 PPP2R5E
Mean 13.5
Standard deviation 2.7
Values 12 15
[66]
HepG2.C3A PPP2R5E
Mean 13.6
Standard deviation 2.9
Values 11 16
[67]
HuH.7 PPP2R5E
Mean 9.42
Standard deviation 2.1
Values 12 9.4 7.3
[68]
SNU475 PPP2R5E
Mean 18.8
Standard deviation 1.2
Values 20 18
[69]
THLE PPP2R5E
Mean 18.2
Standard deviation 0.7
Values 18 19
[70]
liver PPP2R5E
Mean 9.17
Standard deviation 1.5
Values 11 9.6 9.4 7
[71]
ref_hepatocyte AXIN1
Mean 4.86
Standard deviation 2.8
Values 6.8 6.1 7.6 2.2 1.6
[72]
HepG2 AXIN1
Mean 27.3
Standard deviation 5.7
Values 31 23
[73]
HepG2.C3A AXIN1
Mean 30.4
Standard deviation 14
Values 40 21
[74]
HuH.7 AXIN1
Mean 9.87
Standard deviation 0.66
Values 9.1 10 10
[75]
SNU475 AXIN1
Mean 0.0215
Standard deviation 0.0089
Values 0.028 0.015
[76]
THLE AXIN1
Mean 11.1
Standard deviation 0.85
Values 11 12
[77]
liver AXIN1
Mean 4.4
Standard deviation 1.7
Values 3.3 4.8 2.9 6.6
[78]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 5.2 5.9 4.9 2.7 2.1
[79]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 18 26
[80]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 14 17
[81]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 24 26 15
[82]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 29 25
[83]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[84]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 14 15 8.6 16
[85]
ref_hepatocyte PPP2R5B
Mean 2.1
Standard deviation 0.85
Values 1.5 2.2 2.4 3.3 1.2
[86]
HepG2 PPP2R5B
Mean 7.95
Standard deviation 0.71
Values 7.4 8.5
[87]
HepG2.C3A PPP2R5B
Mean 6.01
Standard deviation 3.4
Values 8.4 3.6
[88]
HuH.7 PPP2R5B
Mean 3.69
Standard deviation 1.6
Values 2.4 5.5 3.2
[89]
SNU475 PPP2R5B
Mean 4.72
Standard deviation 0.053
Values 4.8 4.7
[90]
THLE PPP2R5B
Mean 11.9
Standard deviation 2.7
Values 14 10
[91]
liver PPP2R5B
Mean 3.19
Standard deviation 1.1
Values 3.5 2 4.5 2.8
[92]
ref_hepatocyte APC
Mean 1.09
Standard deviation 0.39
Values 1.4 1.5 1 0.53 0.97
[93]
HepG2 APC
Mean 3.57
Standard deviation 1.5
Values 2.5 4.6
[94]
HepG2.C3A APC
Mean 10.1
Standard deviation 2.6
Values 8.3 12
[95]
HuH.7 APC
Mean 8.67
Standard deviation 2.6
Values 9.7 11 5.7
[96]
SNU475 APC
Mean 9.33
Standard deviation 3.4
Values 6.9 12
[97]
THLE APC
Mean 16.3
Standard deviation 4.6
Values 20 13
[98]
liver APC
Mean 20.6
Standard deviation 6.3
Values 20 28 12 22
[99]
ref_hepatocyte AMER1
Missing
[100]
HepG2 AMER1
Mean 9.18
Standard deviation 1.7
Values 8 10
[101]
HepG2.C3A AMER1
Mean 5.8
Standard deviation 1.8
Values 4.5 7.1
[102]
HuH.7 AMER1
Mean 0.0271
Standard deviation 0.025
Values 0.049 0.032 0
[103]
SNU475 AMER1
Mean 3.6
Standard deviation 0.66
Values 4.1 3.1
[104]
THLE AMER1
Mean 2.85
Standard deviation 0.51
Values 2.5 3.2
[105]
liver AMER1
Mean 4.6
Standard deviation 4.1
Values 1.6 6.8 0.67 9.3