REACTOME_SIGNALING_BY_ALK_IN_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | NPM1 | Nucleophosmin | [8] | -1.93[9] | -0.90[10] | -0.36[11] | -2.36[12] | -2.31[13] | -3.42[14] |
3 | SQSTM1 | Sequestosome-1 | [15] | -1.80[16] | -2.69[17] | -2.28[18] | -1.05[19] | -1.12[20] | -1.27[21] |
4 | EEF1G | Elongation factor 1-gamma | [22] | -0.23[23] | 0.20[24] | 0.47[25] | -1.29[26] | -1.01[27] | -1.81[28] |
5 | FN1 | Fibronectin | [29] | 3.45[30] | 3.09[31] | 2.84[32] | 3.04[33] | 3.26[34] | 2.82[35] |
6 | TPM4 | Tropomyosin alpha-4 chain | [36] | -0.20[37] | -0.82[38] | -0.89[39] | -0.03[40] | 0.60[41] | -2.38[42] |
7 | MSN | Moesin | [43] | -8.13[44] | -10.27[45] | -9.10[46] | 1.12[47] | 0.15[48] | -0.75[49] |
8 | MYH9 | Myosin-9 | [50] | 1.38[51] | -0.01[52] | -0.19[53] | 1.34[54] | 1.25[55] | 0.92[56] |
9 | TPM3 | Tropomyosin alpha-3 chain | [57] | -0.21[58] | -0.38[59] | 0.17[60] | 0.56[61] | 0.18[62] | -0.37[63] |
10 | SKP1 | S-phase kinase-associated protein 1 | [64] | -1.02[65] | -0.47[66] | -1.48[67] | -0.39[68] | -0.14[69] | -0.17[70] |
11 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [71] | -2.10[72] | -1.51[73] | -1.76[74] | -2.59[75] | -2.14[76] | -1.57[77] |
12 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [78] | 0.03[79] | 0.32[80] | 0.33[81] | 0.03[82] | -0.05[83] | 1.12[84] |
13 | RRBP1 | Ribosome-binding protein 1 | [85] | 0.38[86] | 0.94[87] | 1.10[88] | -0.21[89] | -0.41[90] | 1.28[91] |
14 | TFG | Protein TFG | [92] | -1.04[93] | -0.95[94] | -0.35[95] | -0.48[96] | -0.59[97] | -0.07[98] |
15 | JUNB | Transcription factor jun-B | [99] | -2.00[100] | -2.70[101] | -2.13[102] | -2.05[103] | -1.19[104] | -0.86[105] |
16 | CEBPB | CCAAT/enhancer-binding protein beta | [106] | -1.22[107] | -1.69[108] | -1.80[109] | -1.30[110] | -0.34[111] | -1.15[112] |
17 | STAT3 | Signal transducer and activator of transcription 3 | [113] | 0.51[114] | -0.83[115] | -0.23[116] | 0.36[117] | -0.34[118] | 2.93[119] |
18 | CLTC | Clathrin heavy chain 1 | [120] | 1.57[121] | 1.83[122] | 1.87[123] | 1.80[124] | 1.96[125] | 2.98[126] |
19 | ATIC | Bifunctional purine biosynthesis protein PURH | [127] | 1.10[128] | 1.11[129] | 0.93[130] | -0.26[131] | 0.09[132] | -0.74[133] |
20 | GRB2 | Growth factor receptor-bound protein 2 | [134] | 1.15[135] | 1.15[136] | 1.13[137] | 0.67[138] | 0.61[139] | 0.82[140] |
21 | SEC31A | Protein transport protein Sec31A | [141] | 1.74[142] | 1.89[143] | 1.83[144] | 1.15[145] | 1.11[146] | 2.19[147] |
22 | PPM1B | Protein phosphatase 1B | [148] | -1.66[149] | -0.80[150] | -0.96[151] | -1.38[152] | -1.00[153] | 0.40[154] |
23 | SHC1 | SHC-transforming protein 1 | [155] | 1.12[156] | 1.50[157] | 1.44[158] | 2.77[159] | 2.28[160] | 1.31[161] |
24 | DCTN1 | Dynactin subunit 1 | [162] | 1.82[163] | 1.14[164] | 0.35[165] | 1.54[166] | 1.58[167] | 1.08[168] |
25 | KLC1 | Kinesin light chain 1 | [169] | 0.19[170] | -0.29[171] | -0.47[172] | 0.80[173] | 0.68[174] | 0.44[175] |
26 | CUL1 | Cullin-1 | [176] | -0.43[177] | 0.42[178] | -0.17[179] | 0.70[180] | 0.38[181] | 1.27[182] |
27 | LMO7 | LIM domain only protein 7 | [183] | 0.06[184] | 1.26[185] | 0.70[186] | -1.50[187] | -0.79[188] | 1.06[189] |
28 | KIF5B | Kinesin-1 heavy chain | [190] | 0.37[191] | 2.51[192] | 2.13[193] | 2.97[194] | 2.07[195] | 1.86[196] |
29 | VCL | Vinculin | [197] | 0.73[198] | 0.61[199] | 0.61[200] | 2.95[201] | 2.07[202] | 1.33[203] |
30 | MAPK1 | Mitogen-activated protein kinase 1 | [204] | 1.67[205] | 1.97[206] | 1.66[207] | 1.97[208] | 1.64[209] | 2.30[210] |
31 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [211] | -0.51[212] | -0.23[213] | 0.72[214] | 2.18[215] | 1.71[216] | 3.53[217] |
32 | EML4 | Echinoderm microtubule-associated protein-like 4 | [218] | 3.05[219] | 4.31[220] | 2.71[221] | 2.22[222] | 0.72[223] | 2.65[224] |
33 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [225] | 0.44[226] | 2.28[227] | 1.88[228] | 1.65[229] | 1.83[230] | 3.48[231] |
34 | BCL2A1 | Bcl-2-related protein A1 | [232] | -4.81[233] | -6.47[234] | -11.02[235] | -9.14[236] | -5.58[237] | -4.37[238] |
35 | ZC3HC1 | Nuclear-interacting partner of ALK | [239] | 0.07[240] | 0.05[241] | 0.36[242] | 0.61[243] | 0.16[244] | 0.16[245] |
36 | TPR | Nucleoprotein TPR | [246] | 0.59[247] | 2.62[248] | 2.79[249] | 2.66[250] | 2.91[251] | 3.12[252] |
37 | MECP2 | Methyl-CpG-binding protein 2 | [253] | 0.68[254] | 1.14[255] | 1.20[256] | 1.70[257] | 1.83[258] | 1.36[259] |
38 | MAPK3 | Mitogen-activated protein kinase 3 | [260] | 1.81[261] | 2.02[262] | 1.92[263] | 0.54[264] | 0.58[265] | -0.51[266] |
39 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.45[267] | 3.23[268] | 2.42[269] | 2.94[270] | 2.46[271] | 0.87[272] | |
40 | EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | [273] | 0.50[274] | 1.48[275] | 1.52[276] | 0.31[277] | 0.86[278] | 2.28[279] |
41 | PPFIBP1 | Liprin-beta-1 | [280] | 1.10[281] | 1.15[282] | 1.81[283] | 2.56[284] | 2.55[285] | 2.93[286] |
42 | IRS1 | Insulin receptor substrate 1 | [287] | 2.05[288] | 1.66[289] | 2.94[290] | 1.82[291] | 1.43[292] | 2.64[293] |
43 | RNF213 | E3 ubiquitin-protein ligase RNF213 | [294] | 3.96[295] | 2.42[296] | 4.10[297] | 4.47[298] | 3.58[299] | 5.61[300] |
44 | GCC2 | GRIP and coiled-coil domain-containing protein 2 | [301] | 0.07[302] | 2.67[303] | 1.76[304] | 1.22[305] | 1.40[306] | 2.98[307] |
45 | STAT5A | Signal transducer and activator of transcription 5A | [308] | -1.99[309] | -0.65[310] | -1.72[311] | -0.73[312] | 0.05[313] | 0.76[314] |
46 | BIRC6 | Baculoviral IAP repeat-containing protein 6 | [315] | 2.91[316] | 3.94[317] | 3.74[318] | 4.10[319] | 3.47[320] | 6.08[321] |
47 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.42[322] | 1.38[323] | 1.43[324] | 1.25[325] | 1.47[326] | 2.44[327] | |
48 | HIP1 | Huntingtin-interacting protein 1 | [328] | 1.53[329] | 1.77[330] | 2.35[331] | 3.11[332] | 2.51[333] | 3.09[334] |
49 | FRS2 | Fibroblast growth factor receptor substrate 2 | [335] | 1.25[336] | 2.50[337] | 2.86[338] | 3.02[339] | 2.67[340] | 3.87[341] |
50 | STRN | Striatin | [342] | 1.92[343] | 3.05[344] | 2.53[345] | 3.44[346] | 3.36[347] | 3.42[348] |
51 | FRS3 | Fibroblast growth factor receptor substrate 3 | [349] | 0.58[350] | 0.58[351] | -0.58[352] | 0.41[353] | 0.09[354] | -0.38[355] |
52 | BCL11A | B-cell lymphoma/leukemia 11A | [356] | -0.66[357] | [358] | -0.73[359] | 3.46[360] | [361] | 2.83[362] |
53 | CARS1 | [363] | [364] | [365] | [366] | [367] | [368] | [369] | |
54 | WDCP | WD repeat and coiled-coil-containing protein | [370] | [371] | [372] | [373] | [374] | [375] | [376] |
55 | ALK | ALK tyrosine kinase receptor | [377] | [378] | [379] | [380] | [381] | [382] | [383] |