REACTOME_SIGNALING_BY_ALK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | MDK | Midkine | [1] | -0.50[2] | -1.02[3] | -0.53[4] | -6.57[5] | -4.52[6] | -5.69[7] |
2 | STAT3 | Signal transducer and activator of transcription 3 | [8] | -0.31[9] | -1.73[10] | -1.29[11] | -0.82[12] | -1.54[13] | 1.69[14] |
3 | MYC | Myc proto-oncogene protein | [15] | -0.43[16] | -0.69[17] | -3.02[18] | -3.85[19] | -1.48[20] | -2.72[21] |
4 | HIF1A | Hypoxia-inducible factor 1-alpha | [22] | -1.01[23] | -1.26[24] | -0.77[25] | 1.23[26] | 1.61[27] | -1.53[28] |
5 | HDAC1 | Histone deacetylase 1 | [29] | -0.35[30] | -0.26[31] | 0.12[32] | -0.42[33] | -0.63[34] | -1.18[35] |
6 | SHC1 | SHC-transforming protein 1 | [36] | 0.31[37] | 0.60[38] | 0.37[39] | 1.59[40] | 1.08[41] | 0.06[42] |
7 | HDAC3 | Histone deacetylase 3 | [43] | -0.38[44] | -0.24[45] | -0.74[46] | -1.11[47] | -0.95[48] | -1.12[49] |
8 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [50] | -1.33[51] | -1.13[52] | -0.35[53] | 1.01[54] | 0.51[55] | 2.28[56] |
9 | HDAC2 | Histone deacetylase 2 | [57] | 0.87[58] | 2.27[59] | 1.34[60] | 1.10[61] | 1.24[62] | -0.52[63] |
10 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [64] | -1.32[65] | -1.05[66] | -0.78[67] | -8.20[68] | -3.18[69] | -0.90[70] |
11 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [71] | 1.02[72] | 1.32[73] | 1.62[74] | -0.35[75] | 0.21[76] | -1.01[77] |
12 | SIN3A | Paired amphipathic helix protein Sin3a | [78] | 0.52[79] | 0.69[80] | 1.58[81] | 0.93[82] | 0.68[83] | 0.56[84] |
13 | SRC | Proto-oncogene tyrosine-protein kinase Src | [85] | 2.17[86] | 2.23[87] | 0.92[88] | 1.34[89] | 0.52[90] | -1.57[91] |
14 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.63[92] | 2.33[93] | 1.36[94] | 1.76[95] | 1.26[96] | -0.38[97] | |
15 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.35[98] | 0.94[99] | 0.79[100] | -0.01[101] | 0.15[102] | 0.44[103] | |
16 | IRS1 | Insulin receptor substrate 1 | [104] | 1.23[105] | 0.76[106] | 1.88[107] | 0.64[108] | 0.23[109] | 1.39[110] |
17 | EP300 | Histone acetyltransferase p300 | [111] | 1.86[112] | 1.54[113] | 2.12[114] | 1.51[115] | 1.57[116] | 2.03[117] |
18 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.24[118] | 0.48[119] | 0.36[120] | 0.07[121] | 0.28[122] | 1.19[123] | |
19 | FRS2 | Fibroblast growth factor receptor substrate 2 | [124] | 0.43[125] | 1.60[126] | 1.80[127] | 1.84[128] | 1.47[129] | 2.62[130] |
20 | IL2RG | Cytokine receptor common subunit gamma | [131] | -2.51[132] | -4.32[133] | -3.98[134] | -4.66[135] | [136] | -0.83[137] |
21 | CD274 | Programmed cell death 1 ligand 1 | [138] | -4.00[139] | -5.19[140] | -6.94[141] | -1.31[142] | 3.10[143] | -0.07[144] |
22 | PTN | Pleiotrophin | [145] | [146] | [147] | -8.97[148] | -0.55[149] | 0.91[150] | 0.26[151] |
23 | MYCN | N-myc proto-oncogene protein | [152] | -2.48[153] | -2.90[154] | 5.95[155] | -3.67[156] | -3.60[157] | -3.36[158] |
24 | JAK3 | Tyrosine-protein kinase JAK3 | [159] | 1.39[160] | 3.74[161] | -2.57[162] | -1.69[163] | -0.96[164] | 2.38[165] |
25 | PTPRZ1 | Receptor-type tyrosine-protein phosphatase zeta | [166] | -6.75[167] | [168] | [169] | -5.59[170] | -4.95[171] | -1.97[172] |
26 | PRDM1 | PR domain zinc finger protein 1 | [173] | -4.67[174] | -6.42[175] | 0.35[176] | 2.30[177] | -0.02[178] | 2.65[179] |
27 | ALK | ALK tyrosine kinase receptor | [180] | [181] | [182] | [183] | [184] | [185] | [186] |