REACTOME_SIGNALING_BY_ACTIVIN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DRAP1 Dr1-associated corepressor [1] -2.58[2] -2.63[3] -3.00[4] -1.91[5] -2.07[6] -2.81[7]
2 MAPK1 Mitogen-activated protein kinase 1 [8] 0.65[9] 1.12[10] 0.84[11] 1.14[12] 0.43[13] 1.25[14]
3 FSTL3 Follistatin-related protein 3 [15] 1.82[16] -1.16[17] -1.21[18] -0.16[19] 0.77[20] -2.38[21]
4 SMAD3 Mothers against decapentaplegic homolog 3 [22] 0.87[23] 0.60[24] 0.72[25] 1.09[26] 1.61[27] -0.31[28]
5 ACVR1B Activin receptor type-1B [29] -0.37[30] -0.07[31] 1.73[32] 0.38[33] 0.32[34] 0.49[35]
6 MAPK3 Mitogen-activated protein kinase 3 [36] 0.79[37] 1.17[38] 1.10[39] -0.28[40] -0.63[41] -1.57[42]
7 FST Follistatin [43] -1.10[44] 0.89[45] -2.92[46] -5.46[47] -4.55[48] -0.48[49]
8 SMAD4 Mothers against decapentaplegic homolog 4 [50] 0.33[51] 1.30[52] 1.15[53] 1.21[54] 1.20[55] 2.26[56]
9 SMAD2 Mothers against decapentaplegic homolog 2 [57] 0.96[58] 1.56[59] 0.94[60] 1.68[61] 1.50[62] 2.04[63]
10 INHBB Inhibin beta B chain [64] 2.09[65] -4.23[66] -6.30[67] -3.12[68] 2.51[69] -0.24[70]
11 INHBA Inhibin beta A chain [71] -8.56[72] -7.93[73] -7.59[74] 2.22[75] -1.75[76] 0.08[77]
12 ACVR2A Activin receptor type-2A [78] -0.21[79] 1.14[80] 0.87[81] 0.12[82] 0.26[83] 2.15[84]
13 ACVR2B Activin receptor type-2B [85] 1.22[86] 2.95[87] 3.66[88] 0.39[89] -0.18[90] 2.64[91]
14 ACVR1C Activin receptor type-1C [92] -2.34[93] -1.01[94] 4.10[95] -1.75[96] -3.02[97] 3.26[98]
15 FOXH1 Forkhead box protein H1 [99] -4.00[100] 2.11[101] -4.79[102] -3.75[103] -4.18[104] -3.75[105]
[1]
ref_hepatocyte DRAP1
Mean 39.9
Standard deviation 23
Values 11 75 47 38 29
[2]
HepG2 DRAP1
Mean 30.9
Standard deviation 7.3
Values 36 26
[3]
HepG2.C3A DRAP1
Mean 20.9
Standard deviation 2
Values 22 20
[4]
HuH.7 DRAP1
Mean 16.8
Standard deviation 3
Values 15 15 20
[5]
SNU475 DRAP1
Mean 31.8
Standard deviation 1.1
Values 31 33
[6]
THLE DRAP1
Mean 41.2
Standard deviation 4.7
Values 38 45
[7]
liver DRAP1
Mean 11.7
Standard deviation 10
Values 22 3.9 19 2.3
[8]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[9]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[10]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[11]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[12]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[13]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[14]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[15]
ref_hepatocyte FSTL3
Mean 6
Standard deviation 5.3
Values 5.5 11 12 0.9 0.73
[16]
HepG2 FSTL3
Mean 97.9
Standard deviation 46
Values 1.3e+02 65
[17]
HepG2.C3A FSTL3
Mean 8.71
Standard deviation 2
Values 10 7.3
[18]
HuH.7 FSTL3
Mean 8.73
Standard deviation 0.88
Values 7.7 9.3 9.2
[19]
SNU475 FSTL3
Mean 16
Standard deviation 2.3
Values 18 14
[20]
THLE FSTL3
Mean 44.2
Standard deviation 7.2
Values 39 49
[21]
liver FSTL3
Mean 2.35
Standard deviation 0.46
Values 2 2.2 3 2.2
[22]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[23]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[24]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[25]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[26]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[27]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[28]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[29]
ref_hepatocyte ACVR1B
Mean 4.32
Standard deviation 1.8
Values 1.8 3.4 5.3 6.3 4.8
[30]
HepG2 ACVR1B
Mean 15.4
Standard deviation 2.5
Values 17 14
[31]
HepG2.C3A ACVR1B
Mean 13.3
Standard deviation 0.78
Values 14 13
[32]
HuH.7 ACVR1B
Mean 48.4
Standard deviation 11
Values 59 37 49
[33]
SNU475 ACVR1B
Mean 16.8
Standard deviation 1.8
Values 18 16
[34]
THLE ACVR1B
Mean 23.4
Standard deviation 6.1
Values 19 28
[35]
liver ACVR1B
Mean 12.4
Standard deviation 7.1
Values 7.6 19 5.1 18
[36]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[37]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[38]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[39]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[40]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[41]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[42]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[43]
ref_hepatocyte FST
Mean 3.43
Standard deviation 3.2
Values 0.64 2.9 4.6 8.4 0.66
[44]
HepG2 FST
Mean 7.39
Standard deviation 1
Values 8.1 6.7
[45]
HepG2.C3A FST
Mean 20.7
Standard deviation 4.4
Values 24 18
[46]
HuH.7 FST
Mean 1.53
Standard deviation 0.3
Values 1.4 1.3 1.9
[47]
SNU475 FST
Mean 0.234
Standard deviation 0.042
Values 0.2 0.26
[48]
THLE FST
Mean 0.634
Standard deviation 0.091
Values 0.7 0.57
[49]
liver FST
Mean 5.01
Standard deviation 4.3
Values 11 2.9 3.6 2.1
[50]
ref_hepatocyte SMAD4
Mean 3.16
Standard deviation 0.71
Values 2.9 2.8 4.2 2.4 3.4
[51]
HepG2 SMAD4
Mean 18.3
Standard deviation 3.2
Values 16 21
[52]
HepG2.C3A SMAD4
Mean 25.2
Standard deviation 3
Values 27 23
[53]
HuH.7 SMAD4
Mean 23.6
Standard deviation 3.4
Values 24 27 20
[54]
SNU475 SMAD4
Mean 21.8
Standard deviation 2.7
Values 24 20
[55]
THLE SMAD4
Mean 31.4
Standard deviation 1.4
Values 30 32
[56]
liver SMAD4
Mean 31
Standard deviation 13
Values 23 40 16 44
[57]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 4.5 2.8 1.9 1.9 1.6
[58]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 21 24
[59]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 25 23
[60]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 17 18 15
[61]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 27 22
[62]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[63]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 17 29 15 25
[64]
ref_hepatocyte INHBB
Mean 1.29
Standard deviation 1.3
Values 0 0 1.9 3 1.6
[65]
HepG2 INHBB
Mean 25.5
Standard deviation 11
Values 34 17
[66]
HepG2.C3A INHBB
Mean 0.223
Standard deviation 0.028
Values 0.24 0.2
[67]
HuH.7 INHBB
Mean 0.0551
Standard deviation 0.048
Values 0.082 0.083 0
[68]
SNU475 INHBB
Mean 0.446
Standard deviation 0.44
Values 0.76 0.14
[69]
THLE INHBB
Mean 32
Standard deviation 8.6
Values 38 26
[70]
liver INHBB
Mean 2.25
Standard deviation 1.4
Values 0.59 3.9 2.2 2.3
[71]
ref_hepatocyte INHBA
Mean 1.17
Standard deviation 2
Values 0 0.86 4.7 0.069 0.22
[72]
HepG2 INHBA
Mean 0.0143
Standard deviation 0.004
Values 0.011 0.017
[73]
HepG2.C3A INHBA
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[74]
HuH.7 INHBA
Mean 0.0204
Standard deviation 0.023
Values 0.016 0.045 0
[75]
SNU475 INHBA
Mean 16.3
Standard deviation 7.3
Values 11 21
[76]
THLE INHBA
Mean 1.5
Standard deviation 0.28
Values 1.3 1.7
[77]
liver INHBA
Mean 2.52
Standard deviation 1.2
Values 3.2 1.8 1.2 3.9
[78]
ref_hepatocyte ACVR2A
Mean 0.936
Standard deviation 0.37
Values 1.1 0.98 0.3 1.1 1.2
[79]
HepG2 ACVR2A
Mean 3.74
Standard deviation 1
Values 3 4.5
[80]
HepG2.C3A ACVR2A
Mean 6.72
Standard deviation 1.6
Values 7.9 5.6
[81]
HuH.7 ACVR2A
Mean 5.74
Standard deviation 0.84
Values 5.9 6.5 4.8
[82]
SNU475 ACVR2A
Mean 3.04
Standard deviation 0.25
Values 2.9 3.2
[83]
THLE ACVR2A
Mean 4.84
Standard deviation 0.58
Values 5.2 4.4
[84]
liver ACVR2A
Mean 8.52
Standard deviation 0.53
Values 7.8 8.6 9.1 8.6
[85]
ref_hepatocyte ACVR2B
Mean 0.673
Standard deviation 0.59
Values 1.7 0.32 0.36 0.37 0.62
[86]
HepG2 ACVR2B
Mean 7.22
Standard deviation 2
Values 8.6 5.8
[87]
HepG2.C3A ACVR2B
Mean 16.9
Standard deviation 7.7
Values 22 12
[88]
HuH.7 ACVR2B
Mean 28.7
Standard deviation 6.3
Values 32 33 21
[89]
SNU475 ACVR2B
Mean 2.64
Standard deviation 0.036
Values 2.6 2.7
[90]
THLE ACVR2B
Mean 2.58
Standard deviation 0.1
Values 2.5 2.6
[91]
liver ACVR2B
Mean 8.61
Standard deviation 5.5
Values 4.7 11 3.4 15
[92]
ref_hepatocyte ACVR1C
Mean 0.114
Standard deviation 0.13
Values 0 0.17 0 0.086 0.31
[93]
HepG2 ACVR1C
Mean 0.104
Standard deviation 0.11
Values 0.023 0.18
[94]
HepG2.C3A ACVR1C
Mean 0.183
Standard deviation 0.14
Values 0.087 0.28
[95]
HuH.7 ACVR1C
Mean 6.57
Standard deviation 0.82
Values 7 7.1 5.6
[96]
SNU475 ACVR1C
Mean 0.101
Standard deviation 0.0073
Values 0.11 0.096
[97]
THLE ACVR1C
Mean 0.0606
Standard deviation 0.048
Values 0.095 0.027
[98]
liver ACVR1C
Mean 2.23
Standard deviation 0.55
Values 2.9 2.3 1.6 2.1
[99]
ref_hepatocyte FOXH1
Mean 0.109
Standard deviation 0.064
Values 0.11 0 0.14 0.16 0.13
[100]
HepG2 FOXH1
Mean 0.0315
Standard deviation 0.004
Values 0.029 0.034
[101]
HepG2.C3A FOXH1
Mean 1.53
Standard deviation 0.21
Values 1.4 1.7
[102]
HuH.7 FOXH1
Mean 0.0133
Standard deviation 0.0053
Values 0.0082 0.013 0.019
[103]
SNU475 FOXH1
Mean 0.0243
Standard deviation 0.0015
Values 0.023 0.025
[104]
THLE FOXH1
Mean 0.026
Standard deviation 0.022
Values 0.041 0.011
[105]
liver FOXH1
Mean 0.0166
Standard deviation 0.021
Values 0.024 0.043 0 0