REACTOME_SHC_MEDIATED_CASCADE_FGFR4 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.32[2] -0.07[3] -0.41[4] -0.37[5] -0.20[6] -0.12[7]
2 SHC1 SHC-transforming protein 1 [8] 0.29[9] 0.29[10] -0.11[11] 1.72[12] 1.47[13] 0.37[14]
3 FGFR4 Fibroblast growth factor receptor 4 [15] 1.08[16] 1.20[17] 1.31[18] -5.16[19] -5.03[20] 0.08[21]
4 NRAS GTPase NRas [22] -0.25[23] -0.04[24] -0.09[25] 0.07[26] -0.10[27] -0.67[28]
5 HRAS GTPase HRas [29] -1.88[30] -2.81[31] -4.07[32] -1.88[33] -1.83[34] -3.08[35]
6 KLB Beta-klotho [36] -0.28[37] -0.67[38] 0.31[39] -6.89[40] -7.27[41] 1.13[42]
7 KRAS GTPase KRas [43] -1.39[44] -1.63[45] -0.50[46] -0.13[47] -0.21[48] 0.26[49]
8 SOS1 Son of sevenless homolog 1 [50] -0.98[51] 0.33[52] -0.63[53] -0.08[54] -0.59[55] 0.12[56]
9 FGF2 Fibroblast growth factor 2 [57] -7.56[58] -7.53[59] -3.85[60] 0.01[61] 1.85[62] -2.08[63]
10 FGF1 Fibroblast growth factor 1 [64] -3.64[65] -3.07[66] -8.00[67] -0.34[68] 1.50[69] -0.37[70]
11 FGF19 Fibroblast growth factor 19 [71] -2.94[72] -2.01[73] 4.27[74] -0.10[75] -3.31[76] [77]
12 FGF8 Fibroblast growth factor 8 [78] -4.21[79] -4.08[80] -0.05[81] -2.84[82] [83] 2.28[84]
13 FGF18 Fibroblast growth factor 18 [85] 0.90[86] -3.44[87] -1.73[88] -0.31[89] 0.54[90] 0.17[91]
14 FGF9 Fibroblast growth factor 9 [92] 1.38[93] -2.49[94] [95] 1.86[96] -3.00[97] -0.31[98]
15 FGF20 Fibroblast growth factor 20 [99] [100] [101] [102] [103] [104] [105]
16 FGF4 Fibroblast growth factor 4 [106] [107] [108] [109] [110] [111] [112]
17 FGF23 Fibroblast growth factor 23 [113] [114] [115] [116] [117] [118] [119]
18 FGF17 Fibroblast growth factor 17 [120] [121] [122] [123] [124] [125] [126]
19 FGF16 Fibroblast growth factor 16 [127] [128] [129] [130] [131] [132] [133]
20 FGF6 Fibroblast growth factor 6 [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[16]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[17]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[18]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[19]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[20]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[21]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[37]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[38]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[39]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[40]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[41]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[42]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[43]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[44]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[45]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[46]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[47]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[48]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[49]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[58]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[59]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[60]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[61]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[62]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[63]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[64]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[65]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[66]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[67]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[68]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[69]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[70]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[71]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[72]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[73]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[74]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[75]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[76]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[77]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[78]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[79]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[82]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[83]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[84]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[85]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[86]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[87]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[88]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[89]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[90]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[91]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[92]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[93]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[94]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[97]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[98]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[99]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[101]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[104]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[105]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[106]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[111]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[117]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[119]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[120]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[122]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[123]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[124]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[125]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[126]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[127]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[134]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0