REACTOME_SHC_MEDIATED_CASCADE_FGFR1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.42[2] 0.20[3] 0.02[4] -0.91[5] -0.68[6] 0.07[7]
2 SHC1 SHC-transforming protein 1 [8] 0.39[9] 0.55[10] 0.32[11] 1.19[12] 0.98[13] 0.55[14]
3 NRAS GTPase NRas [15] -0.15[16] 0.23[17] 0.34[18] -0.46[19] -0.58[20] -0.48[21]
4 HRAS GTPase HRas [22] -1.79[23] -2.55[24] -3.64[25] -2.41[26] -2.32[27] -2.89[28]
5 KRAS GTPase KRas [29] -1.29[30] -1.37[31] -0.07[32] -0.66[33] -0.69[34] 0.45[35]
6 SOS1 Son of sevenless homolog 1 [36] -0.88[37] 0.60[38] -0.20[39] -0.62[40] -1.07[41] 0.31[42]
7 FGF2 Fibroblast growth factor 2 [43] -7.46[44] -7.27[45] -3.42[46] -0.53[47] 1.36[48] -1.89[49]
8 FGFR1 Fibroblast growth factor receptor 1 [50] 3.80[51] 2.06[52] 3.41[53] 3.60[54] 3.17[55] 1.43[56]
9 KL Klotho [57] -6.83[58] [59] [60] -2.85[61] -7.80[62] 0.02[63]
10 FGF5 Fibroblast growth factor 5 [64] -1.77[65] -0.50[66] -0.88[67] 0.02[68] 0.02[69] 2.91[70]
11 FGF1 Fibroblast growth factor 1 [71] -3.54[72] -2.81[73] -7.57[74] -0.87[75] 1.01[76] -0.19[77]
12 FGF8 Fibroblast growth factor 8 [78] -4.11[79] -3.82[80] 0.38[81] -3.38[82] [83] 2.47[84]
13 FGF9 Fibroblast growth factor 9 [85] 1.48[86] -2.23[87] [88] 1.32[89] -3.48[90] -0.12[91]
14 FGF6 Fibroblast growth factor 6 [92] [93] [94] [95] [96] [97] [98]
15 FGF17 Fibroblast growth factor 17 [99] [100] [101] [102] [103] [104] [105]
16 FGF22 Fibroblast growth factor 22 [106] [107] [108] [109] [110] [111] [112]
17 FGF10 Fibroblast growth factor 10 [113] [114] [115] [116] [117] [118] [119]
18 FGF23 Fibroblast growth factor 23 [120] [121] [122] [123] [124] [125] [126]
19 FGF20 Fibroblast growth factor 20 [127] [128] [129] [130] [131] [132] [133]
20 FGF3 Fibroblast growth factor 3 [134] [135] [136] [137] [138] [139] [140]
21 FGF4 Fibroblast growth factor 4 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[37]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[38]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[39]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[40]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[41]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[42]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[43]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[44]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[45]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[46]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[47]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[48]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[49]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[50]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[51]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[52]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[53]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[54]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[55]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[56]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[57]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0 0 0.4 0.2 0.69
[58]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[59]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.2 0.16
[62]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[63]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.38 0.31 0.15 0.9
[64]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[65]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[66]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[67]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[68]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[69]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[70]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[71]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[72]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[73]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[74]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[75]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[76]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[77]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[78]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[79]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[82]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[83]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[84]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[85]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[86]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[87]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[88]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[90]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[91]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[92]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[94]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[98]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[99]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[101]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[102]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[103]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[104]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[105]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[106]
ref_hepatocyte FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF22
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[108]
HepG2.C3A FGF22
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FGF22
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[110]
SNU475 FGF22
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[111]
THLE FGF22
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte FGF10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF10
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A FGF10
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 FGF10
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 FGF10
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE FGF10
Mean 0
Standard deviation 0
Values 0 0
[119]
liver FGF10
Mean 0.0234
Standard deviation 0.038
Values 0 0.014 0 0.079
[120]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[124]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[126]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[127]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[129]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[132]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[133]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[134]
ref_hepatocyte FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF3
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A FGF3
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[138]
SNU475 FGF3
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[139]
THLE FGF3
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[146]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[147]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0