REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.58[2] 0.24[3] 0.16[4] -0.74[5] -0.40[6] 0.11[7]
2 SHC1 SHC-transforming protein 1 [8] 0.55[9] 0.59[10] 0.47[11] 1.36[12] 1.27[13] 0.59[14]
3 NRAS GTPase NRas [15] 0.01[16] 0.27[17] 0.48[18] -0.30[19] -0.30[20] -0.44[21]
4 HRAS GTPase HRas [22] -1.62[23] -2.51[24] -3.49[25] -2.24[26] -2.03[27] -2.85[28]
5 KRAS GTPase KRas [29] -1.13[30] -1.33[31] 0.07[32] -0.49[33] -0.41[34] 0.49[35]
6 SOS1 Son of sevenless homolog 1 [36] -0.72[37] 0.64[38] -0.05[39] -0.45[40] -0.79[41] 0.35[42]
7 HBEGF Proheparin-binding EGF-like growth factor [43] -1.60[44] -2.59[45] -3.86[46] -0.99[47] -0.88[48] -2.62[49]
8 NRG1 Pro-neuregulin-1, membrane-bound isoform [50] -0.28[51] -6.60[52] -3.90[53] 0.76[54] -6.29[55] 0.58[56]
9 BTC Probetacellulin [57] -8.76[58] -9.33[59] -5.30[60] -4.17[61] -3.77[62] -3.10[63]
10 NRG4 Pro-neuregulin-4, membrane-bound isoform [64] -4.71[65] -2.01[66] -2.26[67] -1.01[68] -2.78[69] -1.12[70]
11 EREG Proepiregulin [71] 1.14[72] 0.89[73] -3.72[74] -2.86[75] 2.81[76] -1.66[77]
12 ERBB4 Receptor tyrosine-protein kinase erbB-4 [78] [79] [80] [81] [82] [83] [84]
13 NRG3 Pro-neuregulin-3, membrane-bound isoform [85] [86] [87] [88] [89] [90] [91]
14 NRG2 Pro-neuregulin-2, membrane-bound isoform [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[37]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[38]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[39]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[40]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[41]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[42]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[43]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[44]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[45]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[46]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[47]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[48]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[49]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[50]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[51]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[52]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[53]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[54]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[55]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[56]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[57]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[58]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[59]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[61]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[62]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[63]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[64]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[65]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[66]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[67]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[68]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[69]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[70]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[71]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[72]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[73]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[74]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[75]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[76]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[77]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[78]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[80]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[81]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[82]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[83]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[84]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[85]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[89]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[91]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[92]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[94]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[97]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[98]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053