REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.19[2] -0.27[3] -0.19[4] -0.65[5] -0.37[6] -0.47[7]
2 SHC1 SHC-transforming protein 1 [8] 0.16[9] 0.08[10] 0.11[11] 1.45[12] 1.30[13] 0.01[14]
3 NRAS GTPase NRas [15] -0.37[16] -0.24[17] 0.12[18] -0.21[19] -0.27[20] -1.02[21]
4 HRAS GTPase HRas [22] -2.01[23] -3.02[24] -3.85[25] -2.15[26] -2.00[27] -3.43[28]
5 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 [29] -0.22[30] -0.14[31] -1.22[32] 0.55[33] -0.01[34] -1.22[35]
6 KRAS GTPase KRas [36] -1.52[37] -1.84[38] -0.29[39] -0.40[40] -0.38[41] -0.09[42]
7 ERBB3 Receptor tyrosine-protein kinase erbB-3 [43] 1.00[44] 2.08[45] 1.08[46] -7.08[47] -6.46[48] 1.54[49]
8 SOS1 Son of sevenless homolog 1 [50] -1.10[51] 0.12[52] -0.41[53] -0.36[54] -0.76[55] -0.23[56]
9 ERBB2 Receptor tyrosine-protein kinase erbB-2 [57] 1.37[58] -0.11[59] 1.01[60] 0.05[61] 0.02[62] -0.61[63]
10 EGFR Epidermal growth factor receptor [64] -1.70[65] -2.38[66] 0.46[67] -0.77[68] 0.21[69] 1.89[70]
11 PRKCD Protein kinase C delta type [71] 0.10[72] 0.04[73] -0.52[74] -1.71[75] -0.19[76] -1.83[77]
12 PRKCA Protein kinase C alpha type [78] 1.83[79] 1.57[80] 1.89[81] 0.95[82] 1.67[83] 1.15[84]
13 HBEGF Proheparin-binding EGF-like growth factor [85] -1.99[86] -3.10[87] -4.22[88] -0.90[89] -0.85[90] -3.20[91]
14 NRG1 Pro-neuregulin-1, membrane-bound isoform [92] -0.67[93] -7.11[94] -4.26[95] 0.85[96] -6.26[97] 0.00[98]
15 BTC Probetacellulin [99] -9.14[100] -9.84[101] -5.66[102] -4.08[103] -3.74[104] -3.68[105]
16 PRKCE Protein kinase C epsilon type [106] -0.36[107] -2.18[108] 0.27[109] -0.22[110] 0.51[111] 2.80[112]
17 NRG4 Pro-neuregulin-4, membrane-bound isoform [113] -5.10[114] -2.52[115] -2.62[116] -0.92[117] -2.75[118] -1.70[119]
18 EREG Proepiregulin [120] 0.75[121] 0.37[122] -4.08[123] -2.77[124] 2.84[125] -2.24[126]
19 EGF Pro-epidermal growth factor [127] 0.96[128] 2.45[129] 6.02[130] 7.82[131] 5.61[132] 0.81[133]
20 ERBB4 Receptor tyrosine-protein kinase erbB-4 [134] [135] [136] [137] [138] [139] [140]
21 NRG3 Pro-neuregulin-3, membrane-bound isoform [141] [142] [143] [144] [145] [146] [147]
22 NRG2 Pro-neuregulin-2, membrane-bound isoform [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte PTPN12
Mean 9.2
Standard deviation 4.5
Values 11 14 12 5.3 3.4
[30]
HepG2 PTPN12
Mean 35
Standard deviation 1.2
Values 34 36
[31]
HepG2.C3A PTPN12
Mean 40.5
Standard deviation 2.5
Values 42 39
[32]
HuH.7 PTPN12
Mean 18.9
Standard deviation 1.1
Values 19 18 20
[33]
SNU475 PTPN12
Mean 57
Standard deviation 14
Values 47 67
[34]
THLE PTPN12
Mean 33.7
Standard deviation 3.5
Values 36 31
[35]
liver PTPN12
Mean 9.55
Standard deviation 3.7
Values 15 9.1 6.7 7.5
[36]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[37]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[38]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[39]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[40]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[41]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[42]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[43]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[44]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[45]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[46]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[47]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[48]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[49]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[50]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[51]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[52]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[53]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[54]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[55]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[56]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[57]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[58]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[59]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[60]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[61]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[62]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[63]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[64]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[65]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[66]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[67]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[68]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[69]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[70]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[71]
ref_hepatocyte PRKCD
Mean 3.58
Standard deviation 2
Values 5.9 2.9 5.5 2.1 1.5
[72]
HepG2 PRKCD
Mean 16.9
Standard deviation 3.4
Values 19 15
[73]
HepG2.C3A PRKCD
Mean 17.9
Standard deviation 3.3
Values 20 16
[74]
HuH.7 PRKCD
Mean 12
Standard deviation 0.2
Values 12 12 12
[75]
SNU475 PRKCD
Mean 4.64
Standard deviation 0.32
Values 4.4 4.9
[76]
THLE PRKCD
Mean 11.6
Standard deviation 1.2
Values 11 12
[77]
liver PRKCD
Mean 2.43
Standard deviation 1
Values 3.9 1.4 2.2 2.3
[78]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[79]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[80]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[81]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[82]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[83]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[84]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[85]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[86]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[87]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[88]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[89]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[90]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[91]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[92]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[93]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[94]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[95]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[96]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[97]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[98]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[99]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[100]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[101]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[102]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[103]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[104]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[105]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[106]
ref_hepatocyte PRKCE
Mean 0.713
Standard deviation 0.29
Values 0.58 0.57 0.38 0.94 1.1
[107]
HepG2 PRKCE
Mean 2.46
Standard deviation 0.34
Values 2.7 2.2
[108]
HepG2.C3A PRKCE
Mean 0.767
Standard deviation 0.098
Values 0.84 0.7
[109]
HuH.7 PRKCE
Mean 4.14
Standard deviation 0.97
Values 4.1 5.1 3.2
[110]
SNU475 PRKCE
Mean 2.58
Standard deviation 0.11
Values 2.5 2.7
[111]
THLE PRKCE
Mean 3.72
Standard deviation 0.4
Values 3.4 4
[112]
liver PRKCE
Mean 12
Standard deviation 13
Values 5.6 7.3 3.9 31
[113]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[114]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[115]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[116]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[117]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[118]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[119]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[120]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[121]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[122]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[123]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[124]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[125]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[126]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[127]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[128]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[129]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[130]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[131]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[132]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[133]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[134]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[137]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[138]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[139]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[140]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[141]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[145]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[147]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[148]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[150]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[153]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[154]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053