REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.65[2] 0.26[3] 0.18[4] -0.60[5] -0.42[6] -0.15[7]
2 SHC1 SHC-transforming protein 1 [8] 0.62[9] 0.61[10] 0.49[11] 1.50[12] 1.25[13] 0.33[14]
3 NRAS GTPase NRas [15] 0.09[16] 0.29[17] 0.50[18] -0.15[19] -0.32[20] -0.70[21]
4 HRAS GTPase HRas [22] -1.55[23] -2.49[24] -3.48[25] -2.10[26] -2.05[27] -3.11[28]
5 KRAS GTPase KRas [29] -1.06[30] -1.31[31] 0.09[32] -0.35[33] -0.43[34] 0.23[35]
6 SOS1 Son of sevenless homolog 1 [36] -0.64[37] 0.65[38] -0.03[39] -0.31[40] -0.81[41] 0.09[42]
7 EGFR Epidermal growth factor receptor [43] -1.24[44] -1.84[45] 0.84[46] -0.72[47] 0.17[48] 2.21[49]
8 AREG Amphiregulin [50] -3.40[51] -6.88[52] -8.83[53] -10.85[54] -0.28[55] -10.75[56]
9 TGFA Protransforming growth factor alpha [57] 1.25[58] 2.08[59] -9.17[60] -2.11[61] -3.07[62] -0.84[63]
10 HBEGF Proheparin-binding EGF-like growth factor [64] -1.53[65] -2.57[66] -3.84[67] -0.85[68] -0.89[69] -2.87[70]
11 BTC Probetacellulin [71] -8.68[72] -9.31[73] -5.28[74] -4.02[75] -3.79[76] -3.36[77]
12 EREG Proepiregulin [78] 1.21[79] 0.90[80] -3.71[81] -2.72[82] 2.80[83] -1.92[84]
13 EGF Pro-epidermal growth factor [85] 1.43[86] 2.98[87] 6.40[88] 7.87[89] 5.56[90] 1.13[91]
14 EPGN Epigen [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[37]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[38]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[39]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[40]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[41]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[42]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[43]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[44]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[45]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[46]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[47]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[48]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[49]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[50]
ref_hepatocyte AREG
Mean 5.24
Standard deviation 9.3
Values 1.7 22 1.7 0.57 0.4
[51]
HepG2 AREG
Mean 1.59
Standard deviation 1.3
Values 2.5 0.67
[52]
HepG2.C3A AREG
Mean 0.15
Standard deviation 0.061
Values 0.11 0.19
[53]
HuH.7 AREG
Mean 0.0425
Standard deviation 0.021
Values 0.057 0.051 0.019
[54]
SNU475 AREG
Mean 0.0116
Standard deviation 0.016
Values 0.023 0
[55]
THLE AREG
Mean 16.4
Standard deviation 1.7
Values 15 18
[56]
liver AREG
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[57]
ref_hepatocyte TGFA
Mean 2
Standard deviation 1.3
Values 3.8 2.7 2.1 0.72 0.76
[58]
HepG2 TGFA
Mean 15.3
Standard deviation 2.1
Values 17 14
[59]
HepG2.C3A TGFA
Mean 28.4
Standard deviation 4.2
Values 25 31
[60]
HuH.7 TGFA
Mean 0.0129
Standard deviation 0.0035
Values 0.016 0.013 0.0094
[61]
SNU475 TGFA
Mean 1.88
Standard deviation 0.53
Values 1.5 2.3
[62]
THLE TGFA
Mean 0.903
Standard deviation 0.47
Values 1.2 0.57
[63]
liver TGFA
Mean 2.16
Standard deviation 0.15
Values 2.1 2.3 2.2 2
[64]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[65]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[66]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[67]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[68]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[69]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[70]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[71]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[72]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[73]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[74]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[75]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[76]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[77]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[78]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[79]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[80]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[81]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[82]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[83]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[84]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[85]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[86]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[87]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[88]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[89]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[90]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[91]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[92]
ref_hepatocyte EPGN
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 EPGN
Mean 0.0544
Standard deviation 0.028
Values 0.074 0.034
[94]
HepG2.C3A EPGN
Mean 0.0501
Standard deviation 0.025
Values 0.068 0.032
[95]
HuH.7 EPGN
Mean 0.127
Standard deviation 0.084
Values 0.082 0.22 0.075
[96]
SNU475 EPGN
Mean 0.503
Standard deviation 0.27
Values 0.31 0.69
[97]
THLE EPGN
Mean 4.76
Standard deviation 1.2
Values 5.6 3.9
[98]
liver EPGN
Mean 0.161
Standard deviation 0.11
Values 0.12 0.17 0.051 0.3