REACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 VAMP2 Vesicle-associated membrane protein 2 [1] -2.25[2] -2.07[3] -2.37[4] -3.02[5] -1.95[6] -1.63[7]
2 PPFIA1 Liprin-alpha-1 [8] 0.70[9] 0.27[10] 0.48[11] 1.63[12] 0.62[13] 0.39[14]
3 UNC13B Protein unc-13 homolog B [15] 0.87[16] 0.79[17] 0.81[18] -2.18[19] -0.32[20] 1.13[21]
4 RAB3A Ras-related protein Rab-3A [22] -0.98[23] -2.23[24] -0.74[25] -3.36[26] -1.91[27] -2.66[28]
5 SLC18A2 Synaptic vesicular amine transporter [29] -1.93[30] 0.23[31] -0.05[32] -2.78[33] -0.80[34] 1.85[35]
6 SYN1 Synapsin-1 [36] -3.14[37] -0.97[38] [39] -6.12[40] -0.92[41] -2.22[42]
7 STX1A Syntaxin-1A [43] 0.04[44] -0.18[45] -2.32[46] 0.04[47] 0.31[48] -2.60[49]
8 STXBP1 Syntaxin-binding protein 1 [50] 0.84[51] 1.05[52] 0.84[53] 1.64[54] 2.76[55] -0.60[56]
9 CPLX1 Complexin-1 [57] -1.81[58] -3.06[59] 1.12[60] -5.44[61] -4.22[62] -1.24[63]
10 PPFIA3 Liprin-alpha-3 [64] 1.82[65] 2.05[66] 1.39[67] -1.66[68] -0.82[69] -1.36[70]
11 SNAP25 Synaptosomal-associated protein 25 [71] -4.39[72] -4.39[73] 0.64[74] -0.10[75] 3.21[76] -0.40[77]
12 SYN3 Synapsin-3 [78] 2.31[79] 3.92[80] -0.22[81] [82] -5.60[83] -1.83[84]
13 SYT1 Synaptotagmin-1 [85] -3.00[86] -3.94[87] 4.05[88] 4.64[89] 2.07[90] 2.78[91]
14 SYN2 Synapsin-2 [92] -1.34[93] -1.60[94] -2.78[95] 0.81[96] 2.72[97] 0.36[98]
15 PPFIA2 Liprin-alpha-2 [99] 3.29[100] 6.02[101] 4.70[102] -1.83[103] -0.15[104] 5.46[105]
16 PPFIA4 Liprin-alpha-4 [106] [107] [108] [109] [110] [111] [112]
17 TSPOAP1 Peripheral-type benzodiazepine receptor-associated protein 1 [113] [114] [115] [116] [117] [118] [119]
18 RIMS1 Regulating synaptic membrane exocytosis protein 1 [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte VAMP2
Mean 7.38
Standard deviation 2
Values 9.9 5.1 8 8.2 5.7
[2]
HepG2 VAMP2
Mean 6.41
Standard deviation 1.5
Values 7.4 5.4
[3]
HepG2.C3A VAMP2
Mean 7.34
Standard deviation 3
Values 9.5 5.2
[4]
HuH.7 VAMP2
Mean 8.97
Standard deviation 0.78
Values 8.3 8.8 9.8
[5]
SNU475 VAMP2
Mean 9.81
Standard deviation 1.6
Values 11 8.7
[6]
THLE VAMP2
Mean 9.61
Standard deviation 0.14
Values 9.5 9.7
[7]
liver VAMP2
Mean 9.18
Standard deviation 10
Values 22 1 11 1.9
[8]
ref_hepatocyte PPFIA1
Mean 4.38
Standard deviation 1.7
Values 4 5.6 6.7 2.7 2.9
[9]
HepG2 PPFIA1
Mean 29.4
Standard deviation 3.9
Values 27 32
[10]
HepG2.C3A PPFIA1
Mean 22.1
Standard deviation 1.5
Values 23 21
[11]
HuH.7 PPFIA1
Mean 38.2
Standard deviation 5.1
Values 38 43 33
[12]
SNU475 PPFIA1
Mean 146
Standard deviation 15
Values 1.6e+02 1.4e+02
[13]
THLE PPFIA1
Mean 33.9
Standard deviation 4
Values 31 37
[14]
liver PPFIA1
Mean 22.1
Standard deviation 4.2
Values 21 25 16 25
[15]
ref_hepatocyte UNC13B
Mean 3.23
Standard deviation 1.4
Values 2.5 5.5 2.6 3.4 2.1
[16]
HepG2 UNC13B
Mean 24.3
Standard deviation 2.4
Values 23 26
[17]
HepG2.C3A UNC13B
Mean 23.4
Standard deviation 3.3
Values 26 21
[18]
HuH.7 UNC13B
Mean 35.5
Standard deviation 5.6
Values 40 37 29
[19]
SNU475 UNC13B
Mean 7.69
Standard deviation 1.6
Values 8.8 6.5
[20]
THLE UNC13B
Mean 13
Standard deviation 0.26
Values 13 13
[21]
liver UNC13B
Mean 27.3
Standard deviation 11
Values 17 41 19 33
[22]
ref_hepatocyte RAB3A
Mean 0.786
Standard deviation 0.29
Values 0.95 0.55 0.49 0.76 1.2
[23]
HepG2 RAB3A
Mean 1.64
Standard deviation 0.46
Values 2 1.3
[24]
HepG2.C3A RAB3A
Mean 0.703
Standard deviation 0.33
Values 0.93 0.47
[25]
HuH.7 RAB3A
Mean 2.95
Standard deviation 0.48
Values 3.5 2.5 2.8
[26]
SNU475 RAB3A
Mean 0.823
Standard deviation 0.069
Values 0.77 0.87
[27]
THLE RAB3A
Mean 1.06
Standard deviation 0.15
Values 1.2 0.95
[28]
liver RAB3A
Mean 0.48
Standard deviation 0.46
Values 0.47 0.19 1.1 0.13
[29]
ref_hepatocyte SLC18A2
Mean 0.784
Standard deviation 0.93
Values 0 0 0.35 1.9 1.7
[30]
HepG2 SLC18A2
Mean 0.848
Standard deviation 0.11
Values 0.93 0.77
[31]
HepG2.C3A SLC18A2
Mean 3.83
Standard deviation 2.4
Values 5.5 2.2
[32]
HuH.7 SLC18A2
Mean 4.73
Standard deviation 0.58
Values 4.1 5.2 5
[33]
SNU475 SLC18A2
Mean 1.23
Standard deviation 0.21
Values 1.1 1.4
[34]
THLE SLC18A2
Mean 2.27
Standard deviation 1.1
Values 3 1.5
[35]
liver SLC18A2
Mean 10.9
Standard deviation 2.2
Values 14 9.4 9.1 11
[36]
ref_hepatocyte SYN1
Mean 0.678
Standard deviation 0.79
Values 0.038 0.036 0.98 1.9 0.43
[37]
HepG2 SYN1
Mean 0.317
Standard deviation 0.35
Values 0.56 0.073
[38]
HepG2.C3A SYN1
Mean 1.45
Standard deviation 0.014
Values 1.4 1.5
[39]
HuH.7 SYN1
Mean 0
Standard deviation 0
Values 0 0 0
[40]
SNU475 SYN1
Mean 0.105
Standard deviation 0.031
Values 0.083 0.13
[41]
THLE SYN1
Mean 1.81
Standard deviation 0.5
Values 2.2 1.5
[42]
liver SYN1
Mean 0.561
Standard deviation 0.32
Values 0.96 0.43 0.64 0.21
[43]
ref_hepatocyte STX1A
Mean 0.672
Standard deviation 0.98
Values 0.23 0.39 2.4 0.095 0.24
[44]
HepG2 STX1A
Mean 2.85
Standard deviation 0.85
Values 3.4 2.2
[45]
HepG2.C3A STX1A
Mean 2.48
Standard deviation 0.71
Values 3 2
[46]
HuH.7 STX1A
Mean 0.845
Standard deviation 0.25
Values 0.57 0.91 1.1
[47]
SNU475 STX1A
Mean 7.45
Standard deviation 3.6
Values 4.9 10
[48]
THLE STX1A
Mean 4.19
Standard deviation 1.3
Values 5.1 3.3
[49]
liver STX1A
Mean 0.426
Standard deviation 0.18
Values 0.35 0.31 0.69 0.34
[50]
ref_hepatocyte STXBP1
Mean 0.658
Standard deviation 0.63
Values 1.7 0.64 0.69 0.22 0.065
[51]
HepG2 STXBP1
Mean 4.83
Standard deviation 0.73
Values 5.4 4.3
[52]
HepG2.C3A STXBP1
Mean 5.71
Standard deviation 0.79
Values 6.3 5.1
[53]
HuH.7 STXBP1
Mean 7.36
Standard deviation 1.4
Values 8.9 6.5 6.7
[54]
SNU475 STXBP1
Mean 22.1
Standard deviation 0.72
Values 23 22
[55]
THLE STXBP1
Mean 22.4
Standard deviation 6
Values 18 27
[56]
liver STXBP1
Mean 1.67
Standard deviation 0.8
Values 2 1.1 2.6 0.91
[57]
ref_hepatocyte CPLX1
Mean 0.58
Standard deviation 0.61
Values 0.11 0 0.34 1.1 1.4
[58]
HepG2 CPLX1
Mean 0.678
Standard deviation 0.18
Values 0.8 0.55
[59]
HepG2.C3A CPLX1
Mean 0.29
Standard deviation 0.016
Values 0.3 0.28
[60]
HuH.7 CPLX1
Mean 7.91
Standard deviation 0.96
Values 9 7.3 7.4
[61]
SNU475 CPLX1
Mean 0.143
Standard deviation 0.012
Values 0.13 0.15
[62]
THLE CPLX1
Mean 0.156
Standard deviation 0.063
Values 0.2 0.11
[63]
liver CPLX1
Mean 0.943
Standard deviation 0.4
Values 0.73 1.3 0.49 1.3
[64]
ref_hepatocyte PPFIA3
Mean 0.55
Standard deviation 0.41
Values 1.1 0 0.71 0.53 0.39
[65]
HepG2 PPFIA3
Mean 8
Standard deviation 2.9
Values 10 6
[66]
HepG2.C3A PPFIA3
Mean 9.56
Standard deviation 2.5
Values 11 7.8
[67]
HuH.7 PPFIA3
Mean 9.06
Standard deviation 0.25
Values 9.3 9 8.8
[68]
SNU475 PPFIA3
Mean 1.88
Standard deviation 0.44
Values 1.6 2.2
[69]
THLE PPFIA3
Mean 1.58
Standard deviation 0.29
Values 1.8 1.4
[70]
liver PPFIA3
Mean 0.826
Standard deviation 0.32
Values 1 0.4 1.1 0.77
[71]
ref_hepatocyte SNAP25
Mean 0.146
Standard deviation 0.17
Values 0 0 0.3 0.069 0.36
[72]
HepG2 SNAP25
Mean 0.0286
Standard deviation 0.032
Values 0.0057 0.051
[73]
HepG2.C3A SNAP25
Mean 0.0292
Standard deviation 0.041
Values 0.058 0
[74]
HuH.7 SNAP25
Mean 1.43
Standard deviation 0.14
Values 1.4 1.3 1.6
[75]
SNU475 SNAP25
Mean 1.47
Standard deviation 0.63
Values 1 1.9
[76]
THLE SNAP25
Mean 6.82
Standard deviation 0.47
Values 7.1 6.5
[77]
liver SNAP25
Mean 0.427
Standard deviation 0.11
Values 0.42 0.34 0.36 0.58
[78]
ref_hepatocyte SYN3
Mean 0.0513
Standard deviation 0.11
Values 0.26 0 0 0 0
[79]
HepG2 SYN3
Mean 1.04
Standard deviation 0.36
Values 0.79 1.3
[80]
HepG2.C3A SYN3
Mean 3.25
Standard deviation 0.096
Values 3.2 3.3
[81]
HuH.7 SYN3
Mean 0.276
Standard deviation 0.078
Values 0.28 0.35 0.2
[82]
SNU475 SYN3
Mean 0
Standard deviation 0
Values 0 0
[83]
THLE SYN3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[84]
liver SYN3
Mean 0.0555
Standard deviation 0.034
Values 0.024 0.043 0.1 0.053
[85]
ref_hepatocyte SYT1
Mean 0.0375
Standard deviation 0.071
Values 0 0 0.16 0 0.024
[86]
HepG2 SYT1
Mean 0.0193
Standard deviation 0.021
Values 0.034 0.0043
[87]
HepG2.C3A SYT1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[88]
HuH.7 SYT1
Mean 3.9
Standard deviation 1.6
Values 3.6 5.6 2.5
[89]
SNU475 SYT1
Mean 10
Standard deviation 0.7
Values 9.5 11
[90]
THLE SYT1
Mean 0.793
Standard deviation 0.075
Values 0.85 0.74
[91]
liver SYT1
Mean 0.992
Standard deviation 0.082
Values 0.94 1.1 0.98 0.94
[92]
ref_hepatocyte SYN2
Mean 0.00706
Standard deviation 0.016
Values 0.035 0 0 0 0
[93]
HepG2 SYN2
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[94]
HepG2.C3A SYN2
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[95]
HuH.7 SYN2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[96]
SNU475 SYN2
Mean 0.133
Standard deviation 0.07
Values 0.083 0.18
[97]
THLE SYN2
Mean 0.235
Standard deviation 0.061
Values 0.28 0.19
[98]
liver SYN2
Mean 0.0349
Standard deviation 0.046
Values 0.024 0 0.1 0.013
[99]
ref_hepatocyte PPFIA2
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[100]
HepG2 PPFIA2
Mean 0.196
Standard deviation 0.026
Values 0.18 0.21
[101]
HepG2.C3A PPFIA2
Mean 1.33
Standard deviation 0.86
Values 1.9 0.72
[102]
HuH.7 PPFIA2
Mean 0.797
Standard deviation 0.16
Values 0.71 0.98 0.7
[103]
SNU475 PPFIA2
Mean 0.0148
Standard deviation 0.0078
Values 0.0093 0.02
[104]
THLE PPFIA2
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[105]
liver PPFIA2
Mean 0.827
Standard deviation 0.62
Values 0.54 0.87 0.23 1.7
[106]
ref_hepatocyte PPFIA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 PPFIA4
Mean 1.54
Standard deviation 0.4
Values 1.3 1.8
[108]
HepG2.C3A PPFIA4
Mean 1.94
Standard deviation 0.4
Values 1.7 2.2
[109]
HuH.7 PPFIA4
Mean 3.04
Standard deviation 1.1
Values 2.1 4.2 2.9
[110]
SNU475 PPFIA4
Mean 5.33
Standard deviation 1.6
Values 6.5 4.2
[111]
THLE PPFIA4
Mean 2.71
Standard deviation 1.5
Values 3.8 1.6
[112]
liver PPFIA4
Mean 0.136
Standard deviation 0.079
Values 0.19 0.2 0.13 0.026
[113]
ref_hepatocyte TSPOAP1
Missing
[114]
HepG2 TSPOAP1
Missing
[115]
HepG2.C3A TSPOAP1
Missing
[116]
HuH.7 TSPOAP1
Missing
[117]
SNU475 TSPOAP1
Missing
[118]
THLE TSPOAP1
Missing
[119]
liver TSPOAP1
Missing
[120]
ref_hepatocyte RIMS1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 RIMS1
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A RIMS1
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 RIMS1
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 RIMS1
Mean 0.0774
Standard deviation 0.002
Values 0.079 0.076
[125]
THLE RIMS1
Mean 0.0387
Standard deviation 0.013
Values 0.03 0.048
[126]
liver RIMS1
Mean 0.0607
Standard deviation 0.064
Values 0 0.071 0.026 0.15