REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.24[2] | -1.20[3] | -1.05[4] | -1.41[5] | -1.07[6] | -0.42[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.80[16] | -0.45[17] | -0.68[18] | -0.56[19] | -0.69[20] | 0.03[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.57[23] | -2.04[24] | -1.65[25] | -1.27[26] | -1.92[27] | -0.92[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.39[30] | -1.66[31] | -1.74[32] | -1.06[33] | -1.45[34] | -0.55[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.57[37] | 0.80[38] | -0.49[39] | 0.57[40] | 0.02[41] | 0.48[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.11[44] | 0.36[45] | -0.69[46] | -0.68[47] | -0.02[48] | 0.31[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.37[51] | -1.03[52] | 0.03[53] | -0.70[54] | -0.92[55] | 0.02[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.12[58] | 0.17[59] | 0.33[60] | 0.73[61] | 0.62[62] | -0.31[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.07[65] | -0.93[66] | -0.76[67] | -1.05[68] | -0.71[69] | -0.75[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.33[72] | 0.03[73] | -0.01[74] | -0.32[75] | -0.15[76] | -0.27[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.46[79] | 0.31[80] | 0.27[81] | 0.21[82] | 0.12[83] | -0.19[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.47[86] | 0.33[87] | 0.15[88] | 0.51[89] | 0.23[90] | -0.27[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.03[93] | 0.61[94] | -0.26[95] | 0.87[96] | 0.96[97] | 0.76[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.50[100] | -0.43[101] | 0.21[102] | -0.69[103] | -0.59[104] | 0.20[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.09[107] | 0.05[108] | -0.60[109] | 0.05[110] | -0.49[111] | -0.02[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.54[114] | -0.26[115] | -0.08[116] | -0.49[117] | -0.86[118] | 0.13[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.63[121] | 0.47[122] | 0.83[123] | 0.00[124] | 0.28[125] | 0.36[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.11[128] | 0.04[129] | 0.27[130] | 0.71[131] | 0.07[132] | 0.04[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.19[135] | 0.32[136] | 0.21[137] | -0.38[138] | 0.00[139] | -0.14[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.02[142] | 0.35[143] | 0.52[144] | -0.10[145] | 0.56[146] | -0.11[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.51[149] | 0.82[150] | 0.92[151] | 1.01[152] | 2.20[153] | 0.92[154] |
23 | CKS1B | Cyclin-dependent kinases regulatory subunit 1 | [155] | -0.78[156] | 0.06[157] | 0.78[158] | 0.07[159] | -0.19[160] | -1.60[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.17[163] | 0.03[164] | -0.59[165] | 1.19[166] | 0.62[167] | 0.08[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | 0.01[170] | 0.54[171] | 0.63[172] | 0.77[173] | 0.17[174] | 0.57[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.63[177] | 1.78[178] | 2.83[179] | 0.84[180] | 1.53[181] | 0.80[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.33[184] | 0.36[185] | 0.47[186] | 0.17[187] | 0.49[188] | 0.34[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.73[191] | 0.36[192] | 0.98[193] | 0.71[194] | 0.83[195] | 0.05[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.67[198] | -2.12[199] | -9.31[200] | 0.68[201] | -0.72[202] | -0.64[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | -0.10[205] | 0.65[206] | 0.93[207] | 0.57[208] | 0.51[209] | -0.09[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.33[212] | 0.50[213] | 0.46[214] | 0.20[215] | 0.22[216] | 0.39[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.82[219] | -0.20[220] | -1.26[221] | -0.43[222] | 0.29[223] | -0.20[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.37[226] | 0.63[227] | 1.15[228] | 0.63[229] | 0.04[230] | -0.02[231] |
34 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [232] | 1.79[233] | 0.64[234] | -2.04[235] | -0.62[236] | 1.82[237] | -0.38[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.45[240] | -0.23[241] | -0.51[242] | 0.25[243] | 0.22[244] | -0.10[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.15[247] | 1.57[248] | 0.41[249] | 0.61[250] | 0.44[251] | 0.56[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.73[254] | 0.49[255] | 1.11[256] | 1.02[257] | 1.08[258] | 1.38[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.49[261] | 1.03[262] | 0.83[263] | 1.41[264] | 1.14[265] | 1.44[266] |
39 | PSME3 | Proteasome activator complex subunit 3 | [267] | 1.72[268] | 1.57[269] | 1.28[270] | 1.44[271] | 1.61[272] | 1.00[273] |
40 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [274] | 1.48[275] | 1.93[276] | 1.84[277] | 2.24[278] | 2.15[279] | 2.19[280] |
41 | CCND1 | G1/S-specific cyclin-D1 | [281] | 4.01[282] | 1.74[283] | 2.58[284] | 3.25[285] | 1.65[286] | 2.51[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.25[289] | -0.51[290] | -2.37[291] | 0.03[292] | -1.23[293] | 0.04[294] |
43 | PSMA5 | Proteasome subunit alpha type-5 | [295] | 1.80[296] | 2.37[297] | 1.96[298] | 2.29[299] | 1.76[300] | 2.03[301] |
44 | PSMF1 | Proteasome inhibitor PI31 subunit | [302] | 2.18[303] | 2.37[304] | 1.20[305] | 1.30[306] | 0.97[307] | 1.97[308] |
45 | CDK4 | Cyclin-dependent kinase 4 | [309] | 2.29[310] | 3.11[311] | 2.75[312] | 1.55[313] | 2.08[314] | 0.62[315] |
46 | PSMB2 | Proteasome subunit beta type-2 | [316] | 1.96[317] | 1.84[318] | 2.25[319] | 2.60[320] | 2.49[321] | 2.51[322] |
47 | PSMB9 | Proteasome subunit beta type-9 | [323] | -2.04[324] | -4.52[325] | -6.80[326] | 1.85[327] | -0.52[328] | -0.38[329] |
48 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [330] | 0.34[331] | 0.97[332] | 0.01[333] | 0.47[334] | 0.82[335] | 0.84[336] |
49 | CUL1 | Cullin-1 | [337] | 0.57[338] | 1.49[339] | 1.05[340] | 1.95[341] | 1.48[342] | 2.20[343] |
50 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [344] | 0.87[345] | 1.55[346] | 1.75[347] | 0.26[348] | 0.60[349] | 0.55[350] |
51 | CDK2 | Cyclin-dependent kinase 2 | [351] | 0.54[352] | 0.95[353] | 1.33[354] | 1.35[355] | 1.82[356] | -0.73[357] |
52 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [358] | 0.90[359] | 1.36[360] | 1.41[361] | 2.15[362] | 1.37[363] | 0.83[364] |
53 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [365] | 1.31[366] | 1.01[367] | 2.59[368] | 2.53[369] | 2.52[370] | 2.28[371] |
54 | SKP2 | S-phase kinase-associated protein 2 | [372] | 2.27[373] | 2.97[374] | 4.11[375] | 2.63[376] | 2.60[377] | 2.54[378] |
55 | CCNE1 | G1/S-specific cyclin-E1 | [379] | 2.19[380] | 2.54[381] | 0.74[382] | 0.97[383] | 1.44[384] | -3.17[385] |
56 | CCNA2 | Cyclin-A2 | [386] | 3.16[387] | 4.41[388] | 3.76[389] | 3.37[390] | 4.64[391] | 0.23[392] |
57 | CCNE2 | G1/S-specific cyclin-E2 | [393] | 1.38[394] | 2.02[395] | 1.56[396] | 4.41[397] | 4.19[398] | 1.10[399] |
58 | PTK6 | Protein-tyrosine kinase 6 | [400] | -0.17[401] | 2.28[402] | 0.53[403] | -0.28[404] | -0.83[405] | 0.88[406] |
59 | CCNA1 | Cyclin-A1 | [407] | [408] | -2.19[409] | [410] | 0.58[411] | 7.86[412] | [413] |
60 | SEM1 | Putative protein SEM1, isoform 2 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |