REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YES1 Tyrosine-protein kinase Yes [1] -2.03[2] -0.57[3] -0.27[4] -1.09[5] -1.89[6] -1.16[7]
2 HDAC3 Histone deacetylase 3 [8] -0.69[9] -0.66[10] -0.78[11] -1.59[12] -1.70[13] -1.68[14]
3 YAP1 Transcriptional coactivator YAP1 [15] 0.79[16] 0.22[17] -0.06[18] 0.75[19] -0.11[20] -0.93[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 0.54[23] 0.65[24] 0.56[25] 0.31[26] -0.31[27] 0.49[28]
5 CBFB Core-binding factor subunit beta [29] -0.63[30] -0.05[31] -0.93[32] -0.70[33] -0.55[34] -1.66[35]
6 HES1 Transcription factor HES-1 [36] -1.61[37] -4.13[38] -1.80[39] -2.81[40] -3.91[41] -2.68[42]
7 HDAC6 Histone deacetylase 6 [43] -0.52[44] 0.40[45] 0.58[46] -1.26[47] -2.05[48] 0.87[49]
8 WWTR1 WW domain-containing transcription regulator protein 1 [50] 0.72[51] 0.28[52] -0.63[53] 0.77[54] -0.18[55] -0.55[56]
9 AR Androgen receptor [57] -11.62[58] -10.97[59] -12.73[60] -3.28[61] -6.59[62] 2.36[63]
10 MAPK3 Mitogen-activated protein kinase 3 [64] 0.68[65] 0.70[66] 0.82[67] -1.11[68] -1.36[69] -2.32[70]
11 ABL1 Tyrosine-protein kinase ABL1 [71] 1.06[72] 0.42[73] 1.30[74] 0.53[75] 0.95[76] -0.34[77]
12 SRC Proto-oncogene tyrosine-protein kinase Src [78] 1.85[79] 1.81[80] 0.89[81] 0.86[82] -0.23[83] -2.13[84]
13 RB1 Retinoblastoma-associated protein [85] 0.05[86] 0.52[87] 1.16[88] 0.74[89] 0.80[90] 0.19[91]
14 MAF Transcription factor Maf [92] -4.06[93] -7.13[94] 0.08[95] -1.39[96] -2.59[97] 1.12[98]
15 HEY1 Hairy/enhancer-of-split related with YRPW motif protein 1 [99] 0.47[100] -1.10[101] -0.95[102] -2.03[103] -3.50[104] -1.23[105]
16 SATB2 DNA-binding protein SATB2 [106] 0.05[107] 1.49[108] 1.17[109] -0.44[110] 0.31[111] -0.42[112]
17 HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2 [113] -4.89[114] -6.72[115] -6.73[116] -5.40[117] -8.49[118] -0.53[119]
18 COL1A1 Collagen alpha-1(I) chain [120] 3.57[121] -3.97[122] -2.07[123] 5.47[124] 6.74[125] 5.07[126]
19 RUNX2 Runt-related transcription factor 2 [127] -2.02[128] -2.40[129] 2.74[130] 5.59[131] 7.28[132] 2.34[133]
20 GLI3 Transcriptional activator GLI3 [134] -2.40[135] [136] -1.39[137] 7.40[138] 5.50[139] 2.87[140]
21 ZNF521 Zinc finger protein 521 [141] -0.86[142] [143] [144] 2.76[145] -0.71[146] 5.15[147]
22 BGLAP Osteocalcin [148] [149] [150] [151] [152] [153] [154]
23 SP7 Transcription factor Sp7 [155] [156] [157] [158] [159] [160] [161]
24 UCMA Unique cartilage matrix-associated protein [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[2]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[3]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[4]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[5]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[6]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[7]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[8]
ref_hepatocyte HDAC3
Mean 12.4
Standard deviation 2.7
Values 17 10 11 14 10
[9]
HepG2 HDAC3
Mean 38.3
Standard deviation 1.2
Values 37 39
[10]
HepG2.C3A HDAC3
Mean 35.4
Standard deviation 3.2
Values 33 38
[11]
HuH.7 HDAC3
Mean 29.6
Standard deviation 5.9
Values 28 24 36
[12]
SNU475 HDAC3
Mean 22
Standard deviation 2.2
Values 24 20
[13]
THLE HDAC3
Mean 27.5
Standard deviation 0.73
Values 27 28
[14]
liver HDAC3
Mean 13.3
Standard deviation 5.1
Values 19 8.2 16 10
[15]
ref_hepatocyte YAP1
Mean 11.1
Standard deviation 8.2
Values 25 11 7.6 4.3 7.3
[16]
HepG2 YAP1
Mean 95.6
Standard deviation 11
Values 88 1e+02
[17]
HepG2.C3A YAP1
Mean 58.4
Standard deviation 12
Values 50 67
[18]
HuH.7 YAP1
Mean 43.3
Standard deviation 5.4
Values 49 44 38
[19]
SNU475 YAP1
Mean 99
Standard deviation 6.2
Values 1e+02 95
[20]
THLE YAP1
Mean 73.9
Standard deviation 11
Values 66 81
[21]
liver YAP1
Mean 20.1
Standard deviation 14
Values 9.5 26 7.2 38
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[29]
ref_hepatocyte CBFB
Mean 7.69
Standard deviation 6.8
Values 17 12 3.4 2.3 3.1
[30]
HepG2 CBFB
Mean 24.8
Standard deviation 2.9
Values 23 27
[31]
HepG2.C3A CBFB
Mean 33.6
Standard deviation 8
Values 28 39
[32]
HuH.7 CBFB
Mean 16.5
Standard deviation 4.3
Values 19 12 19
[33]
SNU475 CBFB
Mean 25.2
Standard deviation 0.84
Values 26 25
[34]
THLE CBFB
Mean 37.8
Standard deviation 4.4
Values 35 41
[35]
liver CBFB
Mean 8.39
Standard deviation 1.4
Values 7.5 9 10 7
[36]
ref_hepatocyte HES1
Mean 7.15
Standard deviation 5.3
Values 9.1 1 3.7 15 7
[37]
HepG2 HES1
Mean 11.7
Standard deviation 5.7
Values 16 7.7
[38]
HepG2.C3A HES1
Mean 1.84
Standard deviation 0.56
Values 2.2 1.4
[39]
HuH.7 HES1
Mean 8.41
Standard deviation 1.4
Values 6.9 8.7 9.7
[40]
SNU475 HES1
Mean 5.42
Standard deviation 0.41
Values 5.7 5.1
[41]
THLE HES1
Mean 3.42
Standard deviation 0.023
Values 3.4 3.4
[42]
liver HES1
Mean 3.86
Standard deviation 1.7
Values 6.2 3 4.1 2.2
[43]
ref_hepatocyte HDAC6
Mean 6.59
Standard deviation 5
Values 5.6 0.94 2.9 12 12
[44]
HepG2 HDAC6
Mean 22.9
Standard deviation 2.2
Values 25 21
[45]
HepG2.C3A HDAC6
Mean 39.4
Standard deviation 17
Values 51 28
[46]
HuH.7 HDAC6
Mean 40.3
Standard deviation 7
Values 36 48 36
[47]
SNU475 HDAC6
Mean 14.7
Standard deviation 3
Values 17 13
[48]
THLE HDAC6
Mean 11.4
Standard deviation 0.42
Values 12 11
[49]
liver HDAC6
Mean 41.8
Standard deviation 2.9
Values 40 40 46 41
[50]
ref_hepatocyte WWTR1
Mean 5.02
Standard deviation 4.3
Values 12 3.8 5.4 1.2 2.6
[51]
HepG2 WWTR1
Mean 41.2
Standard deviation 0.072
Values 41 41
[52]
HepG2.C3A WWTR1
Mean 27.5
Standard deviation 7.8
Values 33 22
[53]
HuH.7 WWTR1
Mean 13.3
Standard deviation 1.5
Values 13 15 12
[54]
SNU475 WWTR1
Mean 45.7
Standard deviation 8.3
Values 52 40
[55]
THLE WWTR1
Mean 31.8
Standard deviation 6
Values 28 36
[56]
liver WWTR1
Mean 11.9
Standard deviation 2.9
Values 14 11 15 8.4
[57]
ref_hepatocyte AR
Mean 4.54
Standard deviation 5.3
Values 0 1.3 1.1 8.4 12
[58]
HepG2 AR
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[59]
HepG2.C3A AR
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[60]
HuH.7 AR
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[61]
SNU475 AR
Mean 2.48
Standard deviation 0.22
Values 2.6 2.3
[62]
THLE AR
Mean 0.34
Standard deviation 0.18
Values 0.47 0.21
[63]
liver AR
Mean 80.8
Standard deviation 45
Values 61 91 33 1.4e+02
[64]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[65]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[66]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[67]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[68]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[69]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[70]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[71]
ref_hepatocyte ABL1
Mean 3.99
Standard deviation 2.5
Values 4.1 4.1 8 1.7 2
[72]
HepG2 ABL1
Mean 41.3
Standard deviation 2.2
Values 43 40
[73]
HepG2.C3A ABL1
Mean 24.2
Standard deviation 1.3
Values 23 25
[74]
HuH.7 ABL1
Mean 40.3
Standard deviation 6.6
Values 48 38 35
[75]
SNU475 ABL1
Mean 30.8
Standard deviation 0.67
Values 31 30
[76]
THLE ABL1
Mean 55.5
Standard deviation 15
Values 45 66
[77]
liver ABL1
Mean 10.9
Standard deviation 3.5
Values 8.1 13 7.7 14
[78]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[79]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[80]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[81]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[82]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[83]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[84]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[85]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 5 3.8 3 1.4 2.2
[86]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 10 21
[87]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 16 24
[88]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 32 25 28
[89]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 28 27
[90]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[91]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 12 14 13 9
[92]
ref_hepatocyte MAF
Mean 2.64
Standard deviation 1.4
Values 2.6 2.4 0.9 2.4 4.9
[93]
HepG2 MAF
Mean 0.788
Standard deviation 0.5
Values 0.44 1.1
[94]
HepG2.C3A MAF
Mean 0.0853
Standard deviation 0.11
Values 0.0097 0.16
[95]
HuH.7 MAF
Mean 11.4
Standard deviation 8.2
Values 6.2 21 7.3
[96]
SNU475 MAF
Mean 5.39
Standard deviation 2.7
Values 7.3 3.5
[97]
THLE MAF
Mean 3.15
Standard deviation 0.074
Values 3.2 3.1
[98]
liver MAF
Mean 19.9
Standard deviation 6.7
Values 30 17 17 16
[99]
ref_hepatocyte HEY1
Mean 0.786
Standard deviation 0.62
Values 1.6 0.56 1.2 0.43 0.098
[100]
HepG2 HEY1
Mean 5.41
Standard deviation 3.1
Values 7.6 3.2
[101]
HepG2.C3A HEY1
Mean 1.65
Standard deviation 0.44
Values 2 1.3
[102]
HuH.7 HEY1
Mean 1.67
Standard deviation 0.046
Values 1.6 1.7 1.7
[103]
SNU475 HEY1
Mean 1.02
Standard deviation 0.89
Values 0.39 1.7
[104]
THLE HEY1
Mean 0.501
Standard deviation 0.0059
Values 0.5 0.51
[105]
liver HEY1
Mean 1.16
Standard deviation 1.3
Values 3.1 0.3 0.62 0.61
[106]
ref_hepatocyte SATB2
Mean 0.689
Standard deviation 0.41
Values 1 0.64 1.1 0.51 0.12
[107]
HepG2 SATB2
Mean 3.54
Standard deviation 0.76
Values 3 4.1
[108]
HepG2.C3A SATB2
Mean 8.73
Standard deviation 0.44
Values 9 8.4
[109]
HuH.7 SATB2
Mean 6.33
Standard deviation 1.5
Values 7.5 6.9 4.6
[110]
SNU475 SATB2
Mean 2.7
Standard deviation 0.11
Values 2.6 2.8
[111]
THLE SATB2
Mean 6.13
Standard deviation 0.47
Values 6.5 5.8
[112]
liver SATB2
Mean 1.78
Standard deviation 0.41
Values 2 2.2 1.5 1.4
[113]
ref_hepatocyte HEY2
Mean 0.577
Standard deviation 0.4
Values 0.22 0.17 0.54 1.1 0.85
[114]
HepG2 HEY2
Mean 0.0967
Standard deviation 0.058
Values 0.14 0.056
[115]
HepG2.C3A HEY2
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[116]
HuH.7 HEY2
Mean 0.0222
Standard deviation 0.021
Values 0.041 0.026 0
[117]
SNU475 HEY2
Mean 0.0728
Standard deviation 0.0046
Values 0.07 0.076
[118]
THLE HEY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[119]
liver HEY2
Mean 1.38
Standard deviation 1.1
Values 2.6 0.27 1.9 0.75
[120]
ref_hepatocyte COL1A1
Mean 0.396
Standard deviation 0.34
Values 0.021 0.18 0.62 0.31 0.85
[121]
HepG2 COL1A1
Mean 23.3
Standard deviation 12
Values 15 32
[122]
HepG2.C3A COL1A1
Mean 0.114
Standard deviation 0.051
Values 0.078 0.15
[123]
HuH.7 COL1A1
Mean 0.386
Standard deviation 0.18
Values 0.55 0.41 0.2
[124]
SNU475 COL1A1
Mean 93.4
Standard deviation 25
Values 76 1.1e+02
[125]
THLE COL1A1
Mean 304
Standard deviation 1.2e+02
Values 2.2e+02 3.9e+02
[126]
liver COL1A1
Mean 46
Standard deviation 44
Values 24 30 1.1e+02 19
[127]
ref_hepatocyte RUNX2
Mean 0.0228
Standard deviation 0.051
Values 0 0 0 0 0.11
[128]
HepG2 RUNX2
Mean 0.0279
Standard deviation 0.033
Values 0.052 0.0043
[129]
HepG2.C3A RUNX2
Mean 0.0194
Standard deviation 0.027
Values 0.039 0
[130]
HuH.7 RUNX2
Mean 0.624
Standard deviation 0.22
Values 0.54 0.87 0.46
[131]
SNU475 RUNX2
Mean 5.82
Standard deviation 3.1
Values 3.6 8
[132]
THLE RUNX2
Mean 25.4
Standard deviation 0.45
Values 26 25
[133]
liver RUNX2
Mean 0.398
Standard deviation 0.22
Values 0.71 0.29 0.21 0.4
[134]
ref_hepatocyte GLI3
Mean 0.0152
Standard deviation 0.021
Values 0 0 0.043 0 0.033
[135]
HepG2 GLI3
Mean 0.0143
Standard deviation 0.02
Values 0.029 0
[136]
HepG2.C3A GLI3
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 GLI3
Mean 0.0238
Standard deviation 0.021
Values 0.033 0.039 0
[138]
SNU475 GLI3
Mean 13.7
Standard deviation 1.2
Values 14 13
[139]
THLE GLI3
Mean 4.94
Standard deviation 1.2
Values 4.1 5.8
[140]
liver GLI3
Mean 0.384
Standard deviation 0.18
Values 0.59 0.37 0.15 0.42
[141]
ref_hepatocyte ZNF521
Mean 0.0133
Standard deviation 0.019
Values 0 0 0 0.026 0.041
[142]
HepG2 ZNF521
Mean 0.0365
Standard deviation 0.021
Values 0.052 0.021
[143]
HepG2.C3A ZNF521
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 ZNF521
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 ZNF521
Mean 0.48
Standard deviation 0.24
Values 0.31 0.65
[146]
THLE ZNF521
Mean 0.0585
Standard deviation 0.0075
Values 0.053 0.064
[147]
liver ZNF521
Mean 1.64
Standard deviation 0.67
Values 1 2.6 1.5 1.4
[148]
ref_hepatocyte BGLAP
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 BGLAP
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[150]
HepG2.C3A BGLAP
Mean 0.0662
Standard deviation 0.0026
Values 0.068 0.064
[151]
HuH.7 BGLAP
Mean 0.0222
Standard deviation 0.02
Values 0 0.039 0.028
[152]
SNU475 BGLAP
Mean 0.0222
Standard deviation 0.012
Values 0.014 0.03
[153]
THLE BGLAP
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[154]
liver BGLAP
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte SP7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 SP7
Mean 0.0315
Standard deviation 0.045
Values 0.063 0
[157]
HepG2.C3A SP7
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 SP7
Mean 0.0306
Standard deviation 0.022
Values 0.016 0.019 0.056
[159]
SNU475 SP7
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[160]
THLE SP7
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[161]
liver SP7
Mean 0.0201
Standard deviation 0.031
Values 0 0.014 0 0.066
[162]
ref_hepatocyte UCMA
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 UCMA
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A UCMA
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[165]
HuH.7 UCMA
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 UCMA
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE UCMA
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[168]
liver UCMA
Mean 0
Standard deviation 0
Values 0 0 0 0