REACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CALR Calreticulin [1] -0.07[2] -1.02[3] -0.98[4] -0.63[5] -0.50[6] -0.54[7]
2 HSP90B1 Endoplasmin [8] -0.39[9] 0.77[10] 0.02[11] 0.63[12] 0.39[13] 0.42[14]
3 HSPA5 78 kDa glucose-regulated protein [15] 0.45[16] 0.03[17] -0.42[18] 0.19[19] 0.13[20] 0.12[21]
4 ATF4 Cyclic AMP-dependent transcription factor ATF-4 [22] -0.27[23] 0.35[24] 0.55[25] -1.53[26] -0.25[27] -1.76[28]
5 XBP1 X-box-binding protein 1 [29] -0.65[30] -0.85[31] 1.12[32] -1.40[33] -1.83[34] 0.83[35]
6 DDIT3 DNA damage-inducible transcript 3 protein [36] -1.08[37] -0.79[38] -0.67[39] -0.60[40] 0.11[41] -1.74[42]
7 MBTPS1 Membrane-bound transcription factor site-1 protease [43] 2.48[44] 1.81[45] 2.11[46] 2.89[47] 2.78[48] 1.77[49]
8 NFYC Nuclear transcription factor Y subunit gamma [50] 0.60[51] -0.02[52] 0.36[53] 1.25[54] 0.38[55] 0.02[56]
9 NFYB Nuclear transcription factor Y subunit beta [57] 0.26[58] 1.39[59] 1.05[60] 1.89[61] 2.07[62] 0.45[63]
10 ATF6 Cyclic AMP-dependent transcription factor ATF-6 alpha [64] 2.64[65] 2.20[66] 2.09[67] 3.95[68] 3.89[69] 3.15[70]
11 NFYA Nuclear transcription factor Y subunit alpha [71] 2.45[72] 2.18[73] 2.36[74] 2.94[75] 2.23[76] 0.92[77]
12 MBTPS2 Membrane-bound transcription factor site-2 protease [78] 1.84[79] 1.71[80] 2.80[81] 3.59[82] 3.34[83] 2.01[84]
[1]
ref_hepatocyte CALR
Mean 617
Standard deviation 2.8e+02
Values 7.7e+02 4.7e+02 3.5e+02 1e+03 4.6e+02
[2]
HepG2 CALR
Mean 698
Standard deviation 0.66
Values 7e+02 7e+02
[3]
HepG2.C3A CALR
Mean 448
Standard deviation 1.7e+02
Values 3.3e+02 5.7e+02
[4]
HuH.7 CALR
Mean 360
Standard deviation 34
Values 3.3e+02 3.5e+02 4e+02
[5]
SNU475 CALR
Mean 258
Standard deviation 1.5e+02
Values 3.6e+02 1.6e+02
[6]
THLE CALR
Mean 356
Standard deviation 52
Values 3.2e+02 3.9e+02
[7]
liver CALR
Mean 440
Standard deviation 89
Values 4e+02 3.7e+02 5.7e+02 4.2e+02
[8]
ref_hepatocyte HSP90B1
Mean 367
Standard deviation 3.6e+02
Values 3.1e+02 1.4e+02 1.2e+02 9.9e+02 2.8e+02
[9]
HepG2 HSP90B1
Mean 332
Standard deviation 69
Values 2.8e+02 3.8e+02
[10]
HepG2.C3A HSP90B1
Mean 925
Standard deviation 72
Values 8.7e+02 9.8e+02
[11]
HuH.7 HSP90B1
Mean 428
Standard deviation 74
Values 3.7e+02 5.1e+02 4e+02
[12]
SNU475 HSP90B1
Mean 369
Standard deviation 1.2e+02
Values 4.5e+02 2.9e+02
[13]
THLE HSP90B1
Mean 393
Standard deviation 13
Values 3.8e+02 4e+02
[14]
liver HSP90B1
Mean 511
Standard deviation 1.5e+02
Values 4e+02 6e+02 6.8e+02 3.6e+02
[15]
ref_hepatocyte HSPA5
Mean 323
Standard deviation 1.8e+02
Values 2.1e+02 1.7e+02 4.7e+02 5.6e+02 2.1e+02
[16]
HepG2 HSPA5
Mean 522
Standard deviation 17
Values 5.1e+02 5.3e+02
[17]
HepG2.C3A HSPA5
Mean 488
Standard deviation 22
Values 5e+02 4.7e+02
[18]
HuH.7 HSPA5
Mean 279
Standard deviation 1e+02
Values 2.1e+02 4e+02 2.3e+02
[19]
SNU475 HSPA5
Mean 240
Standard deviation 1.2e+02
Values 3.2e+02 1.6e+02
[20]
THLE HSPA5
Mean 287
Standard deviation 62
Values 2.4e+02 3.3e+02
[21]
liver HSPA5
Mean 365
Standard deviation 1.6e+02
Values 2.5e+02 3.1e+02 6.1e+02 2.9e+02
[22]
ref_hepatocyte ATF4
Mean 212
Standard deviation 1.7e+02
Values 76 1.1e+02 4.8e+02 2.7e+02 1.3e+02
[23]
HepG2 ATF4
Mean 208
Standard deviation 25
Values 2.3e+02 1.9e+02
[24]
HepG2.C3A ATF4
Mean 397
Standard deviation 1.4e+02
Values 4.9e+02 3e+02
[25]
HuH.7 ATF4
Mean 356
Standard deviation 84
Values 3.1e+02 3.1e+02 4.5e+02
[26]
SNU475 ATF4
Mean 47.8
Standard deviation 2.6
Values 50 46
[27]
THLE ATF4
Mean 145
Standard deviation 1.3
Values 1.5e+02 1.4e+02
[28]
liver ATF4
Mean 64.9
Standard deviation 27
Values 1e+02 44 68 46
[29]
ref_hepatocyte XBP1
Mean 168
Standard deviation 1.5e+02
Values 56 56 60 2.9e+02 3.8e+02
[30]
HepG2 XBP1
Mean 127
Standard deviation 20
Values 1.1e+02 1.4e+02
[31]
HepG2.C3A XBP1
Mean 137
Standard deviation 17
Values 1.5e+02 1.3e+02
[32]
HuH.7 XBP1
Mean 422
Standard deviation 17
Values 4e+02 4.3e+02 4.3e+02
[33]
SNU475 XBP1
Mean 41.4
Standard deviation 13
Values 51 32
[34]
THLE XBP1
Mean 38.5
Standard deviation 6.1
Values 34 43
[35]
liver XBP1
Mean 311
Standard deviation 1.9e+02
Values 5.8e+02 1.8e+02 3e+02 1.9e+02
[36]
ref_hepatocyte DDIT3
Mean 23.4
Standard deviation 23
Values 7.5 13 17 64 15
[37]
HepG2 DDIT3
Mean 13.1
Standard deviation 8.7
Values 19 7
[38]
HepG2.C3A DDIT3
Mean 19.9
Standard deviation 9
Values 26 14
[39]
HuH.7 DDIT3
Mean 16.9
Standard deviation 6.4
Values 10 23 18
[40]
SNU475 DDIT3
Mean 10
Standard deviation 0.8
Values 9.5 11
[41]
THLE DDIT3
Mean 20.6
Standard deviation 4
Values 23 18
[42]
liver DDIT3
Mean 7.31
Standard deviation 5.6
Values 12 2.7 12 2.3
[43]
ref_hepatocyte MBTPS1
Mean 12.1
Standard deviation 4.1
Values 19 13 9.9 9.7 9
[44]
HepG2 MBTPS1
Mean 80.3
Standard deviation 2.9
Values 82 78
[45]
HepG2.C3A MBTPS1
Mean 62.7
Standard deviation 9.8
Values 70 56
[46]
HuH.7 MBTPS1
Mean 59.9
Standard deviation 6.7
Values 65 53 62
[47]
SNU475 MBTPS1
Mean 58.2
Standard deviation 23
Values 75 42
[48]
THLE MBTPS1
Mean 67.8
Standard deviation 8.7
Values 62 74
[49]
liver MBTPS1
Mean 42.8
Standard deviation 5.9
Values 34 46 46 45
[50]
ref_hepatocyte NFYC
Mean 10
Standard deviation 3.8
Values 16 5.5 8.7 11 9.2
[51]
HepG2 NFYC
Mean 18
Standard deviation 1.9
Values 17 19
[52]
HepG2.C3A NFYC
Mean 14.6
Standard deviation 0.89
Values 15 14
[53]
HuH.7 NFYC
Mean 14.8
Standard deviation 0.42
Values 15 15 15
[54]
SNU475 NFYC
Mean 15.5
Standard deviation 1
Values 16 15
[55]
THLE NFYC
Mean 10.7
Standard deviation 1.4
Values 9.7 12
[56]
liver NFYC
Mean 10.6
Standard deviation 6.2
Values 19 5 12 6.6
[57]
ref_hepatocyte NFYB
Mean 4.68
Standard deviation 1.8
Values 4.3 7.4 2.9 3.6 5.2
[58]
HepG2 NFYB
Mean 6.64
Standard deviation 1.1
Values 5.8 7.5
[59]
HepG2.C3A NFYB
Mean 18
Standard deviation 5.3
Values 14 22
[60]
HuH.7 NFYB
Mean 11.1
Standard deviation 3
Values 12 7.7 13
[61]
SNU475 NFYB
Mean 11.3
Standard deviation 0.64
Values 12 11
[62]
THLE NFYB
Mean 16
Standard deviation 0.47
Values 16 16
[63]
liver NFYB
Mean 6.62
Standard deviation 2.1
Values 9.6 4.9 6.5 5.4
[64]
ref_hepatocyte ATF6
Mean 4.13
Standard deviation 1.9
Values 1.9 3 5.6 6.5 3.6
[65]
HepG2 ATF6
Mean 30.5
Standard deviation 4.7
Values 27 34
[66]
HepG2.C3A ATF6
Mean 27.9
Standard deviation 2.3
Values 26 29
[67]
HuH.7 ATF6
Mean 20.2
Standard deviation 4.2
Values 21 24 16
[68]
SNU475 ATF6
Mean 41.5
Standard deviation 2.3
Values 43 40
[69]
THLE ATF6
Mean 49.9
Standard deviation 3.5
Values 47 52
[70]
liver ATF6
Mean 38.1
Standard deviation 7
Values 35 48 33 36
[71]
ref_hepatocyte NFYA
Mean 3.88
Standard deviation 3.9
Values 11 3.4 1.1 2.2 1.9
[72]
HepG2 NFYA
Mean 25.1
Standard deviation 8.5
Values 19 31
[73]
HepG2.C3A NFYA
Mean 26
Standard deviation 6.6
Values 21 31
[74]
HuH.7 NFYA
Mean 22.9
Standard deviation 2.6
Values 26 20 23
[75]
SNU475 NFYA
Mean 19.3
Standard deviation 0.21
Values 19 19
[76]
THLE NFYA
Mean 14.8
Standard deviation 1.4
Values 14 16
[77]
liver NFYA
Mean 7.61
Standard deviation 3.9
Values 3.6 9.7 5.2 12
[78]
ref_hepatocyte MBTPS2
Mean 2.91
Standard deviation 1.1
Values 4.3 3.5 1.3 2.3 3.2
[79]
HepG2 MBTPS2
Mean 12.4
Standard deviation 2.3
Values 11 14
[80]
HepG2.C3A MBTPS2
Mean 14.1
Standard deviation 0.19
Values 14 14
[81]
HuH.7 MBTPS2
Mean 23.4
Standard deviation 5.3
Values 25 27 17
[82]
SNU475 MBTPS2
Mean 22.8
Standard deviation 3.1
Values 25 21
[83]
THLE MBTPS2
Mean 23.9
Standard deviation 2.4
Values 22 26
[84]
liver MBTPS2
Mean 12.1
Standard deviation 2.3
Values 11 12 15 9.9