REACTOME_RHO_GTPASES_ACTIVATE_ROCKS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MYL6 Myosin light polypeptide 6 [1] -1.98[2] -1.39[3] -2.29[4] -1.48[5] -1.47[6] -2.02[7]
2 MYL12B Myosin regulatory light chain 12B [8] -0.72[9] -0.19[10] 0.04[11] -0.55[12] -0.90[13] -0.79[14]
3 CFL1 Cofilin-1 [15] 1.02[16] 0.41[17] 0.66[18] 0.49[19] 0.92[20] 0.66[21]
4 RHOA Transforming protein RhoA [22] 0.35[23] 0.26[24] 0.74[25] -0.26[26] 0.55[27] 0.28[28]
5 RHOC Rho-related GTP-binding protein RhoC [29] -0.29[30] -0.28[31] -0.44[32] -0.05[33] 0.19[34] -1.09[35]
6 RHOB Rho-related GTP-binding protein RhoB [36] 0.49[37] 0.33[38] -1.54[39] -1.33[40] -1.82[41] 1.48[42]
7 MYH9 Myosin-9 [43] 2.70[44] 1.56[45] 1.79[46] 2.18[47] 2.43[48] 1.99[49]
8 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit [50] 1.05[51] 2.02[52] 2.38[53] 1.72[54] 1.90[55] 2.10[56]
9 ROCK1 Rho-associated protein kinase 1 [57] 0.33[58] 2.27[59] 3.30[60] 2.32[61] 2.03[62] 3.19[63]
10 MYH14 Myosin-14 [64] 2.17[65] 2.69[66] 2.93[67] 1.45[68] -1.62[69] 2.85[70]
11 MYH10 Myosin-10 [71] 3.62[72] 4.05[73] 4.87[74] 3.43[75] 3.68[76] 3.66[77]
12 ROCK2 Rho-associated protein kinase 2 [78] 2.76[79] 4.41[80] 3.14[81] 3.59[82] 1.73[83] 3.53[84]
13 MYL9 Myosin regulatory light polypeptide 9 [85] 2.34[86] 2.56[87] 0.14[88] 5.55[89] 3.36[90] 1.52[91]
14 PPP1R12A Protein phosphatase 1 regulatory subunit 12A [92] 1.45[93] 3.59[94] 3.57[95] 3.69[96] 2.97[97] 3.35[98]
15 LIMK2 LIM domain kinase 2 [99] 2.78[100] 3.57[101] 3.98[102] 1.33[103] 2.33[104] 2.88[105]
16 LIMK1 LIM domain kinase 1 [106] 3.59[107] 2.89[108] 2.73[109] 4.47[110] 3.07[111] 0.11[112]
17 PAK1 Serine/threonine-protein kinase PAK 1 [113] 1.28[114] 0.93[115] 3.60[116] -0.90[117] 3.25[118] 1.87[119]
18 PPP1R12B Protein phosphatase 1 regulatory subunit 12B [120] 3.37[121] 4.63[122] 5.30[123] 4.97[124] 4.23[125] 6.18[126]
19 MYH11 Myosin-11 [127] 4.65[128] 4.69[129] 5.24[130] 4.63[131] 4.13[132] 11.56[133]
[1]
ref_hepatocyte MYL6
Mean 1.19e+03
Standard deviation 1.2e+03
Values 9.4e+02 3.2e+03 7.6e+02 5.1e+02 5.1e+02
[2]
HepG2 MYL6
Mean 272
Standard deviation 59
Values 2.3e+02 3.1e+02
[3]
HepG2.C3A MYL6
Mean 275
Standard deviation 92
Values 2.1e+02 3.4e+02
[4]
HuH.7 MYL6
Mean 118
Standard deviation 30
Values 1.1e+02 94 1.5e+02
[5]
SNU475 MYL6
Mean 403
Standard deviation 1.9e+02
Values 5.4e+02 2.7e+02
[6]
THLE MYL6
Mean 354
Standard deviation 52
Values 3.2e+02 3.9e+02
[7]
liver MYL6
Mean 138
Standard deviation 1.3e+02
Values 2.6e+02 37 2.3e+02 21
[8]
ref_hepatocyte MYL12B
Mean 317
Standard deviation 2e+02
Values 2e+02 6.8e+02 2.5e+02 2.4e+02 2.1e+02
[9]
HepG2 MYL12B
Mean 174
Standard deviation 36
Values 1.5e+02 2e+02
[10]
HepG2.C3A MYL12B
Mean 168
Standard deviation 40
Values 1.4e+02 2e+02
[11]
HuH.7 MYL12B
Mean 158
Standard deviation 19
Values 1.5e+02 1.4e+02 1.8e+02
[12]
SNU475 MYL12B
Mean 204
Standard deviation 67
Values 2.5e+02 1.6e+02
[13]
THLE MYL12B
Mean 140
Standard deviation 22
Values 1.2e+02 1.6e+02
[14]
liver MYL12B
Mean 85.6
Standard deviation 68
Values 1.5e+02 34 1.4e+02 20
[15]
ref_hepatocyte CFL1
Mean 201
Standard deviation 66
Values 1.2e+02 2.6e+02 2.6e+02 2.3e+02 1.5e+02
[16]
HepG2 CFL1
Mean 370
Standard deviation 16
Values 3.8e+02 3.6e+02
[17]
HepG2.C3A CFL1
Mean 162
Standard deviation 39
Values 1.3e+02 1.9e+02
[18]
HuH.7 CFL1
Mean 154
Standard deviation 66
Values 1.8e+02 78 2e+02
[19]
SNU475 CFL1
Mean 267
Standard deviation 62
Values 3.1e+02 2.2e+02
[20]
THLE CFL1
Mean 313
Standard deviation 56
Values 2.7e+02 3.5e+02
[21]
liver CFL1
Mean 148
Standard deviation 1.2e+02
Values 2.4e+02 50 2.7e+02 36
[22]
ref_hepatocyte RHOA
Mean 177
Standard deviation 1.2e+02
Values 2.2e+02 3.8e+02 1.4e+02 75 79
[23]
HepG2 RHOA
Mean 204
Standard deviation 38
Values 2.3e+02 1.8e+02
[24]
HepG2.C3A RHOA
Mean 129
Standard deviation 1.6
Values 1.3e+02 1.3e+02
[25]
HuH.7 RHOA
Mean 144
Standard deviation 23
Values 1.6e+02 1.2e+02 1.6e+02
[26]
SNU475 RHOA
Mean 139
Standard deviation 21
Values 1.5e+02 1.2e+02
[27]
THLE RHOA
Mean 214
Standard deviation 38
Values 1.9e+02 2.4e+02
[28]
liver RHOA
Mean 101
Standard deviation 59
Values 1.6e+02 54 1.4e+02 46
[29]
ref_hepatocyte RHOC
Mean 128
Standard deviation 1.2e+02
Values 28 2.1e+02 3.1e+02 56 39
[30]
HepG2 RHOC
Mean 95.1
Standard deviation 9.4
Values 1e+02 88
[31]
HepG2.C3A RHOC
Mean 64.3
Standard deviation 2.3
Values 66 63
[32]
HuH.7 RHOC
Mean 45.7
Standard deviation 7.4
Values 39 53 45
[33]
SNU475 RHOC
Mean 117
Standard deviation 12
Values 1.3e+02 1.1e+02
[34]
THLE RHOC
Mean 120
Standard deviation 7.4
Values 1.1e+02 1.3e+02
[35]
liver RHOC
Mean 28.1
Standard deviation 21
Values 52 13 38 9.2
[36]
ref_hepatocyte RHOB
Mean 121
Standard deviation 74
Values 81 64 88 2.5e+02 1.3e+02
[37]
HepG2 RHOB
Mean 154
Standard deviation 31
Values 1.8e+02 1.3e+02
[38]
HepG2.C3A RHOB
Mean 92.7
Standard deviation 27
Values 1.1e+02 74
[39]
HuH.7 RHOB
Mean 20.2
Standard deviation 3.4
Values 17 24 20
[40]
SNU475 RHOB
Mean 45.5
Standard deviation 23
Values 61 30
[41]
THLE RHOB
Mean 28.2
Standard deviation 1.3
Values 27 29
[42]
liver RHOB
Mean 158
Standard deviation 87
Values 1.3e+02 1.5e+02 71 2.8e+02
[43]
ref_hepatocyte MYH9
Mean 89.9
Standard deviation 85
Values 42 2e+02 1.7e+02 21 22
[44]
HepG2 MYH9
Mean 531
Standard deviation 80
Values 5.9e+02 4.7e+02
[45]
HepG2.C3A MYH9
Mean 161
Standard deviation 42
Values 1.9e+02 1.3e+02
[46]
HuH.7 MYH9
Mean 151
Standard deviation 45
Values 2e+02 1.3e+02 1.2e+02
[47]
SNU475 MYH9
Mean 384
Standard deviation 1.4e+02
Values 4.8e+02 2.9e+02
[48]
THLE MYH9
Mean 399
Standard deviation 1.2e+02
Values 3.1e+02 4.9e+02
[49]
liver MYH9
Mean 167
Standard deviation 46
Values 1.1e+02 2e+02 1.5e+02 2.1e+02
[50]
ref_hepatocyte PPP1CB
Mean 31.9
Standard deviation 30
Values 65 64 8.8 6.2 16
[51]
HepG2 PPP1CB
Mean 59.8
Standard deviation 14
Values 50 70
[52]
HepG2.C3A PPP1CB
Mean 78.8
Standard deviation 12
Values 71 87
[53]
HuH.7 PPP1CB
Mean 80.4
Standard deviation 9.9
Values 92 76 74
[54]
SNU475 PPP1CB
Mean 99.4
Standard deviation 25
Values 1.2e+02 82
[55]
THLE PPP1CB
Mean 98.3
Standard deviation 1.6
Values 99 97
[56]
liver PPP1CB
Mean 64.1
Standard deviation 7.2
Values 67 68 67 53
[57]
ref_hepatocyte ROCK1
Mean 6.73
Standard deviation 4.9
Values 9.7 14 3.6 2.5 3.9
[58]
HepG2 ROCK1
Mean 7.68
Standard deviation 2.4
Values 6 9.4
[59]
HepG2.C3A ROCK1
Mean 19.7
Standard deviation 1.6
Values 19 21
[60]
HuH.7 ROCK1
Mean 32.3
Standard deviation 9
Values 36 39 22
[61]
SNU475 ROCK1
Mean 31.8
Standard deviation 1.6
Values 31 33
[62]
THLE ROCK1
Mean 22.6
Standard deviation 6.2
Values 27 18
[63]
liver ROCK1
Mean 28.7
Standard deviation 3.4
Values 30 32 25 27
[64]
ref_hepatocyte MYH14
Mean 5.98
Standard deviation 2.3
Values 4.5 5.3 3.5 9.3 7.3
[65]
HepG2 MYH14
Mean 24.3
Standard deviation 8.5
Values 30 18
[66]
HepG2.C3A MYH14
Mean 23.4
Standard deviation 7
Values 28 18
[67]
HuH.7 MYH14
Mean 22.1
Standard deviation 4.6
Values 26 23 17
[68]
SNU475 MYH14
Mean 15.5
Standard deviation 1.9
Values 17 14
[69]
THLE MYH14
Mean 1.6
Standard deviation 1.1
Values 2.4 0.85
[70]
liver MYH14
Mean 20.2
Standard deviation 6.7
Values 20 21 12 28
[71]
ref_hepatocyte MYH10
Mean 5.81
Standard deviation 6.6
Values 17 5.7 1.9 1.6 2.5
[72]
HepG2 MYH10
Mean 64.6
Standard deviation 17
Values 53 76
[73]
HepG2.C3A MYH10
Mean 58.3
Standard deviation 5
Values 55 62
[74]
HuH.7 MYH10
Mean 82.4
Standard deviation 29
Values 1.1e+02 57 76
[75]
SNU475 MYH10
Mean 59.2
Standard deviation 10
Values 66 52
[76]
THLE MYH10
Mean 61.3
Standard deviation 12
Values 53 70
[77]
liver MYH10
Mean 34.4
Standard deviation 12
Values 23 47 25 43
[78]
ref_hepatocyte ROCK2
Mean 5.22
Standard deviation 4.8
Values 11 9.5 3.5 0.65 1.3
[79]
HepG2 ROCK2
Mean 32
Standard deviation 6.2
Values 28 36
[80]
HepG2.C3A ROCK2
Mean 67.4
Standard deviation 23
Values 51 84
[81]
HuH.7 ROCK2
Mean 22.4
Standard deviation 6.9
Values 28 24 15
[82]
SNU475 ROCK2
Mean 59.5
Standard deviation 0.12
Values 59 60
[83]
THLE ROCK2
Mean 14.2
Standard deviation 4.3
Values 17 11
[84]
liver ROCK2
Mean 28.1
Standard deviation 15
Values 20 42 12 39
[85]
ref_hepatocyte MYL9
Mean 5.03
Standard deviation 4.9
Values 5.1 13 5.9 0.6 0.89
[86]
HepG2 MYL9
Mean 23.1
Standard deviation 1.3
Values 22 24
[87]
HepG2.C3A MYL9
Mean 18
Standard deviation 3.8
Values 15 21
[88]
HuH.7 MYL9
Mean 2.69
Standard deviation 0.26
Values 2.9 2.4 2.7
[89]
SNU475 MYL9
Mean 222
Standard deviation 1.5e+02
Values 3.3e+02 1.2e+02
[90]
THLE MYL9
Mean 42.5
Standard deviation 9.6
Values 36 49
[91]
liver MYL9
Mean 6.76
Standard deviation 7.5
Values 5.5 1.6 18 2.2
[92]
ref_hepatocyte PPP1R12A
Mean 4
Standard deviation 2.4
Values 6.7 6 4 1.4 1.8
[93]
HepG2 PPP1R12A
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[94]
HepG2.C3A PPP1R12A
Mean 29.1
Standard deviation 5.2
Values 25 33
[95]
HuH.7 PPP1R12A
Mean 23.1
Standard deviation 3.3
Values 22 27 20
[96]
SNU475 PPP1R12A
Mean 48.8
Standard deviation 7.9
Values 54 43
[97]
THLE PPP1R12A
Mean 25.8
Standard deviation 4.4
Values 29 23
[98]
liver PPP1R12A
Mean 19.1
Standard deviation 2.7
Values 18 23 17 19
[99]
ref_hepatocyte LIMK2
Mean 3.59
Standard deviation 2.1
Values 1.5 3.8 4.5 6.5 1.6
[100]
HepG2 LIMK2
Mean 22.4
Standard deviation 2.3
Values 21 24
[101]
HepG2.C3A LIMK2
Mean 25.9
Standard deviation 5.4
Values 30 22
[102]
HuH.7 LIMK2
Mean 27.6
Standard deviation 1.4
Values 26 29 27
[103]
SNU475 LIMK2
Mean 8.52
Standard deviation 1
Values 7.8 9.3
[104]
THLE LIMK2
Mean 14.9
Standard deviation 3.1
Values 13 17
[105]
liver LIMK2
Mean 12.4
Standard deviation 4.3
Values 6.1 14 15 14
[106]
ref_hepatocyte LIMK1
Mean 2.47
Standard deviation 1.8
Values 1.9 3.4 5.1 1.2 0.66
[107]
HepG2 LIMK1
Mean 26.9
Standard deviation 5.2
Values 31 23
[108]
HepG2.C3A LIMK1
Mean 11.2
Standard deviation 0.18
Values 11 11
[109]
HuH.7 LIMK1
Mean 7.98
Standard deviation 3.2
Values 11 4.9 7.7
[110]
SNU475 LIMK1
Mean 51.7
Standard deviation 1.7
Values 53 50
[111]
THLE LIMK1
Mean 17
Standard deviation 2
Values 16 18
[112]
liver LIMK1
Mean 1.25
Standard deviation 0.53
Values 0.82 1.6 0.77 1.8
[113]
ref_hepatocyte PAK1
Mean 2.3
Standard deviation 0.59
Values 1.7 3 2.9 2.1 1.9
[114]
HepG2 PAK1
Mean 5.05
Standard deviation 1.5
Values 6.1 4
[115]
HepG2.C3A PAK1
Mean 2.65
Standard deviation 0.51
Values 3 2.3
[116]
HuH.7 PAK1
Mean 13.5
Standard deviation 2.2
Values 12 16 12
[117]
SNU475 PAK1
Mean 1.17
Standard deviation 0.24
Values 1 1.3
[118]
THLE PAK1
Mean 18
Standard deviation 0.72
Values 18 17
[119]
liver PAK1
Mean 3.94
Standard deviation 1.1
Values 5.3 4 3.9 2.6
[120]
ref_hepatocyte PPP1R12B
Mean 0.528
Standard deviation 0.18
Values 0.4 0.82 0.5 0.55 0.37
[121]
HepG2 PPP1R12B
Mean 4.96
Standard deviation 2.1
Values 3.5 6.4
[122]
HepG2.C3A PPP1R12B
Mean 7.94
Standard deviation 1.3
Values 8.8 7
[123]
HuH.7 PPP1R12B
Mean 10.1
Standard deviation 2.3
Values 11 12 7.4
[124]
SNU475 PPP1R12B
Mean 15.7
Standard deviation 8.1
Values 21 10
[125]
THLE PPP1R12B
Mean 8.14
Standard deviation 0.7
Values 7.6 8.6
[126]
liver PPP1R12B
Mean 18
Standard deviation 8.2
Values 11 23 11 27
[127]
ref_hepatocyte MYH11
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[128]
HepG2 MYH11
Mean 0.21
Standard deviation 0.067
Values 0.26 0.16
[129]
HepG2.C3A MYH11
Mean 0.145
Standard deviation 0.068
Values 0.097 0.19
[130]
HuH.7 MYH11
Mean 0.169
Standard deviation 0.067
Values 0.15 0.12 0.24
[131]
SNU475 MYH11
Mean 0.217
Standard deviation 0.044
Values 0.19 0.25
[132]
THLE MYH11
Mean 0.133
Standard deviation 0.03
Values 0.11 0.15
[133]
liver MYH11
Mean 13
Standard deviation 16
Values 3 6.1 6.2 37