REACTOME_RHO_GTPASES_ACTIVATE_PAKS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MYL6 Myosin light polypeptide 6 [1] -2.36[2] -1.73[3] -2.56[4] -2.48[5] -1.94[6] -2.27[7]
2 MYL12B Myosin regulatory light chain 12B [8] -1.10[9] -0.53[10] -0.23[11] -1.55[12] -1.37[13] -1.05[14]
3 CDC42 Cell division control protein 42 homolog [15] 0.08[16] 1.25[17] 0.57[18] -0.57[19] -0.41[20] -0.74[21]
4 MYH9 Myosin-9 [22] 2.32[23] 1.23[24] 1.52[25] 1.18[26] 1.96[27] 1.74[28]
5 RAC1 Ras-related C3 botulinum toxin substrate 1 [29] 0.51[30] 0.64[31] 1.68[32] -0.02[33] 0.85[34] 0.38[35]
6 CTTN Src substrate cortactin [36] 1.07[37] 0.75[38] 1.42[39] 1.90[40] 0.69[41] 0.93[42]
7 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit [43] 0.67[44] 1.69[45] 2.11[46] 0.72[47] 1.43[48] 1.84[49]
8 CALM1 Calmodulin-1 [50] 0.98[51] 1.47[52] 2.26[53] 1.55[54] 1.71[55] 2.96[56]
9 FLNA Filamin-A [57] 5.04[58] 3.95[59] 1.33[60] 5.51[61] 5.03[62] 3.50[63]
10 PAK2 Serine/threonine-protein kinase PAK 2 [64] 2.35[65] 2.55[66] 3.18[67] 0.72[68] 2.15[69] 2.71[70]
11 MYLK Myosin light chain kinase, smooth muscle [71] 0.15[72] 0.97[73] 0.67[74] 2.24[75] 0.73[76] 4.36[77]
12 NF2 Merlin [78] 0.88[79] 0.98[80] 2.68[81] 0.40[82] 1.04[83] 2.48[84]
13 MYH14 Myosin-14 [85] 1.79[86] 2.36[87] 2.66[88] 0.46[89] -2.09[90] 2.60[91]
14 MYH10 Myosin-10 [92] 3.24[93] 3.71[94] 4.60[95] 2.43[96] 3.21[97] 3.40[98]
15 MYL9 Myosin regulatory light polypeptide 9 [99] 1.96[100] 2.23[101] -0.13[102] 4.55[103] 2.88[104] 1.27[105]
16 PPP1R12A Protein phosphatase 1 regulatory subunit 12A [106] 1.07[107] 3.25[108] 3.30[109] 2.69[110] 2.50[111] 3.09[112]
17 LIMK1 LIM domain kinase 1 [113] 3.21[114] 2.56[115] 2.46[116] 3.47[117] 2.59[118] -0.14[119]
18 PAK1 Serine/threonine-protein kinase PAK 1 [120] 0.90[121] 0.59[122] 3.33[123] -1.89[124] 2.77[125] 1.61[126]
19 PPP1R12B Protein phosphatase 1 regulatory subunit 12B [127] 2.99[128] 4.29[129] 5.03[130] 3.98[131] 3.75[132] 5.93[133]
20 PAK3 Serine/threonine-protein kinase PAK 3 [134] -5.50[135] [136] [137] -1.64[138] 0.97[139] 2.13[140]
21 MYH11 Myosin-11 [141] 4.27[142] 4.36[143] 4.97[144] 3.64[145] 3.66[146] 11.30[147]
[1]
ref_hepatocyte MYL6
Mean 1.19e+03
Standard deviation 1.2e+03
Values 9.4e+02 3.2e+03 7.6e+02 5.1e+02 5.1e+02
[2]
HepG2 MYL6
Mean 272
Standard deviation 59
Values 2.3e+02 3.1e+02
[3]
HepG2.C3A MYL6
Mean 275
Standard deviation 92
Values 2.1e+02 3.4e+02
[4]
HuH.7 MYL6
Mean 118
Standard deviation 30
Values 1.1e+02 94 1.5e+02
[5]
SNU475 MYL6
Mean 403
Standard deviation 1.9e+02
Values 5.4e+02 2.7e+02
[6]
THLE MYL6
Mean 354
Standard deviation 52
Values 3.2e+02 3.9e+02
[7]
liver MYL6
Mean 138
Standard deviation 1.3e+02
Values 2.6e+02 37 2.3e+02 21
[8]
ref_hepatocyte MYL12B
Mean 317
Standard deviation 2e+02
Values 2e+02 6.8e+02 2.5e+02 2.4e+02 2.1e+02
[9]
HepG2 MYL12B
Mean 174
Standard deviation 36
Values 1.5e+02 2e+02
[10]
HepG2.C3A MYL12B
Mean 168
Standard deviation 40
Values 1.4e+02 2e+02
[11]
HuH.7 MYL12B
Mean 158
Standard deviation 19
Values 1.5e+02 1.4e+02 1.8e+02
[12]
SNU475 MYL12B
Mean 204
Standard deviation 67
Values 2.5e+02 1.6e+02
[13]
THLE MYL12B
Mean 140
Standard deviation 22
Values 1.2e+02 1.6e+02
[14]
liver MYL12B
Mean 85.6
Standard deviation 68
Values 1.5e+02 34 1.4e+02 20
[15]
ref_hepatocyte CDC42
Mean 121
Standard deviation 1e+02
Values 1.6e+02 2.8e+02 75 45 46
[16]
HepG2 CDC42
Mean 150
Standard deviation 13
Values 1.4e+02 1.6e+02
[17]
HepG2.C3A CDC42
Mean 220
Standard deviation 55
Values 1.8e+02 2.6e+02
[18]
HuH.7 CDC42
Mean 105
Standard deviation 19
Values 1.2e+02 83 1.1e+02
[19]
SNU475 CDC42
Mean 153
Standard deviation 20
Values 1.7e+02 1.4e+02
[20]
THLE CDC42
Mean 104
Standard deviation 15
Values 93 1.1e+02
[21]
liver CDC42
Mean 40.5
Standard deviation 9.1
Values 42 43 49 28
[22]
ref_hepatocyte MYH9
Mean 89.9
Standard deviation 85
Values 42 2e+02 1.7e+02 21 22
[23]
HepG2 MYH9
Mean 531
Standard deviation 80
Values 5.9e+02 4.7e+02
[24]
HepG2.C3A MYH9
Mean 161
Standard deviation 42
Values 1.9e+02 1.3e+02
[25]
HuH.7 MYH9
Mean 151
Standard deviation 45
Values 2e+02 1.3e+02 1.2e+02
[26]
SNU475 MYH9
Mean 384
Standard deviation 1.4e+02
Values 4.8e+02 2.9e+02
[27]
THLE MYH9
Mean 399
Standard deviation 1.2e+02
Values 3.1e+02 4.9e+02
[28]
liver MYH9
Mean 167
Standard deviation 46
Values 1.1e+02 2e+02 1.5e+02 2.1e+02
[29]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[30]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[31]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[32]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[33]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[34]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[35]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[36]
ref_hepatocyte CTTN
Mean 46.5
Standard deviation 43
Values 46 1.2e+02 40 15 12
[37]
HepG2 CTTN
Mean 115
Standard deviation 10
Values 1.2e+02 1.1e+02
[38]
HepG2.C3A CTTN
Mean 59.8
Standard deviation 11
Values 67 52
[39]
HuH.7 CTTN
Mean 72.8
Standard deviation 19
Values 82 51 86
[40]
SNU475 CTTN
Mean 327
Standard deviation 70
Values 3.8e+02 2.8e+02
[41]
THLE CTTN
Mean 85.4
Standard deviation 15
Values 75 96
[42]
liver CTTN
Mean 49.4
Standard deviation 14
Values 59 43 63 32
[43]
ref_hepatocyte PPP1CB
Mean 31.9
Standard deviation 30
Values 65 64 8.8 6.2 16
[44]
HepG2 PPP1CB
Mean 59.8
Standard deviation 14
Values 50 70
[45]
HepG2.C3A PPP1CB
Mean 78.8
Standard deviation 12
Values 71 87
[46]
HuH.7 PPP1CB
Mean 80.4
Standard deviation 9.9
Values 92 76 74
[47]
SNU475 PPP1CB
Mean 99.4
Standard deviation 25
Values 1.2e+02 82
[48]
THLE PPP1CB
Mean 98.3
Standard deviation 1.6
Values 99 97
[49]
liver PPP1CB
Mean 64.1
Standard deviation 7.2
Values 67 68 67 53
[50]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[51]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[52]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[53]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[54]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[55]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[56]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[57]
ref_hepatocyte FLNA
Mean 15.1
Standard deviation 16
Values 15 40 17 0.88 2.3
[58]
HepG2 FLNA
Mean 584
Standard deviation 2.4e+02
Values 7.5e+02 4.1e+02
[59]
HepG2.C3A FLNA
Mean 179
Standard deviation 17
Values 1.9e+02 1.7e+02
[60]
HuH.7 FLNA
Mean 22.3
Standard deviation 8.8
Values 32 18 16
[61]
SNU475 FLNA
Mean 1.29e+03
Standard deviation 6.6e+02
Values 1.8e+03 8.3e+02
[62]
THLE FLNA
Mean 565
Standard deviation 1.5e+02
Values 4.6e+02 6.7e+02
[63]
liver FLNA
Mean 95.8
Standard deviation 81
Values 16 1.3e+02 44 1.9e+02
[64]
ref_hepatocyte PAK2
Mean 10.9
Standard deviation 2.8
Values 11 15 11 7.6 9.9
[65]
HepG2 PAK2
Mean 65.6
Standard deviation 14
Values 56 75
[66]
HepG2.C3A PAK2
Mean 49.1
Standard deviation 0.79
Values 49 50
[67]
HuH.7 PAK2
Mean 57.7
Standard deviation 11
Values 66 61 46
[68]
SNU475 PAK2
Mean 33.8
Standard deviation 4.3
Values 37 31
[69]
THLE PAK2
Mean 55.3
Standard deviation 9.9
Values 48 62
[70]
liver PAK2
Mean 39.9
Standard deviation 5.7
Values 44 41 43 32
[71]
ref_hepatocyte MYLK
Mean 9.23
Standard deviation 6.3
Values 2.8 9.4 5.4 9.3 19
[72]
HepG2 MYLK
Mean 12.1
Standard deviation 7.2
Values 7 17
[73]
HepG2.C3A MYLK
Mean 13.8
Standard deviation 0.72
Values 13 14
[74]
HuH.7 MYLK
Mean 8.57
Standard deviation 4
Values 7.7 13 5.1
[75]
SNU475 MYLK
Mean 82.4
Standard deviation 48
Values 1.2e+02 49
[76]
THLE MYLK
Mean 17.5
Standard deviation 3.9
Values 15 20
[77]
liver MYLK
Mean 106
Standard deviation 26
Values 93 1.1e+02 79 1.4e+02
[78]
ref_hepatocyte NF2
Mean 6.12
Standard deviation 5.8
Values 2.6 15 9.6 1.8 1.8
[79]
HepG2 NF2
Mean 13.2
Standard deviation 2
Values 12 15
[80]
HepG2.C3A NF2
Mean 9.21
Standard deviation 0.36
Values 9.5 9
[81]
HuH.7 NF2
Mean 22.9
Standard deviation 7.1
Values 29 15 24
[82]
SNU475 NF2
Mean 15.2
Standard deviation 2
Values 17 14
[83]
THLE NF2
Mean 14.3
Standard deviation 4.1
Values 11 17
[84]
liver NF2
Mean 19.1
Standard deviation 3.3
Values 18 19 16 23
[85]
ref_hepatocyte MYH14
Mean 5.98
Standard deviation 2.3
Values 4.5 5.3 3.5 9.3 7.3
[86]
HepG2 MYH14
Mean 24.3
Standard deviation 8.5
Values 30 18
[87]
HepG2.C3A MYH14
Mean 23.4
Standard deviation 7
Values 28 18
[88]
HuH.7 MYH14
Mean 22.1
Standard deviation 4.6
Values 26 23 17
[89]
SNU475 MYH14
Mean 15.5
Standard deviation 1.9
Values 17 14
[90]
THLE MYH14
Mean 1.6
Standard deviation 1.1
Values 2.4 0.85
[91]
liver MYH14
Mean 20.2
Standard deviation 6.7
Values 20 21 12 28
[92]
ref_hepatocyte MYH10
Mean 5.81
Standard deviation 6.6
Values 17 5.7 1.9 1.6 2.5
[93]
HepG2 MYH10
Mean 64.6
Standard deviation 17
Values 53 76
[94]
HepG2.C3A MYH10
Mean 58.3
Standard deviation 5
Values 55 62
[95]
HuH.7 MYH10
Mean 82.4
Standard deviation 29
Values 1.1e+02 57 76
[96]
SNU475 MYH10
Mean 59.2
Standard deviation 10
Values 66 52
[97]
THLE MYH10
Mean 61.3
Standard deviation 12
Values 53 70
[98]
liver MYH10
Mean 34.4
Standard deviation 12
Values 23 47 25 43
[99]
ref_hepatocyte MYL9
Mean 5.03
Standard deviation 4.9
Values 5.1 13 5.9 0.6 0.89
[100]
HepG2 MYL9
Mean 23.1
Standard deviation 1.3
Values 22 24
[101]
HepG2.C3A MYL9
Mean 18
Standard deviation 3.8
Values 15 21
[102]
HuH.7 MYL9
Mean 2.69
Standard deviation 0.26
Values 2.9 2.4 2.7
[103]
SNU475 MYL9
Mean 222
Standard deviation 1.5e+02
Values 3.3e+02 1.2e+02
[104]
THLE MYL9
Mean 42.5
Standard deviation 9.6
Values 36 49
[105]
liver MYL9
Mean 6.76
Standard deviation 7.5
Values 5.5 1.6 18 2.2
[106]
ref_hepatocyte PPP1R12A
Mean 4
Standard deviation 2.4
Values 6.7 6 4 1.4 1.8
[107]
HepG2 PPP1R12A
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[108]
HepG2.C3A PPP1R12A
Mean 29.1
Standard deviation 5.2
Values 25 33
[109]
HuH.7 PPP1R12A
Mean 23.1
Standard deviation 3.3
Values 22 27 20
[110]
SNU475 PPP1R12A
Mean 48.8
Standard deviation 7.9
Values 54 43
[111]
THLE PPP1R12A
Mean 25.8
Standard deviation 4.4
Values 29 23
[112]
liver PPP1R12A
Mean 19.1
Standard deviation 2.7
Values 18 23 17 19
[113]
ref_hepatocyte LIMK1
Mean 2.47
Standard deviation 1.8
Values 1.9 3.4 5.1 1.2 0.66
[114]
HepG2 LIMK1
Mean 26.9
Standard deviation 5.2
Values 31 23
[115]
HepG2.C3A LIMK1
Mean 11.2
Standard deviation 0.18
Values 11 11
[116]
HuH.7 LIMK1
Mean 7.98
Standard deviation 3.2
Values 11 4.9 7.7
[117]
SNU475 LIMK1
Mean 51.7
Standard deviation 1.7
Values 53 50
[118]
THLE LIMK1
Mean 17
Standard deviation 2
Values 16 18
[119]
liver LIMK1
Mean 1.25
Standard deviation 0.53
Values 0.82 1.6 0.77 1.8
[120]
ref_hepatocyte PAK1
Mean 2.3
Standard deviation 0.59
Values 1.7 3 2.9 2.1 1.9
[121]
HepG2 PAK1
Mean 5.05
Standard deviation 1.5
Values 6.1 4
[122]
HepG2.C3A PAK1
Mean 2.65
Standard deviation 0.51
Values 3 2.3
[123]
HuH.7 PAK1
Mean 13.5
Standard deviation 2.2
Values 12 16 12
[124]
SNU475 PAK1
Mean 1.17
Standard deviation 0.24
Values 1 1.3
[125]
THLE PAK1
Mean 18
Standard deviation 0.72
Values 18 17
[126]
liver PAK1
Mean 3.94
Standard deviation 1.1
Values 5.3 4 3.9 2.6
[127]
ref_hepatocyte PPP1R12B
Mean 0.528
Standard deviation 0.18
Values 0.4 0.82 0.5 0.55 0.37
[128]
HepG2 PPP1R12B
Mean 4.96
Standard deviation 2.1
Values 3.5 6.4
[129]
HepG2.C3A PPP1R12B
Mean 7.94
Standard deviation 1.3
Values 8.8 7
[130]
HuH.7 PPP1R12B
Mean 10.1
Standard deviation 2.3
Values 11 12 7.4
[131]
SNU475 PPP1R12B
Mean 15.7
Standard deviation 8.1
Values 21 10
[132]
THLE PPP1R12B
Mean 8.14
Standard deviation 0.7
Values 7.6 8.6
[133]
liver PPP1R12B
Mean 18
Standard deviation 8.2
Values 11 23 11 27
[134]
ref_hepatocyte PAK3
Mean 0.0826
Standard deviation 0.14
Values 0 0 0.33 0 0.081
[135]
HepG2 PAK3
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[136]
HepG2.C3A PAK3
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 PAK3
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 PAK3
Mean 0.05
Standard deviation 0.051
Values 0.014 0.086
[139]
THLE PAK3
Mean 0.185
Standard deviation 0.065
Values 0.23 0.14
[140]
liver PAK3
Mean 0.202
Standard deviation 0.041
Values 0.24 0.14 0.21 0.23
[141]
ref_hepatocyte MYH11
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[142]
HepG2 MYH11
Mean 0.21
Standard deviation 0.067
Values 0.26 0.16
[143]
HepG2.C3A MYH11
Mean 0.145
Standard deviation 0.068
Values 0.097 0.19
[144]
HuH.7 MYH11
Mean 0.169
Standard deviation 0.067
Values 0.15 0.12 0.24
[145]
SNU475 MYH11
Mean 0.217
Standard deviation 0.044
Values 0.19 0.25
[146]
THLE MYH11
Mean 0.133
Standard deviation 0.03
Values 0.11 0.15
[147]
liver MYH11
Mean 13
Standard deviation 16
Values 3 6.1 6.2 37