REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAC1 Ras-related C3 botulinum toxin substrate 1 [1] -0.65[2] -1.00[3] -0.15[4] 0.01[5] -0.11[6] -0.84[7]
2 S100A9 Protein S100-A9 [8] -6.43[9] -8.93[10] -6.82[11] -8.73[12] -9.35[13] -1.82[14]
3 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [15] -1.29[16] -1.26[17] -0.87[18] -1.66[19] -0.63[20] -1.23[21]
4 CYBA Cytochrome b-245 light chain [22] 1.24[23] 1.25[24] 0.29[25] 0.21[26] 0.00[27] -1.29[28]
5 NCF2 Neutrophil cytosol factor 2 [29] -2.06[30] -4.79[31] -8.41[32] -2.89[33] -9.61[34] -2.29[35]
6 MAPK1 Mitogen-activated protein kinase 1 [36] 1.46[37] 1.57[38] 1.54[39] 1.84[40] 1.39[41] 1.90[42]
7 MAPK14 Mitogen-activated protein kinase 14 [43] 1.22[44] 1.26[45] 0.98[46] 1.68[47] 1.05[48] 1.41[49]
8 PRKCZ Protein kinase C zeta type [50] 0.22[51] 0.57[52] -1.29[53] -2.30[54] -4.60[55] -1.51[56]
9 PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 [57] 0.13[58] 0.73[59] -0.04[60] 0.80[61] 0.91[62] 0.76[63]
10 MAPK3 Mitogen-activated protein kinase 3 [64] 1.60[65] 1.61[66] 1.80[67] 0.42[68] 0.34[69] -0.91[70]
11 S100A8 Protein S100-A8 [71] [72] [73] [74] -9.48[75] [76] 0.18[77]
12 RAC2 Ras-related C3 botulinum toxin substrate 2 [78] -1.96[79] -7.98[80] -8.45[81] -1.39[82] 2.31[83] -1.10[84]
13 PRKCD Protein kinase C delta type [85] 0.85[86] 1.07[87] 0.69[88] -0.51[89] 0.55[90] -0.94[91]
14 PRKCA Protein kinase C alpha type [92] 2.58[93] 2.60[94] 3.10[95] 2.15[96] 2.40[97] 2.05[98]
15 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 [99] 0.91[100] 0.94[101] 2.05[102] 1.66[103] 2.03[104] 3.00[105]
16 NOXA1 NADPH oxidase activator 1 [106] -2.61[107] -0.88[108] -1.77[109] -2.39[110] -3.71[111] -0.85[112]
17 NCF1 Neutrophil cytosol factor 1 [113] -7.41[114] -9.50[115] [116] [117] -9.40[118] -2.67[119]
18 CYBB Cytochrome b-245 heavy chain [120] [121] [122] -10.36[123] -4.48[124] -10.13[125] 3.18[126]
19 NCF4 Neutrophil cytosol factor 4 [127] -6.02[128] -8.37[129] [130] -8.06[131] [132] 1.04[133]
20 MAPK11 Mitogen-activated protein kinase 11 [134] -0.42[135] -0.56[136] -1.30[137] 0.35[138] 2.24[139] 0.29[140]
21 NOXO1 NADPH oxidase organizer 1 [141] -0.76[142] 0.52[143] -2.02[144] -2.50[145] -2.37[146] -0.59[147]
22 PRKCB Protein kinase C beta type [148] -7.06[149] -5.90[150] [151] 2.48[152] -2.93[153] 3.66[154]
23 NOX1 NADPH oxidase 1 [155] 0.10[156] -0.70[157] 4.61[158] -0.07[159] 1.21[160] 0.96[161]
24 NOX3 NADPH oxidase 3 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[2]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[3]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[4]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[5]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[6]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[7]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[8]
ref_hepatocyte S100A9
Mean 27.8
Standard deviation 27
Values 0 0.21 61 46 32
[9]
HepG2 S100A9
Mean 0.849
Standard deviation 0.92
Values 1.5 0.2
[10]
HepG2.C3A S100A9
Mean 0.136
Standard deviation 0.11
Values 0.058 0.21
[11]
HuH.7 S100A9
Mean 0.51
Standard deviation 0.36
Values 0.57 0.12 0.84
[12]
SNU475 S100A9
Mean 0.121
Standard deviation 0.15
Values 0.014 0.23
[13]
THLE S100A9
Mean 0.0943
Standard deviation 0.051
Values 0.13 0.059
[14]
liver S100A9
Mean 10.3
Standard deviation 5.8
Values 7.9 4.3 18 11
[15]
ref_hepatocyte PIN1
Mean 17.7
Standard deviation 5
Values 10 23 15 21 20
[16]
HepG2 PIN1
Mean 19
Standard deviation 0.013
Values 19 19
[17]
HepG2.C3A PIN1
Mean 17.6
Standard deviation 3.2
Values 15 20
[18]
HuH.7 PIN1
Mean 20
Standard deviation 7.8
Values 21 12 27
[19]
SNU475 PIN1
Mean 10.3
Standard deviation 1.6
Values 11 9.1
[20]
THLE PIN1
Mean 25.3
Standard deviation 2.3
Values 24 27
[21]
liver PIN1
Mean 9.77
Standard deviation 5.8
Values 15 4.4 15 5.2
[22]
ref_hepatocyte CYBA
Mean 14.8
Standard deviation 11
Values 26 0 10 13 25
[23]
HepG2 CYBA
Mean 91.8
Standard deviation 21
Values 1.1e+02 77
[24]
HepG2.C3A CYBA
Mean 84.2
Standard deviation 25
Values 1e+02 67
[25]
HuH.7 CYBA
Mean 37.6
Standard deviation 8.2
Values 39 29 45
[26]
SNU475 CYBA
Mean 31.6
Standard deviation 8
Values 37 26
[27]
THLE CYBA
Mean 32.9
Standard deviation 4.2
Values 30 36
[28]
liver CYBA
Mean 7.9
Standard deviation 3.4
Values 12 5.8 9.4 4.5
[29]
ref_hepatocyte NCF2
Mean 11.1
Standard deviation 17
Values 2.1 41 8.8 0.91 2.3
[30]
HepG2 NCF2
Mean 6.97
Standard deviation 4
Values 9.8 4.1
[31]
HepG2.C3A NCF2
Mean 0.954
Standard deviation 0.27
Values 1.1 0.76
[32]
HuH.7 NCF2
Mean 0.0674
Standard deviation 0.042
Values 0.049 0.12 0.037
[33]
SNU475 NCF2
Mean 2.75
Standard deviation 1.4
Values 1.7 3.8
[34]
THLE NCF2
Mean 0.0313
Standard deviation 0.014
Values 0.041 0.021
[35]
liver NCF2
Mean 2.95
Standard deviation 1.6
Values 1 3.9 2.3 4.5
[36]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[37]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[38]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[39]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[40]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[41]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[42]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[43]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[44]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[45]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[46]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[47]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[48]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[49]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[50]
ref_hepatocyte PRKCZ
Mean 7.98
Standard deviation 3.5
Values 14 4.6 6.7 8.2 6.6
[51]
HepG2 PRKCZ
Mean 24.4
Standard deviation 2
Values 26 23
[52]
HepG2.C3A PRKCZ
Mean 28.4
Standard deviation 7.3
Values 33 23
[53]
HuH.7 PRKCZ
Mean 6.79
Standard deviation 1.7
Values 6.1 8.8 5.5
[54]
SNU475 PRKCZ
Mean 2.98
Standard deviation 1.9
Values 4.4 1.6
[55]
THLE PRKCZ
Mean 0.727
Standard deviation 0.035
Values 0.75 0.7
[56]
liver PRKCZ
Mean 3.64
Standard deviation 0.55
Values 2.9 3.9 4.2 3.5
[57]
ref_hepatocyte PIK3C3
Mean 4.59
Standard deviation 2.3
Values 8 5.9 2.3 3.8 3
[58]
HepG2 PIK3C3
Mean 13.2
Standard deviation 3.3
Values 11 16
[59]
HepG2.C3A PIK3C3
Mean 18.2
Standard deviation 1.3
Values 17 19
[60]
HuH.7 PIK3C3
Mean 9.26
Standard deviation 1.9
Values 9.1 11 7.5
[61]
SNU475 PIK3C3
Mean 14.7
Standard deviation 3.2
Values 17 12
[62]
THLE PIK3C3
Mean 19.1
Standard deviation 0.92
Values 18 20
[63]
liver PIK3C3
Mean 10.1
Standard deviation 4.2
Values 6.9 15 6.8 11
[64]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[65]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[66]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[67]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[68]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[69]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[70]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[71]
ref_hepatocyte S100A8
Mean 3.94
Standard deviation 5.3
Values 0 0 0.42 8.5 11
[72]
HepG2 S100A8
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A S100A8
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 S100A8
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 S100A8
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[76]
THLE S100A8
Mean 0
Standard deviation 0
Values 0 0
[77]
liver S100A8
Mean 5.79
Standard deviation 5.5
Values 9.2 0.63 12 1.6
[78]
ref_hepatocyte RAC2
Mean 3.71
Standard deviation 4.6
Values 0 0.72 11 1.6 5.1
[79]
HepG2 RAC2
Mean 2.5
Standard deviation 2.1
Values 4 1
[80]
HepG2.C3A RAC2
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[81]
HuH.7 RAC2
Mean 0.0221
Standard deviation 0.018
Values 0.041 0.0064 0.019
[82]
SNU475 RAC2
Mean 2.6
Standard deviation 0.081
Values 2.5 2.7
[83]
THLE RAC2
Mean 40.7
Standard deviation 12
Values 32 49
[84]
liver RAC2
Mean 2.24
Standard deviation 1.8
Values 3.9 0.44 3.7 0.86
[85]
ref_hepatocyte PRKCD
Mean 3.58
Standard deviation 2
Values 5.9 2.9 5.5 2.1 1.5
[86]
HepG2 PRKCD
Mean 16.9
Standard deviation 3.4
Values 19 15
[87]
HepG2.C3A PRKCD
Mean 17.9
Standard deviation 3.3
Values 20 16
[88]
HuH.7 PRKCD
Mean 12
Standard deviation 0.2
Values 12 12 12
[89]
SNU475 PRKCD
Mean 4.64
Standard deviation 0.32
Values 4.4 4.9
[90]
THLE PRKCD
Mean 11.6
Standard deviation 1.2
Values 11 12
[91]
liver PRKCD
Mean 2.43
Standard deviation 1
Values 3.9 1.4 2.2 2.3
[92]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[93]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[94]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[95]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[96]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[97]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[98]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[99]
ref_hepatocyte PIK3R4
Mean 1.95
Standard deviation 0.81
Values 1.4 1.7 1.2 2.4 3.2
[100]
HepG2 PIK3R4
Mean 9.67
Standard deviation 3.2
Values 7.4 12
[101]
HepG2.C3A PIK3R4
Mean 8.97
Standard deviation 1.7
Values 7.8 10
[102]
HuH.7 PIK3R4
Mean 16.8
Standard deviation 2.8
Values 20 14 16
[103]
SNU475 PIK3R4
Mean 11.4
Standard deviation 0.1
Values 11 11
[104]
THLE PIK3R4
Mean 17.7
Standard deviation 1.3
Values 17 19
[105]
liver PIK3R4
Mean 20.3
Standard deviation 7.7
Values 15 27 12 27
[106]
ref_hepatocyte NOXA1
Mean 1.89
Standard deviation 1.8
Values 0.22 0.24 1.3 3.9 3.9
[107]
HepG2 NOXA1
Mean 0.811
Standard deviation 0.3
Values 1 0.6
[108]
HepG2.C3A NOXA1
Mean 2.46
Standard deviation 1.3
Values 3.4 1.5
[109]
HuH.7 NOXA1
Mean 1.15
Standard deviation 0.47
Values 0.78 1.7 0.98
[110]
SNU475 NOXA1
Mean 0.661
Standard deviation 0.38
Values 0.93 0.39
[111]
THLE NOXA1
Mean 0.319
Standard deviation 0.23
Values 0.48 0.16
[112]
liver NOXA1
Mean 1.37
Standard deviation 0.56
Values 2.2 0.98 1.3 0.98
[113]
ref_hepatocyte NCF1
Mean 1.62
Standard deviation 1.4
Values 0.59 0 3.2 1.3 3
[114]
HepG2 NCF1
Mean 0.0251
Standard deviation 0.029
Values 0.046 0.0043
[115]
HepG2.C3A NCF1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[116]
HuH.7 NCF1
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 NCF1
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE NCF1
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[119]
liver NCF1
Mean 0.332
Standard deviation 0.26
Values 0.71 0.11 0.28 0.23
[120]
ref_hepatocyte CYBB
Mean 1.35
Standard deviation 1.5
Values 0 0.46 0.67 1.8 3.8
[121]
HepG2 CYBB
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A CYBB
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 CYBB
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[124]
SNU475 CYBB
Mean 0.112
Standard deviation 0.007
Values 0.11 0.12
[125]
THLE CYBB
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[126]
liver CYBB
Mean 15.9
Standard deviation 11
Values 5.9 32 9.6 16
[127]
ref_hepatocyte NCF4
Mean 0.67
Standard deviation 0.95
Values 0 0 0 1.3 2
[128]
HepG2 NCF4
Mean 0.0272
Standard deviation 0.026
Values 0.046 0.0086
[129]
HepG2.C3A NCF4
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[130]
HuH.7 NCF4
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 NCF4
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[132]
THLE NCF4
Mean 0
Standard deviation 0
Values 0 0
[133]
liver NCF4
Mean 1.79
Standard deviation 0.9
Values 2.7 0.63 2.2 1.6
[134]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0 0.34 0.22 0.71 0.64
[135]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.62 0.88
[136]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.53 0.71
[137]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.28 0.2 0.49
[138]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 1.1 0.66
[139]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[140]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.96 0.49 0.23 0.75
[141]
ref_hepatocyte NOXO1
Mean 0.29
Standard deviation 0.33
Values 0.21 0 0 0.47 0.76
[142]
HepG2 NOXO1
Mean 0.451
Standard deviation 0.2
Values 0.31 0.59
[143]
HepG2.C3A NOXO1
Mean 0.996
Standard deviation 0.24
Values 1.2 0.83
[144]
HuH.7 NOXO1
Mean 0.148
Standard deviation 0.04
Values 0.16 0.1 0.18
[145]
SNU475 NOXO1
Mean 0.0941
Standard deviation 0.068
Values 0.046 0.14
[146]
THLE NOXO1
Mean 0.124
Standard deviation 0.058
Values 0.083 0.16
[147]
liver NOXO1
Mean 0.25
Standard deviation 0.1
Values 0.12 0.24 0.28 0.36
[148]
ref_hepatocyte PRKCB
Mean 0.255
Standard deviation 0.29
Values 0 0 0.4 0.2 0.67
[149]
HepG2 PRKCB
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[150]
HepG2.C3A PRKCB
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[151]
HuH.7 PRKCB
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 PRKCB
Mean 2.62
Standard deviation 2.8
Values 0.61 4.6
[153]
THLE PRKCB
Mean 0.0742
Standard deviation 0.037
Values 0.1 0.048
[154]
liver PRKCB
Mean 4.2
Standard deviation 2.1
Values 2.7 6.8 2.2 5
[155]
ref_hepatocyte NOX1
Mean 0.0251
Standard deviation 0.034
Values 0 0 0 0.06 0.065
[156]
HepG2 NOX1
Mean 0.0708
Standard deviation 0.027
Values 0.052 0.09
[157]
HepG2.C3A NOX1
Mean 0.037
Standard deviation 0.039
Values 0.0097 0.064
[158]
HuH.7 NOX1
Mean 1.27
Standard deviation 0.85
Values 1.8 0.29 1.8
[159]
SNU475 NOX1
Mean 0.0441
Standard deviation 0.016
Values 0.032 0.056
[160]
THLE NOX1
Mean 0.129
Standard deviation 0.069
Values 0.18 0.08
[161]
liver NOX1
Mean 0.0636
Standard deviation 0.1
Values 0.21 0.043 0 0
[162]
ref_hepatocyte NOX3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 NOX3
Mean 0.0644
Standard deviation 0.055
Values 0.1 0.026
[164]
HepG2.C3A NOX3
Mean 0.0662
Standard deviation 0.0026
Values 0.068 0.064
[165]
HuH.7 NOX3
Mean 0.0259
Standard deviation 0.016
Values 0.0082 0.032 0.037
[166]
SNU475 NOX3
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[167]
THLE NOX3
Mean 0
Standard deviation 0
Values 0 0
[168]
liver NOX3
Mean 0
Standard deviation 0
Values 0 0 0 0