REACTOME_RHOG_GTPASE_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSPE1 | 10 kDa heat shock protein, mitochondrial | [1] | -2.78[2] | -2.15[3] | -3.72[4] | -4.44[5] | -4.46[6] | -2.75[7] |
2 | ITGB1 | Integrin beta-1 | [8] | 0.24[9] | 0.03[10] | 0.20[11] | 1.23[12] | 1.37[13] | 0.10[14] |
3 | CDC42 | Cell division control protein 42 homolog | [15] | -0.82[16] | -0.33[17] | -1.31[18] | -0.76[19] | -1.42[20] | -2.15[21] |
4 | RAB7A | Ras-related protein Rab-7a | [22] | -0.79[23] | -1.54[24] | -1.31[25] | -1.30[26] | -0.70[27] | -1.37[28] |
5 | ARHGDIA | Rho GDP-dissociation inhibitor 1 | [29] | -0.51[30] | -1.42[31] | -2.14[32] | -1.22[33] | -0.80[34] | -1.89[35] |
6 | SHMT2 | Serine hydroxymethyltransferase, mitochondrial | [36] | -0.11[37] | 0.74[38] | 0.29[39] | -1.88[40] | -0.55[41] | -0.19[42] |
7 | LMAN1 | Protein ERGIC-53 | [43] | -0.18[44] | 0.71[45] | 0.75[46] | -0.19[47] | 0.33[48] | 1.68[49] |
8 | NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | -1.24[50] | -1.46[51] | -1.10[52] | -2.77[53] | -2.28[54] | -1.41[55] | |
9 | STBD1 | Starch-binding domain-containing protein 1 | [56] | -4.52[57] | -4.96[58] | -5.02[59] | -5.83[60] | -7.37[61] | -3.09[62] |
10 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [63] | -0.61[64] | -1.59[65] | -1.65[66] | -1.31[67] | -1.29[68] | -1.36[69] |
11 | CDC42EP1 | Cdc42 effector protein 1 | [70] | 0.16[71] | -0.88[72] | -0.50[73] | -2.80[74] | -0.96[75] | -0.67[76] |
12 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | [77] | -1.90[78] | -0.95[79] | -0.81[80] | -1.72[81] | -1.47[82] | -0.30[83] |
13 | KTN1 | Kinectin | [84] | -0.71[85] | 1.24[86] | 0.91[87] | 1.68[88] | 0.29[89] | 0.86[90] |
14 | CAV1 | Caveolin-1 | [91] | -6.83[92] | -9.88[93] | -3.58[94] | 1.15[95] | -0.14[96] | -2.06[97] |
15 | VAMP3 | Vesicle-associated membrane protein 3 | [98] | 0.24[99] | 0.55[100] | -0.22[101] | 0.49[102] | 0.10[103] | -1.08[104] |
16 | YKT6 | Synaptobrevin homolog YKT6 | [105] | 0.40[106] | -0.21[107] | -0.72[108] | 0.28[109] | 0.11[110] | -1.97[111] |
17 | ARFGAP3 | ADP-ribosylation factor GTPase-activating protein 3 | [112] | -0.73[113] | -0.08[114] | -0.54[115] | -1.47[116] | -1.30[117] | 0.22[118] |
18 | ESYT1 | Extended synaptotagmin-1 | [119] | 1.16[120] | 0.30[121] | 0.23[122] | 0.50[123] | 0.74[124] | 1.00[125] |
19 | EMD | Emerin | [126] | -1.08[127] | -1.36[128] | -1.61[129] | -0.65[130] | -0.60[131] | -2.12[132] |
20 | PGRMC2 | Membrane-associated progesterone receptor component 2 | [133] | -0.32[134] | 0.19[135] | -0.14[136] | -0.70[137] | 0.14[138] | -0.32[139] |
21 | IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | [140] | -0.81[141] | 1.18[142] | 1.39[143] | -4.72[144] | -7.16[145] | 2.54[146] |
22 | TFRC | Transferrin receptor protein 1 | [147] | 3.45[148] | 2.71[149] | 2.86[150] | 1.22[151] | 2.77[152] | 1.52[153] |
23 | STX5 | Syntaxin-5 | [154] | -0.56[155] | -0.42[156] | -0.32[157] | -1.12[158] | -0.74[159] | -0.76[160] |
24 | PAK2 | Serine/threonine-protein kinase PAK 2 | [161] | 1.46[162] | 0.97[163] | 1.30[164] | 0.53[165] | 1.13[166] | 1.30[167] |
25 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | [168] | 1.10[169] | 0.81[170] | 0.46[171] | -0.08[172] | -0.16[173] | 0.40[174] |
26 | LBR | Lamin-B receptor | [175] | 0.75[176] | 1.23[177] | 2.11[178] | 1.11[179] | 0.22[180] | 0.72[181] |
27 | CYFIP1 | Cytoplasmic FMR1-interacting protein 1 | [182] | 1.28[183] | 0.64[184] | 0.30[185] | 0.90[186] | 0.71[187] | 1.26[188] |
28 | TMPO | Lamina-associated polypeptide 2, isoform alpha | [189] | 0.96[190] | 1.50[191] | 1.80[192] | 1.93[193] | 1.88[194] | 0.74[195] |
29 | ITSN1 | Intersectin-1 | [196] | -0.10[197] | -0.22[198] | 0.57[199] | 0.78[200] | 1.10[201] | 1.66[202] |
30 | VAV2 | Guanine nucleotide exchange factor VAV2 | [203] | 1.31[204] | 1.33[205] | 0.85[206] | -0.76[207] | -0.28[208] | 0.45[209] |
31 | DSG2 | Desmoglein-2 | [210] | 1.66[211] | 1.90[212] | 1.13[213] | 2.33[214] | 1.91[215] | 0.48[216] |
32 | ANKLE2 | Ankyrin repeat and LEM domain-containing protein 2 | [217] | 0.28[218] | 0.54[219] | 0.29[220] | 0.89[221] | 1.45[222] | 0.04[223] |
33 | EPHA2 | Ephrin type-A receptor 2 | [224] | 2.26[225] | 2.24[226] | 0.10[227] | 0.71[228] | 1.33[229] | -0.84[230] |
34 | RHOG | Rho-related GTP-binding protein RhoG | [231] | 0.28[232] | -1.14[233] | -1.17[234] | -0.20[235] | -0.57[236] | -0.76[237] |
35 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [238] | -0.46[239] | -0.58[240] | 0.55[241] | 1.84[242] | 1.40[243] | 2.94[244] |
36 | LETM1 | Mitochondrial proton/calcium exchanger protein | [245] | 1.00[246] | 0.22[247] | 0.90[248] | 0.43[249] | 0.62[250] | 1.51[251] |
37 | VAPB | Vesicle-associated membrane protein-associated protein B/C | [252] | 1.73[253] | 1.62[254] | 1.17[255] | 1.89[256] | 1.25[257] | 1.29[258] |
38 | ARHGDIB | Rho GDP-dissociation inhibitor 2 | [259] | -5.04[260] | -5.47[261] | -6.39[262] | -1.83[263] | -1.34[264] | 0.66[265] |
39 | ELMO2 | Engulfment and cell motility protein 2 | [266] | 0.98[267] | 0.91[268] | -0.67[269] | 1.21[270] | 0.28[271] | 0.10[272] |
40 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [273] | -4.00[274] | -2.99[275] | -2.73[276] | -2.52[277] | -2.39[278] | -2.47[279] |
41 | PAK4 | Serine/threonine-protein kinase PAK 4 | [280] | 0.90[281] | 0.71[282] | 1.44[283] | 0.80[284] | 0.58[285] | -0.39[286] |
42 | VRK2 | Serine/threonine-protein kinase VRK2 | [287] | -1.05[288] | -0.15[289] | -1.29[290] | -0.43[291] | -0.73[292] | -0.66[293] |
43 | ARHGAP2 | Rho GTPase-activating protein 21 | [294] | 0.58[295] | 1.32[296] | 2.23[297] | 2.89[298] | 1.69[299] | 1.67[300] |
44 | ARHGAP3 | Rho GTPase-activating protein 35 | [301] | 2.35[302] | 2.25[303] | 2.83[304] | 2.51[305] | 2.15[306] | 3.20[307] |
45 | ARHGAP1 | Rho GTPase-activating protein 1 | [308] | 1.79[309] | 1.16[310] | 1.69[311] | 0.27[312] | 0.53[313] | 1.57[314] |
46 | TRIO | Triple functional domain protein | [315] | 2.01[316] | 1.51[317] | 1.79[318] | 2.38[319] | 3.32[320] | 2.69[321] |
47 | ARHGAP5 | Rho GTPase-activating protein 5 | [322] | 2.42[323] | 1.79[324] | 5.13[325] | 2.34[326] | 1.99[327] | 3.08[328] |
48 | PLEKHG3 | Pleckstrin homology domain-containing family G member 3 | [329] | -0.20[330] | -0.20[331] | 0.59[332] | 0.03[333] | -0.72[334] | 0.74[335] |
49 | MCAM | Cell surface glycoprotein MUC18 | [336] | 3.42[337] | 0.43[338] | -1.55[339] | 4.05[340] | 1.31[341] | 0.17[342] |
50 | DOCK1 | Dedicator of cytokinesis protein 1 | [343] | 1.99[344] | 2.30[345] | 2.31[346] | -2.88[347] | 1.99[348] | 2.46[349] |
51 | LEMD3 | Inner nuclear membrane protein Man1 | [350] | 0.91[351] | 1.65[352] | 1.63[353] | 0.99[354] | 1.53[355] | 1.40[356] |
52 | DEPDC1B | DEP domain-containing protein 1B | [357] | 1.19[358] | 2.50[359] | 2.74[360] | 0.78[361] | 1.38[362] | -3.05[363] |
53 | PLD1 | Phospholipase D1 | [364] | 2.43[365] | 2.91[366] | 3.43[367] | 0.82[368] | 1.47[369] | 2.00[370] |
54 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | [371] | -0.94[372] | -0.18[373] | 0.43[374] | 0.15[375] | 1.81[376] | 3.17[377] |
55 | DIAPH3 | Protein diaphanous homolog 3 | [378] | -0.03[379] | 0.83[380] | 1.34[381] | 1.34[382] | 2.25[383] | -2.65[384] |
56 | DOCK4 | Dedicator of cytokinesis protein 4 | [385] | 2.61[386] | 2.01[387] | 2.26[388] | 2.09[389] | 0.48[390] | 3.60[391] |
57 | DOCK5 | Dedicator of cytokinesis protein 5 | [392] | 2.02[393] | 2.34[394] | 1.94[395] | 1.48[396] | 2.21[397] | 3.77[398] |
58 | MCF2L | Guanine nucleotide exchange factor DBS | [399] | 2.29[400] | 2.24[401] | 0.08[402] | -4.84[403] | -8.00[404] | 1.45[405] |
59 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | [406] | 2.88[407] | 4.02[408] | 0.23[409] | 1.73[410] | -1.77[411] | 0.83[412] |
60 | MPP7 | MAGUK p55 subfamily member 7 | [413] | 0.10[414] | 2.44[415] | -2.07[416] | 3.10[417] | -1.95[418] | 1.07[419] |
61 | KALRN | Kalirin | [420] | 1.36[421] | 2.67[422] | 2.20[423] | 1.68[424] | -2.92[425] | 3.50[426] |
62 | VANGL1 | Vang-like protein 1 | [427] | 2.98[428] | 2.19[429] | 1.64[430] | 3.98[431] | 3.72[432] | 2.63[433] |
63 | VAV3 | Guanine nucleotide exchange factor VAV3 | [434] | 1.82[435] | -0.13[436] | 2.08[437] | 3.46[438] | -2.46[439] | 1.29[440] |
64 | OPHN1 | Oligophrenin-1 | [441] | 1.72[442] | 1.51[443] | 2.12[444] | 2.96[445] | 1.59[446] | 4.68[447] |
65 | VAV1 | Proto-oncogene vav | [448] | -8.49[449] | -3.89[450] | -5.57[451] | -6.31[452] | -7.52[453] | 1.12[454] |
66 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -0.41[455] | -6.46[456] | -4.12[457] | 4.88[458] | 3.29[459] | 4.14[460] | |
67 | ARHGAP3 | Rho GTPase-activating protein 32 | [461] | 3.74[462] | 3.30[463] | 2.40[464] | 4.25[465] | 2.87[466] | 4.11[467] |
68 | DOCK2 | Dedicator of cytokinesis protein 2 | [468] | -4.44[469] | [470] | -6.80[471] | 2.26[472] | 1.21[473] | 4.27[474] |
69 | ARHGAP3 | Rho GTPase-activating protein 39 | [475] | 2.96[476] | 2.59[477] | 2.62[478] | 2.50[479] | 0.86[480] | 0.69[481] |
70 | DOCK3 | Dedicator of cytokinesis protein 3 | [482] | 0.73[483] | 0.40[484] | 1.34[485] | 4.80[486] | 1.31[487] | 2.96[488] |
71 | ERBIN | Erbin | [489] | [490] | [491] | [492] | [493] | [494] | [495] |
72 | GARRE1 | [496] | [497] | [498] | [499] | [500] | [501] | [502] | |
73 | ARHGDIG | Rho GDP-dissociation inhibitor 3 | [503] | [504] | [505] | [506] | [507] | [508] | [509] |
74 | MCF2 | Proto-oncogene DBL | [510] | [511] | [512] | [513] | [514] | [515] | [516] |