REACTOME_RHOC_GTPASE_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.20[2] | -1.82[3] | -1.69[4] | -1.67[5] | -1.10[6] | -1.83[7] |
2 | RHOC | Rho-related GTP-binding protein RhoC | [8] | -1.84[9] | -2.36[10] | -2.88[11] | -1.45[12] | -1.47[13] | -3.20[14] |
3 | C1QBP | Complement component 1 Q subcomponent-binding protein, mitochondrial | -1.31[15] | -1.63[16] | -1.83[17] | -2.46[18] | -2.41[19] | -2.35[20] | |
4 | ARHGDIA | Rho GDP-dissociation inhibitor 1 | [21] | -0.78[22] | -1.59[23] | -2.42[24] | -1.44[25] | -0.96[26] | -2.34[27] |
5 | STOM | Erythrocyte band 7 integral membrane protein | [28] | -1.59[29] | -1.56[30] | -1.24[31] | -1.51[32] | -2.78[33] | 0.72[34] |
6 | FLOT1 | Flotillin-1 | [35] | -0.89[36] | -0.50[37] | -1.22[38] | -0.24[39] | -0.97[40] | -1.76[41] |
7 | LMAN1 | Protein ERGIC-53 | [42] | -0.46[43] | 0.55[44] | 0.47[45] | -0.41[46] | 0.17[47] | 1.23[48] |
8 | FLOT2 | Flotillin-2 | [49] | -0.78[50] | -0.97[51] | -0.69[52] | -0.80[53] | -0.98[54] | 0.04[55] |
9 | DIAPH1 | Protein diaphanous homolog 1 | [56] | 0.35[57] | -0.12[58] | 0.22[59] | -0.52[60] | 0.01[61] | 0.42[62] |
10 | CAV1 | Caveolin-1 | [63] | -7.10[64] | -10.05[65] | -3.86[66] | 0.93[67] | -0.31[68] | -2.51[69] |
11 | RTKN | Rhotekin | [70] | -0.46[71] | 0.25[72] | -1.68[73] | -3.56[74] | -3.54[75] | -0.57[76] |
12 | VAMP3 | Vesicle-associated membrane protein 3 | [77] | -0.03[78] | 0.39[79] | -0.51[80] | 0.28[81] | -0.06[82] | -1.53[83] |
13 | JUP | Junction plakoglobin | [84] | 0.73[85] | -0.61[86] | -0.43[87] | -1.00[88] | -1.57[89] | -0.10[90] |
14 | TJP2 | Tight junction protein ZO-2 | [91] | 1.16[92] | 0.81[93] | 0.89[94] | -1.95[95] | 0.72[96] | -0.03[97] |
15 | ABCD3 | ATP-binding cassette sub-family D member 3 | [98] | -0.42[99] | 0.31[100] | 0.27[101] | -0.63[102] | -0.59[103] | 1.20[104] |
16 | TFRC | Transferrin receptor protein 1 | [105] | 3.17[106] | 2.54[107] | 2.58[108] | 1.00[109] | 2.60[110] | 1.07[111] |
17 | ARHGAP1 | Rho GTPase-activating protein 18 | [112] | 0.07[113] | 1.66[114] | 0.10[115] | -1.33[116] | -0.45[117] | -2.83[118] |
18 | STX5 | Syntaxin-5 | [119] | -0.83[120] | -0.58[121] | -0.61[122] | -1.34[123] | -0.90[124] | -1.21[125] |
19 | LBR | Lamin-B receptor | [126] | 0.47[127] | 1.06[128] | 1.83[129] | 0.89[130] | 0.05[131] | 0.27[132] |
20 | PKN1 | Serine/threonine-protein kinase N1 | [133] | 1.76[134] | 0.60[135] | 1.56[136] | 0.43[137] | 1.23[138] | -1.06[139] |
21 | TMPO | Lamina-associated polypeptide 2, isoform alpha | [140] | 0.69[141] | 1.34[142] | 1.52[143] | 1.71[144] | 1.72[145] | 0.29[146] |
22 | ACBD5 | Acyl-CoA-binding domain-containing protein 5 | [147] | -1.22[148] | -0.08[149] | 1.14[150] | 0.58[151] | -0.47[152] | 0.53[153] |
23 | VAV2 | Guanine nucleotide exchange factor VAV2 | [154] | 1.04[155] | 1.16[156] | 0.57[157] | -0.98[158] | -0.44[159] | 0.00[160] |
24 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [161] | 0.25[162] | 2.42[163] | 1.13[164] | -0.53[165] | -2.00[166] | 2.49[167] |
25 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [168] | -0.73[169] | -0.74[170] | 0.26[171] | 1.62[172] | 1.24[173] | 2.49[174] |
26 | ROCK1 | Rho-associated protein kinase 1 | [175] | -1.22[176] | 0.18[177] | 0.87[178] | 0.92[179] | 0.38[180] | 1.07[181] |
27 | VAPB | Vesicle-associated membrane protein-associated protein B/C | [182] | 1.46[183] | 1.46[184] | 0.88[185] | 1.67[186] | 1.09[187] | 0.84[188] |
28 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [189] | 1.75[190] | 1.39[191] | 0.94[192] | 2.55[193] | 1.83[194] | 3.66[195] |
29 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [196] | 0.66[197] | 0.85[198] | 1.07[199] | 0.48[200] | 0.86[201] | -0.12[202] |
30 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [203] | -4.27[204] | -3.16[205] | -3.01[206] | -2.74[207] | -2.55[208] | -2.91[209] |
31 | SLK | STE20-like serine/threonine-protein kinase | [210] | -1.01[211] | 1.09[212] | 1.02[213] | 0.34[214] | 1.02[215] | 0.90[216] |
32 | ROCK2 | Rho-associated protein kinase 2 | [217] | 1.21[218] | 2.33[219] | 0.71[220] | 2.19[221] | 0.08[222] | 1.42[223] |
33 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [224] | 1.59[225] | 1.02[226] | 1.34[227] | 3.53[228] | 3.48[229] | 1.52[230] |
34 | ARHGAP2 | Rho GTPase-activating protein 21 | [231] | 0.30[232] | 1.16[233] | 1.95[234] | 2.67[235] | 1.53[236] | 1.22[237] |
35 | ARHGEF40 | Rho guanine nucleotide exchange factor 40 | [238] | 0.44[239] | 1.11[240] | -0.71[241] | 1.43[242] | 1.16[243] | 1.44[244] |
36 | ARHGAP3 | Rho GTPase-activating protein 35 | [245] | 2.08[246] | 2.09[247] | 2.54[248] | 2.29[249] | 1.98[250] | 2.75[251] |
37 | DLC1 | Rho GTPase-activating protein 7 | [252] | 2.05[253] | 1.58[254] | 0.80[255] | 0.43[256] | 1.03[257] | 1.89[258] |
38 | ANLN | Anillin | [259] | 0.81[260] | 2.27[261] | 2.36[262] | 2.96[263] | 3.50[264] | -2.25[265] |
39 | ARHGAP1 | Rho GTPase-activating protein 1 | [266] | 1.52[267] | 1.00[268] | 1.40[269] | 0.06[270] | 0.37[271] | 1.12[272] |
40 | ARHGAP5 | Rho GTPase-activating protein 5 | [273] | 2.15[274] | 1.63[275] | 4.84[276] | 2.12[277] | 1.83[278] | 2.63[279] |
41 | BCR | Breakpoint cluster region protein | [280] | 1.96[281] | 1.09[282] | 1.25[283] | 0.58[284] | 1.06[285] | 1.19[286] |
42 | PKN2 | Serine/threonine-protein kinase N2 | [287] | 0.70[288] | 1.88[289] | 1.89[290] | 1.71[291] | 1.66[292] | 1.33[293] |
43 | AKAP13 | A-kinase anchor protein 13 | [294] | 1.48[295] | 0.48[296] | 1.35[297] | 2.26[298] | 1.99[299] | 3.63[300] |
44 | FMNL2 | Formin-like protein 2 | [301] | 1.88[302] | 2.91[303] | 1.47[304] | 1.66[305] | 0.33[306] | -0.21[307] |
45 | MCAM | Cell surface glycoprotein MUC18 | [308] | 3.15[309] | 0.26[310] | -1.84[311] | 3.83[312] | 1.15[313] | -0.28[314] |
46 | MYO9B | Unconventional myosin-IXb | [315] | 2.03[316] | 1.49[317] | 3.01[318] | 1.86[319] | 2.13[320] | 1.85[321] |
47 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | [322] | 0.10[323] | 0.99[324] | 0.07[325] | 0.37[326] | 0.53[327] | 1.45[328] |
48 | RACGAP1 | Rac GTPase-activating protein 1 | [329] | 1.83[330] | 2.18[331] | 2.33[332] | 2.73[333] | 3.40[334] | -1.22[335] |
49 | DEPDC1B | DEP domain-containing protein 1B | [336] | 0.91[337] | 2.33[338] | 2.46[339] | 0.56[340] | 1.22[341] | -3.50[342] |
50 | STARD13 | StAR-related lipid transfer protein 13 | [343] | -0.34[344] | 0.93[345] | 0.12[346] | -0.91[347] | 0.66[348] | 1.14[349] |
51 | DIAPH3 | Protein diaphanous homolog 3 | [350] | -0.31[351] | 0.66[352] | 1.05[353] | 1.12[354] | 2.09[355] | -3.10[356] |
52 | STK10 | Serine/threonine-protein kinase 10 | [357] | 1.44[358] | 0.79[359] | -0.34[360] | 0.98[361] | 1.28[362] | 1.02[363] |
53 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [364] | 1.78[365] | 1.77[366] | 1.37[367] | 2.82[368] | 2.23[369] | 2.08[370] |
54 | PKN3 | Serine/threonine-protein kinase N3 | [371] | 1.78[372] | 1.44[373] | 0.95[374] | 0.86[375] | 1.18[376] | -1.23[377] |
55 | MCF2L | Guanine nucleotide exchange factor DBS | [378] | 2.01[379] | 2.08[380] | -0.21[381] | -5.06[382] | -8.17[383] | 1.00[384] |
56 | ARHGAP2 | Rho GTPase-activating protein 26 | [385] | 2.40[386] | 2.62[387] | 1.05[388] | 1.35[389] | 1.44[390] | 1.77[391] |
57 | ABR | Active breakpoint cluster region-related protein | [392] | 3.69[393] | 3.14[394] | 2.58[395] | 2.99[396] | 3.81[397] | 1.33[398] |
58 | VANGL1 | Vang-like protein 1 | [399] | 2.70[400] | 2.02[401] | 1.36[402] | 3.77[403] | 3.56[404] | 2.19[405] |
59 | OPHN1 | Oligophrenin-1 | [406] | 1.45[407] | 1.34[408] | 1.83[409] | 2.74[410] | 1.43[411] | 4.23[412] |
60 | ARHGEF25 | Rho guanine nucleotide exchange factor 25 | [413] | 2.76[414] | 3.83[415] | 2.92[416] | 0.94[417] | 2.67[418] | -0.57[419] |
61 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -0.68[420] | -6.63[421] | -4.41[422] | 4.67[423] | 3.13[424] | 3.70[425] | |
62 | IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | [426] | 3.51[427] | 4.37[428] | 3.74[429] | 4.31[430] | 5.61[431] | 0.44[432] |
63 | ARHGAP3 | Rho GTPase-activating protein 32 | [433] | 3.46[434] | 3.14[435] | 2.12[436] | 4.03[437] | 2.71[438] | 3.66[439] |
64 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [440] | -4.27[441] | -3.92[442] | -4.97[443] | 2.67[444] | 3.66[445] | 1.36[446] |
65 | ARHGAP3 | Rho GTPase-activating protein 39 | [447] | 2.68[448] | 2.43[449] | 2.33[450] | 2.29[451] | 0.70[452] | 0.24[453] |
66 | CIT | Citron Rho-interacting kinase | [454] | 3.99[455] | 4.35[456] | 5.19[457] | 4.85[458] | 5.59[459] | 1.54[460] |
67 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [461] | 4.93[462] | 5.46[463] | 4.03[464] | 7.31[465] | 5.22[466] | 3.83[467] |
68 | FMNL3 | Formin-like protein 3 | [468] | 2.37[469] | 2.04[470] | 2.83[471] | 3.13[472] | 5.00[473] | 3.55[474] |
69 | MCF2 | Proto-oncogene DBL | [475] | [476] | [477] | [478] | [479] | [480] | [481] |
70 | MACO1 | [482] | [483] | [484] | [485] | [486] | [487] | [488] | |
71 | ARHGEF28 | Rho guanine nucleotide exchange factor 28 | [489] | [490] | [491] | [492] | [493] | [494] | [495] |
72 | ERBIN | Erbin | [496] | [497] | [498] | [499] | [500] | [501] | [502] |
73 | CCDC187 | Coiled-coil domain-containing protein 187 | [503] | [504] | [505] | [506] | [507] | [508] | [509] |
74 | CAVIN1 | Caveolae-associated protein 1 | [510] | [511] | [512] | [513] | [514] | [515] | [516] |